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Free Radicals In Synthesis And Biology
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Book Synopsis Free Radicals in Synthesis and Biology by : F. Minisci
Download or read book Free Radicals in Synthesis and Biology written by F. Minisci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free-radical reactions have been for long time the domain of the physical chemists and the basic chemical industry (polymerization of vinyl monomers, oxidation by molecular oxygen, chlorination of methane etc.), where the use of simple molecules and the possibility of partial conversions without heavy problems of product separations makes less dramatic the aspects of regio and chemoselectivity. As synonym of unselectivity, free radical reactions were considered of poor use in the synthesis of fine chemicals or sophisticated molecules, where a high selectivity is an essential condition for the success, or in the involvement of biological processes. Within the last 15 years, however, an authentic explosion of synthetic applications of free radical reactions occurred; they have gained a remarkable position among the selective methods of synthesis. At the same time the great importance of free radical reactions in fundamental biological processes and in the metabolism of drugs has been recognized. Thus a specialized meeting on these topics was generally felt appropriate. I had the honour and the onus to organize this workshop because for more than 30 years I have been involved in the research of free radical reactions. Thanks to a generous grant from NATO Scientific Affairs Division and the financial support of CNR and chemical industry (Montedison, Enichem, Zambon) such a meeting among almost 50 specialists and 15 observers of sufficient standard to take advantage of the discussion, became possible at Bardolino (Italy).
Book Synopsis Free Radicals in Synthesis and Biology by : F Minisci
Download or read book Free Radicals in Synthesis and Biology written by F Minisci and published by . This book was released on 1988-12-31 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Free Radicals in Biology and Medicine by : Barry Halliwell
Download or read book Free Radicals in Biology and Medicine written by Barry Halliwell and published by OUP Oxford. This book was released on 2015-08-21 with total page 961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Book Synopsis Free Radicals in Chemistry, Biology and Medicine by : Toshikazu Yoshikawa
Download or read book Free Radicals in Chemistry, Biology and Medicine written by Toshikazu Yoshikawa and published by . This book was released on 2000 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advanced Free Radical Reactions for Organic Synthesis by :
Download or read book Advanced Free Radical Reactions for Organic Synthesis written by and published by Elsevier. This book was released on 2004-01-14 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radical reactions have become increasingly important and a very attractive tool in organic synthesis in the last two decades, due to their powerful, selective, specific, and mild reaction abilities. Advanced Free Radical Reactions for Organic Synthesis reviews information on all types of practical radical reactions, e.g. cyclizations, additions, hydrogen-atom abstractions, decarboxylation reactions. The book usefully provides experimental details for the most important reactions as well as numerous references to the original literature. By covering both the fundamentals and synthetic applications it is therefore suitable for both new and experienced researchers, chemists, biochemists, natural product chemists and graduate students. This title is the definitive guide to radical chemistry for all scientists. Introduces and reviews the use of radicals to perform synthetic transformations Practical details are provided for the most important methods Numerous references to the original literature
Book Synopsis Free Radicals in Biology and Environment by : F. Minisci
Download or read book Free Radicals in Biology and Environment written by F. Minisci and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the quantitative aspects of free radical chemistry and the involvement of radicals in such areas as biology, medicine, the environment, etc., has developed spectacularly over recent years, yet the various topics are commonly discussed separately, in specific meetings and specialised publications. Free Radicals in Biology and Environment draws together two important areas of free radical chemistry, using as a bridge the fundamental physical chemistry of free radicals (spectroscopic detection of free radicals, evaluation of absolute rate constants, elucidation of mechanisms of free radical reactions and catalysis, photochemical and radiation processes, etc.). The most relevant topics covered are the EPR detection of radicals in biochemical systems and in pollutant formation and degradation, oxidation processes in biology and in the troposphere, radiation and induced damage, and atmospheric pollutants arising from incomplete combustion. Also covered are the chemistry and biochemistry of nitric oxide and peroxynitrite, the chemistry and biochemistry of DNA radicals, the role of radicals in myeloperoxidase, lignineperoxidase, radicals and cardiovascular injury, radiation and the fragmentation of cells and tissues.
Book Synopsis Techniques in Free Radical Research by : A.T. Diplock
Download or read book Techniques in Free Radical Research written by A.T. Diplock and published by Elsevier. This book was released on 1991-12-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.
Book Synopsis Free Radicals and Oxidation Phenomena in Biological Systems by : Roberfroid
Download or read book Free Radicals and Oxidation Phenomena in Biological Systems written by Roberfroid and published by CRC Press. This book was released on 1994-12-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work offers an analysis of the biological processes mediated by free radicals, from a toxicological point of view, providing easy access to information in an integrated, coherent presentation. The chemistry and biochemistry of all principal types of radical are explained, and the multiple forms in whch radicals participate in living organisms are investigated.;This work should be of use to biochemists, pharmacologists, pharmaceutical researchers, food scientists and technologists, nutritionists, toxicologists, chemists, biologists and graduate students in these disciplines.
Book Synopsis Free Radicals in Chemistry and Biology by : Milan Lazar
Download or read book Free Radicals in Chemistry and Biology written by Milan Lazar and published by CRC Press. This book was released on 1989-03-31 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elementary radical reactions are described in terms of fundamental knowledge of organic chemistry and chemical physics in this valuable reference text. The complex radical processes of nonchain and chain mechanisms, such as dimerization, alkylation, polymerization, telomerization, halogenation pyrolysis, oxidation and combustion, are complemented by reactions in chemical lasers and in the cosmos, as well as by reactions in biological objects under normal or pathological metabolism. The text also provides the synthesis of facts from various fields of research and involves mechanisms where free radicals appear either as main or side intermediates in one of the several alternatives of the reaction pathway. Highlights include 38 tables and 39 figures.
Book Synopsis Free Radicals in Biology V5 by : William Pryor
Download or read book Free Radicals in Biology V5 written by William Pryor and published by Elsevier. This book was released on 2012-12-02 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free Radicals in Biology, Volume V covers the mechanisms for the generation of free radicals. This volume contains eight chapters that discuss the biology and chemistry of oxy-radicals in mitochondria and the radical-mediated metabolism of xenobiotics. The opening chapter describes the mechanisms of free radical production in enzymatically promoted lipid peroxidation, generally in microsomes or microsomal lipids. The subsequent chapters explore the biochemistry and biology of plant and animal lipoxygenases; the production of superoxide and hydrogen peroxide in mitochondria; and the biological role of these species in mitochondria and related systems. The discussions then shift to the effects of superoxide production in white blood cells, with an emphasis on an evaluation of the oxygen-dependent reactions of the important phagocytic cells, the monocytes, and the polymorphonuclear leukocytes. This volume further covers the formation and the role of oxy-radicals in the red blood cell, which is a very useful system for studying the protection of biological tissue against radical-mediated damage. A chapter presents a comprehensive review of the production of free radicals during the metabolism of xenobiotics. The last chapters provide an overview of the enzymology, biological functions, and free radical chemistry of glutathione peroxidase. These chapters also examine a number of gerontological principles and the effect of antioxidants in aging. Chemists, biologists, and physicists will find this book of great value.
Book Synopsis An Introduction to Free Radical Chemistry by : Andrew F. Parsons
Download or read book An Introduction to Free Radical Chemistry written by Andrew F. Parsons and published by Wiley-Blackwell. This book was released on 2000-11-30 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past twenty years has seen an explosion of interest in free radicals, as their pivotal role in both chemistry and biology has come to light. This introductory textbook aims to capture this excitement for advanced level undergraduates, with particular emphasis on the importance of radical reactions in organic synthesis. The book provides a gentle, stepwise introduction to the subject, taking the student from the basic principles of radical reactions through to their applications in industry and their role in biological and environmental processes, allowing the relevance of the subject to be grasped more easily. Suitable for advanced level undergraduates and postgraduates in chemistry and biochemistry, the book will also be invaluable for research level scientists requiring an update in the area.
Book Synopsis Free Radicals in Biology V1 by : William Pryor
Download or read book Free Radicals in Biology V1 written by William Pryor and published by Elsevier. This book was released on 2012-12-02 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free Radicals in Biology, Volume 1, provides an introduction to some of the basic concepts of free radical biology. The book emerged from the President's Symposium of the American Society for Experimental Pathology held in Atlantic City in April 1970. The book's opening chapter introduces a mechanistic view of free radical reactions using examples from biological systems. This is followed by a discussion of autoxidative damage to lipids in membranes. Some of the special chemistry of lipid oxidation are presented, and a number of novel ideas are suggested. The third chapter deals with the uses of electron-spin resonance in biology. Spin labeling is also discussed, which is one of the most useful methods of probing the chemical and physical environment of molecules in cells. The remaining chapters cover free radicals which occur in photosynthesis and the importance of the enzyme, superoxide dismutase. The study of the occurrence and reactions of this enzyme provides an important and extensive body of data clearly pointing to the significance of free radicals in cellular chemistry.
Book Synopsis Encyclopedia of Radicals in Chemistry, Biology and Materials by : Chryssostomos Chatgilialoglu
Download or read book Encyclopedia of Radicals in Chemistry, Biology and Materials written by Chryssostomos Chatgilialoglu and published by Wiley. This book was released on 2012-02-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting the growing applications of free radicals in key chemical, biological and medical processes Over the last two decades the application of free radicals in organic synthesis, materials science and life science has steadily increased, this Encyclopedia presents methodologies and mechanisms involving free radicals of chemical and biological research, including applications in materials science and medicine. The aim of this Encyclopedia is to offer for the first time a description of free radicals within an interdisciplinary and multidisciplinary context, connecting structural characteristics and chemical properties to their applications in different areas of chemistry and related disciplines. It covers not only basic concepts and chemical synthesis, but also touches on various aspects concerning the role of free radicals in materials and life sciences. The reader will find a balanced contribution of topics related to free radicals covering for example, their role in proteomics, genomics and lipidomics as well as their enormous potential in synthesis and technology. Covers topical areas such as: Alzheimer's disease and antioxidants in food within medicine and life sciences Synthesis and catalysis, combustion and atmospheric chemistry within chemistry Ageing and signalling in biological processes Of interest to anybody working in the field of free radicals in the broadest sense. It will address scientists who want to enter the interdisciplinary field of free radicals. In particular, it is aimed primarily at chemists and life science researchers who want to gain a wider and deeper understanding of free radicals which will allow them to apply free radicals in their own scientific field. The book consists of four themed volumes: Basic Concepts & Methodologies Synthetic Strategies & Applications Chemical Biology Polymers & Materials Online Edition Encyclopedia of Radicals in Chemistry, Biology and Materials is also available online, click here for more details: http://onlinelibrary.wiley.com/book/10.1002/9781119953678
Download or read book Free Radicals written by Gerald M. Rosen and published by Oxford University Press, USA. This book was released on 1999-12-02 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radicals play key roles in physiologic regulation and in many degenerative and pathologic processes, making them a fertile area of research. This book focuses on spin trapping, a sophisticated technique for the identification of free radicals in biological systems. The method is complex, and this book offers an in-depth guide to all of the critical aspects needed for its application to free radicals in biology. This includes advice on interpreting results, trouble-shooting, and experimental designs.
Book Synopsis Free Radicals in Biology V4 by : William Pryor
Download or read book Free Radicals in Biology V4 written by William Pryor and published by Elsevier. This book was released on 2012-12-02 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free Radicals in Biology, Volume IV reviews diverse topics in free radical biology and covers topics ranging from radiation biology to lipid peroxidation, radical-mediated liver pathology, and chemical carcinogenesis. Radical mechanisms in prostaglandin biochemistry are also discussed, along with the use of electron spin resonance and spin trap methods to probe mechanisms of radical reactions in biological systems. Comprised of 10 chapters, this volume begins with an overview of the mechanisms of lipid peroxidation, focusing on the chemistry of fluorescent products from in vivo lipid peroxidation; the production of pentane in the expired breath of animals exposed to oxidative threats; and the chemistry of the enzyme glutathione peroxidase. The next chapter is devoted to the kinetic aspects of lipid peroxidation and the multiple ways in which autoxidants can react. The reader is then introduced to the mechanisms of hepatoxicity by synthetic chemicals present in the environment, together with direct mechanisms of radiation damage to nucleic acids. Subsequent chapters deal with spin trapping in biological systems; the role of free radicals in arylamine carcinogenesis and their influence on the structure and reactivity of melanins; and the involvement of vitamin ? and lipid antioxidants in free-radical-initiated reactions. This book will be of value to chemists, biologists, and physicians.
Book Synopsis Encyclopedia of Radicals in Chemistry, Biology and Materials by : Chryssostomos Chatgilialoglu
Download or read book Encyclopedia of Radicals in Chemistry, Biology and Materials written by Chryssostomos Chatgilialoglu and published by Wiley. This book was released on 2012-02-20 with total page 2324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting the growing applications of free radicals in key chemical, biological and medical processes Over the last two decades the application of free radicals in organic synthesis, materials science and life science has steadily increased, this Encyclopedia presents methodologies and mechanisms involving free radicals of chemical and biological research, including applications in materials science and medicine. The aim of this Encyclopedia is to offer for the first time a description of free radicals within an interdisciplinary and multidisciplinary context, connecting structural characteristics and chemical properties to their applications in different areas of chemistry and related disciplines. It covers not only basic concepts and chemical synthesis, but also touches on various aspects concerning the role of free radicals in materials and life sciences. The reader will find a balanced contribution of topics related to free radicals covering for example, their role in proteomics, genomics and lipidomics as well as their enormous potential in synthesis and technology. Covers topical areas such as: Alzheimer's disease and antioxidants in food within medicine and life sciences Synthesis and catalysis, combustion and atmospheric chemistry within chemistry Ageing and signalling in biological processes Of interest to anybody working in the field of free radicals in the broadest sense. It will address scientists who want to enter the interdisciplinary field of free radicals. In particular, it is aimed primarily at chemists and life science researchers who want to gain a wider and deeper understanding of free radicals which will allow them to apply free radicals in their own scientific field. The book consists of four themed volumes: Basic Concepts & Methodologies Synthetic Strategies & Applications Chemical Biology Polymers & Materials Online Edition Encyclopedia of Radicals in Chemistry, Biology and Materials is also available online, click here for more details: http://onlinelibrary.wiley.com/book/10.1002/9781119953678
Book Synopsis Free Radical Medicine and Biology by :
Download or read book Free Radical Medicine and Biology written by and published by BoD – Books on Demand. This book was released on 2020-07-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although free radicals perform some useful immune functions, they can also damage healthy cells through a process called oxidation. Antioxidants reduce the effect of free radicals by binding together with these harmful molecules, decreasing their destructive power. This book highlights various issues of free radical biology from the perspective of antioxidant defense mechanisms. It also provides useful information on gene modulation, radiation-generated reactive oxygen species-induced apoptosis in cancer, and environmental aspects associated with free radicals’ exposure on living systems.
