Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Free Radical And Radiation Induced Damage To Dna full books in PDF, epub, and Kindle. Read online Free Radical And Radiation Induced Damage To Dna ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : D. Schulte-Frohlinde
Publisher : CRC Press
ISBN 13 : 9783718648740
Total Pages : 138 pages
Book Rating : 4.6/5 (487 download)
Download or read book Free-Radical and Radiation-Induced Damage to DNA written by D. Schulte-Frohlinde and published by CRC Press. This book was released on 1989 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Clemens Sonntag
Publisher : Springer Science & Business Media
ISBN 13 : 3540305920
Total Pages : 523 pages
Book Rating : 4.5/5 (43 download)
Download or read book Free-Radical-Induced DNA Damage and Its Repair written by Clemens Sonntag and published by Springer Science & Business Media. This book was released on 2006-03-20 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Author :
Publisher :
ISBN 13 :
Total Pages : 84 pages
Book Rating : 4.:/5 (354 download)
Download or read book Free-radical- and Radiation-induced Damage to DNA written by and published by . This book was released on 1989 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Lett
Publisher :
ISBN 13 : 9780120354146
Total Pages : 348 pages
Book Rating : 4.3/5 (541 download)
Download or read book Relative Radiation Sensitivities of Human Organ Systems written by John Lett and published by . This book was released on 1990 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emph ...
Author : John T. Lett
Publisher : Academic Press
ISBN 13 : 1483282279
Total Pages : 520 pages
Book Rating : 4.4/5 (832 download)
Download or read book DNA and Chromatin Damage Caused by Radiation written by John T. Lett and published by Academic Press. This book was released on 2013-10-22 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Radiation Biology, Volume 17: DNA and Chromatin Damage Caused by Radiation outlines the different biological reactions to radiation. This book discusses the linear energy transfer and energy loss; DNA breaks and track structure; DNA radicals from water radicals; and radiation-induced strand breaks in isolated DNA. The radiation damage to DNA and its nearby environment; thiol radioprotectors and mechanism of action; radiolysis of water and track reactions; and computer simulation of higher order structure of DNA are also elaborated. This publication likewise covers the concept of chromatin structure; DNA supercoiling studied by sedimentation; measurement of radiation-induced DNA breakage; and analysis of damage in interphase cells. This volume is a useful reference to biologists and students concerned with DNA and chromatin damage caused by radiation.
Author : Clemens von Sonntag
Publisher : Springer
ISBN 13 : 9783540811398
Total Pages : 523 pages
Book Rating : 4.8/5 (113 download)
Download or read book Free-Radical-Induced DNA Damage and Its Repair written by Clemens von Sonntag and published by Springer. This book was released on 2009-09-02 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Author : John T. Lett
Publisher : Academic Press
ISBN 13 : 1483281892
Total Pages : 493 pages
Book Rating : 4.4/5 (832 download)
Download or read book Advances in Radiation Biology written by John T. Lett and published by Academic Press. This book was released on 2013-10-22 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Radiation Biology, Volume 9, provides an overview of the state of knowledge in radiation biology. The book contains nine chapters and begins with a study on the ways in which physical and chemical agents might trigger "regulatory dysfunction" and how these agents might interact with each other. This is followed by separate chapters on the mechanisms underlying changes in vascular function after doses of radiation in the therapeutic range and their role in the development of late effects in normal tissues; the future of hypoxic cell sensitizers in the clinical setting; DNA strand break formation by ionizing radiation; and major pathways which result in radiation-induced loss of cellular proliferative capacity. Subsequent chapters deal with the solid-state radiation chemistry of DNA; radiosensitivity of proliferating mammalian cells; the use of microwave/radiofrequency energy cancer treatment; and the decline of basic radiobiology.
Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher : National Academies Press
ISBN 13 : 0309133343
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)
Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Author : Antonio Monari
Publisher : Frontiers Media SA
ISBN 13 : 2889196607
Total Pages : 95 pages
Book Rating : 4.8/5 (891 download)
Download or read book Radiation-induced and oxidative DNA damages written by Antonio Monari and published by Frontiers Media SA. This book was released on 2015-10-02 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA stores and passes the genetic information of almost all living organisms. Its molecular structure and their intramolecular interactions are particularly suitable to maximize stability against oxidative stress and UV-light absorption. Yet the protection and repair strategies are still error-prone: DNA lesions are produced, including the most complex and highly mutagenic ones. An important threat to DNA stability comes from photosensitization, i.e. from the dramatic multiplication of radiation-induced defects mediated by the presence of organic or organometallic dyes compared to the direct exposure to UVA radiation. Moreover, the photo-induced production of singlet oxygen generates an extremely high oxidative stress on DNA that, in vivo, normally results in extended cellular apoptosis. Elucidating the processes leading to DNA damages, from the production of a simple radical entity to deleterious lesions, as well as the opportunities of repair by devoted enzymes, is a cornerstone towards the development of more efficient protection strategies. Sensitization and selective production of DNA lesions can also be exploited to induce the selective apoptosis of cancer cells upon exposition to radiation or to oxidative stress, for instance in the field of photodynamic therapy. The importance and relevance of the field is witnessed by the impressive amount of high-level papers dealing with this complex subject, and notably tackling the structural elucidation of DNA and DNA-drug adducts, the mechanisms of formation of DNA lesions (including the precise detection of the final lesion products), as well as the influence of the lesions on the DNA stability and dynamics and the consequences on the ease of repair. Due to the complexity of the field lying at the frontiers between chemistry, physics and biology, multidisciplinary strategies allying modeling and experience are needed. This topic aims at giving an extended overview of the current research in the domain, with fundamental contribution from the leading groups in the field of DNA reactivity, structural characterization, photo-chemistry and photo-physics, as well as repair mechanism. It will therefore be a fundamental guide for scientists wanting to address the field of DNA lesion and repair, but also more generally for researchers working in rational drug design or in the development of biomarkers and medical imaging techniques
Author : Alfred F. Fuciarelli
Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)
Download or read book Radiation Damage in DNA written by Alfred F. Fuciarelli and published by . This book was released on 1995 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Miral Dizdaroglu
Publisher : Springer Science & Business Media
ISBN 13 : 1461548659
Total Pages : 502 pages
Book Rating : 4.4/5 (615 download)
Download or read book Advances in DNA Damage and Repair written by Miral Dizdaroglu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.
Author : National Research Council
Publisher : National Academies
ISBN 13 : 0309039959
Total Pages : 436 pages
Book Rating : 4.3/5 (9 download)
Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Author : P. Howard-Flanders
Publisher :
ISBN 13 :
Total Pages : 10 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Effect of Nitric Oxide on the Radiosensitivity of Bacteria written by P. Howard-Flanders and published by . This book was released on 1957 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : E.M. Fielden
Publisher : Springer Science & Business Media
ISBN 13 : 3642751482
Total Pages : 437 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Early Effects of Radiation on DNA written by E.M. Fielden and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the biological effects of ionising radiation closely followed the identification of such radiation. The realisation that DNA is the site of genetic infonnation in cells subsequently focussed attention on DNA as an important target in the lethal and mutagenic effects of ionising radiation. Thus radiation effects upon DNA became an important area for fundamental scientific studies by radiation biologists, chemists and physicists. To a first approximation, the concerns of the three disciplines can be divided by time scales: the physical process of energy deposition from photon or charged 16 12 particle and subsequent relaxation (-10- to 10- secs), followed by chemical 12 2 reactions (- 10- to 10 secs), and fmally, the expression of biological effect (minutes to years). Thus, the concept of 'early processes' conveys different ideas to different scientists, although they are all interrelated. To attempt to describe in any detail all these processes is a mammoth task which is not made easier by the different conventions and experimental approaches of the three disciplines. However, the recent advances in all these scientific areas seemed, to the organisers at least, to offer the opportunity to stimulate more active interaction between physicists, chemists and biologists. With this in mind, a multi-disciplinary workshop was organised, which brought together some fifty scientists to present their own specialist interests and, through extensive discussion, explore which problems are of high priority and require input from the different disciplines to resolve them.
Author : Errol C. Friedberg
Publisher : American Society for Microbiology Press
ISBN 13 : 1555813194
Total Pages : 2587 pages
Book Rating : 4.5/5 (558 download)
Download or read book DNA Repair and Mutagenesis written by Errol C. Friedberg and published by American Society for Microbiology Press. This book was released on 2005-11-22 with total page 2587 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
Author : Colin J. Martin
Publisher : Oxford University Press, USA
ISBN 13 : 0199655219
Total Pages : 551 pages
Book Rating : 4.1/5 (996 download)
Download or read book Practical Radiation Protection in Healthcare written by Colin J. Martin and published by Oxford University Press, USA. This book was released on 2015 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide for medical physicists and those whose work involves any aspect of hospital radiation protection. It provides guidance on methods that may be used to tackle the tasks that a physicist working in this area might encounter.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309058953
Total Pages : 78 pages
Book Rating : 4.3/5 (9 download)
Download or read book An Evaluation of Radiation Exposure Guidance for Military Operations written by Institute of Medicine and published by National Academies Press. This book was released on 1997-10-28 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
