Botulinum Neurotoxins

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Publisher : Springer
ISBN 13 : 9783642448898
Total Pages : 0 pages
Book Rating : 4.4/5 (488 download)

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Book Synopsis Botulinum Neurotoxins by : Andreas Rummel

Download or read book Botulinum Neurotoxins written by Andreas Rummel and published by Springer. This book was released on 2015-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Myofibrillogenesis

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Publisher : Springer Science & Business Media
ISBN 13 : 9780817642266
Total Pages : 304 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Myofibrillogenesis by : Dipak K. Dube

Download or read book Myofibrillogenesis written by Dipak K. Dube and published by Springer Science & Business Media. This book was released on 2001-10-19 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.

Musculoskeletal Disorders and the Workplace

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Publisher : National Academies Press
ISBN 13 : 0309132991
Total Pages : 510 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Musculoskeletal Disorders and the Workplace by : Institute of Medicine

Download or read book Musculoskeletal Disorders and the Workplace written by Institute of Medicine and published by National Academies Press. This book was released on 2001-05-24 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.

First and Last Experiments in Muscle Mechanics

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis First and Last Experiments in Muscle Mechanics by : Archibald Vivian Hill

Download or read book First and Last Experiments in Muscle Mechanics written by Archibald Vivian Hill and published by . This book was released on 1970 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Disorders of Voluntary Muscle

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Publisher : Cambridge University Press
ISBN 13 : 9780521650625
Total Pages : 800 pages
Book Rating : 4.6/5 (56 download)

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Book Synopsis Disorders of Voluntary Muscle by : George Karpati

Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Multiple Muscle Systems

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Publisher : Springer Science & Business Media
ISBN 13 : 1461390303
Total Pages : 818 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Multiple Muscle Systems by : Jack M. Winters

Download or read book Multiple Muscle Systems written by Jack M. Winters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 818 pages. Available in PDF, EPUB and Kindle. Book excerpt: The picture on the front cover of this book depicts a young man pulling a fishnet, a task of practical relevance for many centuries. It is a complex task, involving load transmission throughout the body, intricate balance, and eye head-hand coordination. The quest toward understanding how we perform such tasks with skill and grace, often in the presence of unpredictable pertur bations, has a long history. However, despite a history of magnificent sculptures and drawings of the human body which vividly depict muscle ac tivity and interaction, until more recent times our state of knowledge of human movement was rather primitive. During the past century this has changed; we now have developed a considerable database regarding the com position and basic properties of muscle and nerve tissue and the basic causal relations between neural function and biomechanical movement. Over the last few decades we have also seen an increased appreciation of the impor tance of musculoskeletal biomechanics: the neuromotor system must control movement within a world governed by mechanical laws. We have now col lected quantitative data for a wealth of human movements. Our capacity to understand the data we collect has been enhanced by our continually evolving modeling capabilities and by the availability of computational power. What have we learned? This book is designed to help synthesize our current knowledge regarding the role of muscles in human movement. The study of human movement is not a mature discipline.

Biomechanics and Motor Control of Human Movement

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Publisher : John Wiley & Sons
ISBN 13 : 0470398183
Total Pages : 384 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Biomechanics and Motor Control of Human Movement by : David A. Winter

Download or read book Biomechanics and Motor Control of Human Movement written by David A. Winter and published by John Wiley & Sons. This book was released on 2009-10-12 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classic book on human movement in biomechanics, newly updated Widely used and referenced, David Winter's Biomechanics and Motor Control of Human Movement is a classic examination of techniques used to measure and analyze all body movements as mechanical systems, including such everyday movements as walking. It fills the gap in human movement science area where modern science and technology are integrated with anatomy, muscle physiology, and electromyography to assess and understand human movement. In light of the explosive growth of the field, this new edition updates and enhances the text with: Expanded coverage of 3D kinematics and kinetics New materials on biomechanical movement synergies and signal processing, including auto and cross correlation, frequency analysis, analog and digital filtering, and ensemble averaging techniques Presentation of a wide spectrum of measurement and analysis techniques Updates to all existing chapters Basic physical and physiological principles in capsule form for quick reference An essential resource for researchers and student in kinesiology, bioengineering (rehabilitation engineering), physical education, ergonomics, and physical and occupational therapy, this text will also provide valuable to professionals in orthopedics, muscle physiology, and rehabilitation medicine. In response to many requests, the extensive numerical tables contained in Appendix A: "Kinematic, Kinetic, and Energy Data" can also be found at the following Web site: www.wiley.com/go/biomechanics

Fatigue

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Publisher : Springer Science & Business Media
ISBN 13 : 1489910166
Total Pages : 540 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Fatigue by : Patricia A. Pierce

Download or read book Fatigue written by Patricia A. Pierce and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the current state of our knowledge on the neurobiology of muscle fatigue, with consideration also given to selected integrative cardiorespiratory mechanisms. Our charge to the authors of the various chapters was twofold: to provide a systematic review of the topic that could serve as a balanced reference text for practicing health-care professionals, teaching faculty, and pre-and postdoctoral trainees in the biomedi cal sciences; and to stimulate further experimental and theoretical work on neurobiology. Key issues are addressed in nine interrelated areas: fatigue of single muscle fibers, fatigue at the neuromuscular junction, fatigue of single motor units, metabolic fatigue studied with nuclear magnetic resonance, fatigue of the segmental motor system, fatigue involving suprasegmental mechanisms, the task dependency of fatigue mechanisms, integrative (largely cardiorespiratory) systems issues, and fatigue of adapted systems (due to aging, under-and overuse, and pathophysiology). The product is a volume that provides compre of processes that operate from the forebrain to the contractile proteins.

Anatomy & Physiology

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Publisher :
ISBN 13 : 9781955101158
Total Pages : pages
Book Rating : 4.1/5 (11 download)

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Book Synopsis Anatomy & Physiology by : Lindsay Biga

Download or read book Anatomy & Physiology written by Lindsay Biga and published by . This book was released on 2019-09-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A version of the OpenStax text

Anatomy and Physiology

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Publisher :
ISBN 13 : 9781947172807
Total Pages : 0 pages
Book Rating : 4.1/5 (728 download)

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Book Synopsis Anatomy and Physiology by : J. Gordon Betts

Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomechanics of Skeletal Muscles

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Publisher : Human Kinetics
ISBN 13 : 1492582107
Total Pages : 543 pages
Book Rating : 4.4/5 (925 download)

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Book Synopsis Biomechanics of Skeletal Muscles by : Vladimir M. Zatsiorsky

Download or read book Biomechanics of Skeletal Muscles written by Vladimir M. Zatsiorsky and published by Human Kinetics. This book was released on 2012-04-10 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Richly illustrated and presented in clear, concise language, Biomechanics of Skeletal Muscles is an essential resource for those seeking advanced knowledge of muscle biomechanics. Written by leading experts Vladimir Zatsiorsky and Boris Prilutsky, the text is one of the few to look at muscle biomechanics in its entirety—from muscle fibers to muscle coordination—making it a unique contribution to the field. Using a blend of experimental evidence and mechanical models, Biomechanics of Skeletal Muscles provides an explanation of whole muscle biomechanics at work in the body in motion. The book first addresses the mechanical behavior of single muscles—from the sarcomere level up to the entire muscle. The architecture of human muscle, the mechanical properties of tendons and passive muscles, the biomechanics of active muscles, and the force transmission and shock absorption aspects of muscle are explored in detail. Next, the various issues of muscle functioning during human motion are addressed. The transformation from muscle force to joint movements, two-joint muscle function, eccentric muscle action, and muscle coordination are analyzed. This advanced text assumes some knowledge of algebra and calculus; however, the emphasis is on understanding physical concepts. Higher-level computational descriptions are placed in special sections in the later chapters of the book, allowing those with a strong mathematical background to explore this material in more detail. Readers who choose to skip over these sections will find that the book still provides a strong conceptual understanding of advanced topics. Biomechanics of Skeletal Muscles also contains numerous special features that facilitate readers’ comprehension of the topics presented. More than 300 illustrations and accompanying explanations provide an extensive visual representation of muscle biomechanics. Refresher sidebars offer brief reminders of mathematical and biomechanical concepts, and From the Literature sidebars present practical examples that illustrate the concepts under discussion. Chapter summaries and review questions provide an opportunity for reflection and self-testing, and reference lists at the end of each chapter provide a starting point for further study. Biomechanics of Skeletal Muscles offers a thorough explanation of whole muscle biomechanics, bridging the gap between foundational biomechanics texts and scientific literature. With the information found in this text, readers can prepare themselves to better understand the latest in cutting-edge research. Biomechanics of Skeletal Muscles is the third volume in the Biomechanics of Human Motion series. Advanced readers in human movement science gain a comprehensive understanding of the biomechanics of human motion as presented by one of the world’s foremost researchers on the subject, Dr. Vladimir Zatsiorsky. The series begins with Kinematics of Human Motion, which details human body positioning and movement in three dimensions; continues with Kinetics of Human Motion, which examines the forces that create body motion and their effects; and concludes with Biomechanics of Skeletal Muscles, which explains the action of the biological motors that exert force and produce mechanical work during human movement.

Molecular Biology of the Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Muscle and Exercise Physiology

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Publisher : Academic Press
ISBN 13 : 0128145943
Total Pages : 619 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Muscle and Exercise Physiology by : Jerzy A. Zoladz

Download or read book Muscle and Exercise Physiology written by Jerzy A. Zoladz and published by Academic Press. This book was released on 2018-11-05 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscle and Exercise Physiology is a comprehensive reference covering muscle and exercise physiology, from basic science to advanced knowledge, including muscle power generating capabilities, muscle energetics, fatigue, aging and the cardio-respiratory system in exercise performance. Topics presented include the clinical importance of body responses to physical exercise, including its impact on oxygen species production, body immune system, lipid and carbohydrate metabolism, cardiac energetics and its functional reserves, and the health-related effects of physical activity and inactivity. Novel topics like critical power, ROS and muscle, and heart muscle physiology are explored. This book is ideal for researchers and scientists interested in muscle and exercise physiology, as well as students in the biological sciences, including medicine, human movements and sport sciences. - Contains basic and state-of-the-art knowledge on the most important issues of muscle and exercise physiology, including muscle and body adaptation to physical training, the impact of aging and physical activity/inactivity - Provides both the basic and advanced knowledge required to understand mechanisms that limit physical capacity in both untrained people and top class athletes - Covers advanced content on muscle power generating capabilities, muscle energetics, fatigue and aging

Handbook of Human Motion

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Author :
Publisher : Springer
ISBN 13 : 9783319144177
Total Pages : 0 pages
Book Rating : 4.1/5 (441 download)

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Book Synopsis Handbook of Human Motion by :

Download or read book Handbook of Human Motion written by and published by Springer. This book was released on 2018-04-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Human Motion is a large cross-disciplinary reference work which covers the many interlinked facets of the science and technology of human motion and its measurement. Individual chapters cover fundamental principles and technological developments, the state-of-the-art and consider applications across four broad and interconnected fields; medicine, sport, forensics and animation. The huge strides in technological advancement made over the past century make it possible to measure motion with unprecedented precision, but also lead to new challenges. This work introduces the many different approaches and systems used in motion capture, including IR and ultrasound, mechanical systems and video, plus some emerging techniques. The large variety of techniques used for the study of motion science in medicine can make analysis a complicated process, but extremely effective for the treatment of the patient when well utilised. The handbook descri bes how motion capture techniques are applied in medicine, and shows how the resulting analysis can help in diagnosis and treatment. A closely related field, sports science involves a combination of in-depth medical knowledge and detailed understanding of performance and training techniques, and motion capture can play an extremely important role in linking these disciplines. The handbook considers which technologies are most appropriate in specific circumstances, how they are applied and how this can help prevent injury and improve sporting performance. The application of motion capture in forensic science and security is reviewed, with chapters dedicated to specific areas including employment law, injury analysis, criminal activity and motion/facial recognition. And in the final area of application, the book describes how novel motion capture techniques have been designed specifically to aid the creation of increasingly realistic animation within films and v ideo games, with Lord of the Rings and Avatar just two examples. Chapters will provide an overview of the bespoke motion capture techniques developed for animation, how these have influenced advances in film and game design, and the links to behavioural studies, both in humans and in robotics. Comprising a cross-referenced compendium of different techniques and applications across a broad field, the Handbook of Human Motion provides the reader with a detailed reference and simultaneously a source of inspiration for future work. The book will be of use to students, researchers, engineers and others working in any field relevant to human motion capture.

Skeletal Muscle Circulation

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Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041834
Total Pages : 147 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Skeletal Muscle Circulation by : Ronald J. Korthuis

Download or read book Skeletal Muscle Circulation written by Ronald J. Korthuis and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References

Skeletal Muscle

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Author :
Publisher : Human Kinetics
ISBN 13 : 9780736045179
Total Pages : 436 pages
Book Rating : 4.0/5 (451 download)

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Book Synopsis Skeletal Muscle by : Brian R. MacIntosh

Download or read book Skeletal Muscle written by Brian R. MacIntosh and published by Human Kinetics. This book was released on 2006 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides readers with a detailed understanding of the different facets of muscle physiology. Examines motoneuron and muscle structure and function. It is intended for those need to know about skeletal muscle--from undergraduate and graduate students gaining advanced knowledge in kinesiology to physiotherapists, physiatrists, and other professionals whose work demands understanding of muscle form and function.

The Stretch-shortening Cycle of Active Muscle and Muscle-tendon Complex: What, Why and How It Increases Muscle Performance?

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889669939
Total Pages : 144 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis The Stretch-shortening Cycle of Active Muscle and Muscle-tendon Complex: What, Why and How It Increases Muscle Performance? by : Wolfgang Seiberl

Download or read book The Stretch-shortening Cycle of Active Muscle and Muscle-tendon Complex: What, Why and How It Increases Muscle Performance? written by Wolfgang Seiberl and published by Frontiers Media SA. This book was released on 2021-07-09 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: