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Flux Control In Biological Systems
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Book Synopsis Flux Control in Biological Systems by : Ernst-Detlef Schulze
Download or read book Flux Control in Biological Systems written by Ernst-Detlef Schulze and published by Academic Press. This book was released on 2012-12-02 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehending and modelling biomass production, nutrient, and water fluxes in biological systems requires understanding control mechanisms at various levels of organiztion. This new book, with 16 pages of four-colorplates, compares patterns and mechanisms of regulation-starting from enzyme reactions and ending at the population and ecosystem level. By doing so, the book investigates the general principles of how fluxes are adjusted and regulated. Such principles areessential for preparing effective models and for predicting human impacts on ecosystems. Flux Control in Biological Systems: From Enzymes to Populations and Ecosystems will be an essential personal library addition for student and professional environmental biologists, ecologists, physiologists, biochemists, botanists, microbiologists, soil scientists, and zoologists; as well as anyone who investigate patterns of matter and energy transfer in biological systems of different levels of complexity. * Presents the mechanisms of flux control * Explains the similarities of flux control at various levels of complexity and organization * Demonstrates how fluxes are adjusted in complex systems of interacting groups of organisms
Book Synopsis Modeling Biological Systems with Cybernetic Control Laws and Steady State Flux Distributions by : Kritika Kashyap
Download or read book Modeling Biological Systems with Cybernetic Control Laws and Steady State Flux Distributions written by Kritika Kashyap and published by . This book was released on 2019 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism is a process by which organisms extract energy from its environment to power itself. The interplay between cellular environment, nutrients present and the chemical reactions occurring within the organisms dictate the execution of metabolism. Single cell microbes, such as E. coli, P. putida and yeast, can be redesigned to be miniature chemical reactors that transform sugars and other carbon sources into biofuels. Enhancing bio-process conditions can stimulate the production of therapeutic proteins in mammalian cells. Hence, understanding the strategy of metabolism in organisms would help us build better technologies for controlling formation of end products like cell mass, biofuels,therapeutic proteins etc. Steady state flux analysis techniques have gained a lot of popularity in the field of systems biology due to successful qualitative analysis of large scale metabolic networks. This technique has been used to improve production of ethanol in Saccharomyces cerevisiae and lactic acid in Escherichia coli (E. coli), to name a few examples. Despite this success, its major shortcoming re-mains in providing quantitative measurements of metabolite profiles that can be further validated with experiments. Previous cybernetic models have accurately validated experimental results and described molecular processes governing metabolism, but their application is limited to small scale metabolic net-works. We have built a mathematical framework that combines solutions from steady state flux analysis with cybernetic principles to overcome the challenge of describing metabolic data for large scale metabolic networks. We have established computational models that can capture dynamic metabolic regulation in bacterial and mammalian cells. These models integrate chemical kinetics, mass balances, enzyme catalysis and stoichiometric laws to predict biology that can help us optimize cellular machinery towards bioproduct formation.
Book Synopsis A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems by : Vishwesh V. Kulkarni
Download or read book A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems written by Vishwesh V. Kulkarni and published by Springer. This book was released on 2014-07-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume II contains chapters contributed by leading researchers in the field of systems and synthetic biology that concern modeling physiological processes and bottom-up constructions of scalable biological systems. The modeling problems include characterisation and synthesis of memory, understanding how homoeostasis is maintained in the face of shocks and relatively gradual perturbations, understanding the functioning and robustness of biological clocks such as those at the core of circadian rhythms, and understanding how the cell cycles can be regulated, among others. Some of the bottom-up construction problems investigated in Volume II are as follows: How should biomacromolecules, platforms, and scalable architectures be chosen and synthesised in order to build programmable de novo biological systems? What are the types of constrained optimisation problems encountered in this process and how can these be solved efficiently? As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.
Book Synopsis Photosynthesis: Physiology and Metabolism by : Richard C. Leegood
Download or read book Photosynthesis: Physiology and Metabolism written by Richard C. Leegood and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photosynthesis: Physiology and Metabolism is the we have concentrated on the acquisition and ninth volume in theseries Advances in Photosynthesis metabolism of carbon. However, a full understanding (Series Editor, Govindjee). Several volumes in this of reactions involved in the conversion of to series have dealt with molecular and biophysical sugars requires an integrated view of metabolism. aspects of photosynthesis in the bacteria, algae and We have, therefore, commissioned international cyanobacteria, focussing largely on what have been authorities to write chapters on, for example, traditionally, though inaccurately, termed the ‘light interactionsbetween carbon and nitrogen metabolism, reactions’(Volume 1, The Molecular Biology of on respiration in photosynthetic tissues and on the Cyanobacteria;Volume2,AnoxygenicPhotosynthetic control of gene expression by metabolism. Photo- Bacteria, Volume 3, Biophysical Techniques in synthetic carbon assimilation is also one of the most Photosynthesis and Volume 7, The Molecular Biology rapid metabolic processes that occurs in plant cells, of the Chloroplasts and Mitochondria in Chlamy- and therefore has to be considered in relation to domonas). Volume 4 dealt with Oxygenic Photo- transport, whether it be the initial uptake of carbon, synthesis: The Light Reactions, and volume 5 with intracellular transport between organelles, inter- Photosynthesis and the Environment, whereas the cellular transport, as occurs in plants, or transport structure and function of lipids in photosynthesis of photosynthates through and out of the leaf. All was covered in Volume 6 of this series: Lipids in these aspects of transport are also covered in the Photosynthesis: Structure, Function and Genetics, book.
Book Synopsis Function and Regulation of Cellular Systems by : Andreas Deutsch
Download or read book Function and Regulation of Cellular Systems written by Andreas Deutsch and published by Birkhäuser. This book was released on 2012-12-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current biological research demands the extensive use of sophisticated mathematical methods and computer-aided analysis of experiments and data. This highly interdisciplinary volume focuses on structural, dynamical and functional aspects of cellular systems and presents corresponding experiments and mathematical models. The book may serve as an introduction for biologists, mathematicians and physicists to key questions in cellular systems which can be studied with mathematical models. Recent model approaches are presented with applications in cellular metabolism, intra- and intercellular signaling, cellular mechanics, network dynamics and pattern formation. In addition, applied issues such as tumor cell growth, dynamics of the immune system and biotechnology are included.
Book Synopsis Systems Biology in Practice by : Edda Klipp
Download or read book Systems Biology in Practice written by Edda Klipp and published by John Wiley & Sons. This book was released on 2008-07-15 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation. It provides readers with guidance on how a specific complex biological question may be tackled: - How to formulate questions that can be answered - Which experiments to perform - Where to find information in databases and on the Internet - What kinds of models are appropriate - How to use simulation tools - What can be learned from the comparison of experimental data and modeling results - How to make testable predictions. The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.
Book Synopsis World in Transition by : Wissenschaftlicher Beirat der Bundesregierung Globale Umweltveränderungen (Germany)
Download or read book World in Transition written by Wissenschaftlicher Beirat der Bundesregierung Globale Umweltveränderungen (Germany) and published by Earthscan. This book was released on 2001 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: * Comprehensive assessment from the leading German environmental scientists of the state of the world's living resources or biosphere * Covers all aspects of the subject: biodiversity and genetic diversity, landscape and ecosystems, its role in the Earth's system and human impacts on it * Reviews global policies and research strategies on the biosphere and advocates urgent policy actions * A major, authoritative contribution to environmental science and policy Biodiversity- the planet's natural capital- is undergoing a dramatic collapse: its " Sixth Extinction". The losses, which are do to human activities and overexploitation of the biosphere, are irreversible. They are undermining the basis of future well-being and prosperity, including genetic resources and food production, climate stability, and coastal and soil protection. The scientists of the German Advisory Council on Global Change have produced an authoritative and alarming analysis of the state of the biosphere. They show that the time remaining for remedial action is fast disappearing and they set out a range of initiatives to be undertaken at different levels. Among their main urgent recommendations are: * protecting 10-20% of the global land area * an Intergovernmental Panel on Biodiversity to provide scientific advice * conservation of the diversity of cultivated as well as wild plant species * greater multilateral cooperation and implementation of the Convention on Biological Diversity The volume makes a highly significant contribution to the scientific and policy debates on these critical issues. It will be essential reading for those engaged with them.
Book Synopsis Carbon Sequestration in the Biosphere by : Max A. Beran
Download or read book Carbon Sequestration in the Biosphere written by Max A. Beran and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anthropogenic release of carbon dioxide into the atmosphere has been recognized as the primary agent in global climate change. The volume discusses the possibilities for limiting that increase by the long-term storage of carbon in soils, vegetation, wetlands and oceans. Each of these storage media is analysed in detail to elucidate those processes responsible for the uptake and release of carbon. Several chapters address the practical prospects for deliberate interventions aimed at adjusting the balance in favour of uptake over release, i.e. sequestration, while having regard to simultaneous changes in the various environments.
Book Synopsis A First Course in Systems Biology by : Eberhard Voit
Download or read book A First Course in Systems Biology written by Eberhard Voit and published by Garland Science. This book was released on 2017-09-05 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling, then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way, it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks, understanding the modern literature, and launching into specialized courses or projects that address biological questions using theoretical and computational means. New topics in this edition include: default modules for model design, limit cycles and chaos, parameter estimation in Excel, model representations of gene regulation through transcription factors, derivation of the Michaelis-Menten rate law from the original conceptual model, different types of inhibition, hysteresis, a model of differentiation, system adaptation to persistent signals, nonlinear nullclines, PBPK models, and elementary modes. The format is a combination of instructional text and references to primary literature, complemented by sets of small-scale exercises that enable hands-on experience, and large-scale, often open-ended questions for further reflection.
Book Synopsis Asian Change in the Context of Global Climate Change by : James Galloway
Download or read book Asian Change in the Context of Global Climate Change written by James Galloway and published by Cambridge University Press. This book was released on 1998-09-28 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly two-thirds of the world's population live in Asia, and many countries in that region are currently undergoing very rapid industrial, agricultural and economic development. The Framework Convention on Climate Change constrains developed countries with regard to their future emissions of greenhouse gases, but recognizes the special needs of developing countries. There is growing appreciation of the ways in which developing countries in the Asian region both contribute to global changes (by altering biogeochemical pathways and cycles) and are themselves affected by those changes. This volume uses the intellectual efforts and findings of the International Geosphere-Biosphere Programme (IGBP) community to provide the first integrated analysis of the interactions between global change and Asian change, giving particular attention to China's role. The book will be of interest to readers in a wide range of academic disciplines (natural sciences and socio-economic) and for those involved in national and international policy development relevant to global change.
Book Synopsis Environmental Pollution and Plant Responses by : Shashi Bhushan Agrawal
Download or read book Environmental Pollution and Plant Responses written by Shashi Bhushan Agrawal and published by CRC Press. This book was released on 2023-01-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and global in scope, Environmental Pollution and Plant Responses provides an analysis of the research on the factors contributing to the deteriorating environmental quality and its effect on plant performance. The issues include: environmental pollution and global climate change, response patterns of plants at different levels, mechanisms of interaction, tolerance strategies and future research prospects. The author evaluates trends and gives management strategies for abating the problem. This volume highlights the complexities of environmental problems and the affect of pollution on every level of the ecosystem.
Book Synopsis Encyclopedia of Agrophysics by : Jan Gliński
Download or read book Encyclopedia of Agrophysics written by Jan Gliński and published by Springer Science & Business Media. This book was released on 2011-06-07 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Encyclopedia of Agrophysics will provide up-to-date information on the physical properties and processes affecting the quality of the environment and plant production. It will be a "first-up" volume which will nicely complement the recently published Encyclopedia of Soil Science, (November 2007) which was published in the same series. In a single authoritative volume a collection of about 250 informative articles and ca 400 glossary terms covering all aspects of agrophysics will be presented. The authors will be renowned specialists in various aspects in agrophysics from a wide variety of countries. Agrophysics is important both for research and practical use not only in agriculture, but also in areas like environmental science, land reclamation, food processing etc. Agrophysics is a relatively new interdisciplinary field closely related to Agrochemistry, Agrobiology, Agroclimatology and Agroecology. Nowadays it has been fully accepted as an agricultural and environmental discipline. As such this Encyclopedia volume will be an indispensable working tool for scientists and practitioners from different disciplines, like agriculture, soil science, geosciences, environmental science, geography, and engineering.
Book Synopsis Advances in Supramolecular Chemistry by : G.W. Gokel
Download or read book Advances in Supramolecular Chemistry written by G.W. Gokel and published by Elsevier. This book was released on 1997-09-22 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of a series which presents reports of efforts in all areas of supramolecular science, this volume discusses a variety of topics in the field.
Book Synopsis Systems Biology by : Isidore Rigoutsos
Download or read book Systems Biology written by Isidore Rigoutsos and published by . This book was released on 2006-09-14 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes.Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.
Book Synopsis Fermentation Microbiology and Biotechnology by : E. M. T. El-Mansi
Download or read book Fermentation Microbiology and Biotechnology written by E. M. T. El-Mansi and published by CRC Press. This book was released on 2011-12-12 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fermentation Microbiology and Biotechnology, Third Edition explores and illustrates the diverse array of metabolic pathways employed for the production of primary and secondary metabolites as well as biopharmaceuticals. This updated and expanded edition addresses the whole spectrum of fermentation biotechnology, from fermentation kinetics and dynam
Book Synopsis Metal Ions in Biological Systems by : Helmut Sigel
Download or read book Metal Ions in Biological Systems written by Helmut Sigel and published by . This book was released on 1984 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Terrestrial Biosphere and Global Change by : Brian Walker
Download or read book The Terrestrial Biosphere and Global Change written by Brian Walker and published by Cambridge University Press. This book was released on 1999-03-25 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarises understanding of global change interactions with terrestrial ecosystems.
