Fluorine

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Fluorine

Author : Alain Tressaud
Publisher : Academic Press
ISBN 13 : 0128129913
Total Pages : 271 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Fluorine by : Alain Tressaud

Download or read book Fluorine written by Alain Tressaud and published by Academic Press. This book was released on 2018-10-06 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine: A Paradoxical Element, Volume Five, deals with the link between fluorine, humanity and the environment. It is divided into three main sections, including i) The history and developmental stages of fluorinated products, ii) Awareness of its importance in our environment, and iii) Recent contributions of fluoride products in medicine, pharmacy and our daily lives. Made engaging through interesting figures and accessible language, and written by a leading expert, Professor Tressaud, the book supports the work of scientists working in materials, toxicology and environmental science. It complements the author’s edited series, Progress in Fluorine Science, covering recent advances. Describes background and contextual information regarding the history, development of understanding, and applications of this important element Explores the impacts of fluorine, both positive and negative, in the environment and biological systems Includes applied, real-world information from agencies, such as CNRS, NASA, HWS and DOH

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals

Author : Gunter Haufe
Publisher : Academic Press
ISBN 13 : 0128127341
Total Pages : 686 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals by : Gunter Haufe

Download or read book Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals written by Gunter Haufe and published by Academic Press. This book was released on 2018-09-19 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, volume four in Alain Tressaud’s Progress in Fluorine Science series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. Edited by recognized experts, this book provides unique coverage of the wide-ranging uses and implications of fluorine and fluorinated compounds. Topics include medicinal monitoring and diagnosis, 19F MRI in medicine and in vivo cell tracking, 18F-labeled radiopharmaceuticals, brain imaging and neurology, risk assessment of reactive metabolites in drug discovery, and more. Edited by Alain Tressaud, past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry who bring valuable and varied content to this active field. Covers a wide range of topics - from organic and physical chemistry, to pharmaceuticals, agrochemicals and medical diagnostics Describes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settings Features contributions from a wealth of global experts Acts as the fourth volume in Alain Tressaud’s Progress in Fluorine Science

Fluorine Chemistry

Author : J.H. Simons
Publisher : Elsevier
ISBN 13 : 0323142451
Total Pages : 804 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Fluorine Chemistry by : J.H. Simons

Download or read book Fluorine Chemistry written by J.H. Simons and published by Elsevier. This book was released on 2012-12-02 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine Chemistry, Volume IV provides an extensive survey and discussion on the physiological properties of fluoride ion and substances capable of producing it in aqueous solution. This book elaborates the detrimental effects of excessive fluoride ingestion, through the beneficial effects of optimal amounts, to recognized detrimental effects, such as dental caries accompanied by suboptimal fluoride intake. Fluoride metabolism is discussed in detail, including the capacity for storage of fluoride by the bones and rates of excretion of fluoride from the body. This text also covers the relation of fluoride ion to the health of teeth and bones. This publication is a good source for chemists and clinicians intending to acquire knowledge of the biological effects of fluoride.

Fluorine in Organic Chemistry

Author : Richard D. Chambers
Publisher : CRC Press
ISBN 13 : 9780849317903
Total Pages : 426 pages
Book Rating : 4.3/5 (179 download)

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Book Synopsis Fluorine in Organic Chemistry by : Richard D. Chambers

Download or read book Fluorine in Organic Chemistry written by Richard D. Chambers and published by CRC Press. This book was released on 2004 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: The introduction of carbon-fluorine bonds into organic compounds can profoundly influence their chemical and physical properties when compared to their non-fluorine-containing analogues, leading to a range of man-made materials with highly desirable properties. These molecules are of interest across the wide spectrum of industrial and academic organic chemistry, from pharmaceuticals, through fine and specialty chemicals to polymers. From Prozac to Teflon, many of the most important products of the chemical and life-science industries rely on organic fluorine chemistry for their useful properties. This book covers both the preparative methodologies and chemical properties of partially and highly fluorinated organic systems.

Fluorine

Author : Victor R Preedy
Publisher : Royal Society of Chemistry
ISBN 13 : 1782624929
Total Pages : 360 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Fluorine by : Victor R Preedy

Download or read book Fluorine written by Victor R Preedy and published by Royal Society of Chemistry. This book was released on 2015-04-17 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine is best known for its role in the prevention of cavities and in improving oral and bone health however equally there are millions of people around the world suffering from dental fluorosis due to chronic exposure to high levels of fluoride in drinking water. This volume, written by leading researchers in this area, examines the positives and negatives of fluorine and its effects on humans for example fluoride-induced oxidative stress in the liver, effects of fluoride on insulin and preventing fluoride toxicity. Extremely useful for underpinning cross-disciplinary fluorine research, this book provides a fascinating insight for those with an interest in the health and nutritional sciences.

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Author : Henri Groult
Publisher : Elsevier
ISBN 13 : 0128037903
Total Pages : 760 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Modern Synthesis Processes and Reactivity of Fluorinated Compounds by : Henri Groult

Download or read book Modern Synthesis Processes and Reactivity of Fluorinated Compounds written by Henri Groult and published by Elsevier. This book was released on 2016-11-04 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Efficient Preparations of Fluorine Compounds

Author : Herbert W. Roesky
Publisher : John Wiley & Sons
ISBN 13 : 1118409442
Total Pages : 490 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Efficient Preparations of Fluorine Compounds by : Herbert W. Roesky

Download or read book Efficient Preparations of Fluorine Compounds written by Herbert W. Roesky and published by John Wiley & Sons. This book was released on 2012-10-11 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to creating fluorine-based compounds—and the materials of tomorrow Discovered as an element by the French chemist Henri Moissan in 1886, through electrolysis of potassium fluoride in anhydrous hydrogen fluoride—"le fluor," or fluorine, began its chemical history as a substance both elusive and dangerous. With a slight pale yellow hue, fluorine is at room temperature a poisonous diatomic gas. Resembling a spirit from a chemical netherworld, fluorine is highly reactive, difficult to handle, yet very versatile as a reagent—with the power to form compounds with almost any other element. Comprising 20% of pharmaceutical products and 30% of agrochemical compounds, as well as playing a key role in electric cars, electronic devices, and space technology, compounds containing fluorine have grown in importance across the globe. Learning how to safely handle fluorine in the preparation of innovative new materials—with valuable new properties—is of critical importance to chemists today. Bringing together the research and methods of leading scientists in the fluorine field, Efficient Preparations of Fluorine Compounds is the definitive manual to creating, and understanding the reaction mechanisms integral to a wide variety of fluorine compounds. With sixty-eight contributed chapters, the book's extensive coverage includes: Preparation of Elemental Fluorine Synthesis Methods for Exotic Inorganic Fluorides with Varied Applications Introduction of Fluorine into Compounds via Electrophilic and Nucleophilic Reactions Direct Fluorination of Organic Compounds with Elemental Fluorine Efficient Preparations of Bioorganic Fluorine Compounds Asymmetric Fluorocyclization Reactions Preparations of Rare Earth Fluorosulfides and Oxyfluorosulfides The book offers methods and results that can be reproduced by students involved in advanced studies, as well as practicing chemists, pharmaceutical scientists, biologists, and environmental researchers. The only chemical resource of its kind, Efficient Preparations of Fluorine Compounds—from its first experiment to its last—is a unique window into the centuries old science of fluorine and the limitless universe of fluorine-based compounds.

Fluorine and Health

Author : Alain Tressaud
Publisher : Elsevier
ISBN 13 : 9780080558110
Total Pages : 816 pages
Book Rating : 4.5/5 (581 download)

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Book Synopsis Fluorine and Health by : Alain Tressaud

Download or read book Fluorine and Health written by Alain Tressaud and published by Elsevier. This book was released on 2008-06-06 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms. Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics

Guide to Fluorine NMR for Organic Chemists

Author : William R. Dolbier, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 1118831098
Total Pages : 472 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Guide to Fluorine NMR for Organic Chemists by : William R. Dolbier, Jr.

Download or read book Guide to Fluorine NMR for Organic Chemists written by William R. Dolbier, Jr. and published by John Wiley & Sons. This book was released on 2016-08-24 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following its well-received predecessor, this book offers an essential guide to chemists for understanding fluorine in spectroscopy. With over 1000 compounds and 100 spectra, the second edition adds new data – featuring fluorine effects on nitrogen NMR, chemical shifts, and coupling constants. • Explains how to successfully incorporate fluorine into target molecules and utilize fluorine substituents to structurally characterize organic compounds • Includes new data on nitrogen NMR, focusing on N-15, to portray the influence of fluorine upon nitrogen NMR chemical shifts and coupling constants • Expands on each chapter from the first edition with additional data and updated discussion from recent findings • "The flawless ordering of material covered in this stand-alone volume is such that information can be found very easily." – Angewandte Chemie review of the first edition, 2010

Fluorine Chemistry at the Millennium

Author : R.E. Banks
Publisher : Elsevier
ISBN 13 : 9780080531793
Total Pages : 660 pages
Book Rating : 4.5/5 (317 download)

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Book Synopsis Fluorine Chemistry at the Millennium by : R.E. Banks

Download or read book Fluorine Chemistry at the Millennium written by R.E. Banks and published by Elsevier. This book was released on 2000-12-04 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together contributions by leading researchers covering a wide scope so characteristic of fluorine chemistry. It is a monograph of historical character comprising personalized accounts of progress and events in areas of particular interest. There is also much to interest and instruct chemists from other disciplines as a good proportion of the chapters contain a considerable amount of 'hard' referenced information relating to modern organic, organoelemental and inorganic chemistry. Historians of chemistry and technology will no doubt be tempted to dip into this book, and surely whoever addresses the task of commemorating Moissan's achievement at the 150-years stage will bless us all in some measure for its existence.

The Chemistry of Fluorine

Author : T. A. O'Donnell
Publisher : Elsevier
ISBN 13 : 1483146421
Total Pages : 111 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis The Chemistry of Fluorine by : T. A. O'Donnell

Download or read book The Chemistry of Fluorine written by T. A. O'Donnell and published by Elsevier. This book was released on 2013-10-22 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pergamon Texts in Inorganic Chemistry, Volume 5: The Chemistry of Fluorine comprises a series of reviews on the physical and chemical properties of fluorine compounds. This book discusses the general properties of fluorine and fluorides; hydrogen fluoride solvent system; ionization in halogen fluorides; fluorides of main group elements; and chemical reactivity of higher fluorides of d- and f-transition elements. The production of elemental fluorine; acidity of hydrogen fluoride; preparative reactions in halogen fluorides; specificity of fluorination in rare gas reactivity; and bonding and structure in higher transition metal are also elaborated in this text. This publication is intended for chemical engineering students and chemists researching on the characteristics of fluorine and fluorides.

Bioorganic and Medicinal Chemistry of Fluorine

Author : Jean-Pierre Bégué
Publisher : John Wiley & Sons
ISBN 13 : 0470281871
Total Pages : 385 pages
Book Rating : 4.4/5 (72 download)

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Book Synopsis Bioorganic and Medicinal Chemistry of Fluorine by : Jean-Pierre Bégué

Download or read book Bioorganic and Medicinal Chemistry of Fluorine written by Jean-Pierre Bégué and published by John Wiley & Sons. This book was released on 2008-06-02 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes

Fluorine in Medicinal Chemistry and Chemical Biology

Author : Iwao Ojima
Publisher : John Wiley & Sons
ISBN 13 : 9780470744086
Total Pages : 640 pages
Book Rating : 4.7/5 (44 download)

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Book Synopsis Fluorine in Medicinal Chemistry and Chemical Biology by : Iwao Ojima

Download or read book Fluorine in Medicinal Chemistry and Chemical Biology written by Iwao Ojima and published by John Wiley & Sons. This book was released on 2009-03-23 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

The Curious World of Fluorinated Molecules

Author : Konrad Seppelt
Publisher : Elsevier
ISBN 13 : 0128198753
Total Pages : 456 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Curious World of Fluorinated Molecules by : Konrad Seppelt

Download or read book The Curious World of Fluorinated Molecules written by Konrad Seppelt and published by Elsevier. This book was released on 2020-10-30 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Curious World of Fluorinated Molecules: Molecules Containing Fluorine is the sixth volume in the Progress in Fluorine Science series and is edited by the world-renowned scientist Konrad Seppelt. Dr. Seppelt brings together a team of global experts to uncover the multifaceted nature of the most electronegative element in the Periodic Table. The book explores the fascinating world of unpredictable, fluorine-containing molecules through their discoveries, path to recognition, current state of the art, and impact on the broader fields of fluorinated materials development. This volume will inspire and energize researchers, future scientists, and educators working in fluorine chemistry. Highlights the current state of fundamental research of fluorinated molecules that either helped to rewrite the fundamental rules of chemistry or impacted modern material technologies Features contributions from a global team of leading experts in the field Provides a unique combination of the historical and current examples that explain the unique role that fluorine can play in advancing our understanding of the scientific method at large

Organic and Inorganic Fluorine Chemistry

Author : Axel Haupt
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110659506
Total Pages : 846 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Organic and Inorganic Fluorine Chemistry by : Axel Haupt

Download or read book Organic and Inorganic Fluorine Chemistry written by Axel Haupt and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-03-22 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic and Inorganic Fluorine Chemistry provides an introduction to fluorine chemistry and an overview of the most important fluorinated compounds and general preparation techniques. The book is divided into three parts, covering general aspects, inorganic fluorides and fluoroorganic compounds. The inorganic part presents the most important element fluorides and oxyfluorides, their preparation as well as their most characteristic properties. The organic section focuses on the different types of fluorination and the corresponding reagents. The application of these techniques is discussed for many different types of substrates. The book addresses advanced students in chemistry as well as researchers in academia and industry. The readers will benefit from a large number of original references which give access to further information. In addition, study questions at the end of each chapter will help to repeat and internalise the most important aspects.

Experimental Methods in Organic Fluorine Chemistry

Author : Tomoya Kitazume
Publisher : CRC Press
ISBN 13 : 9789056991227
Total Pages : 278 pages
Book Rating : 4.9/5 (912 download)

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Book Synopsis Experimental Methods in Organic Fluorine Chemistry by : Tomoya Kitazume

Download or read book Experimental Methods in Organic Fluorine Chemistry written by Tomoya Kitazume and published by CRC Press. This book was released on 1999-03-08 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the fields of biologically active materials and functional materials, fluorinated organic materials are becoming a focus of significant interest. Over the past decade synthetic methodologies and reagents in fluorine chemistry have been developed, especially stereocontrolled synthetic methods, enzymatic resolution to synthesize enantiomers, fluoromethylated reagents, and fluorination reagents. These methods have contributed to the opening of new pathways for fluorinated materials. However, few fluorinated materials have been put to commercial use. Furthermore, there remain problems to be solved, such as the handling of the materials, availability of reagents and selectivity (stereo-, regio-, and/or chemoselectivity). Research chemists, technical engineers, and graduate students in all branches of chemistry, pharmaceutics, and material science interested in fluorinated materials need to know detailed experimental procedures of how to synthesize the target fluorinated materials. This volume summarizes the chemical and microbial methods for obtaining functionalized fluorinated materials for use as building blocks; detailed experimental methods (reaction conditions, solvent, temperature, handling techniques, etc.); and the stereoview (possible absolute configuration) of the structures with spectral data. Mono-, di-, tri-, and polyfluorinated materials derived from fluorinating agents, fluoromethylated reagents and building blocks are summarized. A chemical name index, molecular formula index, and reagent index are also included. The publication of this monograph will provide access to the enormous possibilities in fluorine chemistry, biological material chemistry, and functionalized material chemistry.

Guide to Fluorine NMR for Organic Chemists

Author : W. R. Dolbier
Publisher : John Wiley & Sons
ISBN 13 : 0470483393
Total Pages : 272 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Guide to Fluorine NMR for Organic Chemists by : W. R. Dolbier

Download or read book Guide to Fluorine NMR for Organic Chemists written by W. R. Dolbier and published by John Wiley & Sons. This book was released on 2009-05-20 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: AN UNPARALLELED ONE-STOP GUIDE TO FLUORINE NMR Guide to Fluorine NMR for Organic Chemists provides a unique single source on both fluorine NMR and the impact of fluorine substituents on proton and carbon NMR spectra. Helping working chemists overcome the challenges associated with the synthetic methodologies of fluorinated compounds, this guide enables the effective use of these increasingly popular spectroscopic techniques to accurately characterize compounds that contain fluorine. Following a thorough introduction of fluorinated compounds, chapters in the text cover: An overview of fluorine NMR The single fluorine substituent The CF2 group The trifluoromethyl group More heavily fluorinated compounds Compounds and substituents with fluorine directly bound to heteroatoms With unparalleled depth and completeness, the coverage ranges from those compounds containing only a few fluorinated substituents, typically employed in pharmaceutical and agricultural applications, to more heavily fluorinated compounds. Featuring NMR data for more than 1,000 specific compunds and including more than 100 exemplary spectra, Guide to Fluorine NMR for Organic Chemists gives the working chemist and advanced student an essential tool for understanding cutting-edge NMR techniques and interpreting the resulting spectroscopic data.