Fluorescence Guided Tumor Imaging

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Fluorescence Guided Tumor Imaging

Author : Jessica P. Miller
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Fluorescence Guided Tumor Imaging by : Jessica P. Miller

Download or read book Fluorescence Guided Tumor Imaging written by Jessica P. Miller and published by . This book was released on 2018 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging for medical applications is a growing field, and it has the potential to improve medical outcomes through its increased sensitivity and specificity, lower cost, and small instrumentation footprint as compared to other imaging modalities. The method holds great promise, ranging from direct clinical use as a diagnostic or therapeutic tool, to pre-clinical applications for increased understanding of pathology. Additionally, optical imaging uses non-ionizing radiation which is safe for patients, so it can be used for repeated imaging procedures to monitor therapy, guide treatment, and provide real-time feedback. The versatile features of fluorescence-based optical imaging make it suited for cancer related imaging applications to increase patient survival and improve clinical outcomes. This dissertation focuses on the development of image processing methods to obtain semi-quantitative fluorescence imaging data. These methods allow for the standardization of fluorescence imaging data for tumor characterization. When a fluorophore is located within tissue, changes in the fluorescence intensity can be used to isolate structures of interest. Typically, this is done through the accumulation of a dye in a target tissue either by the enhanced permeation and retention effect (EPR), or through targeted peptide sequences that bind receptors present in specific tissue types. When imaged, the contrast generated by a fluorescent probe can be used to indicate the presence or absence of a structure, bio-chemical compound, or receptor. Fluorescence intensity contrast can answer many biological and clinical questions effectively; however, we were interested in analyzing more than solely contrast when using planar fluorescence imaging. To better understand tumor properties, we developed a series of algorithms that harness additional pieces of information present in the fluorescence signal. We demonstrated that adding novel image processing algorithms enhanced the knowledge obtained from planar fluorescence images. Through this work, we gained an understanding of alternative approaches for processing planar fluorescence imaging data with the goal of improving future cancer diagnostics and therapeutics.

Fluorescence-Guided Neurosurgery

Author : Constantinos G. Hadjipanayis
Publisher : Thieme
ISBN 13 : 1626237158
Total Pages : 376 pages
Book Rating : 4.6/5 (262 download)

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Book Synopsis Fluorescence-Guided Neurosurgery by : Constantinos G. Hadjipanayis

Download or read book Fluorescence-Guided Neurosurgery written by Constantinos G. Hadjipanayis and published by Thieme. This book was released on 2018-08-16 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive textbook on state-of-the-art fluorescence-guided neurosurgery Advances in fluorescence-guided surgery (FGS) have resulted in a paradigm shift in neurosurgical approaches to neuro-oncological and cerebrovascular pathologies. Edited by two of the foremost authorities on the topic, Fluorescence-Guided Neurosurgery: Neuro-oncology and Cerebrovascular Applications encompasses the depth and breadth of this groundbreaking, still nascent technology. The book reflects significant contributions made by world renowned neurosurgeons Constantinos Hadjipanayis, Walter Stummer, and esteemed contributors on the growing uses of 5-aminolevulinic acid (5-ALA) and other FGS agents. The European Medicine Agency approved 5-ALA in 2007, heralding the birth of FGS globally. In 2017, the U.S. Food and Drug Administration approved 5-ALA (Gleolan) as an imaging agent to facilitate realtime detection and visualization of malignant tissue during glioma surgery. In the two decades since Dr. Stummer's initial description of 5-ALA FGS in a human patient, major strides have been made in its practical applications, leading to improved resection outcomes. As FGS is increasingly incorporated into neurosurgical practice, it holds promise for future innovations. Generously-illustrated and enhanced with online videos, this textbook is the definitive resource on the subject. Key Features The improved efficacy of 5-ALA for resecting high- and low-grade gliomas, recurrences, meningiomas, brain metastases, spinal cord tumors, pediatric brain tumors, and other adult tumors The future of fluorescence, including potentially powerful new fluorophores molecularly targeted specifically to tumors The use of the fluorescent agent indocyanine green (ICG) for brain tumors, cerebral aneurysms, AVMs, and cerebral vascularization Special topics such as fluorescein, illuminating tumor paint, confocal microscopy, Raman spectroscopy, and integrating FGS with intraoperative imaging and brain mapping This single accessible reference presents the current state-of-the-art on this emerging, exciting surgical technology. As such, it is a must-have for neurosurgical residents, fellows, and practicing neurosurgeons.

Strategies for Curative Fluorescence-Guided Surgery of Cancer

Author : Robert Hoffman
Publisher : Academic Press
ISBN 13 : 0128126779
Total Pages : 296 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Strategies for Curative Fluorescence-Guided Surgery of Cancer by : Robert Hoffman

Download or read book Strategies for Curative Fluorescence-Guided Surgery of Cancer written by Robert Hoffman and published by Academic Press. This book was released on 2020-05-27 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies for Curative Fluorescence-Guided Surgery of Cancer is the first book to discuss how fluorescence-guided surgery can be successfully used during surgeries with several tumor types. FGS is one of the most exciting emerging modalities of surgery, especially cancer surgery, as it potentially allows the surgeon to visualize the actual margin of the tumor, thus greatly increasing the possibility of curative resection. The book discusses the applicability of FGS for several types of cancer, such as pancreatic cancer, liver metastasis, soft-tissue sarcoma, glioma, melanoma, and breast and lung cancer. This book is a valuable resource for cancer surgeons, cancer researchers and members of several other areas in the biomedical field who are interested in understanding this powerful technique. Presents an overview of fluorescence-guided surgery Explains general strategies for curative fluorescence-guided surgery and their applicability for each major tumor type Discusses the current and future achievements of FGS as a precise technique for cancer surgeries

Fluorescence-Guided Surgery

Author : Takeaki Ishizawa
Publisher : Springer Nature
ISBN 13 : 9811973725
Total Pages : 254 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Fluorescence-Guided Surgery by : Takeaki Ishizawa

Download or read book Fluorescence-Guided Surgery written by Takeaki Ishizawa and published by Springer Nature. This book was released on 2023-12-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a practical guide of theranostics using intraoperative fluorescence imaging technology, as an all-out effort by the Japanese Society for Fluorescence Guided Surgery. It describes the various approaches the technique is being used such as vascular imaging, identification of lymphatic vessels by intratissue injection, lymph node imaging, and imaging for identification of anatomical structures. The book is organized into three major parts and the first one delivers the basics, introducing the use of the technology in clinical settings and initial setups. Next comes the description of clinical applications where chapters illustrate perfusion assessment, cancer localization, anatomy visualization, and lymph nodes/ducts mapping. Each chapter is devoted to the specific surgical field and disease areas, presenting images and videos of case studies. The last part presents some upcoming techniques for treatments. The Editor and the authors wish the ideas presented here will be hints to bridge the knowledge between surgeons and basic researchers for further innovation and practicality. It is important to stay up-to-date since intraoperative fluorescence imaging has been applied to clinical settings in various surgical fields and at the same time, novel techniques improving the efficacy of the technology have also been developed actively. Fluorescence-Guided Surgery – From Lab to Operation Room is recommended for surgeons, operating nurses, medical experts, basic researchers and, industry engineers worldwide beyond boundaries of specialties. Edited and written by experts of The Japanese Society for Fluorescence-Guided Surgery, those who are the founders of the technology, it describes the accurate development history and cutting-edge techniques based on the knowledge accumulated over the years.

Intraoperative Fluorescence Imaging and Diagnosis in Central and Peripheral Nervous System Tumors: Established Applications and Future Perspectives

Download Intraoperative Fluorescence Imaging and Diagnosis in Central and Peripheral Nervous System Tumors: Established Applications and Future Perspectives PDF Online Free

Author : Francesco Acerbi
Publisher : Frontiers Media SA
ISBN 13 : 2889747735
Total Pages : 147 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Intraoperative Fluorescence Imaging and Diagnosis in Central and Peripheral Nervous System Tumors: Established Applications and Future Perspectives by : Francesco Acerbi

Download or read book Intraoperative Fluorescence Imaging and Diagnosis in Central and Peripheral Nervous System Tumors: Established Applications and Future Perspectives written by Francesco Acerbi and published by Frontiers Media SA. This book was released on 2022-03-30 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Surgical Oncology: Fluorescence-Guided Surgery

Author : Jaime Allison
Publisher : American Medical Publishers
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (874 download)

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Book Synopsis Surgical Oncology: Fluorescence-Guided Surgery by : Jaime Allison

Download or read book Surgical Oncology: Fluorescence-Guided Surgery written by Jaime Allison and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence-guided surgery (FGS) is a type of surgery that is performed with the guidance of fluorescence imaging. It has emerged as a new approach to detect the primary tumor, tumor margins, and metastatic lymph nodes. A major cause of tumor recurrence is the presence of residual tumor cells after surgery. Therefore, it is necessary to have a negative tumor margin to ensure a successful cancer resection. Despite widespread use of preoperative imaging techniques such as computed tomography (CT) scan, magnetic resonance imaging (MRI) scan, and positron emission tomography (PET) scan, the surgical margin positive rate failed to reflect remarkable improvement. The plausible reason for this failure is the reliance of surgeons on the visual inspection and intraoperative histopathological analysis of the frozen tissue specimen. FGS is now emerging as an effective tool to guide the surgical oncologists by generating real time fluorescence images of the surgical region. It reduces the possibility of recurrence of cancer. This book strives to provide a fair idea about the fluorescence-guided surgery and to help develop a better understanding of the latest advances related to this medical procedure. It is a vital tool for all researching and studying fluorescence-guided surgery as it gives incredible insights into the emerging trends and concepts.

Goggle Augmented Imaging and Navigation System for Fluorescence-guided Surgery

Author : Suman Bikash Mondal
Publisher :
ISBN 13 :
Total Pages : 231 pages
Book Rating : 4.:/5 (954 download)

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Book Synopsis Goggle Augmented Imaging and Navigation System for Fluorescence-guided Surgery by : Suman Bikash Mondal

Download or read book Goggle Augmented Imaging and Navigation System for Fluorescence-guided Surgery written by Suman Bikash Mondal and published by . This book was released on 2016 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgery remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during surgery, often leading to incomplete tumor resection that necessitates repeat surgery. Sentinel lymph node biopsy by conventional radioactive tracking exposes patients and caregivers to ionizing radiation, while blue dye tracking stains the tissue highlighting only superficial lymph nodes. Improper identification of sentinel lymph nodes may misdiagnose the stage of the cancer. Therefore there is a clinical need for accurate intraoperative tumor and sentinel lymph node visualization. Conventional imaging modalities such as x-ray computed tomography, positron emission tomography, magnetic resonance imaging, and ultrasound are excellent for preoperative cancer diagnosis and surgical planning. However, they are not suitable for intraoperative use, due to bulky complicated hardware, high cost, non-real-time imaging, severe restrictions to the surgical workflow and lack of sufficient resolution for tumor boundary assessment. This has propelled interest in fluorescence-guided surgery, due to availability of simple hardware that can achieve real-time, high resolution and sensitive imaging. Near-infrared fluorescence imaging is of particular interest due to low background absorbance by photoactive biomolecules, enabling thick tissue assessment. As a result several near-infrared fluorescence-guided surgery systems have been developed. However, they are limited by bulky hardware, disruptive information display and non-matched field of view to the user. To address these limitations we have developed a compact, light-weight and wearable goggle augmented imaging and navigation system (GAINS). It detects the near-infrared fluorescence from a tumor accumulated contrast agent, along with the normal color view and displays accurately aligned, color-fluorescence images via a head-mounted display worn by the surgeon, in real-time. GAINS is a platform technology and capable of very sensitive fluorescence detection. Image display options include both video see-through and optical see-through head-mounted displays for high-contrast image guidance as well as direct visual access to the surgical bed. Image capture options from large field of view camera as well high magnification handheld microscope, ensures macroscopic as well as microscopic assessment of the tumor bed. Aided by tumor targeted near-infrared contrast agents, GAINS guided complete tumor resection in subcutaneous, metastatic and spontaneous mouse models of cancer with high sensitivity and specificity, in real-time. Using a clinically-approved near-infrared contrast agent, GAINS provided real-time image guidance for accurate visualization of lymph nodes in a porcine model and sentinel lymph nodes in human breast cancer and melanoma patients with high sensitivity. This work has addressed issues that have limited clinical adoption of fluorescence-guided surgery and paved the way for research into developing this approach towards standard-of-care practice that can potentially improve surgical outcomes in cancer.

Fluorescence-Guided Surgery of Cancer

Author : Jaime Allison
Publisher : American Medical Publishers
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (874 download)

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Book Synopsis Fluorescence-Guided Surgery of Cancer by : Jaime Allison

Download or read book Fluorescence-Guided Surgery of Cancer written by Jaime Allison and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgery is an important treatment option for cancer patients. Fluorescence-guided surgery (FGS) of cancer is an intraoperative medical technique that produces real time fluorescence image of the surgical region which helps the surgeons in performing the surgical procedure. Till now, various types of cancers such as head and neck cancer, breast cancer, lung cancer, esophagus cancer, hepatocellular carcinoma, gastric cancer, and melanoma have been treated with the help of FGS. Conventional imaging techniques such as CT and MRI are expensive and difficult and cannot be used at the time of surgery. On the other hand, FGS provides real-time imaging during surgery and it is less costly and easier to use. It is significant to achieve a negative tumor margin for a successful cancer resection as the presence of residual tumor cells after surgery may cause tumor recurrence that leads to poor prognosis. This book is compiled in such a manner, that it will provide an in-depth knowledge about the theory and practice of fluorescence-guided surgery of cancer. It aims to present researches that have transformed this discipline and have aided in its advancement. This book will help the readers in keeping pace with the rapid changes in this field.

Applications of Fluorescence in Surgery and Interventional Diagnostics

Author : Mark Preul
Publisher : Frontiers Media SA
ISBN 13 : 2889668568
Total Pages : 368 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Applications of Fluorescence in Surgery and Interventional Diagnostics by : Mark Preul

Download or read book Applications of Fluorescence in Surgery and Interventional Diagnostics written by Mark Preul and published by Frontiers Media SA. This book was released on 2021-06-04 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fluorescent Imaging

Author : N. Kokudo
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318022934
Total Pages : 134 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Fluorescent Imaging by : N. Kokudo

Download or read book Fluorescent Imaging written by N. Kokudo and published by Karger Medical and Scientific Publishers. This book was released on 2013-09-10 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indocyanine green (ICG) fluorescence has been used for imaging purposes for more than half a century; First employed by ophthalmologists for visualizing the retinal artery in the late 1960s, the application of ICG fluorescence imaging has since been continuously expanded. Recently, advances in imaging technologies have led to renewed attention regarding the use of ICG in the field of hepatobiliary surgery, as a new tool for visualizing the biliary tree and liver tumors.

Imaging of Head and Neck Cancer

Author : A. T. Ahuja
Publisher : Cambridge University Press
ISBN 13 : 9781841100906
Total Pages : 240 pages
Book Rating : 4.1/5 (9 download)

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Book Synopsis Imaging of Head and Neck Cancer by : A. T. Ahuja

Download or read book Imaging of Head and Neck Cancer written by A. T. Ahuja and published by Cambridge University Press. This book was released on 2003-01-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise integrated handbook looks at all available imaging methods for head and neck cancer, highlighting the strengths and weaknesses of each method. The information is provided in a clinical context and will guide radiologists as to the information the clinician actually needs when managing a patient with head and neck cancer. It will also provide the clinician with the advantages and limitations of imaging. The text therefore deals with Ultrasound, CT and MRI. The initial chapters aim to give the reader a core knowledge, which can be used in imaging by the various methods described. The subsequent chapters are directed towards clinical problems and deal with the common cancers in a logical order.

LS301 Fluorescence-guided Photodynamic Therapy of Brain Cancer Using PpIX Photosensitizer

Author : Haini Zhang
Publisher :
ISBN 13 :
Total Pages : 36 pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis LS301 Fluorescence-guided Photodynamic Therapy of Brain Cancer Using PpIX Photosensitizer by : Haini Zhang

Download or read book LS301 Fluorescence-guided Photodynamic Therapy of Brain Cancer Using PpIX Photosensitizer written by Haini Zhang and published by . This book was released on 2017 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Incomplete brain tumor removal always causes neurologic deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation using PpIX is limited by autofluorescence and superficial penetration depth. LS301 is a tumor-targeted near-infrared (NIR) contrast agent developed in our lab which allows deeper tumor imaging and avoids autofluorescence. My project aims to investigate whether LS301 can improve PpIX mediated PDT and tumor removal surgery. We have demonstrated co-localization of LS301 and PpIX in DBT and U87-MG glioma cell lines and are currently testing the effect of LS301 on PpIX mediated PDT in vitro. We will also compare LS301-PpIX with PpIX only PDT and tumor removal in mouse models of brain cancer. This study can potentially increase efficacy of PDT and fluorescence-guided brain tumor resection.

Molecular Imaging in Oncology

Author : Otmar Schober
Publisher : Springer Nature
ISBN 13 : 3030426181
Total Pages : 911 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Molecular Imaging in Oncology by : Otmar Schober

Download or read book Molecular Imaging in Oncology written by Otmar Schober and published by Springer Nature. This book was released on 2020-06-27 with total page 911 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the most significant recent advances in oncological molecular imaging, covering the full spectrum from basic and preclinical research to clinical practice. The content is divided into five sections, the first of which is devoted to standardized and emerging technologies and probe designs for different modalities, such as PET, SPECT, optical and optoacoustic imaging, ultrasound, CT, and MRI. The second section focuses on multiscale preclinical applications ranging from advanced microscopy and mass spectroscopy to whole-body imaging. In the third section, various clinical applications are presented, including image-guided surgery and the radiomic analysis of multiple imaging features. The final two sections are dedicated to the emerging, crucial role that molecular imaging can play in the planning and monitoring of external and internal radiotherapy, and to future challenges and prospects in multimodality imaging. Given its scope, the handbook will benefit all readers who are interested in the revolution in diagnostic and therapeutic oncology that is now being brought about by molecular imaging.

Fluorescence Imaging for Surgeons

Author : Fernando D. Dip
Publisher : Springer
ISBN 13 : 3319156780
Total Pages : 357 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Fluorescence Imaging for Surgeons by : Fernando D. Dip

Download or read book Fluorescence Imaging for Surgeons written by Fernando D. Dip and published by Springer. This book was released on 2015-07-21 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the experiences of leading researchers and surgeons with different fluorescence methods. Chapters range from basic science of fluorescence to current clinical applications and new horizons. The first few chapters describe the historical evolution and physical principles of fluorescence and provide the foundation for the reader to understand the current scope and limits of its use in surgery. The second section focuses on the clinical applications of intraoperative fluorescence imaging including subsections on fluorescence cholangiography, applications to hepatectomy, lymph node navigation, applications to GI tract and pelvic surgery and identification of cancer tissues. The third section focuses on new frontiers including fluorescence probes, imaging systems and applications to photodynamic therapy. Authored by leaders in the development of fluorescent methods worldwide, Fluorescence Imaging for Surgeons: Concepts and Applications will have an impact on numerous medical specialists including general surgeons, colorectal and minimally-invasive surgeons and surgical oncologists. Researchers will find the book to be an invaluable resource on the latest advances in the utilization of nanoparticles and fluorescent probes.

Oncology Imaging: Innovations and Advancements, An Issue of Surgical Oncology Clinics of North America, E-Book

Author : Natalie Lui
Publisher : Elsevier Health Sciences
ISBN 13 : 0323987923
Total Pages : 169 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Oncology Imaging: Innovations and Advancements, An Issue of Surgical Oncology Clinics of North America, E-Book by : Natalie Lui

Download or read book Oncology Imaging: Innovations and Advancements, An Issue of Surgical Oncology Clinics of North America, E-Book written by Natalie Lui and published by Elsevier Health Sciences. This book was released on 2022-10-17 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Surgical Oncology Clinics, guest editor Dr. Natalie Lui brings her considerable expertise to the topic of Oncology Imaging: Updates and Advancements. Treatment planning and implementation in oncology relies heavily on cancer imaging modalities. In this issue, top experts in the field of oncology imaging discuss the latest imaging techniques and modalities for the most common malignancies, such as lung, breast, and liver cancer, as well as a timely article on 3D CT reconstruction and printing to aid surgical planning. Contains 10 practice-oriented topics including fluoroestradiol imaging of ER+ breast cancer; advances in imaging to aid segmentectomy for lung cancer; 3D computed tomography reconstruction and printing to aid surgical planning; molecular imaging of head and neck cancer; contrast-enhanced intraoperative ultrasound of the liver; and more. Provides in-depth clinical reviews on oncology imaging, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Image-Guided Diagnosis and Treatment of Cancer

Author : Anthony V. D’Amico
Publisher : Springer Science & Business Media
ISBN 13 : 1592594220
Total Pages : 273 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Image-Guided Diagnosis and Treatment of Cancer by : Anthony V. D’Amico

Download or read book Image-Guided Diagnosis and Treatment of Cancer written by Anthony V. D’Amico and published by Springer Science & Business Media. This book was released on 2003-07-30 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent physicians review past, current, and future applications of the many powerful imaging techniques now used in the diagnosis, staging, treatment, and outcomes assessment of cancers of the prostate, central nervous system (CNS), and breast. Topics range from the use of screening mammography and approaches to breast cancer detection using MRI to improved visualization of the prostate gland from transrectal ultrasound and MRI, to MRI-guided resection of neoplasms.

"System and Methodology for Receptor-level Fluorescence Imaging During Surgery"

Author : Kristian J. Sexton
Publisher :
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.:/5 (881 download)

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Book Synopsis "System and Methodology for Receptor-level Fluorescence Imaging During Surgery" by : Kristian J. Sexton

Download or read book "System and Methodology for Receptor-level Fluorescence Imaging During Surgery" written by Kristian J. Sexton and published by . This book was released on 2014 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: e"Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted molecular probes. The development of advanced surgical systems has gone hand in hand with probe development, and both aspects are analyzed in this work. A pulsed-light fluorescence guided surgical (FGS) system has been introduced to enable video rate visible light molecular imaging under normal room light conditions. The concepts behind this system design are presented and performance is compared with a commercial system in both phantom and in vivo animal studies using PpIX fluorescence. The second critical advance in the emergence of these technologies has been the development of targeted near infrared (NIR) probes. A small, engineered three-helix protein was analyzed for imaging of glioma tumors. The blood brain barrier affects delivery of probes and the superior delivery of a smaller targeted protein (anti-EGFR Affibody) as compared to a full sized antibody is shown using a murine model, ex vivo tissue slices and a commercial imaging system. This small targeted probe is examined further for its possible application in FGS using the pulsed light imaging system. A concentration sensitivity analysis to determine the lower bounds on concentration needed for effective imaging is performed with this culminating analysis carried out in a murine orthotopic glioma tumor model."