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Fine Mapping Of Quantitative Trait Loci Qtl Using Linkage And Linkage Disequilibrium Analysis In Half Sib Designs Microform
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Author :Davood Kolbehdari Publisher :Library and Archives Canada = Bibliothèque et Archives Canada ISBN 13 :9780494019061 Total Pages :120 pages Book Rating :4.0/5 (19 download)
Book Synopsis Fine Mapping of Quantitative Trait Loci (QTL) Using Linkage and Linkage Disequilibrium Analysis in Half-sib Designs [microform] by : Davood Kolbehdari
Download or read book Fine Mapping of Quantitative Trait Loci (QTL) Using Linkage and Linkage Disequilibrium Analysis in Half-sib Designs [microform] written by Davood Kolbehdari and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2004 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Quantitative Trait Loci by : Nicola J. Camp
Download or read book Quantitative Trait Loci written by Nicola J. Camp and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.
Book Synopsis Fine-mapping Quantitative Trait Loci for Meat Quality Using Linkages and Linkage Disequilibrium Analyses by : Gelson Luís Dias Feijó
Download or read book Fine-mapping Quantitative Trait Loci for Meat Quality Using Linkages and Linkage Disequilibrium Analyses written by Gelson Luís Dias Feijó and published by . This book was released on 2007 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modeling and Inferring Quantitative Trait Loci Using Linkage Disequilibrium in Natural Populations by :
Download or read book Modeling and Inferring Quantitative Trait Loci Using Linkage Disequilibrium in Natural Populations written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative trait loci (QTL) are those chromosome regions that contribute to variation of quantitative traits. Analysis of QTL is helpful for further study of molecular basis of the quantitative genetic variation. The discovery of highly abundant and dense polymorphic markers (e.g., single nucleotide polynorphisms, or SNPs) covering a whole genome provides an opportunity to localize QTL in a variety of populations. While classical linkage studies have a relatively limited resolution in QTL localization, the association mapping or linkage disequilibrium (LD) mapping approach can offer an alternative way for fine mapping of genes. Currently there are few LD methods available for QTL mapping in natural populations. Development of more efficient methods is still a challenging problem. In this thesis, we first review the LD approach for fine mapping of QTL in Chapter 1. Some basic issues in LD analysis and recent developments in LD methodology are discussed. Particular attention is paid to limitations and potential problems of these methods. This provides the motivation for the research in this thesis. Next, we explore Cockerham's genetic model (Cockerham, 1954) for quantitative traits in Chapter 2. A revised form of the Cockerham model is presented using some coding variables. The relationship between Cockerham model and some specific genetic models for designed experimental populations, such as backcross or F2, is then established. We study extensively the properties of QTL effects and partitions of various genetic variance components for these reduced models under both linkage equilibrium and linkage disequilibrium situations. A general multi-locus-two-allele model is also proposed that may serve as a basis for mapping QTL in natural populations. The main research of the thesis is on development of an exact multipoint likelihood approach to infer QTL in natural populations. In Chapter 3, we first generalize the formulation of the likelihood analysis for a polymorphic.
Book Synopsis Quantitative Trait Loci Analysis in Animals by : Joel Ira Weller
Download or read book Quantitative Trait Loci Analysis in Animals written by Joel Ira Weller and published by CABI. This book was released on 2009 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.
Book Synopsis Designing Experiments for Mapping Quantitative Trait Loci in Segregating Animal Populations by : Fengxing Du
Download or read book Designing Experiments for Mapping Quantitative Trait Loci in Segregating Animal Populations written by Fengxing Du and published by . This book was released on 1999 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Statistical Genetics of Quantitative Traits by : Rongling Wu
Download or read book Statistical Genetics of Quantitative Traits written by Rongling Wu and published by Springer Science & Business Media. This book was released on 2007-07-17 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture, forestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping, and assumes a background in regression analysis and maximum likelihood approaches. The strength of this book lies in the construction of general models and algorithms for linkage analysis, as well as in QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops.
Book Synopsis Mapping Quantitative Trait Loci in Outbred Half-sib Populations by :
Download or read book Mapping Quantitative Trait Loci in Outbred Half-sib Populations written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative trait loci (QTL) mapping in outbred populations faces some challenges unique to the divergent genetic background and complex pedigree relationships. Motivated by a dairy cattle half-sib data set from a grand daughter design, we present in this dissertation a series of endeavors to address various challenges along the analysis flow of QTL mapping. A first step is to infer the haplotypes in sires based on the observed genotypes in sires and his offspring. Our method was shown to outperform peer methods with greater robustness and accuracy yet with fast speed performance. Then in light of adapting the multiple interval mapping method to within-family QTL analysis, we extended the modeling framework by allowing for heteroscedastic residual variances and upgraded the Windows QTL Cartographer accordingly. The advantageous post-analysis result parsing from Windows QTL Cartographer and more importantly, the improved analysis outputs due to more powerful maximum likelihood-based mixture modeling than the least squares regression manifest our efforts in delivering better methodology via practically user friendly software. We further developed a mixed model approach for the purpose of QTL mapping across multiple families that was aimed at modeling QTL effects as both the fixed effect across families and the random effect within families. Our mixed model was shown to encompass similar or higher statistical testing performance on QTL variation than the widely used variance component modeling approach, yet still allowing permutations for obtaining chromosome-wide or genome-wide significance threshold. What's more, the flexibility of our mixed model in constructing alternative hypotheses testing on either fixed or random QTL effects or both was shown to offer interesting insight into the varying sources of signal that would not be unveiled by least squares regression or variance component methods. In concluding our comprehensive approach to QTL linkage mapping in dair.
Book Synopsis A Guide to QTL Mapping with R/qtl by : Karl W. Broman
Download or read book A Guide to QTL Mapping with R/qtl written by Karl W. Broman and published by Springer Science & Business Media. This book was released on 2009-07-21 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety
Book Synopsis High Resolution Linkage and Association Study of Quantitative Trait Loci by : Jeesun Jung
Download or read book High Resolution Linkage and Association Study of Quantitative Trait Loci written by Jeesun Jung and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: As a large number of single nucleotide polymorphisms (SNPs) and microsatellite markers are available, high resolution mapping employing multiple markers or multiple allele markers is an important step to identify quantitative trait locus (QTL) of complex human disease. For many complex diseases, quantitative phenotype values contain more information than dichotomous traits do. Much research has been done on conducting high resolution mapping using information of linkage and linkage disequilibrium. The most commonly employed approaches for mapping QTL are pedigree-based linkage analysis and population-based association analysis. As one of the methods dealing with multiple alleles markers, mixed models are developed to work out family-based association study with the information of transmitted allele and nontransmitted allele from one parent to offspring. For multiple markers, variance component models are proposed to perform association study and linkage analysis simultaneously. Linkage analysis provides suggestive linkage based on a broad chromosome region and is robust to population admixtures. One the other hand, allelic association due to linkage disequilibrium (LD) usually operates over very short genetic distance, but is affected by population stratification. Combining both approaches plays a synergistic role in overcoming their limitations and in increasing the efficiency and effectiveness of gene mapping.
Book Synopsis Contributions to the Design and Analysis of Quantitative Trait Loci Experiments by : Chunfang Jin
Download or read book Contributions to the Design and Analysis of Quantitative Trait Loci Experiments written by Chunfang Jin and published by . This book was released on 2004 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fine Mapping Growth and Obesity Quantitative Trait Loci (QTL) Using Subcongenic Strains of Mouse Chromosome 2 by : Lisa Goldberg
Download or read book Fine Mapping Growth and Obesity Quantitative Trait Loci (QTL) Using Subcongenic Strains of Mouse Chromosome 2 written by Lisa Goldberg and published by . This book was released on 2007 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Dissection of Complex Traits by : Andrew H. Paterson
Download or read book Molecular Dissection of Complex Traits written by Andrew H. Paterson and published by CRC Press. This book was released on 2019-09-17 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi
Book Synopsis Quantitative Trait Loci Linkage Mapping for Dynamic Traits by : Hongjuan Liu
Download or read book Quantitative Trait Loci Linkage Mapping for Dynamic Traits written by Hongjuan Liu and published by . This book was released on 2006 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Power and Accuracy of Detecting Linkage Between Quantitative Trait Loci and Genetic Markers by : Zhiwu Zhang
Download or read book Power and Accuracy of Detecting Linkage Between Quantitative Trait Loci and Genetic Markers written by Zhiwu Zhang and published by . This book was released on 1998 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modeling and Inferring Quantitative Trait Loci Using Linkage Disequilibrium in Natural Populations by : Tao Wang
Download or read book Modeling and Inferring Quantitative Trait Loci Using Linkage Disequilibrium in Natural Populations written by Tao Wang and published by . This book was released on 2001 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: quantitative trait, QTL, genetic model, likelihood, linkage disequilibrium, association mapping, natural population.
Book Synopsis Fine Mapping of a Major-effect QTL Controlling Rhizomatous Growth in Perennial Wildrye Hybrids by : Jenny L. Clements
Download or read book Fine Mapping of a Major-effect QTL Controlling Rhizomatous Growth in Perennial Wildrye Hybrids written by Jenny L. Clements and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative trait loci (QTL) analysis is the science of discovering genes or chromosome regions that influence the expression of quantitative traits. Statistical methods for doing this have evolved from single marker analysis of variance (ANOVA) to more complex approaches such as interval mapping and multiple QTL mapping. The goal of this project was to refine a previously identified QTL chromosome region responsible for rhizome growth in grass hybrids developed from two species of the Triticeae tribe by categorically progeny testing seven recombinant genotypes containing cross overs in a major-effect rhizome QTL. In addition, the analysis addressed physical concerns with the field plot, assessing statistical power, multiple comparison testing and linkage segregation assessment.
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