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Fetal Islet Transplantation
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Book Synopsis Fetal Islet Transplantation by : B. Formby
Download or read book Fetal Islet Transplantation written by B. Formby and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advent of insulin for clinical use in 1922, our ability to control hypergly cemia and prevent the long term sequelae ofthe disease remains limited. Thus normalization of the milieu interieur with physiologic responses of insulin and metabolites remains an elusive but critically important goal. The developing endocrine pancreas provides a model system that speaks to many challenges of the transplantation biologist. Thus the attempt to of vascularization, growth and development, immunologic toler recapitulate the ontogeny ance, and glucose responsive insulin secretory capacity of fetal islet tissue provides a tantalizing possibility to replace insulin secreting tissue in persons with diabetes. Studies of this tissue are also important because of the implications such investigations have for genetic and molecular biological approaches to restoring insulin secretion as well as for providing clues to enhancing the growth and repair of islets that have been the target of autoimmune disease. Investigators in the area offetal islet transplantation comprise a small group scattered throughout the world scientific community. Therefore it seemed important to provide a forum where these scientists could gather, share ideas, and achieve consensus such that progress in this rapidly evolving area could be facilitated. The conference would have remained a dream if the support of the Okla Basil Meade, Jr. family had not made it manifest.
Book Synopsis Fetal Islet Transplantation by : Lois Jovanovic
Download or read book Fetal Islet Transplantation written by Lois Jovanovic and published by Springer Science & Business Media. This book was released on 1995 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the October 1994 symposium at Sansum Medical Research Foundation in Santa Barbara, CA, focus on the use of fetal islet tissue in controlling diabetes and repairing islets that have been damaged by autoimmune disease. Papers detail research on fetal islet growth, differentiation, immunology, and transplantation. Other topics include fetal islet transplantation and pregnancy, and networking for the collection of fetal islet tissues. Annotation copyright by Book News, Inc., Portland, OR
Author :Niranjan Bhattacharya Publisher :Springer Science & Business Media ISBN 13 :1447141717 Total Pages :467 pages Book Rating :4.4/5 (471 download)
Book Synopsis Human Fetal Tissue Transplantation by : Niranjan Bhattacharya
Download or read book Human Fetal Tissue Transplantation written by Niranjan Bhattacharya and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many diseases earlier considered to be incurable are now being treated with modern innovations involving fetal tissue transplants and stem cells derived from fetal tissues. Fetal tissues are the richest source of fetal stem cells as well as other varying states of differentiated cells and support or stromal cells. The activity of such stem cells is at their peak provided they are given the correct niche. Stem cells, as we know, are immortal cells with the capacity to regenerate into any kind of differentiated cell as per niche-guidance. As such, fetal tissues have the potential capacity to mend, regenerate and repair damaged cells or tissues in adults, when directly transplanted to the site of injury, or even when transplanted in some other site, because it may have a homing capacity to migrate to the site of the specific injured organ. This is a new area of translational research and needs to be highlighted because of its immense potential. This book will bring together the new work of prominent medical scientists and clinicians who are conducting pioneering research in human fetal tissue transplantation. This will include direct transplant of healthy fetal tissue into mature patients as well as in hosts with genetic diseases. Transplant techniques, donor-host interaction, cell and tissue storage, ethical and legal issues, are some of the many matters which the book will deal with.
Book Synopsis The Foetus as Transplant Donor by : Peter McCullagh
Download or read book The Foetus as Transplant Donor written by Peter McCullagh and published by . This book was released on 1987-05 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ethical issues sourrounding foetal experimentation have been under constant debate since the early 1970s. This book analyzes all aspects of foetal experimentation and suggests answers to the difficult questions concerning its morality and uses, as well as the difficulties associated with diagnosing foetal brain death. Explores the moral implications of experimental, as opposed to therapeutic, rationales for experimentation on foetal subjects. Also offers historical background on current perceptions of the suitability of foetal tissue for transplantation, how current claims have been derived from earlier practice, and the manner in which proposals for transplantation of one specific type of foetal tissue, the pancreas, have been presented to the community.
Book Synopsis Transplantation of Fetal Pig Islet-Like Cell Clusters As Therapy for Diabetes by : Sophia Dean
Download or read book Transplantation of Fetal Pig Islet-Like Cell Clusters As Therapy for Diabetes written by Sophia Dean and published by . This book was released on 2008-04-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 1 diabetes is an autoimmune disease in which the insulin-producing cells of the pancreas are destroyed. Complications that arise from type 1 diabetes include blindness, kidney failure and nerve damage. Current treatment is with daily insulin injections, although some may be eligible for a pancreas or islet transplant. However, this is usually reserve for those with end-stage kidney failure. Furthermore, there are not enough donors to meet this demand should every diabetic receive a pancreas or islet transplant. It is for this reason that alternative sources of insulin-producing cells must be considered as another form of treatment. In this book, the transplantation of insulin cells from the fetal pig pancreas is examined as an alternative therapy, with the use of the outbred pig as an animal model for type 1 diabetes. A historical perspective of diabetes is also discussed as well as the different types of anti-rejection drugs used and the mechanisms of graft rejection. Finally, the possibility of eliminating the need for anti-rejection drugs through the means of encapsulation, is explored.
Book Synopsis Pancreas, Islet and Stem Cell Transplantation for Diabetes by : Nadey S. Hakim
Download or read book Pancreas, Islet and Stem Cell Transplantation for Diabetes written by Nadey S. Hakim and published by Oxford University Press, USA. This book was released on 2010-08-26 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition provides an authoritative account of the current status of whole organ pancreas transplantation and islet and pancreatic stem cell transplantation, reflecting recent advances in the field, including the growing interest in stem cell research applicable to this condition.
Book Synopsis Fetal Tissue Transplants in Medicine by : Robert Geoffrey Edwards
Download or read book Fetal Tissue Transplants in Medicine written by Robert Geoffrey Edwards and published by Cambridge University Press. This book was released on 1992-11-05 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent scientific and clinical developments and techniques in fetal tissue transplants are presented, including both the transplantation of fetal tissue into mature recipients, and the grafting of donor cells into fetuses that are known to be carrying genetic disease.
Book Synopsis Stem Cells and the Future of Regenerative Medicine by : Institute of Medicine
Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Book Synopsis The Transplantation of Fetal Pig Islet-like Cell Clusters Into the Outbred Pig by : Danielle Carolyn Horley
Download or read book The Transplantation of Fetal Pig Islet-like Cell Clusters Into the Outbred Pig written by Danielle Carolyn Horley and published by . This book was released on 2000 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Islet Transplantation and Beta Cell Replacement Therapy by : A. M. James Shapiro
Download or read book Islet Transplantation and Beta Cell Replacement Therapy written by A. M. James Shapiro and published by CRC Press. This book was released on 2007-07-25 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and b
Book Synopsis Pancreas and Islet Transplantation by : Nadey S. Hakim
Download or read book Pancreas and Islet Transplantation written by Nadey S. Hakim and published by . This book was released on 2002 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes Mellitus is the principle cause of kidney failure and blindness in adults and leads to more cases of amputation and impotence than any other disease. It is one of the most common chronic diseases in childhood. The aims of pancreas or islet transplantation are to improve the quality of life of patients with insulin dependent diabetes mellitus and to ameliorate secondary complications. This book provides a comprehensive and international review of the recent advances in pancreas and islet transplantation. It covers surgical techniques, issues surrounding organ preservation, immunosuppression and the control of other complications, all of which contribute to the potential for such transplantations to evolve as the treatment of choice for insulin dependent diabetes. The editors have compiled a strong and international team of contribution authors. This book is essential reading for transplant surgeons and all those involved in researching or treating diabetes mellitus.
Book Synopsis The Endocrine Pancreas by : Ellis Samols
Download or read book The Endocrine Pancreas written by Ellis Samols and published by Lippincott Williams & Wilkins. This book was released on 1991 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas by : Giuseppe Orlando
Download or read book Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas written by Giuseppe Orlando and published by Academic Press. This book was released on 2019-11-09 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Includes sections that address donor selection, immunosuppression, complications, allograft pathology, and more Offers an update on the progress of regenerative medicine research aimed at beta cells replacement in the treatment of diabetes
Book Synopsis Pancreatic Islet Cell Transplantation by : Camillo Ricordi
Download or read book Pancreatic Islet Cell Transplantation written by Camillo Ricordi and published by Landes Bioscience. This book was released on 1992 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for researchers and clinicians who work with cell transplantation, this text discusses the latest methods and gives an overall update of the major fields of islet transplantation. Included are reports of recent clinical trials on successful islet transplantation in humans.
Author :United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health and the Environment Publisher : ISBN 13 : Total Pages :234 pages Book Rating :4.F/5 ( download)
Book Synopsis Fetal Tissue Transplantation Research by : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health and the Environment
Download or read book Fetal Tissue Transplantation Research written by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health and the Environment and published by . This book was released on 1990 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oral Delivery of Insulin by : T.A. Sonia
Download or read book Oral Delivery of Insulin written by T.A. Sonia and published by Elsevier. This book was released on 2014-12-11 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes Mellitus Includes a discussion of various strategies and techniques adopted for oral delivery of insulin Presents an update of research in the field
Book Synopsis Molecular Basis of Pancreas Development and Function by : Joel F. Habener
Download or read book Molecular Basis of Pancreas Development and Function written by Joel F. Habener and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.