Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Fatal Attractions Protein Aggregates In Neurodegenerative Disorders
Download Fatal Attractions Protein Aggregates In Neurodegenerative Disorders full books in PDF, epub, and Kindle. Read online Fatal Attractions Protein Aggregates In Neurodegenerative Disorders ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders by : V.M.-Y. Lee
Download or read book Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders written by V.M.-Y. Lee and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume are contributions based on a meeting arranged by the WHO and the Fondation IPSEN. The scientists focus on neurodegenerative disorders like Alzheimer's Disease, Chromosome 17-Linked Dementia, Parkinson's Disease and disorders with tauopathies.
Book Synopsis Neurodegenerative Diseases by : Uday Kishore
Download or read book Neurodegenerative Diseases written by Uday Kishore and published by BoD – Books on Demand. This book was released on 2013-05-15 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
Book Synopsis The Molecular and Cellular Basis of Neurodegenerative Diseases by : Michael S. Wolfe
Download or read book The Molecular and Cellular Basis of Neurodegenerative Diseases written by Michael S. Wolfe and published by Academic Press. This book was released on 2018-03-29 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts
Book Synopsis Parkinson's Disease by : Marianne J. Willow
Download or read book Parkinson's Disease written by Marianne J. Willow and published by Nova Publishers. This book was released on 2005 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is characterised by an insidious onset with slowing of emotional and voluntary movement, muscular rigidity, postural abnormality and tremor. Parkinson's disease was first described in 1817 by James Parkinson. It is a progressive, neurological disease mainly affecting people over the age of 50, although at least 10 per cent of cases occur at an earlier age. It affects people of either sex and all ethnic groups. In the normal brain, some nerve cells produce the chemical dopamine, which transmits signals within the brain to produce smooth movement of muscles. In Parkinson's patients, 80 percent or more of these dopamine-producing cells are damaged, dead, or otherwise degenerated. This causes the nerve cells to fire wildly, leaving patients unable to control their movements. This new book brings together the latest research in this field.
Book Synopsis Leucine-Rich Repeat Kinase 2 (LRRK2) by : Hardy J. Rideout
Download or read book Leucine-Rich Repeat Kinase 2 (LRRK2) written by Hardy J. Rideout and published by Springer. This book was released on 2017-03-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Author :Peter H. St.George-Hyslop Publisher :Springer Science & Business Media ISBN 13 :3540879412 Total Pages :188 pages Book Rating :4.5/5 (48 download)
Book Synopsis Intracellular Traffic and Neurodegenerative Disorders by : Peter H. St.George-Hyslop
Download or read book Intracellular Traffic and Neurodegenerative Disorders written by Peter H. St.George-Hyslop and published by Springer Science & Business Media. This book was released on 2009-02-03 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.
Book Synopsis Protein Chaperones and Protection from Neurodegenerative Diseases by : Stephan N. Witt
Download or read book Protein Chaperones and Protection from Neurodegenerative Diseases written by Stephan N. Witt and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, partly because of the potential for manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases, and partly because of the ever-aging global population. Discussing the potential to harness the power of protein chaperones, and future directions for research, discovery, and therapeutics, this book is essential reading for scientists working in the fields of biochemistry, molecular medicine, pharmacology and drug discovery, biotechnology and pharmaceutical companies, advanced students, and anyone interested in this cutting-edge topic.
Book Synopsis Novel Drug Delivery Systems in the management of CNS Disorders by : Pooja A Chawla
Download or read book Novel Drug Delivery Systems in the management of CNS Disorders written by Pooja A Chawla and published by Elsevier. This book was released on 2024-10-01 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Drug Delivery Systems in the Management of CNS Disorders offers a comprehensive source of information on delivering drugs to the central nervous system to treat various diseases and conditions. The book covers a wide range of CNS disorders, including epilepsy, Parkinson's, Alzheimer's, Huntington's, multiple sclerosis, schizophrenia, cerebral palsy, autism, ALS, and others. The book begins by presenting the foundations of drug delivery to the brain and addressing the associated challenges. It then delves into clinical trials and explores the future potential of the presented technologies. This reference is designed for drug delivery researchers in academia and corporations, providing them with the essential knowledge about overcoming the Brain-Blood Barrier and achieving targeted drug delivery to the central nervous system. - Consolidates current state of the art research into a single book volume - Presents the challenges of drug delivery to the CNS in a comprehensive way - Covers the most relevant CNS conditions and diseases - Provides future perspectives and the most active research areas in this fast-moving field
Book Synopsis Two Faces of Evil: Cancer and Neurodegeneration by : Thomas Curran
Download or read book Two Faces of Evil: Cancer and Neurodegeneration written by Thomas Curran and published by Springer Science & Business Media. This book was released on 2010-12-16 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Author :Jeffrey L. Cummings Publisher :Springer Science & Business Media ISBN 13 :9783540248354 Total Pages :192 pages Book Rating :4.2/5 (483 download)
Book Synopsis Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases by : Jeffrey L. Cummings
Download or read book Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases written by Jeffrey L. Cummings and published by Springer Science & Business Media. This book was released on 2005-04 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative Disorders as Proteinopathies: Phenotypic Relationships.- Towards a Molecular Classification of Neurodegenerative Disease.- Racial and Ethnic Influences on the Expression of the Genotype in Neurodegenerative Diseases.- Causes and Consequences of Oxidative Stress in Neurodegenerative Diseases.- Early Onset Familial Alzheimer's Disease: Is a Mutation Predictive of Pathology?.- Identification of Genes that Modify the Age of Onset in a Large Familial Alzheimer's Disease Kindred.- Variable Phenotype of Alzheimer's Disease with Spastic Paraparesis.- Presenilin Mutations: Variations in the Behavioral Phenotype with an Emphasis on the Frontotemporal Dementia Phenoytpe.- Frontotemporal Dementias: Genotypes and Phenotypes.- Chromosome 17-Linked Frontotemporal Dementia with Ubiquitin-Positive, tau-Negative Inclusions.- Variations of the Phenotype in Frontotemporal Dementias.- Phenotype/Genotype Correlations in Parkinson's Disease.- Subject Index
Book Synopsis Oxidative Stress and Neurodegenerative Disorders by : G. Ali Qureshi
Download or read book Oxidative Stress and Neurodegenerative Disorders written by G. Ali Qureshi and published by Elsevier. This book was released on 2007-03-22 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Book Synopsis Advances in Research on Neurodegeneration by : R. Horowski
Download or read book Advances in Research on Neurodegeneration written by R. Horowski and published by Springer Science & Business Media. This book was released on 2013-04-09 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 10th International Winter Conference on Neurodegeneration (lWCN) has taken place from February 14-16,2002, at the lovely "SchloB Ziethen", an old prussian manor (in Prussia, 'faute de mieux', called 'SchloB', i. e. cas tle or residence). This place is 20 km off Tegel Airport, Berlin's main airport, and has been beautifully restored by baroness Edith von Thiingen (nee von BUlow, i. e. of historical Prussian aristocracy); it lends itself rather perfectly for the IWCN type of small interdisciplinary workshops on neurodegenera tion which combine short lectures with plenty of discussion. In this context, we could quote Alexander von Humboldt's famous opening words for one of the first international scientific meetings held at Berlin, on September 18, 1828: "The main purpose ... does not consist in a mutual reading of manuscripts all to be printed after at least one year in specialised publications, but in the personal communication amongst those who work in similar scientific fields; the oral and thus more stimulating exchange of ideas, might they represent facts, opinions or doubts; the foundation of friendly relations which convey illumination to our sciences, serene grace to our lives and tolerance and mildness to our habits ... Berlin, Sept. 18, 1828 Alexander von Humboldt To the IWCN aficionado, it may come as a little surprise that this is the pub lication of the 10th Winter Conference as this might mean that they must have missed number 9.
Book Synopsis Synaptic Plasticity and the Mechanism of Alzheimer's Disease by : Dennis J. Selkoe
Download or read book Synaptic Plasticity and the Mechanism of Alzheimer's Disease written by Dennis J. Selkoe and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biochemical hypothesis - that Alzheimer’s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.
Book Synopsis Neurodegenerative Diseases by : G. Jolles
Download or read book Neurodegenerative Diseases written by G. Jolles and published by Academic Press. This book was released on 1994-11-14 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few years, the considerable progress made in biochemistry, virology, molecular biology and genetics has revealed some of the intimate mechanisms of the neurodegenerative diseases. The present volume is an attempt to review the latest data in the field to illuminate new avenues for future research. This volume gathers together chapters and discussions on the etiology and pathogenesis of the neurodegenerative diseases. Apoptosis of programmed cell death as well as other genetic implications are discussed; special attention is given to the coexistence and interconnection of genetic and environmental factors. There is extensive coverage of prions responsible for bovine spongiform encephalopathy, Cruetzfeld-Jacob disease and kuru. The various aspects of non-conventional transmissible agents are thoroughly reviewed. Further contributions deal with the role of growth factors as well as of free radicals. Consideration is given to the molecular mechanisms of Alzheimer's disease, in particular the role of tau protein. Finally, several pharmacological models now available, which throw light upon aspects of Parkinson's disease, Huntington's chorea and multiple sclerosis, are examined and discussed. It is hoped that recent scientific advances will lead to the discovery of new drugs to fill the current therapeutic void. There are hopes of an early indication of this in the case of amyotrophic lateral sclerosis.
Book Synopsis Handbook of Neurochemistry and Molecular Neurobiology by : Naren L. Banik
Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Naren L. Banik and published by Springer Science & Business Media. This book was released on 2009 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic approaches in spinal cord injury.- Cell death and tissue degeneration in traumatic brain injury.- neurotransmitters and electrophysiology in brain injury.- neurotransmitters and electrophysiology in brain injury.- Parkinsonism in the MPTP model.- EAE Demyelination.- EAE Neurodegeneration.- Cataract.- Uveitis.- Optic neuritis.- GBS/peripherial neuropathy, paraproteinemia.- Brain Tumor(Tumor Mechanisma).- Brain Tumor and angiogenesis.- SCIDS.- Phenylketone urea and mental retardation.- Neurofibromatosis.- BBB.- Muscular dystrophy.- Stracher.- Diabetic neuropathy/retinopathy/cataract.- Peroxisomes and adrenoleukodystrophy ALD.- Neuroprotection.- NFkB (Inflammation and spinal cord injury).- spinal cord injury and traumatic brain injury.- free radicals and neuroprotection.- Traumatic brain injury.- white matter degeneration.- Mitochondrial membrane defects.- Encephalomyopathies.- metal induced neurodegenaration.- neurometals in protein misfolding neurodegenerative diseases.- hyperammonemia.- kyneurenines in the brain preclinical and clinical studies, therapeutic condiserations.
Book Synopsis Mild Cognitive Impairment by : Ronald C. Petersen
Download or read book Mild Cognitive Impairment written by Ronald C. Petersen and published by Oxford University Press. This book was released on 2003-01-09 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the boundary zones between normal aging and Alzheimer's disease (AD)? Are many elderly people whom we regard as normal actually in the early stages of AD? Alzheimer's disease does not develop overnight; the early phases may last for years or even decades. Recently, clinical investigators have identified a transitional condition between normal aging and and very early Alzheimer's disease that they have called mild cognitive impairment, or MCI. This term typically refers to memory impairment beyond what one would expect in individuals of a given age whose other abilities to function in daily life are well preserved. Persons who meet the criteria for mild cognitive impairment have an increased risk of progressing to Alzheimer's disease in the near future. Though many questions about this condition and its underlying neuropathology remain open, full clinical trials are currently underway worldwide aimed at preventing the progression from MCI to Alzheimer's disease. This book addresses the spectrum of issues involved in mild cognitive impairment, and includes chapters on clinical studies, neuropsychology, neuroimaging, neuropathology, biological markers, diagnostic approaches, and treatment. It is intended for clinicians, researchers, and students interested in aging and cognition, among them neurologists, psychiatrists, geriatricians, clinical psychologists, and neuropsychologists.
Book Synopsis Advances in Research on Neurodegeneration by : P. Riederer
Download or read book Advances in Research on Neurodegeneration written by P. Riederer and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th International Winter Conference on Neurodegeneration from Febru ary 9 to 13, 2000 took place in Tegernsee, Bavaria, Germany. The interest shown in this symposium, which was carried by invited speakers only, was striking. 28 lectures in 5 sessions dealt with themes on basic science and therapy strategies for neurodegenerative illness. This time especially basic mechanism of cell death and resulting causal treatment possibilities were centre themes of the lectures and lively discussions. In accordance with tradi tion 5 lectures on Multiple Sclerosis finished the convention. 60 scientists from 13 countries discussed current questions to these themes. The Symposium started with a lecture on the history of the develop ment of modern-L-DOPA-therapy. Lectures on cell death of dopaminergic nerve cells, new valuation regarding assembly, built up and function of neuromelanin of Substantia nigra and with this, the question of the physio logic and pathobiochemical role of dopamine and neuromelanin built the first block of themes which consequently extended to molecular and genetic aspects of cell death. Highlights of the symposium were neuroprotective and neuroregenerative future therapy strategies together with discussions on the difficulties of clinical neuroprotection. Developmental biological aspects on nerve cells, reorganisation and neurodegeneration showed a stimulating point of view of momentary and future development possibilities of new and more causal forms of therapy of neurodegenerative illness.
