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Extracellular Rna
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Download or read book Extracellular RNA written by Tushar Patel and published by Humana Press. This book was released on 2018-02-01 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a collection of methods and protocols detailing extracellular RNA and hopes to be a useful resource for those interested in this exciting and emerging field. Chapters are divided into four sections covering an overview of the field, approaches for the isolation of exRNA, protocols for detection and quantitation of exRNA, and approaches that can be useful for studies to evaluate potential therapeutic applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Extracellular RNA: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Arteriogenesis by : Wolfgang Schaper
Download or read book Arteriogenesis written by Wolfgang Schaper and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizes the research activities of Germany’s Nauheim Institute of the Max Planck Society and its group of investigators both past and present, in the field of collateral artery growth. Incorporates a multidisciplinary in vivo approach to the study of arteriogenesis that includes molecular approaches with classical physiology and immunohistochemistry. Full color throughout and well illustrated.
Book Synopsis RNA-Based Regulation in Human Health and Disease by :
Download or read book RNA-Based Regulation in Human Health and Disease written by and published by Academic Press. This book was released on 2020-08-19 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field
Book Synopsis Extracellular Nucleic Acids by : Yo Kikuchi
Download or read book Extracellular Nucleic Acids written by Yo Kikuchi and published by Springer Science & Business Media. This book was released on 2010-07-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular nucleic acids have recently emerged as important players in the fields of biology and the medical sciences. In the last several years, extracellular nucleic acids have been shown to be involved in not only microbial evolution as genetic elements but also to have structural roles in bacterial communities, such as biofilms. Circulating DNA and RNA have been found in human blood and expected to be useful as non-invasive markers for the diagnosis of several diseases. In addition, extracellular nucleic acids have attracted attention as active modulators of the immune system of higher organisms, including humans. This book covers nearly all of the newly developing fields related to extracellular nucleic acids, including those of basic biology, ecology and the medical sciences, and provides readers with the latest knowledge on them.
Book Synopsis Fungal Extracellular Vesicles by : Marcio Rodrigues
Download or read book Fungal Extracellular Vesicles written by Marcio Rodrigues and published by Springer Nature. This book was released on 2022-01-01 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth overview on the manifold functions of fungal extracellular vesicles (EV) which span from cell-to-cell communication, pathogenicity and stimulation of host’s immunity to export of hundreds of biomolecules. The book summarizes the present knowledge on the impact of extracellular vesicles on fungal biology. Extracellular vesicles participate in fundamental biological processes in all living cells but only during the last 15 years the production and functions of EVs were identified and studied in fungal species too. Up to date more than 50 independent studies have shown that extracellular vesicles are produced by at least 20 fungal species. The book addresses researchers and advanced students in Microbiology, Mycology and Biotechnology.
Book Synopsis Use of High-throughput Sequencing for the Characterization of Extracellular RNA and to Study the Dynamics of Bacterial RNA Modification by : Adeline Galvanin
Download or read book Use of High-throughput Sequencing for the Characterization of Extracellular RNA and to Study the Dynamics of Bacterial RNA Modification written by Adeline Galvanin and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Early Diagnosis of Alzheimer’s Disease by : Leonard F. M. Scinto
Download or read book Early Diagnosis of Alzheimer’s Disease written by Leonard F. M. Scinto and published by Springer Science & Business Media. This book was released on 2000-02-09 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of new diagnostic approaches to Alzheimer's disease. The authoritative contributors critically survey the most promising current research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this increasingly widespread disease. It will establish a new standard reference guide for all those working with Alzheimer's patients.
Book Synopsis Exosomal RNA by : Debalina Bhattacharya
Download or read book Exosomal RNA written by Debalina Bhattacharya and published by Elsevier. This book was released on 2024-03-29 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exosomal RNA: Role in Human Diseases and Therapy provides an in-depth study of exosomes and their RNA in the context of a variety of diseases. The book explores the diagnostic and therapeutic potential of exosomal RNA as biomarkers across a range of different conditions, including cancer, type 2 diabetes, cardiovascular and renal disease, as well as bacterial infections and tissue repair. The link between exosomal RNA expression and neurodegenerative disease is also explored. The book goes on to share the significance of exosomal RNA in preserving cellular function, with special attention given to their role in the autophagy process. This book gives an overview of the isolation, characterization, and potential applications of exosomal RNA, providing researchers with an understanding of how they can be manipulated and utilized for the treatment of various diseases and conditions. This is an ideal reference for researchers in the field of molecular biology, cell biology, and related fields, as well as those involved in the development of therapeutics and personalized medicine. - Provides an introduction into exosomal RNA and their potential as predictive and diagnostic biomarkers for various conditions - Considers exosomal RNA in a variety of human disorders, including metabolic diseases, inflammatory diseases, and cancer - Discusses the role of exosomal RNA in preserving the cellular environment and its role in the autophagy process
Book Synopsis Extracellular Vesicles by : Winston Patrick Kuo
Download or read book Extracellular Vesicles written by Winston Patrick Kuo and published by Humana. This book was released on 2018-08-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines established methods and protocols to isolate and characterize extracellular vesicles (EVs) and their composition, among other techniques including purification, imaging, biofluid-specific and cell-specific isolation and downstream genomic and proteomic profiling. The international group of expert scientists who have contributed to this collection provide a variety of different techniques related to the growing assortment of EV applications, given that at times using only one technique or two is insufficient to address the question at hand. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Extracellular Vesicles: Methods and Protocols serves as an ideal guide for researchers seeking to expand our knowledge of EV functions and applications.
Book Synopsis Extracellular RNAs (exRNAs) and Their Function in Host Induced Gene Silencing (HIGS) by : Hana Zand Karimi
Download or read book Extracellular RNAs (exRNAs) and Their Function in Host Induced Gene Silencing (HIGS) written by Hana Zand Karimi and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Host-Induced Gene Silencing (HIGS) is an RNA interference-based strategy used by plants to induce gene silencing in closely associated organisms. HIGS is currently being used by molecular biologists to engineer resistance in crop plants to diverse pathogens and pests, including fungi, nematodes, and insects. However, the mechanism by which silencing RNAs are translocated from host plants to other organisms is poorly understood. Since the apoplast (extracellular space) is the first battlefield between plants and pathogens, I hypothesize that extracellular RNAs (exRNAs) may play a key role in HIGS. To study the possible function of exRNAs, first I aimed to investigate the RNA content of apoplastic fluid and characterize exRNAs and their features. I have thus purified and characterized exRNAs found in the apoplast of Arabidopsis leaves. This work revealed that apoplastic fluid not only contains small RNAs, but also long non-coding RNAs (lncRNAs) ranging from hundreds to thousands of bases in length. Significantly, a large fraction of these exRNAs are circular RNAs (circRNAs). Since apoplastic fluid contains extracellular vesicles (EVs), I investigated whether exRNAs are encapsulated inside EVs. I showed that exRNAs are mostly located outside EVs and are protected by RNA binding proteins (RBPs). I investigated two specific RBPs, AGO2 and GRP7, that had been shown by others in the Innes laboratory to be present in the apoplast. AGO2 and GRP7 were both found to bind to lncRNAs, and to co-immunoprecipitate, suggesting that they form an RNA-protein complex. Mutation of either GRP7 or AGO2 caused large changes in apoplastic RNA content, indicating that these proteins contribute to the secretion or stability of exRNAs. GRP7 contains a putative N6-methyladenosine (m6A) binding domain, which is post-transcriptional modification found on many RNAs, including circRNAs. I thus investigated the presence of m6A on exRNAs and found that exRNAs are highly enriched in m6A modification. These data indicate that m6A modification might play a role in loading selected RNA into the apolast. Collectively, my work has uncovered a previously unknown aspect of plant biology, namely that plants secrete long non-coding RNAs. Future work will need to address the function of this exRNA, especially in the context of plant-microbe interactions.
Download or read book MicroRNA Profiling written by Sweta Rani and published by Springer Nature. This book was released on 2022-11-28 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides updated and comprehensive methods on miRNA biogenesis and their role in the development and progression of various human diseases. Chapters detail miRNA biogenesis, isolating RNA, extracellular vesicles (EVs), circulating miRNAs, analyzing miRNA and miRDeep-P2, protocols for total RNA isolation from cells, cell-derived products, isolation and characterization of exosomes, serum, plasma specimens, and software tools. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, MicroRNA Profiling: Methods and Protocols, Second Edition aims to provide comprehensive and accessible methods to undergraduate, graduate, and established scientist.
Book Synopsis Vascular Biology, Haemostasis and Extracellular Nucleic Acids in Vascular Diseases and Immunity. A Tribute to Klaus T. Preissner by : Ritva Tikkanen
Download or read book Vascular Biology, Haemostasis and Extracellular Nucleic Acids in Vascular Diseases and Immunity. A Tribute to Klaus T. Preissner written by Ritva Tikkanen and published by Frontiers Media SA. This book was released on 2022-01-28 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Prof. Ritva Tikkanen Receives Research Funding From Neurogene Inc. and GC Pharma for Studies Unrelated to the Subject. Topic Editor Prof. Carl Blobel is Co-Inventor on a Patent Describing a Method of Identifying Agents for Combination With Inhibitors of iRhoms. He and the Hospital for Special Surgery (New York, USA) are Investigating Suitable Approaches to Identify iRhom Inhibitors, and are Co-Founders of a Small Company Called SciRhom in Munich to Pursue These Efforts. Topic Editor Dr. Sylvia Fischer Declares no Competing Interests With Regards to the Research Topic Subject.
Book Synopsis The Damaging Nature of Extracellular RNA in Cardiovascular Diseases by : Héctor Alejandro Cabrera Fuentes
Download or read book The Damaging Nature of Extracellular RNA in Cardiovascular Diseases written by Héctor Alejandro Cabrera Fuentes and published by . This book was released on 2014 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modification of Neuroblastoma by : Tahira Zar
Download or read book Modification of Neuroblastoma written by Tahira Zar and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigation of an Extracellular RNA Entity Produced by Human Leukemia Cells in Vitro by : Gertrude Case Buehring
Download or read book Investigation of an Extracellular RNA Entity Produced by Human Leukemia Cells in Vitro written by Gertrude Case Buehring and published by . This book was released on 1972 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Global Landscape of Extracellular RNAs and Their Post-transcriptional Modifications in Human Biofluids by : Kikuye Koyano
Download or read book Global Landscape of Extracellular RNAs and Their Post-transcriptional Modifications in Human Biofluids written by Kikuye Koyano and published by . This book was released on 2021 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coding and noncoding RNAs (ncRNAs) are essential molecules of life. While the roles of RNA have been extensively studied inside the cell, RNA has also been detected outside of the cell and stably expressed in body fluids. These extracellular RNAs (exRNAs) are packaged inside vesicles, lipoproteins, or in ribonucleoprotein complexes which protect them from degradation by ribonucleases. exRNAs are thought to be involved in cell-to-cell communication by sending messages via extracellular vesicles. Previous studies primarily focused on total expression of exRNAs, especially microRNAs whose presence in the extracellular space is now well established. Other aspects of the transcriptome, such as RNA modifications, were rarely investigated in exRNA profiles. In addition to microRNAs, a plural of recent studies reported the detection of mRNA fragments in the extracellular space. However, many questions remain about the mechanisms that enable their stability, sorting, and function. In this dissertation, leveraging a large amount of public and in-house exRNA-seq data, we develop and apply bioinformatic tools to analyze the patterns of post-transcriptional modifications, mRNA fragments, and repeat-derived RNAs.We developed miNTA, a highly accurate bioinformatic method to identify 3' end non-templated additions (NTAs) on microRNAs, a type of post-transcriptional modification. We observed enriched levels of 3' uridylation across 4 biofluids, consistent with previous findings. We demonstrated that 3' uridylation levels enabled improved segregation of biofluids relative to miRNA expression levels. Next, we analyzed mRNA fragments, repeat-derived RNAs and another type of post-transcriptional modifications, RNA editing, in exRNA-seq data of 17 human biofluids. We observed enrichment of RNA binding protein (RBP) binding sites in mRNA fragments, supporting the hypothesis that RBPs play a role in selection and stability of mRNA fragments. Additionally, we reported hundreds of RNA editing sites across biofluids. Expanding upon examples of RNA editing across biofluids, we probed RNA editing differences in Alzheimer's Disease and control individuals using plasma-derived exRNA-seq data. Editing levels of differential editing sites were elevated in Alzheimer's Disease patients, including three sites whose levels correlated with patient cognitive scores. These findings support the potential to uncover useful information via RNA editing analysis in exRNA profiling.
