Extracellular Matrix Remodeling

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Extracellular Matrix Remodeling

Author : Nicoletta Gagliano
Publisher : MDPI
ISBN 13 : 3039216287
Total Pages : 428 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Extracellular Matrix Remodeling by : Nicoletta Gagliano

Download or read book Extracellular Matrix Remodeling written by Nicoletta Gagliano and published by MDPI. This book was released on 2019-11-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix (ECM) is where cells live. It is composed of collagen and elastic fibers, glycosaminoglycans and proteoglycans, and several glycoproteins. In most tissues, fibril-forming collagen type I is the major constituent of ECM.The function of the ECM goes beyond providing mechanical support to cells and tissues. As cells are embedded into the ECM and interact with its components through their surface receptors, cell–ECM interaction plays a key role in influencing different cell activities, such as cell proliferation and migration. The ECM also sequesters and releases growth factors affecting important cellular pathways. Overall, the ECM strongly influences and affects cell behavior and tissue homeostasis. ECM is a highly dynamic structural network that continuously undergoes controlled remodeling mediated by matrix-degrading enzymes, the matrix metalloproteinases (MMPs), under normal conditions. Quantitative and qualitative deregulation of ECM remodeling and, especially, of collagen turnover, is responsible for the alteration of ECM composition and structure, associated with the development and progression of several pathological conditions, such as organ fibrosis (determined by the abnormal accumulation of ECM components) and tumor invasion. The understanding of the diverse biological roles and properties of the ECM components is pivotal to the development of new therapeutic tools for disease treatment.

The Human Gut-Liver-Axis in Health and Disease

Author : Aleksander Krag
Publisher : Springer
ISBN 13 : 3319988905
Total Pages : 296 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis The Human Gut-Liver-Axis in Health and Disease by : Aleksander Krag

Download or read book The Human Gut-Liver-Axis in Health and Disease written by Aleksander Krag and published by Springer. This book was released on 2018-11-09 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.

Intestinal Stem Cell Niche

Author :
Publisher : Academic Press
ISBN 13 : 9780128134818
Total Pages : 150 pages
Book Rating : 4.1/5 (348 download)

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Book Synopsis Intestinal Stem Cell Niche by :

Download or read book Intestinal Stem Cell Niche written by and published by Academic Press. This book was released on 2018-04-24 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Extracellular Matrix Degradation

Author : William C. Parks
Publisher : Springer Science & Business Media
ISBN 13 : 3642168612
Total Pages : 262 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Extracellular Matrix Degradation by : William C. Parks

Download or read book Extracellular Matrix Degradation written by William C. Parks and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

The Extracellular Matrix: an Overview

Author : Robert Mecham
Publisher : Springer Science & Business Media
ISBN 13 : 3642165559
Total Pages : 429 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis The Extracellular Matrix: an Overview by : Robert Mecham

Download or read book The Extracellular Matrix: an Overview written by Robert Mecham and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Extracellular matrix remodeling in atherosclerosis

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)

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Book Synopsis Extracellular matrix remodeling in atherosclerosis by :

Download or read book Extracellular matrix remodeling in atherosclerosis written by and published by . This book was released on with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Author : Yanhang Zhang
Publisher :
ISBN 13 : 9783030201838
Total Pages : 392 pages
Book Rating : 4.2/5 (18 download)

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Book Synopsis Multi-scale Extracellular Matrix Mechanics and Mechanobiology by : Yanhang Zhang

Download or read book Multi-scale Extracellular Matrix Mechanics and Mechanobiology written by Yanhang Zhang and published by . This book was released on 2020 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

Heparanase

Author : Israel Vlodavsky
Publisher : Springer Nature
ISBN 13 : 3030345211
Total Pages : 871 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Heparanase by : Israel Vlodavsky

Download or read book Heparanase written by Israel Vlodavsky and published by Springer Nature. This book was released on 2020-04-09 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Extracellular Matrix Remodeling and Cell Signaling by the First Type III Repeat in Fibronectin

Author : Richard M. Klein
Publisher :
ISBN 13 :
Total Pages : 278 pages
Book Rating : 4.:/5 (565 download)

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Book Synopsis Extracellular Matrix Remodeling and Cell Signaling by the First Type III Repeat in Fibronectin by : Richard M. Klein

Download or read book Extracellular Matrix Remodeling and Cell Signaling by the First Type III Repeat in Fibronectin written by Richard M. Klein and published by . This book was released on 2004 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cell-Extracellular Matrix Interactions in Cancer

Author : Roy Zent
Publisher : Springer Science & Business Media
ISBN 13 : 1441908145
Total Pages : 316 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Cell-Extracellular Matrix Interactions in Cancer by : Roy Zent

Download or read book Cell-Extracellular Matrix Interactions in Cancer written by Roy Zent and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

Relaxin and Related Peptides

Author : Alexander I. Agoulnik
Publisher : Springer Science & Business Media
ISBN 13 : 0387746722
Total Pages : 161 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Relaxin and Related Peptides by : Alexander I. Agoulnik

Download or read book Relaxin and Related Peptides written by Alexander I. Agoulnik and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.

Biomarkers in Liver Disease

Author : Victor R. Preedy
Publisher : Springer
ISBN 13 : 9789400776746
Total Pages : 0 pages
Book Rating : 4.7/5 (767 download)

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Book Synopsis Biomarkers in Liver Disease by : Victor R. Preedy

Download or read book Biomarkers in Liver Disease written by Victor R. Preedy and published by Springer. This book was released on 2017-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Extracellular Matrix Assembly and Structure

Author : Peter D. Yurchenco
Publisher : Academic Press
ISBN 13 : 1483289427
Total Pages : 483 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Extracellular Matrix Assembly and Structure by : Peter D. Yurchenco

Download or read book Extracellular Matrix Assembly and Structure written by Peter D. Yurchenco and published by Academic Press. This book was released on 2013-10-22 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling

Extracellular Matrix Biology

Author : Richard O. Hynes
Publisher :
ISBN 13 : 9781936113385
Total Pages : 0 pages
Book Rating : 4.1/5 (133 download)

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Book Synopsis Extracellular Matrix Biology by : Richard O. Hynes

Download or read book Extracellular Matrix Biology written by Richard O. Hynes and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis. Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.

Extracellular Matrix in Development

Author : Douglas W. DeSimone
Publisher : Springer Science & Business Media
ISBN 13 : 3642359353
Total Pages : 260 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Extracellular Matrix in Development by : Douglas W. DeSimone

Download or read book Extracellular Matrix in Development written by Douglas W. DeSimone and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Connective Tissue and Its Heritable Disorders

Author : Peter M. Royce
Publisher : John Wiley & Sons
ISBN 13 : 0471461172
Total Pages : 1201 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Connective Tissue and Its Heritable Disorders by : Peter M. Royce

Download or read book Connective Tissue and Its Heritable Disorders written by Peter M. Royce and published by John Wiley & Sons. This book was released on 2003-04-14 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects is the definitive reference text in its field, with over 40% more pages on the nature, diagnosis, and treatment of disease than its predecessor. Collecting new research on disorders detailed in the first edition as well as on those previously excluded, editors Peter Royce and Beat Steinmann provide the most up-to-date clinical and scientific information for medical specialists treating affected individuals. Features of this revised and updated volume include detailed reviews of the clinical diagnosis, mode of inheritance, risk of recurrence, and prenatal diagnosis of each inherited connective tissue disorder; a thorough description of the morphology of connective tissues; a completely updated and revised section on the biology of the extracellular matrix; and the addition of syndromes such as craniosyntosis, and disorders of sulfate metabolism.

Extracellular Matrix Remodeling is a Key Event in Atherosclerosis and an Opportunity for Biomarker Development

Author : Helene Skjøt-Arkil
Publisher :
ISBN 13 :
Total Pages : 144 pages
Book Rating : 4.:/5 (858 download)

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Book Synopsis Extracellular Matrix Remodeling is a Key Event in Atherosclerosis and an Opportunity for Biomarker Development by : Helene Skjøt-Arkil

Download or read book Extracellular Matrix Remodeling is a Key Event in Atherosclerosis and an Opportunity for Biomarker Development written by Helene Skjøt-Arkil and published by . This book was released on 2012 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: