Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs)

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Publisher : Mdpi AG
ISBN 13 : 9783036526775
Total Pages : 334 pages
Book Rating : 4.5/5 (267 download)

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Book Synopsis Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) by : Dragana Nikitovi

Download or read book Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) written by Dragana Nikitovi and published by Mdpi AG. This book was released on 2021-12-29 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycosaminoglycans are linear, anionic polysaccharides (GAGs) consisting of repeating disaccharides. GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans, e.g., chondroitin/dermatan sulfate (CS/DS), heparin/heparan sulfate (Hep/HS) and keratan sulfate (KS), as well as non-sulfated hyaluronan (HA). By modulating biological signaling GAGs participate in the regulation of homeostasis and also participate in disease progression. The book, entitled "Exploring the multifaceted roles of glycosaminoglycans (GAGs)-new advances and further challenges", features original research and review articles. These articles cover several GAG-related timely topics in structural biology and imaging; morphogenesis, cancer, and other disease therapy and drug developments; tissue engineering; and metabolic engineering. This book also includes an article illustrating how metabolic engineering can be used to create the novel chondroitin-like polysaccharide. A prerequisite for communicating in any discipline and across disciplines is familiarity with the appropriate terminology. Several nomenclature rules exist in the field of biochemistry. The historical description of GAGs follows IUPAC and IUB nomenclature. New structural depictions such as the structural nomenclature for glycan and their translation into machine-readable formats have opened the route for cross-references with popular bioinformatics resources and further connections with other exciting "omics" fields.

Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges

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Publisher :
ISBN 13 : 9783036526768
Total Pages : 313 pages
Book Rating : 4.5/5 (267 download)

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Book Synopsis Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges by : Dragana Nikitovic

Download or read book Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges written by Dragana Nikitovic and published by . This book was released on 2021 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycosaminoglycans are linear, anionic polysaccharides (GAGs) consisting of repeating disaccharides. GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans, e.g., chondroitin/dermatan sulfate (CS/DS), heparin/heparan sulfate (Hep/HS) and keratan sulfate (KS), as well as non-sulfated hyaluronan (HA). By modulating biological signaling GAGs participate in the regulation of homeostasis and also participate in disease progression. The book, entitled “Exploring the multifaceted roles of glycosaminoglycans (GAGs)--new advances and further challenges”, features original research and review articles. These articles cover several GAG-related timely topics in structural biology and imaging; morphogenesis, cancer, and other disease therapy and drug developments; tissue engineering; and metabolic engineering. This book also includes an article illustrating how metabolic engineering can be used to create the novel chondroitin-like polysaccharide.A prerequisite for communicating in any discipline and across disciplines is familiarity with the appropriate terminology. Several nomenclature rules exist in the field of biochemistry. The historical description of GAGs follows IUPAC and IUB nomenclature. New structural depictions such as the structural nomenclature for glycan and their translation into machine-readable formats have opened the route for cross-references with popular bioinformatics resources and further connections with other exciting “omics” fields.

Glycosaminoglycans

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Author :
Publisher :
ISBN 13 : 9781493917143
Total Pages : 625 pages
Book Rating : 4.9/5 (171 download)

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Book Synopsis Glycosaminoglycans by : Kuberan Balagurunathan

Download or read book Glycosaminoglycans written by Kuberan Balagurunathan and published by . This book was released on 2015 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Glycosaminoglycans and Proteoglycans

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Author :
Publisher : MDPI
ISBN 13 : 3038428353
Total Pages : 247 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Glycosaminoglycans and Proteoglycans by : 978-3-03842-836-7

Download or read book Glycosaminoglycans and Proteoglycans written by 978-3-03842-836-7 and published by MDPI. This book was released on 2018-07-04 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Glycosaminoglycans and Proteoglycans" that was published in Pharmaceuticals

Molecular Biology of the Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemistry and Biology of Heparin and Heparan Sulfate

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Publisher : Elsevier
ISBN 13 : 0080529054
Total Pages : 793 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Chemistry and Biology of Heparin and Heparan Sulfate by : Hari G. Garg

Download or read book Chemistry and Biology of Heparin and Heparan Sulfate written by Hari G. Garg and published by Elsevier. This book was released on 2011-10-10 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. - Comprehensively reviews all aspects of heparin and heparan sulfate research - Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work - Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

Unravelling the complex and multifaceted role of the cerebellum in health and disease

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832521096
Total Pages : 163 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Unravelling the complex and multifaceted role of the cerebellum in health and disease by : Marija Cvetanovic

Download or read book Unravelling the complex and multifaceted role of the cerebellum in health and disease written by Marija Cvetanovic and published by Frontiers Media SA. This book was released on 2023-04-20 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:

On Bullshit

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Publisher : Princeton University Press
ISBN 13 : 1400826535
Total Pages : 80 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis On Bullshit by : Harry G. Frankfurt

Download or read book On Bullshit written by Harry G. Frankfurt and published by Princeton University Press. This book was released on 2009-01-10 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 New York Times bestseller Featured on The Daily Show and 60 Minutes The acclaimed book that illuminates our world and its politics by revealing why bullshit is more dangerous than lying One of the most prominent features of our world is that there is so much bullshit. Yet we have no clear understanding of what bullshit is, how it’s distinct from lying, what functions it serves, and what it means. In his acclaimed bestseller On Bullshit, Harry Frankfurt, who was one of the world’s most influential moral philosophers, explores this important subject, which has become a central problem of politics and our world. With his characteristic combination of philosophical acuity, psychological insight, and wry humor, Frankfurt argues that bullshitters misrepresent themselves to their audience not as liars do, that is, by deliberately making false claims about what is true. Rather, bullshitters seek to convey a certain impression of themselves without being concerned about whether anything at all is true. They quietly change the rules governing their end of the conversation so that claims about truth and falsity are irrelevant. Although bullshit can take many innocent forms, excessive indulgence in it can eventually undermine the bullshitter’s capacity to tell the truth in a way that lying does not. Liars at least acknowledge that the truth matters. Because of this, bullshit is a greater enemy of the truth than lies are. Remarkably prescient and insightful, On Bullshit is a small book that explains a great deal about our time.

The Puppet Masters

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Author :
Publisher : World Bank Publications
ISBN 13 : 0821388967
Total Pages : 230 pages
Book Rating : 4.8/5 (213 download)

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Book Synopsis The Puppet Masters by : Emile van der Does de Willebois

Download or read book The Puppet Masters written by Emile van der Does de Willebois and published by World Bank Publications. This book was released on 2011-11-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report examines the use of these entities in nearly all cases of corruption. It builds upon case law, interviews with investigators, corporate registries and financial institutions and a 'mystery shopping' exercise to provide evidence of this criminal practice.

Essentials of Glycobiology

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Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Heparanase

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Author :
Publisher : Springer Nature
ISBN 13 : 3030345211
Total Pages : 871 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Heparanase by : Israel Vlodavsky

Download or read book Heparanase written by Israel Vlodavsky and published by Springer Nature. This book was released on 2020-04-09 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

The Art of Communication in Nursing and Health Care

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Publisher : Springer Publishing Company
ISBN 13 : 0826110568
Total Pages : 202 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis The Art of Communication in Nursing and Health Care by : Theresa Raphael-Grimm, PhD, CNS

Download or read book The Art of Communication in Nursing and Health Care written by Theresa Raphael-Grimm, PhD, CNS and published by Springer Publishing Company. This book was released on 2014-10-10 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: A handy guide to tackling difficult patient and professional interactions with confidence and compassion In this age of increasing reliance on technology, it is essential that the fundamentals of compassion and good communication—the art of patient care—remain at the heart of health care. This clear, concise guide to professional communication strategies helps nurses and other health care clinicians to build effective patient relationships and navigate a wide variety of difficult patient and professional interactions. Written by a practicing psychotherapist who has devoted nearly 30 years of study to clinician—patient relationships, the book tackles such complex issues as dealing with demanding patients, maintaining professional boundaries, overcoming biases and stereotypes, managing clinician emotions, communicating bad news, challenging a colleague’s clinical opinion, and other common scenarios. The book guides the reader through a conceptual framework for building effective relationships that is based on the principles of mindfulness. These principles are embedded in discussions of the fundamental elements of interpersonal effectiveness, such as hope, empathy, and listening. Chapters apply mindfulness principles to specific challenging situations with concrete examples that describe effective clinical behaviors as well as situations depicting pitfalls that may impede compassionate care. From a focus on everyday manners in difficult situations to beneficial approaches with challenging populations, the guide helps health care professionals confidently resolve common problems. Brief, to-the-point chapters help clinicians channel their clinical knowledge and good intentions into caring behaviors that allow the patient to more fully experience empathy and compassion. With the guiding theme of “using words as precision instruments,” this is a resource that will be referred to again and again. Key Features: • Helps health care professionals and nurses communicate effectively in challenging clinical and professional situations • Uses the principles of mindfulness to build satisfying relationships and resolve problems • Addresses such difficult issues as demanding patients, maintaining boundaries, overcoming biases, managing clinician emotions, and much more • Provides special tips for communicating with family members and caregivers • Authored by a practicing psychotherapist specializing in clinician—patient relationships for nearly 30 years

Glycomics

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Publisher : Humana Press
ISBN 13 : 9781607612407
Total Pages : 390 pages
Book Rating : 4.6/5 (124 download)

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Book Synopsis Glycomics by : Nicolle H. Packer

Download or read book Glycomics written by Nicolle H. Packer and published by Humana Press. This book was released on 2009-07-16 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the significant contributions of carbohydrates to the functional diversity of the cell, the challenging study of the glycome has expanded beyond the research of carbohydrate experts and into the wider scope of the life sciences. To aid all scientists now delving into this vital subject area, Glycomics: Methods and Protocols collects a compendium of detailed laboratory protocols reflecting the increasing availability of sample preparation, chromatographic, electrophoretic, mass spectrometric, and bioinformatic tools specifically designed for the analysis of glycosylation. Leading researchers in the field address subjects such as glycoprotein and proteoglycan analysis, glycosylation structure determination, as well as various approaches to investigate the interaction between glycans and a variety of carbohydrate-recognizing proteins in order to aid exploration into the functional significance of the oligosaccharides. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glycomics: Methods and Protocols serves as a valuable guide for experimenters facing the challenges of glycan analysis in hope of providing further insights into the biology of cell-cell communication and interaction.

Clinical Case Studies for the Family Nurse Practitioner

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Publisher : John Wiley & Sons
ISBN 13 : 1118277856
Total Pages : 432 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Clinical Case Studies for the Family Nurse Practitioner by : Leslie Neal-Boylan

Download or read book Clinical Case Studies for the Family Nurse Practitioner written by Leslie Neal-Boylan and published by John Wiley & Sons. This book was released on 2011-11-28 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.

The Multifaceted Roles of Lipids in Physiological and Pathophysiological States

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832500560
Total Pages : 164 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The Multifaceted Roles of Lipids in Physiological and Pathophysiological States by : Simona Lobasso

Download or read book The Multifaceted Roles of Lipids in Physiological and Pathophysiological States written by Simona Lobasso and published by Frontiers Media SA. This book was released on 2022-09-23 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mimicking the Extracellular Matrix

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Publisher : Royal Society of Chemistry
ISBN 13 : 1849738335
Total Pages : 422 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Mimicking the Extracellular Matrix by : Gregory H. Hudalla

Download or read book Mimicking the Extracellular Matrix written by Gregory H. Hudalla and published by Royal Society of Chemistry. This book was released on 2015-11-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Fundamentals and Applications of Fourier Transform Mass Spectrometry

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Author :
Publisher : Elsevier
ISBN 13 : 0128140143
Total Pages : 780 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Fundamentals and Applications of Fourier Transform Mass Spectrometry by : Philippe Schmitt-Kopplin

Download or read book Fundamentals and Applications of Fourier Transform Mass Spectrometry written by Philippe Schmitt-Kopplin and published by Elsevier. This book was released on 2019-08-11 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. - Covers FT-ICR-MS and Orbitrap's fundamentals, enhancing researcher knowledge - Includes details on ion sources, data processing, chemical analysis and imaging - Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis