Exogenous Factors In Colonic Carcinogenesis

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Exogenous Factors in Colonic Carcinogenesis

Author : W. Scheppach
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387800
Total Pages : 698 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Exogenous Factors in Colonic Carcinogenesis by : W. Scheppach

Download or read book Exogenous Factors in Colonic Carcinogenesis written by W. Scheppach and published by Springer Science & Business Media. This book was released on 2003-01-31 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of Falk Symposium 128, held in Würzburg, Germany, on May 2-3, 2002, and dedicated to the important issue of colonic carcinogenesis and its underlying genetic and environmental factors. Colorectal cancer is one of the leading causes of cancer-related death in industrialized countries. It has been recognized to be the consequence of a dynamic process leading from hyperproliferative epithelium through different classes of adenomas to invasive carcinoma. This adenoma-carcinoma sequence has been characterized on a molecular basis. Modern molecular biology has also helped to clarify the clustering of colorectal cancer within families, a phenomenon that has been known to clinicians for a long time. Thus, the pathogenesis of the two distinct familial colon cancer syndromes FAP (familial adenomatous polyposis) and HNPCC (hereditary non-polyposis colorectal cancer) is increasingly being understood. Thereby, an identification of affected people has become possible before the disease has manifested. There is also convincing evidence that the pathogenesis of sporadic colonic cancer is modulated by environmental, mainly nutritional, factors. Carcinogens seem to be far less important than the components of the `normal' human diet. It is likely that the interplay between protective and noxious dietary compounds determines the progression of the adenoma-carcinoma sequence. Additionally, a broad spectrum of drugs has been shown to affect colonic tumorigenesis, which provides the rationale for chemoprevention strategies. These issues set the scene for discussions on how genetic and environmental factors may interact in the pathogenesis of colonic cancer, contributing fresh ideas to the prevention of this most prevalent malignancy in the industrialized world.

Exogenous Factors in Colonic Carcinogenesis

Author : Wolfgang Scheppach
Publisher :
ISBN 13 : 9783933186485
Total Pages : 52 pages
Book Rating : 4.1/5 (864 download)

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Book Synopsis Exogenous Factors in Colonic Carcinogenesis by : Wolfgang Scheppach

Download or read book Exogenous Factors in Colonic Carcinogenesis written by Wolfgang Scheppach and published by . This book was released on 2002 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Colorectal Cancer

Author : Leonard B. Saltz
Publisher : Springer Science & Business Media
ISBN 13 : 1592591604
Total Pages : 839 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Colorectal Cancer by : Leonard B. Saltz

Download or read book Colorectal Cancer written by Leonard B. Saltz and published by Springer Science & Business Media. This book was released on 2002-05-13 with total page 839 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities. An explosion of understanding in the basic science that underlies both the disease and its potential therapies has translated into remarkable technological advances that can now be applied. So many specialties and subspecialties have now been brought to bear that it is appropriate to attempt to bring the expertise from these areas together in one volume, so that practitioners in one aspect of colorectal cancer management can maintain knowledge and expertise regarding the capabilities of other colleagues working in this disease. Colo rectal Cancer: Multimodality Management provides a concise, focused, and current review of the methodological and technological advances that have recently occurred in the management of colorectal cancer. The book has been divided into six basic parts. The first part, dealing with epidemiology and prevention, focuses on the molecular genetic events that occur in the development of colorectal cancer, as well as on our understanding of dietary and environmental factors, and possible strategies for prevention. Part II focuses on both diagnos tic and therapeutic radiology in the management of colorectal cancer, dealing with innumer able advances in imaging, and with the progress in the science and art of radiation therapy. The third section deals with the surgical aspects of management of colorectal cancer, starting with surgical pathology.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1126 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1983 with total page 1126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Cancer Research

Author :
Publisher : Academic Press
ISBN 13 : 9780080562124
Total Pages : 349 pages
Book Rating : 4.5/5 (621 download)

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Book Synopsis Advances in Cancer Research by :

Download or read book Advances in Cancer Research written by and published by Academic Press. This book was released on 1979-11-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research

Alcohol, Tobacco and Cancer

Author : Chi-Hin Cho
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805581076
Total Pages : 642 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Alcohol, Tobacco and Cancer by : Chi-Hin Cho

Download or read book Alcohol, Tobacco and Cancer written by Chi-Hin Cho and published by Karger Medical and Scientific Publishers. This book was released on 2006-01-01 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part of this book addresses in detail the correlations between alcohol and carcinogenicity, focusing on specific organs such as the upper aerodigestive tract, liver, colon, pancreas and breast. This includes the impairment of methionine-folate metabolism and DNA methylation by alcohol, as well as the use of s-adenosylmethionine to prevent cancer. Furthermore, the synergistic effects of reactive oxygen species and iron in producing liver cancer are addressed. The second part is dedicated to the role of tobacco in lung and digestive tract cancers and to their prevention, highlighting the role of phytochemicals. More specifically, the mutagenic, mitogenic, precarcinogenic, anti-apoptotic, and immunosuppressive properties of nicotine which are involved in the development of cancer, and the possible use of nicotine vaccine in the prevention of mortality associated with tobacco, are discussed.

Novel Approaches to Colorectal Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0128240792
Total Pages : 486 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Novel Approaches to Colorectal Cancer by :

Download or read book Novel Approaches to Colorectal Cancer written by and published by Academic Press. This book was released on 2021-06-18 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research Offers outstanding and original reviews on colorectal cancer research Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer

Journal of the National Cancer Institute

Author :
Publisher :
ISBN 13 :
Total Pages : 1040 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2004 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each issue is packed with extensive news about important cancer related science, policy, politics and people. Plus, there are editorials and reviews by experts in the field, book reviews, and commentary on timely topics.

Autoimmune Liver Disease

Author : H.-P. Dienes
Publisher : Springer Science & Business Media
ISBN 13 : 9781402028946
Total Pages : 332 pages
Book Rating : 4.0/5 (289 download)

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Book Synopsis Autoimmune Liver Disease by : H.-P. Dienes

Download or read book Autoimmune Liver Disease written by H.-P. Dienes and published by Springer Science & Business Media. This book was released on 2005-07-12 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune processes in the liver can cause severe damage and destruction leading to cirrhosis and liver failure. The clinical spectrum of autoimmune liver disease is very wide, and diagnostic difficulties often stand at the beginning of the patient’s medical career. While in autoimmune hepatitis immunosuppressive therapy has long been shown to be life-saving, therapeutic progress is small in primary biliary cirrhosis and questionable in primary sclerosing cholangitis. New approaches to treatment will be needed in the future, but require better understanding of the pathogenesis of the underlying disease process. This book, the proceedings of Falk Symposium 142 on 'Autoimmune Liver Disease’ held in Freiburg, Germany, on 12–13 October 2004 (Part I of the Gastroenterology Week Freiburg), describes possible mechanisms of pathogenesis, discusses diagnostic criteria and takes up controversies concerning treatment options. In view of the relatively frequent manifestation of autoimmune hepatitis in childhood in particular, paediatric aspects of autoimmune liver disease, and the role of liver transplantation, are given prominence.

Bile Acid Biology and its Therapeutic Implications

Author : G. Paumgartner
Publisher : Springer Science & Business Media
ISBN 13 : 9781402028939
Total Pages : 298 pages
Book Rating : 4.0/5 (289 download)

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Book Synopsis Bile Acid Biology and its Therapeutic Implications by : G. Paumgartner

Download or read book Bile Acid Biology and its Therapeutic Implications written by G. Paumgartner and published by Springer Science & Business Media. This book was released on 2005-03-02 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the 18th International Bile Acid Meeting, held as the Falk Symposium 141 in Stockholm, Sweden, on June 18–19, 2004. The International Bile Acid Meetings have become some of the most important meetings in the bile acid field worldwide since Herbert Falk decided to sponsor these Symposia in biannual sequence in 1970. The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids. They have always been a forum where basic scientists and clinicians interact. Many novel results of bile acid research were first presented at these meetings. The meeting in Stockholm again attracted a large number of basic and clinical scientists interested in bile acid and biliary research from all over the world. Knowledge about the regulation of bile acid synthesis, bile acid transport and enterohepatic circulation in health and in disease has increased considerably during recent years. Accordingly, bile acid research is alive as ever. A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids. A large part of the book is devoted to these topics. The 18th International Bile Acid Meeting was again a truly interdisciplinary symposium at the highest scientific level. Its participants enjoyed hearing the latest reports on bile acid research in the city where so many seminal studies on bile acids were performed. It is hoped that the readers of this book will share the enjoyment.

Mechanisms of Intestinal Inflammation

Author : R. Duchmann
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387879
Total Pages : 246 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Mechanisms of Intestinal Inflammation by : R. Duchmann

Download or read book Mechanisms of Intestinal Inflammation written by R. Duchmann and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years considerable progress has been achieved in regard to our understanding of the induction and modulation of the immune response in the intestinal mucosa. It is clear that this mucosal immune reaction is predominantly steered by certain T-cell populations, which are characterized by their cytokine secretion profile. Less well known are the conditions under which the uptake and processing of a specific antigen leads to a certain immune response, whether it be protective, tolerant or inflammatory. However, here again distinct progress has been made in our understanding. Equally significant for immune regulation in the gut appears to be so-called innate immunity. Every shift of equilibrium in the highly regulated mucosal immune reaction is accompanied by an inflammatory reaction and destruction of the mucosa. In nearly all cases, this inflammatory response is dependent on the presence of bacterial intestinal flora. This book, the proceedings of Falk Symposium 133 on Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD', held in Berlin, Germany, on 10-11 June 2003, summarizes present knowledge in the area of unspecific and specific immune reactions in the gut, recording the gaps in our knowledge and, in particular, presenting the possibilities of targeted intervention. The link to inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is always in focus. Chapters by an international panel of basic scientists, clinical researchers and clinicians also record the problems which can originate through today's possible modulation of the immune reaction, setting the basis for review of clinical problems. This book is valuable readings for all scientists and physicians, who, from different perspectives, have an interest in research on IBD and in the clinical management of these diseases.

Pathogenesis and Clinical Practice in Gastroenterology

Author : I. Ferkolj
Publisher : Springer Science & Business Media
ISBN 13 : 1402087675
Total Pages : 289 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Pathogenesis and Clinical Practice in Gastroenterology by : I. Ferkolj

Download or read book Pathogenesis and Clinical Practice in Gastroenterology written by I. Ferkolj and published by Springer Science & Business Media. This book was released on 2011-04-28 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: The translation of new molecular understanding of disease into clinical practice in gastroenterology is a special challenge. The Falk Symposium No. 160, entitled ‘Pathogenesis and Clinical Practice in Gastroenterology’, held 15-16 June 2007 in Portorož, Slovenia, provided a stimulating framework to bridge discussions from bench to bedside. The proceedings of the symposium are contained in this book, and the unifying theme is the growing understanding of inflammation as a driving force in chronic disease leading to disability and malignancy. Aspects of early detection - endoscopically or via molecular markers - are covered as well as in-depth discussions of the validation of new findings in clinical practice. Whilst on a molecular basis gastroenterologists and hepatologists try to shed light on the same intracellular pathways, clinical implications such as surveillance of cancer in IBD or chronic hepatitis with cirrhosis have to be tailored to specific needs. New therapeutic agents - approved or on the horizon of early clinical studies - will dramatically change the options of patients with chronic disease such as Crohn’s disease, viral hepatitis or hepatocellular carcinoma.

Future Perspectives in Gastroenterology

Author : Martin C. Carey
Publisher : Springer Science & Business Media
ISBN 13 : 9781402088322
Total Pages : 310 pages
Book Rating : 4.0/5 (883 download)

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Book Synopsis Future Perspectives in Gastroenterology by : Martin C. Carey

Download or read book Future Perspectives in Gastroenterology written by Martin C. Carey and published by Springer Science & Business Media. This book was released on 2008-08-21 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996, an international symposium entitled "Future Perspectives in Gastroenterology" was held in the city of Leipzig, State of Saxony, Germany. Leading scientists in diverse fields of gastroenterology presented their recent findings and undertook the propitious risk of speculating about future directions. Thanks once again to the generous support of the Falk Foundation, it was possible to revisit a symposium with the same title, but held this time in the beautiful, rebuilt city of Dresden in Saxony. This book contains the proceedings of the Falk Symposium No. 161 on "Future Perspectives in Gastroenterology", held October 11–12, 2007. It presents many innovative themes as well as "new faces" and offers a rich opportunity to learn firsthand about the latest scientific discoveries in the broad field of gastroenterology. Several of these novel developments are probably well on their way to being implemented in clinical practice.

Comprehensive Handbook of Alcohol Related Pathology

Author : Victor R. Preedy
Publisher : Elsevier
ISBN 13 : 0080502318
Total Pages : 3121 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Comprehensive Handbook of Alcohol Related Pathology by : Victor R. Preedy

Download or read book Comprehensive Handbook of Alcohol Related Pathology written by Victor R. Preedy and published by Elsevier. This book was released on 2004-12-24 with total page 3121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike. *Over 100 chapters conveniently divided into 3 sections *Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes *Each chapter is highly illustrated with tables as well as figures

Allergic Diseases and the Environment

Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805576498
Total Pages : 331 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Allergic Diseases and the Environment by :

Download or read book Allergic Diseases and the Environment written by and published by Karger Medical and Scientific Publishers. This book was released on 2004 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades the increase in allergic diseases in children, such as atopic dermatitis and asthma, has been drastic. However, this is not true for the entire world: the incidence of allergies in children has risen only in developed countries. The observation of this socio-geographic discrepancy has led to careful study of the environmental differences that exist between the diverse settings in which children are born and has resulted in the so-called 'hygiene hypothesis': the 'sterility' of modern hospitals and birth places in the developed world might lead to a lack of microbial stimulation required for the development of a balanced mucosal immune response, including expansion of T-helper (Th) cell subsets that can mediate immune responses. Therefore, this workshop was held to consider in depth the environmental factors that influence the changing pattern of worldwide childhood allergy. This publication is a valuable source of knowledge and update for nutritionists, pediatricians, immunologists, microbiologists, as well as professionals concerned with preventive medicine.

Cancer

Author : Victor R Preedy
Publisher : Academic Press
ISBN 13 : 0128195630
Total Pages : 592 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cancer by : Victor R Preedy

Download or read book Cancer written by Victor R Preedy and published by Academic Press. This book was released on 2021-01-14 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer: Oxidative Stress and Dietary Antioxidants, Second Edition, covers the science of oxidative stress in cancer and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor-mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component. Other sections cover new organ site tumors—skin and liver cancer, the role of polymorphisms, cytochrome p450s, COX gene, fatty acids, apoptosis, T cells and mitochondria, prevention/protection with anthocyanins, esculetin, nanoparticles, and more. This book is a valuable resource for cancer researchers, oncologists, nutritionists and other members of the biomedical field who are interested in enhancing treatment outcome, improving the quality of life of patients, and developing new treatments in the fight against cancer. Encompasses updated, revised and state-of-the-art information to advance cancer research Bridges the gaps between nutrition, oxidative stress, and cancer, presenting a holistic approach for health care and research Contains wide applicability to cancer research, from prevention to novel therapeutics

Preventive Nutrition

Author : Adrianne Bendich
Publisher : Springer Science & Business Media
ISBN 13 : 1592592368
Total Pages : 519 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Preventive Nutrition by : Adrianne Bendich

Download or read book Preventive Nutrition written by Adrianne Bendich and published by Springer Science & Business Media. This book was released on 2001-03-06 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition has been recognized as a major determinant of health for centuries. Tradi tionally, nutritional sciences have primarily targeted the prevention of diseases resulting from clinical deficiencies of essential nutrients, such as scurvy and rickets. Contempo rary nutritional research has focused on the prevention of major diseases of Western civilization, particularly cardiovascular disease and cancer, as well as promoting mater nal and child health and healthy aging. Heart disease and cancer, which were rare in most developing countries several decades ago, are increasing dramatically in these countries, in parallel with economic development and dietary transitions, decreases in infectious diseases, and increasing sedentary lifestyle and obesity. Substantial evidence indicates major chronic diseases such as coronary heart disease, type 2 diabetes, and some cancers are largely preventable by relatively simple diet and lifestyle modifications. Despite the great potential of nutrition in preventing diseases and improving health, nutrition is not routinely emphasized in the education and training of physicians and other health care professionals. This has resulted in inadequate nutritional knowledge and lack of skills in providing dietary counseling among many health care professionals. Further more, in the past decade, the public's access to nutritional information has been increas ing rapidly, particularly through the Internet. There are now hundreds of websites providing a wide range of nutritional information and selling numerous dietary products. Because of the explosion in nutritional information, the public's demand for nutritional advice has been increasing rapidly and will continue to rise.