Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Evaluation Of Short Term Tests For Carcinogens Volume 1 full books in PDF, epub, and Kindle. Read online Evaluation Of Short Term Tests For Carcinogens Volume 1 ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Frederick J. De Serres
Publisher : North-Holland
ISBN 13 :
Total Pages : 854 pages
Book Rating : 4.3/5 (91 download)
Download or read book Evaluation of Short-term Tests for Carcinogens written by Frederick J. De Serres and published by North-Holland. This book was released on 1981 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Ashby
Publisher : Cambridge University Press
ISBN 13 : 9780521341523
Total Pages : 0 pages
Book Rating : 4.3/5 (415 download)
Download or read book Evaluation of Short-Term Tests for Carcinogens: Volume 1 written by John Ashby and published by Cambridge University Press. This book was released on 1989-01-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : FJ de Serres (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)
Download or read book EVALUATION OF SHORT TERM TESTS FOR CARCINOGENS; Report of the International Collaborative Program (Volume 1). written by FJ de Serres (Ed) and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evaluation of Short-term Tests for Carcinogens written by and published by . This book was released on 1900 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J ASHBY (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)
Download or read book EVALUATION OF SHORT-TERM TESTS FOR CARCINOGENS; REPORT OF THE INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY'S COLLABORATIVE STUDY ON IN VITRO ASSAYS (Volume 5). written by J ASHBY (Ed) and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Ashby
Publisher : Elsevier Science & Technology
ISBN 13 : 9780444806154
Total Pages : 752 pages
Book Rating : 4.8/5 (61 download)
Download or read book Evaluation of Short-term Tests for Carcinogens written by John Ashby and published by Elsevier Science & Technology. This book was released on 1985-01-01 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evaluation of short-term tests for carcinogens written by and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Ashby
Publisher : Cambridge University Press
ISBN 13 : 9780521341530
Total Pages : 392 pages
Book Rating : 4.3/5 (415 download)
Download or read book Evaluation of Short-Term Tests for Carcinogens: written by John Ashby and published by Cambridge University Press. This book was released on 1989-01-26 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J Ashby (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)
Download or read book Evaluation of Short Term Tests for Carcinogens, Volume 1; Report of the International Programme on Chemical Safety's Collaborative Study on in Vivo Assays written by J Ashby (Ed) and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The IPCS in vivo collaborative study, overview and conclusions; The statistical analysis of in vivo genotoxicity data, case studies of the rat hepatocyte UDS and mouse bone marrow micronucleus assays; Benzo(a)pyrene and pyrene; 2-Acetylaminofluorene and 4-acetylaminofluorene; Summary report on the performance of sister chromatid exchange, micronucleus, and chromosome aberration tests in rodent bone marrow cells; Summary report on the performance of the in vivo mammalian cell cytogenetics chromosome aberrations, metaphase analysis assays; Evaluation of chromosomal aberrations in bone marrow of male IC3F1 mice; Analysis of chromosomal aberrations in bone marrow cells of C57BL/6 mice treated with benzo(a)pyrene, pyrene, 2-acetylaminofluorene, and 4-acetylaminofluorene; Induction of chromosomal aberrations in BALB/c mouse bone marrow cells; Metaphase analysis test results in male ICR Swiss mice; A study of the ability of benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene to damage bone marrow cell chromosomes in five inbred strains of mice; Induction of chromosomal aberrations in bone marrow cells and ascites tumor cells of mice by 2-acetylaminofluorene, 4-acetylaminofluorene and benzo(a)pyrene; A comparative analysis of the induction of chromosomal aberrations in the bone marrow cells of B6C3F1 mice; An in vivo cytogenetic test in bone marrow cells of the Alderley Park Wistar derived rat; Mutagenic activity of four compounds in chromosomal aberration assay using Chinese hamster bone marrow cells; Examination of metaphase chromosomes obtained from the bone marrow of Chinese hamsters (Cricetulus griseus); Summary report on the performance of the in vivo micronucleus assays; Bone marrow micronucleus tests on NMRI mice; Bone marrow micronucleus induction in HPBBL mice; Micronuclei induction in mouse bone marrow cells with benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene; Micronucleus test results for two carcinogen/noncarcinogen chemical pairs in male ICR Swiss mice; The micronucleus test in mutagen sensitive MS/Ae mice; The micronucleus test in strain C57BL/6J mice; Micronucleus test on benzo(a)pyrene and pyrene performed in NMRI mice; Micronucleus test in bone marrow cells of CBA male mice; Induction of micronuclei in BALB/c mouse bone marrow cells; Induction of micronuclei in polychromatic erythrocytes in bone marrow of adult IC3F1, hybrid male mice; Tests on two pairs of structural analogues in the mouse in vivo micronucleus assay; The clastogenic activity of benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene in the mouse bone marrow micronucleus test; Bone marrow micronucleus test in Swiss male mice; Micronucleus incidences induced in bone marrow erythrocytes of pregnant NMRI mice and in liver derived erythrocytes of their foetuses; Detection of micronucleated polychromatic erythrocytes in bone marrow of male mice; The peripheral blood erythrocyte micronucleus assay in weanling and foetal Swiss mice; Micronucleus test in bone marrow of rats exposed to 2-acetylaminofluorene or 4-acetylaminofluorene; Micronucleus test in the Alderley Park Wistar derived albino rat; Summary report on the performance of the in vivo sister chromatid exchange assays; A comparative analysis of the induction of sister chromatid exchanges in the bone marrow cells of B6C3F1 mice; Analysis of sister chromatid exchange in C57BL/6 mouse bone marrow cells following in vivo exposure to carcinogen/noncarcinogen chemical pairs; Detection of sister chromatid exchanges in bone marrow of male mice; In vivo sister chromatid exchanges in mouse bone marrow, test of four compounds in male and female CD-1 mice; Tests with Swiss albino mice to detect the induction of sister chromatid exchanges in bone marrow cells; Sister chromatid exchange induction in bone marrow cells of Swiss mice; In vivo sister chromatid exchange evaluation in Sprague Dawley rats; Analysis of sister chromatid exchange in C57B1/6 mouse peripheral blood lymphocytess following in vivo exposure to carcinogen/noncarcinogen pairs; Discrimination of structurally similar carcinogen/noncarcinogen analogues by analysis of sister chromatid exchange in vivo in bone marrow and intestinal epithelium of Chinese hamster; Introduction, liver specific assays; Summary report of liver specific short term tests; Summary report on the performance of the liver initiation and promotion assays; Early cytomorphological and cytochemical changes induced in liver by single large doses of 2-acetylaminofluorene and 4-acetylaminofluorene; Liver initiation assay, the rat liver foci bioassay of carcinogens and noncarcinogens; Ability of the test chemicals to initiate gamma glutamyltranspeptidase positive foci in female rats; In vivo promotion assay of four compounds on enhancement of the development of gamma glutamyl transpeptidase positive liver cell foci in male F344 rats; A liver cell transplantation assay for promoting activity in rats; Summary report on the performance of the in vivo DNA repair assays; A comparison of the response of carcinogen/noncarcinogen pairs in the rat and mouse hepatocyte DNA repair assays in vivo and in vitro; Activity of 2-acetylaminofluorene and 4-acetylaminofluorene in an in vitro and an in vivo/in vitro assay for unscheduled DNA synthesis in the rat liver; An evaluation of the ability of benzo(a)pyrene, pyrene, 2- and 4-acetylaminofluorene to induce unscheduled DNA synthesis and cell proliferation in the livers of male rats and mice treated in vivo; Unscheduled DNA synthesis in rat liver after in vivo treatment with 2-acetylaminofluorene or 4-acetylaminofluorene; Induction of unscheduled DNA synthesis and DNA replication in rat hepatocytes following in vivo administration of 2-actylaminofluorene and 4-acetylaminofluorene; Testing of 2-acetylaminofluorene and 4-acetylaminofluorene in the in vivo/in vitro rat hepatocyte/DNA repair assay and investigation of lactational exposure of neonatal rats to 2-acetylaminofluorene; In vivo-in vitro assay for quantifying hepatic DNA repair and S phase in F344 rats; Inactivity of benzo(a)pyrene in a weanling rat liver, unscheduled DNA synthesis assay; Summary report on the performance of cytogenetic assays in rat hepatic cells; Chromosome studies in hepatic cells from rats exposed to genotoxic chemicals; Micronucleus test with rat hepatocytes to detect induction of clastogenic damage; Summary report of the measurement of DNA strand breaks; DNA strand break induction in Fischer 344 rat hepatocytes as assessed by the alkaline elution assay; DNA strand breakage monitored by alkaline elution in the livers of male Wistar derived rats administered carcinogenic/noncarcinogenic analogues; Alkaline elution of rat liver DNA for benzo(a)pyrene, pyrene 2-acetylaminofluorene, and 4-acetylaminofluorene; Use of the fluorometric analysis of DNA unwinding (FADU) assay to detect DNA strand breaks in the liver of CD-1 mice exposed to carcinogens and a repair inhibitor.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309053919
Total Pages : 434 pages
Book Rating : 4.3/5 (9 download)
Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-03-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
Author : K.H. Norpoth
Publisher : Springer Science & Business Media
ISBN 13 : 3642672027
Total Pages : 424 pages
Book Rating : 4.6/5 (426 download)
Download or read book Short-Term Test Systems for Detecting Carcinogens written by K.H. Norpoth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids par ticularly in target organs. It is reaction with nucleic acids that provides the basis of a num ber of short-term tests for carcinogens, since the basic composition of DNA is similar in micro-organisms and in human cells.
Author : D. McGregor
Publisher :
ISBN 13 :
Total Pages : 548 pages
Book Rating : 4.:/5 (318 download)
Download or read book The Use of Short- and Medium-term Tests for Carcinogens and Data on Genetic Effects in Carcinogenic Hazard Evaluation written by D. McGregor and published by . This book was released on 1999 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lifetime assays for carcinogenicity in experimental animals, together with data on genetic and related effects on a variety of organisms, have long been the foundation for predictions of carcinogenic hazard to human beings. Recent scientific advances have provided new assays and novel test systems that are beginning to supplement, and in the future may even replace, the well-established tests that have been widely used for the last four decades. This publication reviews the evidence that justifies the use of lesions that precede histologically defined malignancy as endpoints to predict carcinogenicity. It evaluates the utility of non-mammalian species and of genetically engineered rodents as subjects for carcinogenicity tests and mutations in cancer-related genes in human and experimental animal tumours as 'footprints' of environmental carcinogens. It evaluates the use of established and novel assays for genetic toxicity in the prediction of carcinogenicity. Finally it formulates recommendations on the use of such data in the process of evaluation of carcinogenic hazards by the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : IARC Monographs on the Evaluat
ISBN 13 : 9789283213246
Total Pages : 0 pages
Book Rating : 4.2/5 (132 download)
Download or read book Some Chemicals Present in Industrial and Consumer Products, Food and Drinking-water written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC Monographs on the Evaluat. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the IARC Monographs provides an assessment of the carcinogenicity of 18 chemicals present in industrial and consumer products or food (natural constituents, contaminants, or flavorings) or occurring as water-chlorination by-products. The compounds evaluated include the widely used plasticizer di(2-ethylhexyl) phthalate and the food contaminant 4-methylimidazole. In view of the limited agent-specific information available from epidemiological studies, the IARC Monographs Working Group relied mainly on carcinogenicity bioassays, and mechanistic and other relevant data to evaluate the carcinogenic hazards to humans exposed to these agents.
Author :
Publisher : Elsevier-North-Holland Biomedical Press
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation written by and published by Elsevier-North-Holland Biomedical Press. This book was released on 1980 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : International Agency for Research on Cancer
Publisher : World Health Organization
ISBN 13 : 9789283212393
Total Pages : 420 pages
Book Rating : 4.2/5 (123 download)
Download or read book Some Chemicals Used in Plastics and Elastomers written by International Agency for Research on Cancer and published by World Health Organization. This book was released on 1986 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thirty-ninth volume of IARC Monographs comprises considerations of a number of industrial chemicals used in the production of plastics and elastomers; some of the compounds are also used in paints and adhesives. Two compounds - dichloroacetylene and 4-vinylcyclohexene - can occur as by-products in the production or use of some of these chemicals. New data were available on some of the chemicals evaluated previously: methyl acrylate, ethylacrylate, caprolactam, 4 4'-methylene-dianiline, toluene diisocyanate, vinyl acetate, vinyl bromide, and vinylidene chloride, and these have been summarized and taken into consideration in the re-evaluations. 4 4'Methylenediphenyl diisocyanate, a monomer produced from 4 4'-methylenedianiline (MDA), can hydrolyse to MDA when in contact with moisture; however 4 4'-methylenediphenyl diisocyanate was not re-evaluated in the present volume because no new data on carcinogenicity have become available. New evidence is now available of human exposure to several of the substances considered in the present volume and more data are being generated on the environmental levels of certain of the substances in particular contexts. Studies in which reproductive toxicity in experimental animals was evaluated were available previously only for vinylidene chloride and caprolactam; in the present volume such reports are given for acrylamide, n-butyl acrylate, ethyl acrylate, 1 3-butadiene, vinylidene chloride, caprolactam, melamine and 4 4'-methyl-enedianiline. New information is now available on the carcinogenic activity of several of the chemicals considered previously. For several of the monomers considered in this volume there is evidence of carcinogenicity in experimental animals (1 3-butadiene, toluene diisocyanate, vinyl bromide) for others, the data are inadequate and more testing is needed.
Author : International Life Sciences Institute
Publisher : Springer
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (3 download)
Download or read book Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards ; The Use of Short-term Tests for Mutagenicity and Carcinogenicity in Chemical Hazard Evaluation written by International Life Sciences Institute and published by Springer. This book was released on 1984 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : World Health Organization WHO.
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (114 download)
Download or read book Summary report on the evaluation of short-term tests for carcinogens (collaborative study on in vivo tests). written by World Health Organization WHO. and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
