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Estradiol Induced Hepatic Gene Expression In The Rainbow Trout Oncorhynchus Mykiss
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Book Synopsis Estradiol-induced Hepatic Gene Expression in the Rainbow Trout (Oncorhynchus Mykiss). by : Mairi Elizabeth MacKay
Download or read book Estradiol-induced Hepatic Gene Expression in the Rainbow Trout (Oncorhynchus Mykiss). written by Mairi Elizabeth MacKay and published by . This book was released on 1990 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ontogeny and Regulation of Estrogen Receptor Isoform Expression in Rainbow Trout (Oncorhynchus Mykiss) by : Josh Boyce
Download or read book Ontogeny and Regulation of Estrogen Receptor Isoform Expression in Rainbow Trout (Oncorhynchus Mykiss) written by Josh Boyce and published by . This book was released on 2009 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Liver Gene Expression During Vitellogenesis in Male Rainbow Trout by : Kenneth R. Lawless
Download or read book Liver Gene Expression During Vitellogenesis in Male Rainbow Trout written by Kenneth R. Lawless and published by . This book was released on 1987 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Study on the Growth Hormone-regulated Gene Expression of C/EBP Isoforms and Their Relationship with IGF-ll Gene Expression in the Liver of Rainbow Trout (Oncorhynchus Mykiss) by : Hung-Chieh Lo
Download or read book A Study on the Growth Hormone-regulated Gene Expression of C/EBP Isoforms and Their Relationship with IGF-ll Gene Expression in the Liver of Rainbow Trout (Oncorhynchus Mykiss) written by Hung-Chieh Lo and published by . This book was released on 2009 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Effects of Environmental Stressors on Cardiac Gene Expression and Contractility in Rainbow Trout (Oncorhynchus Mykiss) by : Tracey S. Momoda
Download or read book The Effects of Environmental Stressors on Cardiac Gene Expression and Contractility in Rainbow Trout (Oncorhynchus Mykiss) written by Tracey S. Momoda and published by . This book was released on 2014 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rainbow trout (Oncorhynchus mykiss) experience a variety of stressors in their natural environment as well as in aquaculture that can have negative effects on their physiology. The effects of physiological stress and endocrine disruption have been well described in fish. However, there is a scarcity of information on the effects of such stressors on the heart in fish. We examined gene expression in the rainbow trout heart in response to 17[alpha]-ethinylestradiol (EE), the active ingredient in some oral contraceptives, as well as physiological stress. We also assessed contractile function, as a measure of cardiac performance, under conditions of increasing performance demands in sexually immature rainbow trout. In chapter 2, using qRT-PCR, we observed increased vitellogenin (vtg1) in the ventricle, along with, hepatic estrogen receptor (ER[alpha]) and vtg1 mRNA increased with EE exposure, confirming endocrine disruption in both tissues. Stress increased corticotropin-releasing factor receptor 1 (CRF-R1) and JunB in response to stress while nuclear protein 1 (nupr1) and glucocorticoid receptor (GCR2) expression increased only in the population with higher cortisol levels (>100 ng/ml) in response to stress. Interestingly, EE exposure did not affect stress induced gene expression and stress did not have an effect on EE induced gene expression in the heart of rainbow trout. This research highlights the fact that these stressors have the potential to have physiological impacts beyond the target tissues classically thought of for stress (i.e. HPI/A axis) or exposure to estrogenic compounds (i.e. HPG axis). In chapter 3, contractile force production was measured from ventricle strips exposed to increasing concentrations of Ca2 or epinephrine to simulate conditions of increasing performance. Also, to determine the effects of physiological stress, ventricle strips were pre-treated with 100 ng/L cortisol prior to increasing Ca2 or epinephrine. Ventricle strips from males had a greater contractile force production to increasing Ca2+ or epinephrine compared to females, at concentrations greater than 3.5 mM Ca2+ or 1 [micro]M epinephrine. Exposure to cortisol did not have a direct effect on contractility, nor did it have an effect the contractile response to increasing exogenous Ca2+ in either sex. Interestingly, force production did not vary by sex in the cortisol pre-treated exposed to epinephrine, suggesting a sex-dependent response. My findings suggest that there are sex differences in the contractile function in rainbow trout and that these may be modified under conditions related to physiological stress. The rainbow trout is a genetically diverse species found across a variety of habitats. Our results highlight the variation in responses in in contractile function and gene expression in the heart by the different sexes, as well as variation within and among populations that allow rainbow trout to adapt and perform in the presence of stressors in the environment.
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of 17[beta]-estradiol-induced Responses in Fish by Cytochrome P4501A1 Inducing Compounds by : Michael James Anderson
Download or read book Modulation of 17[beta]-estradiol-induced Responses in Fish by Cytochrome P4501A1 Inducing Compounds written by Michael James Anderson and published by . This book was released on 1995 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gene Expression in the Liver of Rainbow Trout, Oncorhynchus Mykiss, During the Stress Response by : Tracey S. Momoda
Download or read book Gene Expression in the Liver of Rainbow Trout, Oncorhynchus Mykiss, During the Stress Response written by Tracey S. Momoda and published by . This book was released on 2006 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extent to which responses to stress are maladaptive or adaptive to the long-term survival of fish remains to be better understood. The aim of this study was to identify differentially expressed genes in the livers of rainbow trout, Oncorhynchus mykiss, responding to an experimental stressor. Gene expression responses were measured using an oligonucleotide microarray specific for Oncorhynchus mykiss, to highlight genes responding to a stressor and to serve as a basis for hypothesis development. We conducted replicate experiments at two different times. In both experiments, fish exposed to a three-hour stressor were compared to control (unstressed) fish. In the second experiment, there were additional treatments of fish that were exposed to only a half-hour of stress and of fish sampled 21 hours after experiencing a three-hour stressor. This 21 hour post-stress treatment was a means to study gene expression during recovery from stress. Plasma cortisol was measured to document the physiological stress response of the fish. Real-time PCR (qPCR) of candidate genes was used to validate the microarray findings. In both experiments the microarray revealed many genes with differential expression after three hours of stress. The genes we report as differentially expressed met a criteria of at least a 1.4 fold change and a statistical difference (p=0.05) from control levels of expression. Among these, five genes responded similarly in both experiments, suggesting that they are robust indicators of stress. These genes are a major histocompatibility complex class I molecule (MHCI), JunB, glucose 6-phosphatase (G6Pase), nuclear protein 1 (Nupr1) and tumor necrosis factor decoy receptor (TNFDR). Interestingly, transcripts of Nupr1 did not return to control levels in the 21 hours after stress. In fact, the transcripts continued to increase during recovery.
Book Synopsis Differential Expression of Growth Genes in the Liver and White Muscle of Small and Large Rainbow Trout (Oncorhynchus Mykiss) Produced in Two Seasons and Co-localization with Quantitative Trait Loci by : Andrea Kocmarek
Download or read book Differential Expression of Growth Genes in the Liver and White Muscle of Small and Large Rainbow Trout (Oncorhynchus Mykiss) Produced in Two Seasons and Co-localization with Quantitative Trait Loci written by Andrea Kocmarek and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Toxicogenomics written by and published by Elsevier. This book was released on 2008-07-11 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks. - Reviews some of the first really fruitful studies made in this area - Covers different organisms ranging from humans to model species and environmental sentinels - Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties
Book Synopsis Characterization and Expression of Rainbow Trout (Oncorhynchus Mykiss) Growth Hormone Family Genes by : Bih-Ying Yang
Download or read book Characterization and Expression of Rainbow Trout (Oncorhynchus Mykiss) Growth Hormone Family Genes written by Bih-Ying Yang and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gene Expression at the Beginning of Animal Development by : M.L. DePamphilis
Download or read book Gene Expression at the Beginning of Animal Development written by M.L. DePamphilis and published by Elsevier. This book was released on 2002-09-30 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The beginning of life may be a miracle to some, and a mystery to others, but it is certainly one of the most exciting and perhaps controversial fields of scientific investigation in the 21st century. Among the metazoa, life begins when an egg is fertilized by a sperm. The sperm provides a genetic blueprint from the father and perhaps some critical proteins. The egg provides a genetic blueprint from the mother together with a large reservoir of mRNAs and proteins that are required for DNA replication, cell division and the onset of zygotic gene expression. All of the thousands of genes in these two mature gametes are transcriptionally silent and remain so until fertilization. This work focuses on three biological systems, providing the reader with a clear understanding of the current state of affairs, and the ability to identify common principles as well as critical differences that are responsible for beginning the process of animal development. The essays presented will be of practical value to all those who are interested in improving fertilization in vitro, in designing novel methods of contraception, in developing preimplantation genetic diagnosis for various diseases, in cloning animals by transplanting nuclei from adult cells to an enucleated egg, and in the application of embryonic stem cells to curing genetic diseases or replacing damaged tissues. But above all, this volume is offered to those who simply have an insatiable curiosity about life and its beginnings.
Book Synopsis Characterization and Expression of Rainbow Trout (Oncorhynchus Mykiss) Growth Hormone Family Genes by : Bih-Ying Yang
Download or read book Characterization and Expression of Rainbow Trout (Oncorhynchus Mykiss) Growth Hormone Family Genes written by Bih-Ying Yang and published by . This book was released on 1997 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Environmental Toxicology by : T.W. Moon
Download or read book Environmental Toxicology written by T.W. Moon and published by Elsevier. This book was released on 2005-02-19 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: This sixth volume in this established series deals with the biochemical responses of fish to different environmental/ecological factors. Environmental Toxicology captures vital issues affecting the responses of fish to the chemical surroundings of their environment. Chapters included in this volume identify the systems found in fish to deal with xenobiotics, hormonal interactions initiated in the presence of these chemicals, the unique mechanisms used by fish to adjust to the present chemicals, and the new and evolving mixtures of chemicals in their environment. Also included, is a crucial review of the new methods being applied in fish systems to understand the effects of xenobiotics to fish fitness - a key theme in environmental health and critical to the future of fish populations.* Entirely new topic discussion and most recent volume in the acclaimed series* Includes chapters detailed on a cellular level * Introduces discussion of pharmaceutical effects on fish
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications of Toxicogenomics in Safety Evaluation and Risk Assessment by : Darrell R. Boverhof
Download or read book Applications of Toxicogenomics in Safety Evaluation and Risk Assessment written by Darrell R. Boverhof and published by John Wiley & Sons. This book was released on 2011-10-11 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Book Synopsis Molecular Biology Frontiers by : Peter W. Hochachka
Download or read book Molecular Biology Frontiers written by Peter W. Hochachka and published by . This book was released on 1993-12 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume in the series covers such topics as DNA fingerprinting of fishes, the cytochromes P450 in fish, the molecular biology of bacterial fish diseases, and new insights into the origins of the diversity and distribution of fish antifreeze proteins. The book will be of great value to fisheries scientists, animal biochemists, physiologists and endocrinologists, and aquaculturists. It will provide researchers and students alike with a pertinent information source from theoretical and experimental angles.
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