Equilibria and Kinetics of Biological Macromolecules

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Publisher : John Wiley & Sons
ISBN 13 : 1118733770
Total Pages : 411 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Equilibria and Kinetics of Biological Macromolecules by : Prof. Jan Hermans

Download or read book Equilibria and Kinetics of Biological Macromolecules written by Prof. Jan Hermans and published by John Wiley & Sons. This book was released on 2013-10-22 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progressively builds a deep understanding of macromolecular behavior Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models. With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules. The text features coverage of: Basic theory, applications, and new research findings Related topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations Principles and applications of molecular simulations in a dedicated chapter and interspersed throughout the text Macromolecular binding equilibria from the perspective of statistical mechanics Stochastic processes related to macromolecules Suggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries. With its classroom-tested pedagogical approach, Equilibria and Kinetics of Biological Macromolecules is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior.

Biomolecular Kinetics

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Publisher : CRC Press
ISBN 13 : 1351646664
Total Pages : 883 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Biomolecular Kinetics by : Clive R. Bagshaw

Download or read book Biomolecular Kinetics written by Clive R. Bagshaw and published by CRC Press. This book was released on 2017-10-04 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: "a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide" –Mark Leake, University of York "destined to become a standard reference.... Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice." –Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.

Energetics of Biological Macromolecules, Part D

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Publisher : Elsevier
ISBN 13 : 0080497179
Total Pages : 315 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Energetics of Biological Macromolecules, Part D by : Jo M. Holt

Download or read book Energetics of Biological Macromolecules, Part D written by Jo M. Holt and published by Elsevier. This book was released on 2004-04-02 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Kinetic Analysis of Macromolecules

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Publisher :
ISBN 13 : 9780198524939
Total Pages : 256 pages
Book Rating : 4.5/5 (249 download)

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Book Synopsis Kinetic Analysis of Macromolecules by : Kenneth Johnson

Download or read book Kinetic Analysis of Macromolecules written by Kenneth Johnson and published by . This book was released on 2003 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Energetics of Biological Macromolecules, Part C

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Publisher : Elsevier
ISBN 13 : 0080496784
Total Pages : 581 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Energetics of Biological Macromolecules, Part C by :

Download or read book Energetics of Biological Macromolecules, Part C written by and published by Elsevier. This book was released on 2000-08-09 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 323 of Methods in Enzymology is dedicated to the energetics of biological macromolecules. Understanding the molecular mechanisms underlying a biological process requires detailed knowledge of the structural relationships within the system and an equally detailed understanding of the energetic driving forces that control the structural interactions. This volume presents modern thermodynamic techniques currently being utilized to study the energetic driving forces in biological systems. It will be a useful reference source and textbook for scientists and students whose goal is to understand the energetic relationships between macromoleculer structures and biological functions. This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology. Key Features * Probing Stability of Helical Transmembrane Proteins * Energetics of Vinca Alkaloid Interactions with Tubulin * Deriving Complex Ligand Binding Formulas * Mathematical Modeling of Cooperative Interactions in Hemoglobin * Analysis of Interactions of Regulatory Protein TyrR with DNA * Parsing Free Energy of Drug-DNA Interactions * Use of Fluorescence as Thermodynamics Tool

Introduction to Macromolecular Binding Equilibria

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Publisher : CRC Press
ISBN 13 : 1420052993
Total Pages : 272 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Introduction to Macromolecular Binding Equilibria by : Charles P. Woodbury

Download or read book Introduction to Macromolecular Binding Equilibria written by Charles P. Woodbury and published by CRC Press. This book was released on 2007-11-08 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat

Equilibrium and Nonequilibrium Statistical Mechanics of Biological Macromolecules

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Publisher :
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.:/5 (37 download)

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Book Synopsis Equilibrium and Nonequilibrium Statistical Mechanics of Biological Macromolecules by : Martin Schwarz

Download or read book Equilibrium and Nonequilibrium Statistical Mechanics of Biological Macromolecules written by Martin Schwarz and published by . This book was released on 1975 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Osmotic Pressure of Biological Macromolecules

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Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 162 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis The Osmotic Pressure of Biological Macromolecules by : M. P. Tombs

Download or read book The Osmotic Pressure of Biological Macromolecules written by M. P. Tombs and published by Oxford University Press, USA. This book was released on 1974 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Kinetics in Condensed Phases

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Publisher : John Wiley & Sons
ISBN 13 : 1119176778
Total Pages : 289 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Molecular Kinetics in Condensed Phases by : Ron Elber

Download or read book Molecular Kinetics in Condensed Phases written by Ron Elber and published by John Wiley & Sons. This book was released on 2020-02-10 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the theoretical and computational toolkits for the modern study of molecular kinetics in condensed phases Molecular Kinetics in Condensed Phases: Theory, Simulation and Analysis puts the focus on the theory, algorithms, simulations methods and analysis of molecular kinetics in condensed phases. The authors – noted experts on the topic – offer a detailed and thorough description of modern theories and simulation methods to model molecular events. They highlight the rigorous stochastic modelling of molecular processes and the use of mathematical models to reproduce experimental observations, such as rate coefficients, mean first passage times and transition path times. The book’s exploration of simulations examines atomically detailed modelling of molecules in action and the connections of these simulations to theory and experiment. The authors also explore the applications that range from simple intuitive examples of one- and two-dimensional systems to complex solvated macromolecules. This important book: Offers an introduction to the topic that combines theory, simulation and analysis Presents a guide written by authors that are well-known and highly regarded leaders in their fields Contains detailed examples and explanation of how to conduct computer simulations of kinetics. A detailed study of a two-dimensional system and of a solvated peptide are discussed. Discusses modern developments in the field and explains their connection to the more traditional concepts in chemical dynamics Written for students and academic researchers in the fields of chemical kinetics, chemistry, computational statistical mechanics, biophysics and computational biology, Molecular Kinetics in Condensed Phases is the authoritative guide to the theoretical and computational toolkits for the study of molecular kinetics in condensed phases.

Molecular Biology

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Publisher : Oxford University Press
ISBN 13 : 0198705972
Total Pages : 945 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Molecular Biology by : Nancy Lynn Craig

Download or read book Molecular Biology written by Nancy Lynn Craig and published by Oxford University Press. This book was released on 2014 with total page 945 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many intriguing questions remain to be answered. It is written with severalguiding themes in mind: - A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline; - An emphasis on thecommonalities that exist between the three kingdoms of life, and the discussion of differences between the three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity; - An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genomefunction by presenting them as themes that recur throughout the book, rather than as artificially separated topics At heart, molecular biology is an experimental science, and a centralelement to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge of introducing the experimental evidence in a way that students can readily comprehend. Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces ofresearch that have been undertaken, and which have been particularly valuable in elucidating difference aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biologytools and techniques, which are presented in a dedicated chapter at the end of the book. Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggested further readings grouped by topic; and an extensive glossary of key terms. Among the students being taught today are the molecular biologists of tomorrow; these individuals will be ina position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfectintroduction to this challenging, dynamic, but ultimately fascinating discipline.

Chemistry for Biologists

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Publisher : Pearson Higher Ed
ISBN 13 : 1408280841
Total Pages : 517 pages
Book Rating : 4.4/5 (82 download)

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Book Synopsis Chemistry for Biologists by : David Reed

Download or read book Chemistry for Biologists written by David Reed and published by Pearson Higher Ed. This book was released on 2013-04-29 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry for Biologists provides a focused yet chemically and mathematically rigorous introduction to those key aspects of chemistry that form the basis of biological processes. Written in a straightforward, accessible style, the book begins with an overview of basic chemical concepts. Building on these core principles, the reader is guided through subjects such as the structure and properties of organic molecules, equilibria, energetics, kinetics, biomolecules, reaction mechanisms, metabolism and structural methods. The relevance of each chemical concept to the study of biology is clearly explained at every stage, enabling students to develop a deep appreciation of the chemistry that underpins their chosen subject, and become confident in applying this knowledge to their own studies. The full text downloaded to your computer With eBooks you can: search for key concepts, words and phrases make highlights and notes as you study share your notes with friends eBooks are downloaded to your computer and accessible either offline through the Bookshelf (available as a free download), available online and also via the iPad and Android apps. Upon purchase, you'll gain instant access to this eBook. Time limit The eBooks products do not have an expiry date. You will continue to access your digital ebook products whilst you have your Bookshelf installed.

Energetics of Biological Macromolecules, Part E

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Author :
Publisher : Elsevier
ISBN 13 : 0080497187
Total Pages : 479 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Energetics of Biological Macromolecules, Part E by :

Download or read book Energetics of Biological Macromolecules, Part E written by and published by Elsevier. This book was released on 2004-04-02 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Energetics of Biological Macromolecules, Part E focuses on methods related to allosteric enzymes and receptors, including fluorescent proves, spectroscopic methods and quantitative analysis as well as on cooperativity in protein folding. NMR and mass spectrometry methods are discussed. Allosteric Enzymes and Receptors Cooperativity in Protein Folding and Assembly

Molecular Biology

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Publisher : Oxford University Press, USA
ISBN 13 : 0198788657
Total Pages : 1018 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Molecular Biology by : Nancy L. Craig

Download or read book Molecular Biology written by Nancy L. Craig and published by Oxford University Press, USA. This book was released on 2021-01-20 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fresh, distinctive approach to the teaching of molecular biology. With its focus on key principles, its emphasis on the commonalities that exist between the three kingdoms of life, and its integrated coverage of experimental methods and approaches, Molecular Biology is the perfect companion to any molecular biology course.

Water and Biological Macromolecules

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Publisher : CRC Press
ISBN 13 : 9780849375705
Total Pages : 492 pages
Book Rating : 4.3/5 (757 download)

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Book Synopsis Water and Biological Macromolecules by : Westhof

Download or read book Water and Biological Macromolecules written by Westhof and published by CRC Press. This book was released on 1993-08-16 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water and Biological Macromolecules presents an excellent description of the structural aspects of water molecules around biological macromolecules. Topics discussed include the properties of water in solid and liquid states; proteins, nucleic acids, polysaccharides, and lipids; and theoretical approaches for understanding the macroscopic observations and integrating microscopic descriptions. The nature and roles of hydration forces in macromolecular complexation and cell-cell interactions are explained, in addition to phenomena such as entropy-enthalpy compensation and the thermodynamic treatment of water bridging. Water and Biological Macromolecules will be a valuable reference for biophysicists, biochemists, and macromolecular biologists.

Biophysical Chemistry

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Publisher : Macmillan
ISBN 13 : 9780716711926
Total Pages : 644 pages
Book Rating : 4.7/5 (119 download)

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Book Synopsis Biophysical Chemistry by : Charles R. Cantor

Download or read book Biophysical Chemistry written by Charles R. Cantor and published by Macmillan. This book was released on 1980-06-15 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three-part series remains the definitive text on the physical properties of biological macromolecules and the physical techniques used to study them. It is appropriate for a broad spectrum of advanced undergraduate and graduate courses and serves as a comprehensive reference for researchers. Part I: The Conformation of Biological Macromolecules 1980, paper, 365 pages, 158 illustrations 0-7167-1188-5 Part II: Techniques for the Study of Biological Structure and Function 1980, paper, 365 pages, 158 illustrations 0-7167-1190-7 Part III: The Behavior of Biological Macromolecules 1980, paper, 597 pages, 243 illustrations 0-7167-1192-3

Quantitative Fundamentals of Molecular and Cellular Bioengineering

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Publisher : MIT Press
ISBN 13 : 0262042657
Total Pages : 593 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Quantitative Fundamentals of Molecular and Cellular Bioengineering by : K. Dane Wittrup

Download or read book Quantitative Fundamentals of Molecular and Cellular Bioengineering written by K. Dane Wittrup and published by MIT Press. This book was released on 2020-01-07 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.

Biophysical Tools for Biologists

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Publisher : Academic Press
ISBN 13 : 0080554946
Total Pages : 996 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Biophysical Tools for Biologists by : John J. Correia

Download or read book Biophysical Tools for Biologists written by John J. Correia and published by Academic Press. This book was released on 2011-09-21 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt: Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vitro and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval. Describes techniques in the context of important biological problems Delineates critical steps and potential pitfalls for each method Includes full-color plates to illustrate techniques