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Progress Toward Transforming the Integrated Risk Information System (IRIS) Program

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309474949
Total Pages : 130 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Progress Toward Transforming the Integrated Risk Information System (IRIS) Program by : National Academies of Sciences, Engineering, and Medicine

Download or read book Progress Toward Transforming the Integrated Risk Information System (IRIS) Program written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-04-11 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past several years, the US Environmental Protection Agency (EPA) has been transforming the procedures of its Integrated Risk Information System (IRIS), a program that produces hazard and doseâ€'response assessments of environmental chemicals and derives toxicity values that can be used to estimate risks posed by exposures to them. The transformation was initiated after suggestions for program reforms were provided in a 2011 report from the National Academies of Sciences, Engineering, and Medicine that reviewed a draft IRIS assessment of formaldehyde. In 2014, the National Academies released a report that reviewed the IRIS program and evaluated the changes implemented in it since the 2011 report. Since 2014, new leadership of EPA's National Center for Environmental Assessment (NCEA) and IRIS program has instituted even more substantive changes in the IRIS program in response to the recommendations in the 2014 report. Progress Toward Transforming the Integrated Risk Information System Program: A 2018 Evaluation reviews the EPA's progress toward addressing the past recommendations from the National Academies.

Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309297095
Total Pages : 128 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic by : National Research Council

Download or read book Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic written by National Research Council and published by National Academies Press. This book was released on 2013-11-20 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) program develops toxicologic assessments of environmental contaminants. IRIS assessments provide hazard identification and dose-response assessment information. The information is then used in conjunction with exposure information to characterize risks to public health and may be used in risk-based decisionmaking, in regulatory actions, and for other risk-management purposes. Since the middle 1990s, EPA has been in the process of updating the IRIS assessment of inorganic arsenic. In response to a congressional mandate for an independent review of the IRIS assessment of inorganic arsenic, EPA requested that the National Research Council convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic is the report of the first phase of that study. This report evaluates critical scientific issues in assessing cancer and noncancer effects of oral exposure to inorganic arsenic and offers recommendations on how the issues could be addressed in EPA's IRIS assessment.

Science and Decisions

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Science and Decisions by : National Research Council

Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Soil Screening Guidance

Author :
Publisher :
ISBN 13 :
Total Pages : 182 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Soil Screening Guidance by :

Download or read book Soil Screening Guidance written by and published by . This book was released on 1996 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Health Risks from Dioxin and Related Compounds

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309133882
Total Pages : 269 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Health Risks from Dioxin and Related Compounds by : National Research Council

Download or read book Health Risks from Dioxin and Related Compounds written by National Research Council and published by National Academies Press. This book was released on 2006-10-20 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the U.S. Environmental Protection Agency presented a comprehensive review of the scientific literature in its 2003 draft reassessment of the risks of dioxin, the agency did not sufficiently quantify the uncertainties and variabilities associated with the risks, nor did it adequately justify the assumptions used to estimate them, according to this new report from the National Academies' National Research Council. The committee that wrote the report recommended that EPA re-estimate the risks using several different assumptions and better communicate the uncertainties in those estimates. The agency also should explain more clearly how it selects both the data upon which the reassessment is based and the methods used to analyze them.

The Use of Systematic Review in Epa's Toxic Substances Control ACT Risk Evaluations

Author : National Academies Of Sciences Engineeri
Publisher : National Academies Press
ISBN 13 : 9780309683869
Total Pages : pages
Book Rating : 4.6/5 (838 download)

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Book Synopsis The Use of Systematic Review in Epa's Toxic Substances Control ACT Risk Evaluations by : National Academies Of Sciences Engineeri

Download or read book The Use of Systematic Review in Epa's Toxic Substances Control ACT Risk Evaluations written by National Academies Of Sciences Engineeri and published by National Academies Press. This book was released on 2021-11-16 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Systematic review - a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies - has become the foundation for assessing evidence to be used for decision making in a variety of health contexts, including health care and public health. At the request of the Environmental Protection Agency (EPA), this publication reviews EPA's 2018 guidance document Application of Systematic Review in TSCA (Toxic Substances and Control Act) Risk Evaluations and associated materials to determine whether the process is comprehensive, workable, objective, and transparent.

Technical Support Document for Water Quality-based Toxics Control

Author : United States. Environmental Protection Agency. Office of Water
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Technical Support Document for Water Quality-based Toxics Control by : United States. Environmental Protection Agency. Office of Water

Download or read book Technical Support Document for Water Quality-based Toxics Control written by United States. Environmental Protection Agency. Office of Water and published by . This book was released on 1991 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Science and Judgment in Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030904894X
Total Pages : 668 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Science and Judgment in Risk Assessment by : National Research Council

Download or read book Science and Judgment in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1994-01-01 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.

Forever Chemicals

Author : David M. Kempisty
Publisher : CRC Press
ISBN 13 : 1000405451
Total Pages : 361 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Forever Chemicals by : David M. Kempisty

Download or read book Forever Chemicals written by David M. Kempisty and published by CRC Press. This book was released on 2021-07-28 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forever Chemicals: Environmental, Economic, and Social Equity Concerns with PFAS in the Environment provides the reader with an understanding of the complex and interwoven issues associated with per- and polyfluorinated substances (PFAS) in our environment. The chapters provide in-depth perspective into various issues, including health, regulation, detection, clean-up strategies and technologies, and more. Taken together or as the reader’s interests lead them, the variety of topics covered in the book present a balanced perspective on this complex topic. It will address the current state of PFAS and where indicators are pointing for future developments. The book is also a deeper investigation of the regulatory challenges, analytical hurdles, and toxicological progress to date for the suite of PFAS chemicals. Features Explains the trends that will affect future policy and regulatory decisions Looks holistically at 4000+ PFAS chemicals Includes PFAS risk assessments at contaminated sites and biomonitoring insights Provides in-depth discussions on remediation technologies Illustrates quality and diversified content Provides a balanced perspective on this complex topic

Health Effects Assessment Summary Tables

Author :
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Health Effects Assessment Summary Tables by :

Download or read book Health Effects Assessment Summary Tables written by and published by . This book was released on 1997 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicological Profile for Lead

Author :
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Lead by :

Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Risk Assessment Guidelines of 1986

Author :
Publisher :
ISBN 13 :
Total Pages : 88 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis The Risk Assessment Guidelines of 1986 by :

Download or read book The Risk Assessment Guidelines of 1986 written by and published by . This book was released on 1987 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

EPA's IRIS Program

Author : United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis EPA's IRIS Program by : United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight

Download or read book EPA's IRIS Program written by United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight and published by . This book was released on 2011 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Risk Assessment Guidance for Superfund: pt. A. Human health evaluation manual

Author :
Publisher :
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Risk Assessment Guidance for Superfund: pt. A. Human health evaluation manual by :

Download or read book Risk Assessment Guidance for Superfund: pt. A. Human health evaluation manual written by and published by . This book was released on 1989 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The EPA's IRIS Program

Author : United States. Congress. House. Committee on Science and Technology (2007). Subcommittee on Investigations and Oversight
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis The EPA's IRIS Program by : United States. Congress. House. Committee on Science and Technology (2007). Subcommittee on Investigations and Oversight

Download or read book The EPA's IRIS Program written by United States. Congress. House. Committee on Science and Technology (2007). Subcommittee on Investigations and Oversight and published by . This book was released on 2008 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Assessing the Human Health Risks of Trichloroethylene

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 9780309102834
Total Pages : 452 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Assessing the Human Health Risks of Trichloroethylene by : National Research Council

Download or read book Assessing the Human Health Risks of Trichloroethylene written by National Research Council and published by National Academies Press. This book was released on 2007-01-08 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews. Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment. Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk.

Toxicological Profile for Carbon Monoxide

Author : U.s. Department of Health and Human Services
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781495287497
Total Pages : 348 pages
Book Rating : 4.2/5 (874 download)

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Book Synopsis Toxicological Profile for Carbon Monoxide by : U.s. Department of Health and Human Services

Download or read book Toxicological Profile for Carbon Monoxide written by U.s. Department of Health and Human Services and published by Createspace Independent Publishing Platform. This book was released on 2014-01-22 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the toxic substances each profile describes. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profiles focus on health and toxicologic information; therefore, each toxicological profile begins with a public health statement that describes, in nontechnical language, a substance's relevant toxicological properties. Following the public health statement is information concerning levels of significant human exposure and, where known, significant health effects. A health effects summary describes the adequacy of information to determine a substance's health effects. ATSDR identifies data needs that are significant to protection of public health. Each profile: (A) Examines, summarizes, and interprets available toxicologic information and epidemiologic evaluations on a toxic substance to ascertain the levels of significant human exposure for the substance and the associated acute, subacute, and chronic health effects; (B) Determines whether adequate information on the health effects of each substance is available or being developed to determine levels of exposure that present a significant risk to human health of acute, subacute, and chronic health effects; and (C) Where appropriate, identifies toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans.