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Enzyme Systems That Metabolise Drugs And Other Xenobiotics
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Book Synopsis Enzyme Systems that Metabolise Drugs and Other Xenobiotics by : Costas Ioannides
Download or read book Enzyme Systems that Metabolise Drugs and Other Xenobiotics written by Costas Ioannides and published by John Wiley & Sons. This book was released on 2002 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work focuses on the enzyme systems that participate in the metabolism of chemicals and other xenobiotics, with emphasis being placed on drug metabolism. Each chapter focuses on a specific enzyme system.
Book Synopsis Biochemistry of Redox Reactions by : Bernard Testa
Download or read book Biochemistry of Redox Reactions written by Bernard Testa and published by Academic Press. This book was released on 1995 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: First in a set of books to provide a comprehensive coverage of drug metabolism; Opening chapter provides a general introduction to the complete set of books; Other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates, and drug-enzyme interactions; Extensive detailed diagrams of reaction pathways and chemical structures * First in a set of books providing a comprehensive coverage of drug metabolism * Opening chapter provides a general introduction to the complete set of books * Other chapters cover reaction mechanisms, catalytic cycles, regio and stereoselectivities, types of substrates, reactivity of intermediates and drug-enzyme interactions * Extensive detailed diagrams of reaction pathways and chemical structures
Book Synopsis Metabolism of Xenobiotics by : Johannes Hendrikus Dewaide
Download or read book Metabolism of Xenobiotics written by Johannes Hendrikus Dewaide and published by . This book was released on 1971 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Metabolizing Enzyme Systems and Their Relationship to Toxic Mechanisms by :
Download or read book Drug Metabolizing Enzyme Systems and Their Relationship to Toxic Mechanisms written by and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs.
Book Synopsis Drug metabolizing enzyme systems by : Bŭlgarska akademii︠a︡ na naukite
Download or read book Drug metabolizing enzyme systems written by Bŭlgarska akademii︠a︡ na naukite and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applied Chemoinformatics by : Thomas Engel
Download or read book Applied Chemoinformatics written by Thomas Engel and published by John Wiley & Sons. This book was released on 2018-06-05 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by world-famous pioneers in chemoinformatics, this is a clearly structured and applications-oriented approach to the topic, providing up-to-date and focused information on the wide range of applications in this exciting field. The authors explain methods and software tools, such that the reader will not only learn the basics but also how to use the different software packages available. Experts describe applications in such different fields as structure-spectra correlations, virtual screening, prediction of active sites, library design, the prediction of the properties of chemicals, the development of new cosmetics products, quality control in food, the design of new materials with improved properties, toxicity modeling, assessment of the risk of chemicals, and the control of chemical processes. The book is aimed at advanced students as well as lectures but also at scientists that want to learn how chemoinformatics could assist them in solving their daily scientific tasks. Together with the corresponding textbook Chemoinformatics - Basic Concepts and Methods (ISBN 9783527331093) on the fundamentals of chemoinformatics readers will have a comprehensive overview of the field.
Author :Paul R. Ortiz de Montellano Publisher :Springer Science & Business Media ISBN 13 :0387274472 Total Pages :702 pages Book Rating :4.3/5 (872 download)
Book Synopsis Cytochrome P450 by : Paul R. Ortiz de Montellano
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Book Synopsis Enzyme-Based Organic Synthesis by : Cheanyeh Cheng
Download or read book Enzyme-Based Organic Synthesis written by Cheanyeh Cheng and published by John Wiley & Sons. This book was released on 2022-02-03 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.
Book Synopsis Intentional Human Dosing Studies for EPA Regulatory Purposes by : National Research Council
Download or read book Intentional Human Dosing Studies for EPA Regulatory Purposes written by National Research Council and published by National Academies Press. This book was released on 2004-06-04 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.
Book Synopsis Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense by : Chang-Hwei Chen
Download or read book Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense written by Chang-Hwei Chen and published by Springer Nature. This book was released on 2020-04-03 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.
Book Synopsis Biocatalysts and Enzyme Technology by : Klaus Buchholz
Download or read book Biocatalysts and Enzyme Technology written by Klaus Buchholz and published by John Wiley & Sons. This book was released on 2012-12-21 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.
Book Synopsis Protein Hydrolysates in Biotechnology by : Vijai K. Pasupuleti
Download or read book Protein Hydrolysates in Biotechnology written by Vijai K. Pasupuleti and published by Springer Science & Business Media. This book was released on 2010-08-28 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein hydrolysates, otherwise commonly known as peptones or peptides, are used in a wide variety of products in fermentation and biotechnology industries. The term “peptone” was first introduced in 1880 by Nagelli for growing bacterial cultures. However, later it was discovered that peptones derived from the partial digestion of proteins would furnish organic nitrogen in readily available form. Ever since, p- tones, which are commonly known as protein hydrolysates, have been used not only for growth of microbial cultures, but also as nitrogen source in commercial fermen- tions using animal cells and recombinant microorganisms for the production of value added products such as therapeutic proteins, hormones, vaccines, etc. Today, the characterization, screening and manufacturing of protein hyd- lysates has become more sophisticated, with the introduction of reliable analytical instrumentation, high throughput screening techniques coupled with statistical design approaches, novel enzymes and efficient downstream processing equipment. This has enabled the introduction of custom-built products for specialized appli- tions in diverse fields of fermentation and biotechnology, such as the following. 1. Protein hydrolysates are used as much more than a simple nitrogen source. For example, the productivities of several therapeutic drugs made by animal cells and recombinant microorganisms have been markedly increased by use of p- tein hydrolysates. This is extremely important when capacities are limited. 2. Protein hydrolysates are employed in the manufacturing of vaccines by ferm- tation processes and also used as vaccine stabilizers.
Book Synopsis Problem Solving in Enzyme Biocatalysis by : Andrés Illanes
Download or read book Problem Solving in Enzyme Biocatalysis written by Andrés Illanes and published by John Wiley & Sons. This book was released on 2013-10-02 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme biocatalysis is a fast-growing area in process biotechnology that has expanded from the traditional fields of foods, detergents, and leather applications to more sophisticated uses in the pharmaceutical and fine-chemicals sectors and environmental management. Conventional applications of industrial enzymes are expected to grow, with major opportunities in the detergent and animal feed sectors, and new uses in biofuel production and human and animal therapy. In order to design more efficient enzyme reactors and evaluate performance properly, sound mathematical expressions must be developed which consider enzyme kinetics, material balances, and eventual mass transfer limitations. With a focus on problem solving, each chapter provides abridged coverage of the subject, followed by a number of solved problems illustrating resolution procedures and the main concepts underlying them, plus supplementary questions and answers. Based on more than 50 years of teaching experience, Problem Solving in Enzyme Biocatalysis is a unique reference for students of chemical and biochemical engineering, as well as biochemists and chemists dealing with bioprocesses. Contains: Enzyme properties and applications; enzyme kinetics; enzyme reactor design and operation 146 worked problems and solutions in enzyme biocatalysis.
Book Synopsis Chemical Synthesis of Nucleoside Analogues by : Pedro Merino
Download or read book Chemical Synthesis of Nucleoside Analogues written by Pedro Merino and published by John Wiley & Sons. This book was released on 2013-02-12 with total page 859 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
Download or read book Drug Metabolism written by Mino R. Caira and published by Springer Science & Business Media. This book was released on 2006-07-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Download or read book Osteoimmunology written by Yongwon Choi and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Key Regulator of Postnatal Skeletal Remodeling.- Ectodomain Shedding of Receptor Activator of NF-KB Ligand.- The Negative Role Of Ids In Osteoclastogenesis.- Functional Genetic and Genomic Analysis of Modeled Arthritis.- Dexamethsone Suppresses Bone Formation via the Osteoclast.- Immunologic Regulation Of Bone Development.- Pth Regulates The Hematopoietic Stem Cell Niche In Bone.- Regulation Of Hematopoietic Stem Cells In The Osteoblastic Niche.- The Chemokine Cxcl12 And Regulation Of Hsc And Lymphocyte Development In The Bone Marrow Niche.- Osteoclast Precursor Cells.- Interaction with estrogen receptors as treatment of arthritis and osteoporosis.- Novel Signaling Pathways And Therapeutic Targets In Osteoclasts.- The Enigmatic Function of TREM-2 in Osteoclastogenesis.- Role of cell-matrix interactions in osteoclast differentiation.- Positive and negative roles of IL-6, STAT3 and SOCS3 in inflammatory arthritis.- Control of Osteoclast activity and bone loss by IKK subunits: new targets for therapy.- Targeting Osteoporosis And Rheumatoid Arthritis By Active Vaccination Against Rankl.- RANKL Inhibition: From Mice to Men (and Women).
Book Synopsis Antioxidants and Antioxidant Enzymes in Higher Plants by : Dharmendra K. Gupta
Download or read book Antioxidants and Antioxidant Enzymes in Higher Plants written by Dharmendra K. Gupta and published by Springer. This book was released on 2018-03-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of antioxidants and antioxidant enzymes and their role in the mechanisms of signaling and cellular tolerance under stress in plant systems. Major reactive oxygen species (ROS)-scavenging/modulating enzymes include the superoxide dismutase (SOD) that dismutates O2 into H2O2, which is followed by the coordinated action of a set of enzymes including catalase (CAT), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and peroxiredoxins (Prx) that remove H2O2. In addition to the ROS scavenging enzymes, a number of other enzymes are found in various subcellular compartments, which are involved in maintaining such redox homeostasis either by directly scavenging particular ROS and ROS-byproducts or by replenishing antioxidants. In that respect, these enzymes can be also considered antioxidants. Such enzymes include monodehydroascorbate reductase (MDAR), dehydroascorbate reductase (DHAR), glutathione reductase (GR), alternative oxidases (AOXs), peroxidases (PODs) and glutathione S-transferases (GSTs). Some non-enzymatic antioxidants, such as ascorbic acid (vitamin C), carotenes (provitamin A), tocopherols (vitamin E), and glutathione (GSH), work in concert with antioxidant enzymes to sustain an intracellular steady-state level of ROS that promotes plant growth, development, cell cycles and hormone signaling, and reinforces the responses to abiotic and biotic environmental stressors. Offering a unique compilation of information on antioxidants and antioxidant enzymes, this is a valuable resource for advanced students and researchers working on plant biochemistry, physiology, biotechnology, and signaling in cell organelles, and those specializing in plant enzyme technology.
