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Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders
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Book Synopsis Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders by : Michael Aschner
Download or read book Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders written by Michael Aschner and published by Academic Press. This book was released on 2015-06-18 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. - Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders - Written by an international selection of the world's foremost experts in the field of neurotoxicology - Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action - An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309683092 Total Pages :87 pages Book Rating :4.3/5 (96 download)
Book Synopsis Environmental Neuroscience by : National Academies of Sciences, Engineering, and Medicine
Download or read book Environmental Neuroscience written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2021-01-22 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical. On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.
Book Synopsis Advances in understanding the pathogenetic mechanisms of neurodevelopmental disorders and neurodegenerative disease - The environment as a putative risk factor by : Anna Maria Lavezzi
Download or read book Advances in understanding the pathogenetic mechanisms of neurodevelopmental disorders and neurodegenerative disease - The environment as a putative risk factor written by Anna Maria Lavezzi and published by Frontiers Media SA. This book was released on 2023-09-05 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodevelopmental disorders are generally influenced by genetic as well as intrauterine and extrauterine factors that affect the fetal-maternal environment and/or brain development that continues after birth. Specific genetic polymorphisms may increase susceptibility to environmental factors that alter the trajectory of brain development via diverse molecular mechanisms. In particular, the pre- and post-natal exposure to neurotoxic metals, pesticides, persistent organic pollutants, and other chemicals is increasingly recognized as involved in the pathogenesis of neurodevelopmental disorders, such as autism, deficiency attention/hyperactivity disorders, neurodegenerative disorders such as Parkinson's and Alzheimer's disease, chronic multiple sclerosis, and even fetal and infant death, including SIUDS (Sudden Unexplained Intrauterine Death Syndrome) and SIDS (Sudden Infant Death Syndrome).
Book Synopsis Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration by : Gustavo Pacheco-Lopez
Download or read book Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration written by Gustavo Pacheco-Lopez and published by Frontiers Media SA. This book was released on 2021-09-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Environmental Factors in Neurodegenerative Diseases by :
Download or read book Environmental Factors in Neurodegenerative Diseases written by and published by Academic Press. This book was released on 2017-09-19 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson's disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. - Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology - Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers - Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America - Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government
Book Synopsis Linking Environmental Exposure to Neurodevelopmental Disorders by :
Download or read book Linking Environmental Exposure to Neurodevelopmental Disorders written by and published by Academic Press. This book was released on 2018-05-24 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Neurotoxicology, Volume Two, addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government
Book Synopsis Analysis of Genetic and Environmental Factors in Neurodegenerative Disease by : Marleshia Dorcell Hall
Download or read book Analysis of Genetic and Environmental Factors in Neurodegenerative Disease written by Marleshia Dorcell Hall and published by . This book was released on 2016 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence of neurodegenerative diseases including Parkinson's, Alzheimer's, and Huntington's disease is ever-increasing. Therefore, it is essential that we understand the mechanisms behind the pathology of these disorders. Extensive study has been conducted on the factors that play a role in these disorders. Through these studies, several pathways have been elucidated that further enlighten our understanding of these pathologies. However, many studies have been conducted on model systems that do not fully recapitulate all of the pathological hallmarks of these diseases. Additionally, a greater understanding into the interplay between multiple pathways has been lacking. Previously, we established a Drosophila model for Parkinson's disease that demonstrates that both genetic and environmental factors play a role in the susceptibility and resistance of the organism to neurodegenerative disease. The herbicide paraquat leads to degeneration of dopamine neurons and reduced mobility as is seen in Parkinson's patients. Using this model, we determined that an integration of the inflammatory and hypoxia pathways ensues whereby ingestion of paraquat induces the production of nitric oxide synthase (NOS) that is associated with hyper-branching of the trachea; this also occurs in adult Drosophila brains. Additionally, we have investigated the role of von Hippel Lindau (VHL), an E3 ubiquitin ligase that regulates the hypoxia response, in sensitivity to paraquat, induction of the inflammatory pathway, and neurodegeneration. We have found that loss of VHL along with exposure to paraquat leads to exacerbated survival truncation and movement abnormalities. Furthermore, Catsup protein levels (a negative regulator of dopamine biosynthesis) are altered in these mutants demonstrating a putative role for VHL in Catsup regulation. Here, we also show that a metabolite from the common soil bacteria Streptomyces venezuelae leads to decreased survival and loss of dopamine neurons and induction of NOS. Additionally, Îł-synuclein, a gene implicated in familial Parkinson's disease was studied to determine susceptibility to this bacterial metabolite. We found that expression of Îł-synuclein in flies leads to increased sensitivity and loss of dopamine neurons due to the toxic bacterial metabolite. Taken together, this work provides a mechanism behind the pathology of neurodegenerative diseases and signifies that both genetic and environmental factors play a role in the development and progression of these diseases. It also demonstrates that a dynamic interplay of pathways exists and provides avenues by which future therapeutics may be developed.
Book Synopsis Environmental Contaminants and Neurological Disorders by : Muhammad Sajid Hamid Akash
Download or read book Environmental Contaminants and Neurological Disorders written by Muhammad Sajid Hamid Akash and published by Springer Nature. This book was released on 2021-05-17 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses how environmental pollutants are involved in the pathogenesis of neurological disorders, and covers specific mechanisms and risk factors, as well as the necessary strategies to reduce the adverse impacts of environmental pollutants on the human nervous system. With a collection of contributions from experts in environmental pollution, neurology and pharmaceutical chemistry, the book provides both an introduction to the pathogenesis of neurodegeneration, including the types and different classes of neurological disorders, and studies demonstrating the clear link between environmental contaminants (e.g. pesticides, smoking, mycotoxins, persistent organic pollutants (POP's), polychlorinated biphenyls, phthalates, nanomaterials) and the development of neurological disorders in vulnerable populations. The book fills in a gap in research on the topic by also covering state-of-the-art treatment strategies and mitigation measures for each type of pollutant. The book will be of interest to environmental scientists, pharmacologists, toxicologists, biochemists, biotechnologists, and food and drug regulatory organizations.
Book Synopsis Pathogenesis of Neurodegenerative Disorders by : Mark P. Mattson
Download or read book Pathogenesis of Neurodegenerative Disorders written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 2001-06-01 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.
Book Synopsis Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches by :
Download or read book Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mounting evidence shows that increasing numbers of children are being diagnosed with neurodevelopmental disorders, and it is clear that this increase cannot be explained by genetic background alone. A number of studies, including epidemiological studies, have found an association between in-utero and childhood exposure to certain chemicals, such as endocrine disruptors, psychoactive pharmaceuticals, volatile organic chemicals, persistent organic compounds and heavy metals, and children's brain development. Yet, the mechanisms by which these chemicals impair brain development and function are not fully understood. In addition, little is known about how these chemicals enter and accumulate in the brain. Experimental approaches are essential to understand how those harmful chemicals enter children's brain and pose discrete effects on specific brain sites. These approaches include the following: improvement of technologies for the detection and measurement of neuroendocrinological and behavioral changes in animal models: development of analytical methods for the identification and quantification of chemicals and their metabolites in the brain; development of in vitro cell line assays; and imaging technologies to illustrate cellular functions. In this research topic, we collected articles that provide state-of-the-art science and technologies that can help us identify environmental chemicals that influence brain development. We also included articles that lead to a better understanding of the actions and dynamics of these chemicals. The articles in this research topics supplied novel information about harmful endpoints of environmental chemicals. The reviews demonstrated the typical and novel interactions between environmental chemicals and the developing brain. We believe that these studies would lead to further understanding of neurodevelopmental disorders caused by environmental factors.
Book Synopsis Environmental Epigenetics by : L. Joseph Su
Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.
Book Synopsis Developmental Origins of Health and Disease by : Peter Gluckman
Download or read book Developmental Origins of Health and Disease written by Peter Gluckman and published by Cambridge University Press. This book was released on 2006-04-20 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.
Book Synopsis Early Environmental Origins of Neurodegenerative Disease in Later Life by : Philip J. Landrigan
Download or read book Early Environmental Origins of Neurodegenerative Disease in Later Life written by Philip J. Landrigan and published by . This book was released on 2008-10 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes: (1) Early Environmental Origins of Neurodegenerative Disease in Later Life, by Philip Landrigan; (2) The Role of Early Life Environmental Risk Factors in Parkinson Disease: What Is the Evidence?, by Giancarlo Logroscino; (3) Fetal Environment and Schizophrenia, by Mark Opler and Ezra Susser; (4) Pharmacokinetic and Pharmacodynamic Factors That Can Affect Sensitivity to Neurotoxic Sequelae in Elderly Individuals, by Gary Ginsberg; (5) Neurodegenerative Diseases: An Overview of Environmental Risk Factors, by Rebecca Brown; (6) Aging and the Environment: A Research Framework, by Andrew Geller and Harold Zenick; (7) Developmental Pesticide Models of the Parkinson Disease Phenotype, by Deborah Cory-Slechta. Illus.
Book Synopsis Neurodegenerative Diseases by : Shamim I. Ahmad
Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Book Synopsis Treatment of Neurodevelopmental Disorders by : Randi Jenssen Hagerman
Download or read book Treatment of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by Oxford University Press, USA. This book was released on 2014 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.
Book Synopsis Handbook of Research on Critical Examinations of Neurodegenerative Disorders by : Uddin, Md. Sahab
Download or read book Handbook of Research on Critical Examinations of Neurodegenerative Disorders written by Uddin, Md. Sahab and published by IGI Global. This book was released on 2018-07-31 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegeneration is a key feature of several diseases that are referred to as neurodegenerative diseases. The process of neurodegeneration is not well-understood so the diseases that stem from it have, as yet, no cures. As such, studying the effects of these disorders can provide insight into the treatment, prevention, and future opportunities and challenges in this growing field. The Handbook of Research on Critical Examinations of Neurodegenerative Disorders is a critical scholarly resource that provides an extensive explanation of various neurodegenerative disorders based on existing studies to clarify etiology, pathological mechanisms, diagnosis, therapeutic interventions, as well as current status and future opportunities and challenges. Featuring coverage on a broad range of topics such as dementia, mitochondrial dysfunction, and risk factors, this book is geared towards neurobiologists, neuropsychologists, neurophysiologists, neuropathologists, medical professionals, academicians, and researchers seeking research on the complexity of neurodegenerative disorders.
Book Synopsis Autism and the Environment by : Institute of Medicine
Download or read book Autism and the Environment written by Institute of Medicine and published by National Academies Press. This book was released on 2008-03-12 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorders (ASD) constitute a major public health problem, affecting one in every 150 children and their families. Unfortunately, there is little understanding of the causes of ASD, and, despite their broad societal impact, many people believe that the overall research program for autism is incomplete, particularly as it relates to the role of environmental factors. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders, in response to a request from the U.S. Secretary of Health and Human Services, hosted a workshop called "Autism and the Environment: Challenges and Opportunities for Research." The focus was on improving the understanding of the ways in which environmental factors such as chemicals, infectious agents, or physiological or psychological stress can affect the development of the brain. Autism and the Environment documents the concerted effort which brought together the key public and private stakeholders to discuss potential ways to improve the understanding of the ways that environmental factors may affect ASD. The presentations and discussions from the workshop that are described in this book identify a number of promising directions for research on the possible role of different environmental agents in the etiology of autism.
