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Endoplasmic Reticulum Homeostasis In The Mouse Mammary Epithelium During Lactation
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Book Synopsis Endoplasmic Reticulum Homeostasis in the Mouse Mammary Epithelium During Lactation by : Kristen Ross Davis
Download or read book Endoplasmic Reticulum Homeostasis in the Mouse Mammary Epithelium During Lactation written by Kristen Ross Davis and published by . This book was released on 2015 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lactation is an essential stage of mammalian life. Milk is a complex fluid that provides complete nutrition for neonates in the early stages of postnatal life. The organic components of milk, such as milk proteins and lipids, are synthesized and secreted by mammary epithelial cells (MEC). A key differentiation event in MEC is the development of an extensive endoplasmic reticulum (ER) network. At the onset of lactation, copious amount of lipid and protein synthesis could perturb the ER luminal environment. However, little is known about ER function in the context of lactation. Professional secretory cells rely on adaptive mechanisms to maintain ER homeostasis including the Unfolded Protein Response (UPR) and elimination of misfolded and improperly modified proteins via the Endoplasmic Reticulum Associated Degradation (ERAD). Two components of the UPR and ERAD, XBP1 and Sel1L respectively, have been implicated in maintaining ER function in secretory cells. However, the roles of XBP1 and Sel1L during lactation have not been investigated. To this end, we specifically ablated XBP1 and Sel1L in MEC during lactation. Our findings indicate that XBP1 is required for sustaining pup growth during lactation. Absence of XBP1 resulted in a severe reduction of the ER compartment and substantially smaller mammary epithelial compartment during lactation. Notably, our findings are the first to directly demonstrate that XBP1 is absolutely necessary for the development and expansion of an extensive ER network in the MEC. In the case of Sel1L, its absence had little impact on lactation, even though the morphology of the ER was abnormal and markers of ER stress were elevated. More importantly, our findings are the first to suggest that Sel1L is dispensable for MEC function. Taken together, our findings provide novel insight of the contribution of the two ER homeostatic systems during the dynamic and metabolically demanding stage of lactation.
Book Synopsis Lipid Metabolism and Health by : Robert Brown
Download or read book Lipid Metabolism and Health written by Robert Brown and published by Murphy & Moore Publishing. This book was released on 2021-11-16 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are macrobiomolecules which are soluble in non-polar solvents. They are utilized for signaling, storing energy and as basic structural component of cell membranes. Lipids are hydrophilic in nature and find extensive use in food industry, cosmetic industry and nanotechnology. Lipids metabolism refers to the synthesis and degradation lipids which are present in cell bodies. This involves the breakdown and storage of fats, and synthesis of functional and structural lipids. The processes studied under this discipline are lipid absorption, lipid transportation, lipid catabolism and lipid biosynthesis. The biosynthesis mechanisms can be further classified into fatty acid biosynthesis, membrane lipid biosynthesis, triglyceride biosynthesis and fatty acid biosynthesis. The lipids involved in these processes can be divided into four categories, namely, phospholipids, sphingolipids, glycolipids and glycerophospholipids. This book presents the complex subject of lipid metabolism in the most comprehensible and easy to understand language. Some of the diverse topics covered herein address the varied branches that fall under this category. The readers would gain knowledge that would broaden their perspective about lipid metabolism and health.
Book Synopsis Diagnosis and Management of Ovarian Disorders by : Albert Altchek
Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine
Book Synopsis Hormonal Control of Lactation by : A. T. Cowie
Download or read book Hormonal Control of Lactation written by A. T. Cowie and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on the hormonal control oflactation - the subject of this monograph - has long been the major interest of this laboratory. Studies were initiated in the mid 1930s by the late Professor S. 1. Folley, FRS, who directed the work with immense enthusiasm and devotion until his untimely death in 1970. This fruitful area of basic and applied research has, in recent years, attracted widespread attention; there have been many exciting events and developments with a dramatic increase in the number of publications. These events are diverse and include the identification, isolation and sequencing of human prolactin; the identification and isolation of placentallactogens in several ruminant species with recognition of their importance in mammary growth and differentiation; the introduction of highly sensitive bioassay, radioimmuno- and radioreceptor-assay techniques for mammotrophic hormones; the growing clinical appreciation of the immunological and nutritional importance of colostrum and milk to the newborn; the intensification of studies on normal mammogenesis to establish a sound basis for studies on mammary cancer; and the exploitation of the mammary gland, with its characteristic differentiation patterns and multiple synthetic abilities, as a valuable tissue for the investigation of basic mechanisms involved in the synthesis under hormonal control of enzymes and secretory proteins; and for the study of hormone - receptor interactions.
Book Synopsis Physiology of Human Female Lactation by : Nikolai Petrovitch Alekseev
Download or read book Physiology of Human Female Lactation written by Nikolai Petrovitch Alekseev and published by Springer Nature. This book was released on 2021-03-27 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.
Book Synopsis Handbook of Vertebrate Immunology by : Paul-Pierre Pastoret
Download or read book Handbook of Vertebrate Immunology written by Paul-Pierre Pastoret and published by Academic Press. This book was released on 1998-05-21 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species. This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Veterinary or Human Medicine, Biology and researchers in Comparative Medicine and Physiology. Each section, devoted to a major animal group covers: Lymphoid organs and their anatomical disposition Leukocytes and their markers Leukocyte traffic and associated molecules Cytokines T cell receptors Immunoglobulins MHC antigens Ontogeny of the immune system Passive transfer of immunity Neonatal immune responses Non-specific immunity Complement system Mucosal immunity Immunodeficiencies Tumours of the immune system Autoimmunity
Book Synopsis Ion Transport Across Epithelial Tissues and Disease by : Kirk L. Hamilton
Download or read book Ion Transport Across Epithelial Tissues and Disease written by Kirk L. Hamilton and published by Springer Nature. This book was released on 2020-12-12 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
Book Synopsis Autophagy - A Double-Edged Sword by : Yannick Bailly
Download or read book Autophagy - A Double-Edged Sword written by Yannick Bailly and published by BoD – Books on Demand. This book was released on 2013-04-17 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this book review the latest advances in the molecular mechanisms of autophagy, highlighting some of the most challenging research topics. The focus is mainly on how this basic cell defense mechanism comes into play in various pathologies, including liver diseases, myopathies, infectious diseases, cancers and neurodegenerative diseases. In these diseases, the contradictory autophagy roles of cell survival versus cell death emphasize the necessity of taking into account this double-edged nature in future development of already promising, autophagy- modulating, therapies.
Book Synopsis Phosphate Metabolism by : Shaul Massry
Download or read book Phosphate Metabolism written by Shaul Massry and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Book Synopsis Gene Expression and Regulation by : Jun Ma
Download or read book Gene Expression and Regulation written by Jun Ma and published by Springer. This book was released on 2010-12-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.
Download or read book Lactogenesis written by Monica Reynolds and published by University of Pennsylvania Press. This book was released on 2016-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a symposium, satellite to the 24th International Congress of Physiological Sciences, University of Pennsylvania.
Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Book Synopsis Maternal-Fetal Nutrition During Pregnancy and Lactation by : Michael E. Symonds
Download or read book Maternal-Fetal Nutrition During Pregnancy and Lactation written by Michael E. Symonds and published by Cambridge University Press. This book was released on 2010-01-28 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the aim to improve clinicians' understanding of the important effects nutrition can have on maternal health and fetal and neonatal development, Maternal-Fetal Nutrition During Pregnancy and Lactation defines the nutritional requirements with regard to the stage of development and growth, placing scientific developments into clinical context.
Book Synopsis Leong's Manual of Diagnostic Antibodies for Immunohistology by : Runjan Chetty
Download or read book Leong's Manual of Diagnostic Antibodies for Immunohistology written by Runjan Chetty and published by Cambridge University Press. This book was released on 2016-11-28 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.
Book Synopsis Mammary Stem Cells by : Maria del Mar Vivanco
Download or read book Mammary Stem Cells written by Maria del Mar Vivanco and published by Humana. This book was released on 2015-06-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of normal and breast cancer stem cells has offered a new vision of this heterogeneous disease and new hopes for its prognosis and treatment. This volume provides an overview of recent developments in mammary stem cell research and discusses the many varieties of approaches used by researchers to investigate the properties and functions of mammary stem cells. The beginning chapters provide readers with an introduction to mammary stem cells, and the processes used to characterize stem cells and isolate them via fluorescent activated cell sorting. The next few chapters discuss DNA and mRNA sequencing, proteomic techniques to help profile cells, lentiviral cell transduction for gene expression, and in vivo lineage tracing. The final few chapters are dedicated to following stem cells from their initial niche to the new microenvironment at their metastasis site, and to studying these cells using physical and mathematical approaches. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and cutting-edge, Mammary Stem Cells: Methods and Protocols aims to help members of the scientific community explore the behavior of stem cells and how to work with them in order to guide the design of new and complimentary strategies to be applied in the clinic with the ultimate end goal of fighting breast cancer.
Book Synopsis The Tyranny of Science by : Paul K. Feyerabend
Download or read book The Tyranny of Science written by Paul K. Feyerabend and published by Polity. This book was released on 2011-05-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paul Feyerabend is one of the greatest philosophers of science of the 20th century and his book Against Method is an international bestseller. In this new book he masterfully weaves together the main elements of his mature philosophy into a gripping tale: the story of the rise of rationalism in Ancient Greece that eventually led to the entrenchment of a mythical ‘scientific worldview’. In this wide-ranging and accessible book Feyerabend challenges some modern myths about science, including the myth that ‘science is successful’. He argues that some very basic assumptions about science are simply false and that substantial parts of scientific ideology were created on the basis of superficial generalizations that led to absurd misconceptions about the nature of human life. Far from solving the pressing problems of our age, such as war and poverty, scientific theorizing glorifies ephemeral generalities, at the cost of confronting the real particulars that make life meaningful. Objectivity and generality are based on abstraction, and as such, they come at a high price. For abstraction drives a wedge between our thoughts and our experience, resulting in the degeneration of both. Theoreticians, as opposed to practitioners, tend to impose a tyranny on the concepts they use, abstracting away from the subjective experience that makes life meaningful. Feyerabend concludes by arguing that practical experience is a better guide to reality than any theory, by itself, ever could be, and he stresses that there is no tyranny that cannot be resisted, even if it is exerted with the best possible intentions. Provocative and iconoclastic, The Tyranny of Science is one of Feyerabend’s last books and one of his best. It will be widely read by everyone interested in the role that science has played, and continues to play, in the shaping of the modern world.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
