Endogenous Interferences In Clinical Laboratory Tests

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Endogenous Interferences in Clinical Laboratory Tests

Author : Martin H. Kroll
Publisher : Walter de Gruyter
ISBN 13 : 3110266229
Total Pages : 155 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Endogenous Interferences in Clinical Laboratory Tests by : Martin H. Kroll

Download or read book Endogenous Interferences in Clinical Laboratory Tests written by Martin H. Kroll and published by Walter de Gruyter. This book was released on 2012-12-19 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of clinical laboratories is to produce accurate information for clinical decision making in medicine. More than half of the medical decisions made depend on clinical laboratory tests. Patient safety represents an important and critical problem for laboratories. They need to assure that the information they deliver to physicians is accurate, and therefore safe for clinicians to use. Endogenous compounds can interfere with laboratory tests, decreasing accuracy and threatening patient safety. Elevated bilirubin (bilirubinemia) and elevated lipids (lipemia) are common conditions that cause significant interferences with laboratory results. Clinicians depend on laboratories to detect these endogenous interferences. Laboratories must have a means to detect these endogenous interferences, make decisions about reporting results, and evaluate their impact. Most clinical pathology books provide only an abbreviated introduction to the subject, or provide a long list of references, without the necessary foundation for evaluating their significance. Package inserts typically provide scant information. This book provides the empirical and theoretical foundation for these interferences, describes the clinical settings where they occur, and explains their evaluation and detection, allowing the laboratory to interpret the available data on interferences and make the appropriate decision to effectively report test results while protecting patient safety.

Accurate Results in the Clinical Laboratory

Author : Amitava Dasgupta
Publisher : Newnes
ISBN 13 : 0124158587
Total Pages : 383 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Accurate Results in the Clinical Laboratory by : Amitava Dasgupta

Download or read book Accurate Results in the Clinical Laboratory written by Amitava Dasgupta and published by Newnes. This book was released on 2013-01-22 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical, easy-to-use guide, named to Doody's Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care. Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management. - Named to Doody's Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises - Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference - Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks - Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing

Contemporary Practice in Clinical Chemistry

Author : William Clarke
Publisher : Academic Press
ISBN 13 : 0128158336
Total Pages : 1070 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Contemporary Practice in Clinical Chemistry by : William Clarke

Download or read book Contemporary Practice in Clinical Chemistry written by William Clarke and published by Academic Press. This book was released on 2020-06-11 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry. - Includes enhanced illustration and new and revised color figures - Provides improved self-assessment questions and end-of-chapter assessment questions

Tietz Clinical Guide to Laboratory Tests - E-Book

Author : Alan H. B. Wu
Publisher : Elsevier Health Sciences
ISBN 13 : 1437719872
Total Pages : 1857 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Tietz Clinical Guide to Laboratory Tests - E-Book by : Alan H. B. Wu

Download or read book Tietz Clinical Guide to Laboratory Tests - E-Book written by Alan H. B. Wu and published by Elsevier Health Sciences. This book was released on 2006-06-08 with total page 1857 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition of Norbert Tietz's classic handbook presents information on common tests as well as rare and highly specialized tests and procedures - including a summary of the utility and merit of each test. Biological variables that may affect test results are discussed, and a focus is placed on reference ranges, diagnostic information, clinical interpretation of laboratory data, interferences, and specimen types. New and updated content has been added in all areas, with over 100 new tests added. - Tests are divided into 8 main sections and arranged alphabetically. - Each test includes necessary information such as test name (or disorder) and method, specimens and special requirements, reference ranges, chemical interferences and in vivo effects, kinetic values, diagnostic information, factors influencing drug disposition, and clinical comments and remarks. - The most current and relevant tests are included; outdated tests have been eliminated. - Test index (with extensive cross references) and disease index provide the reader with an easy way to find necessary information - Four new sections in key areas (Preanalytical, Flow Cytometry, Pharmacogenomics, and Allergy) make this edition current and useful. - New editor Alan Wu, who specializes in Clinical Chemistry and Toxicology, brings a wealth of experience and expertise to this edition. - The Molecular Diagnostics section has been greatly expanded due to the increased prevalence of new molecular techniques being used in laboratories. - References are now found after each test, rather than at the end of each section, for easier access.

Interference Testing in Clinical Chemistry

Author :
Publisher :
ISBN 13 : 9781562384807
Total Pages : 104 pages
Book Rating : 4.3/5 (848 download)

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Book Synopsis Interference Testing in Clinical Chemistry by :

Download or read book Interference Testing in Clinical Chemistry written by and published by . This book was released on 2002 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Samples:From the Patient to the Laboratory

Author : Walter G. Guder
Publisher : John Wiley & Sons
ISBN 13 : 3527612513
Total Pages : 115 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Samples:From the Patient to the Laboratory by : Walter G. Guder

Download or read book Samples:From the Patient to the Laboratory written by Walter G. Guder and published by John Wiley & Sons. This book was released on 2008-01-08 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: This forth updated edition contains the latest developments in analytical techniques. An international team of authors summarizes the information on biological influences, analytical interferences and on the variables affecting the collection, transport and storage as well as preparation of samples. They cover age, gender, race, pregnancy, diet, exercise and altitude, plus the effects of stimulants and drugs. National and international standards are described for sampling procedures, transport, sample identification and all safety aspects, while quality assurance procedures are shown for total laboratory management. In addition, the authors provide a glossary as well as a separate list of analytes containing the available data on reference intervals, biological half-life times, stability and influence and interference factors. For everyone involved in patient care and using or performing laboratory tests.

Handbook of Drug Monitoring Methods

Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
ISBN 13 : 1588297802
Total Pages : 441 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Handbook of Drug Monitoring Methods by : Amitava Dasgupta

Download or read book Handbook of Drug Monitoring Methods written by Amitava Dasgupta and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Handbook of Diagnostic Endocrinology

Author : William Winter E
Publisher : Academic Press
ISBN 13 : 0128182784
Total Pages : 747 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Handbook of Diagnostic Endocrinology by : William Winter E

Download or read book Handbook of Diagnostic Endocrinology written by William Winter E and published by Academic Press. This book was released on 2020-10-06 with total page 747 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical laboratory plays a critical role in the diagnosis and management of endocrine and related metabolic disorders, which are leading causes of morbidity and mortality in children and adults. The Handbook of Diagnostic Endocrinology, Third Edition, provides a ready reference for the evaluation, diagnosis, and monitoring of such disorders. This revision incorporates translational medicine, connecting what clinicians need to know with those in research providing a clinical context to which they can relate their molecular findings. This book solves the needs of clinicians and researchers by bringing together in one book endocrinology at the molecular and clinical levels. As the intricacies of intracellular signaling have become better understood, states of hormone resistance are now increasingly recognized. The most common endocrinopathy in westernized countries, the metabolic syndrome, results, to a large extent, from insulin resistance. The complexity of the circulating forms of various hormones are acknowledged in this revision. - Each chapter focuses on the biochemical tests that are required, either in the basal state or following provocation or suppression, to assist in the diagnosis of the various disorders - Describes proper sample collection and relevant interpretations of laboratory tests - Contains essential molecular biology and incorporates it with the clinical information - Includes the discovery of new diagnostic and treatment methods

Interference Testing in Clinical Chemistry

Author : National Committee for Clinical Laboratory Standards (U.S.)
Publisher :
ISBN 13 :
Total Pages : 113 pages
Book Rating : 4.:/5 (22 download)

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Book Synopsis Interference Testing in Clinical Chemistry by : National Committee for Clinical Laboratory Standards (U.S.)

Download or read book Interference Testing in Clinical Chemistry written by National Committee for Clinical Laboratory Standards (U.S.) and published by . This book was released on 1986 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Effective Communication in Clinical Handover

Author : Suzanne Eggins
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 311037904X
Total Pages : 368 pages
Book Rating : 4.1/5 (13 download)

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Book Synopsis Effective Communication in Clinical Handover by : Suzanne Eggins

Download or read book Effective Communication in Clinical Handover written by Suzanne Eggins and published by Walter de Gruyter GmbH & Co KG. This book was released on 2016-03-21 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on detailed multi-disciplinary analyses of more than 800 recorded handover interactions, audits of written handover documentation, interviews and survey responses, the contributing authors identify features of effective and ineffective clinical handovers in diverse hospital contexts. The authors then translate their descriptive findings into practical protocols, communication strategies and checklists that clinicians, managers and policy makers can apply to improve the safety and quality of clinical handovers. All the contributors are affiliated with the International Research Centre for Communication in Healthcare (IRCCH), an international multidisciplinary organisation of over 90 healthcare professionals from more than 17 countries committed to improving improving communication in healthcare systems around the world. 'The authors have created a new and tightly woven systems safety net that will, if implemented, significantly reduce the occurrence of errors resulting from cumulative communication failures.' -H. Esterbrook Longmaid III, MD, FACR, President of Medical Staff, Beth Israel Deaconess-Milton Hospital, Milton, MA USA 'Uncommonly valuable for the rigorous, original communication research it reports and for the careful translation of the research findings into practical strategies that actually improve clinical handovers in the real world of practice.' -Professor Suzanne Kurtz, Washington State University 'This clear, plain English book is an outstanding resource for the training of all involved in healthcare.' -Elizabeth Trickett, (Former) Director of Safety and Quality, ACT Health, Australia

Cardiac Biomarkers

Author : Alan S. Maisel
Publisher : Springer
ISBN 13 : 3319429825
Total Pages : 368 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Cardiac Biomarkers by : Alan S. Maisel

Download or read book Cardiac Biomarkers written by Alan S. Maisel and published by Springer. This book was released on 2016-10-24 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know. The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.

Meningitis and Encephalitis

Author : Rodrigo Hasbun
Publisher : Springer
ISBN 13 : 3319926780
Total Pages : 242 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Meningitis and Encephalitis by : Rodrigo Hasbun

Download or read book Meningitis and Encephalitis written by Rodrigo Hasbun and published by Springer. This book was released on 2018-07-19 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meningitis and Encephalitis are associated with high rates of mortality and neurological sequelae. The differential diagnosis includes a wide spectrum of infectious and non-infectious etiologies, some requiring urgent therapy for survival. The current management challenges in patients with meningitis and encephalitis include a low sensitivity of meningeal signs, overutilization of unnecessary screening cranial imaging, delays in diagnosis of urgent treatable causes, a large proportion of unknown etiologies, low sensitivity of current microbiological techniques especially in the setting of previous antibiotic therapy, underutilization of available molecular diagnostic tests, and empiric antibiotic therapy and hospitalization for viral meningitis cases. Even though there are published guidelines, compliance with them is not optimal and physicians do not follow standardized algorithms in their empirical approach. As meningitis and encephalitis is associated with high rates of adverse clinical outcomes, prevention, when feasible is of upmost importance. Adherence to protocols to prevent health-care associated meningitis and ventriculitis are effective but compliance with them is not uniformly performed. This book seeks to improve outcomes for meningitis and encephalitis cases handled by physicians who may or may not be thoroughly trained for these challenges. The text introduces the current guidelines but also discusses the gaps that leave clinicians struggling to implement the most appropriate approaches for these particular neurological infections. Each chapter delivers the tools necessary to identify and adhere to the most appropriate diagnostic technique, management protocols, and prevention approach for each situation. All chapters conclude with discourse on future directions in research and quality improvement. Written by experts in infectious diseases, the book covers topics that are the most devastating, including healthcare-acquired infections, autoimmune encephalitis, and infections as they present in HIV patients. Meningitis and Encephalitis is a well-rounded resource for all medical professionals encountering these neurological syndromes, including infectious disease specialists, neurologists, primary care physicians, and immunologists.

Biotin and Other Interferences in Immunoassays

Author : Amitava Dasgupta
Publisher : Elsevier
ISBN 13 : 0128167416
Total Pages : 145 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biotin and Other Interferences in Immunoassays by : Amitava Dasgupta

Download or read book Biotin and Other Interferences in Immunoassays written by Amitava Dasgupta and published by Elsevier. This book was released on 2019-01-15 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotin and Other Interferences in Immunoassays: A Concise Guide is aimed at clinical laboratory scientists, medical technologists and pathologists who are often the first individuals contacted by a clinician when a laboratory test result does not correlate with clinical presentation. Research scientists working in diagnostics companies will also find this information essential. Sources of errors in non-immunoassay based methods used in clinical chemistry and toxicology laboratory are also discussed so readers can get all important information from one concise guide. This succinct, user-friendly reference provides the necessary information to address high levels of biotin in clinical laboratory results. - Discusses issues of biotin interferences and ways to avoid them for accurate clinical laboratory results - Provides sources of errors in non-immunoassay based methods used in clinical chemistry and toxicology laboratories - Highlights how to handle specimens in the lab and how to eliminate the effect of biotin in precious samples

Principles and Practice of Immunoassay

Author : Christopher P. Price
Publisher : Springer
ISBN 13 : 1349112348
Total Pages : 665 pages
Book Rating : 4.3/5 (491 download)

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Book Synopsis Principles and Practice of Immunoassay by : Christopher P. Price

Download or read book Principles and Practice of Immunoassay written by Christopher P. Price and published by Springer. This book was released on 1991-06-18 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each chapter of this book aims to explore the basic physical and chemical principles involved in the immunoassay techniques discussed. The book also looks at the optimization and limitations of methodology and concludes with a brief overview of the application of the performance of the technology.

Mass Spectrometry for the Clinical Laboratory

Author : Hari Nair
Publisher : Academic Press
ISBN 13 : 0128009926
Total Pages : 306 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mass Spectrometry for the Clinical Laboratory by : Hari Nair

Download or read book Mass Spectrometry for the Clinical Laboratory written by Hari Nair and published by Academic Press. This book was released on 2016-11-02 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Biomarkers in Cancer Screening and Early Detection

Author : Sudhir Srivastava
Publisher : John Wiley & Sons
ISBN 13 : 1118468805
Total Pages : 334 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Biomarkers in Cancer Screening and Early Detection by : Sudhir Srivastava

Download or read book Biomarkers in Cancer Screening and Early Detection written by Sudhir Srivastava and published by John Wiley & Sons. This book was released on 2017-08-28 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers

Clinical Core Laboratory Testing

Author : Ross Molinaro
Publisher : Springer
ISBN 13 : 1489977945
Total Pages : 115 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Clinical Core Laboratory Testing by : Ross Molinaro

Download or read book Clinical Core Laboratory Testing written by Ross Molinaro and published by Springer. This book was released on 2016-12-26 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical laboratory is often known as a “black box” to nurses, physicians, and surgeons, but this concise book removes the veil by covering all the pertinent aspects of the clinical laboratory. This book bridges between medicine and chemistry by offering an overview to a clinical laboratory’s structure and function, the importance of laboratory utilization and test ordering, as well as pre-analytical, analytical, and post-analytical issues of importance to recognize in any clinical laboratory. An interactive FAQ and a detailed index are also available.