Endocrine And Hormonal Toxicology

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Endocrine and Hormonal Toxicology

Author : Philip W. Harvey
Publisher : John Wiley & Sons
ISBN 13 : 9780471970866
Total Pages : 618 pages
Book Rating : 4.9/5 (78 download)

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Book Synopsis Endocrine and Hormonal Toxicology by : Philip W. Harvey

Download or read book Endocrine and Hormonal Toxicology written by Philip W. Harvey and published by John Wiley & Sons. This book was released on 1999-06-18 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine and Hormonal Toxicology Edited by Philip W. Harvey, Kevin C. Rush and Andrew Cockburn AgrEvo UK Ltd, Saffron Walden, UK This is the first book to consider the integrated role of the classical endocrine system and hormones (including those from tissues outside the classical endocrine system) in toxicological responses. Although focusing on the latest knowledge on endocrine glands as target organs and the mechanistic and molecular basis for toxicity in these organs, Endocrine and Hormonal Toxicology has been written to cover toxicological responses at the whole body level mediated by endocrine or hormonal mechanisms. This whole body, multi-organ approach significantly broadens the relevance of this volume to toxicologists. Following an introductory section on the types of endocrine toxicity including primary, secondary and indirect mechanisms, the next section deals with endocrine organs as toxicological targets. International contributions focus on the pituitary, thyroid and parathyroids, adrenals, testes, ovaries and the pancreas, and comparative endocrine carcinogenesis. A third section of the book develops the whole body approach, in which chapters are devoted to hormonal mechanisms of toxicity to the immune, nervous, cardiovascular, gastrointestinal and reproductive systems, as well as to the liver, kidney and skin. The final section covers human and environmental health perspectives discussing endocrine disrupting chemicals, hormonal mechanisms in breast cancer and current regulatory trends in endocrine and hormonal toxicology. The comprehensive nature of Endocrine and Hormonal Toxicology makes it accessible to both specialist and general toxicologists, and to those within the fields of endocrinology, pharmacology and pathology.

Endocrine Toxicology

Author : J. Charles Eldridge
Publisher : CRC Press
ISBN 13 : 142009310X
Total Pages : 424 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Endocrine Toxicology by : J. Charles Eldridge

Download or read book Endocrine Toxicology written by J. Charles Eldridge and published by CRC Press. This book was released on 2016-04-19 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology's increased importance in environmental safety issues

Endocrine Disrupting Chemicals

Author : R M Harrison
Publisher : Royal Society of Chemistry
ISBN 13 : 1847550746
Total Pages : 167 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Endocrine Disrupting Chemicals by : R M Harrison

Download or read book Endocrine Disrupting Chemicals written by R M Harrison and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long-term environmental effects of chemical exposure have long been of concern and, more recently, chemicals which cause changes to the sexual development of exposed organisms have been identified. It is thought that low-level exposure to a wide range of chemicals may be affecting endocrine function, leading to a reduction in fertility and an increase in reproductive cancers. Endocrine Disrupting Chemicals reviews the scientific evidence and attempts to put the subject into context. Along with an overview of the issue, there is discussion of the specialised aspects in relation to wildlife; environmental oestrogens and male reproduction; and naturally occurring oestrogenic substances. With contributions from representatives of the Medical Research Council's Institute for Environment and Health and the US Environmental Protection Agency, the articles provide a comprehensive and detailed review of current issues. This book will be of interest to a wide readership, including industrial and environmental scientists, managers and policy makers.

Endocrine Disruption and Human Health

Author : Philippa D. Darbre
Publisher : Academic Press
ISBN 13 : 0128219882
Total Pages : 536 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2021-09-19 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology

Endocrine-Disrupting Chemicals

Author : Andrea C. Gore
Publisher : Springer Science & Business Media
ISBN 13 : 159745107X
Total Pages : 361 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Endocrine-Disrupting Chemicals by : Andrea C. Gore

Download or read book Endocrine-Disrupting Chemicals written by Andrea C. Gore and published by Springer Science & Business Media. This book was released on 2007-06-08 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.

Hormonally Active Agents in the Environment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309064198
Total Pages : 453 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Hormonally Active Agents in the Environment by : National Research Council

Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Endocrine Toxicology, Second Edition

Author : John A. Thomas
Publisher : CRC Press
ISBN 13 : 9781560326137
Total Pages : 339 pages
Book Rating : 4.3/5 (261 download)

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Book Synopsis Endocrine Toxicology, Second Edition by : John A. Thomas

Download or read book Endocrine Toxicology, Second Edition written by John A. Thomas and published by CRC Press. This book was released on 1997-01-29 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents a range of topics from the molecular events surrounding hormone actions to epidemiologic studies of the effects of environmental and occupational chemicals on reproductive organs. The endocrine systems covered include the adrenal cortex, thyroid and parathyroid, gonads, and the endocrine pancreas. Of particular importance are the chapters covering the general characteristics of the estrogen receptors and the androgen receptors. The book also describes some of the underlying toxic mechanisms involving pancreatic B cells and metal-induced changes in male sex accessory glands.

Endocrine Disruption

Author : David O. Norris
Publisher : Oxford University Press on Demand
ISBN 13 : 0195137493
Total Pages : 492 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis Endocrine Disruption by : David O. Norris

Download or read book Endocrine Disruption written by David O. Norris and published by Oxford University Press on Demand. This book was released on 2006 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the biological effects of the large number of compounds that have been recognized as endocrine disrupters. This book presents the relevant fundamentals of the endocrine systems of animals and humans, the toxicology, developmental toxicology, ecology, and risk assessment methods, and lays out the state of understanding for the field.

Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies

Author : Muhammad Sajid Hamid Akash
Publisher : Springer Nature
ISBN 13 : 3030459233
Total Pages : 526 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies by : Muhammad Sajid Hamid Akash

Download or read book Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies written by Muhammad Sajid Hamid Akash and published by Springer Nature. This book was released on 2020-08-04 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

Environmental Endocrinology

Author : I. Assenmacher
Publisher : Springer Science & Business Media
ISBN 13 : 3642669816
Total Pages : 344 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Environmental Endocrinology by : I. Assenmacher

Download or read book Environmental Endocrinology written by I. Assenmacher and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: From 11 to 15 July 1977 about 60 physiologists, endo crinologists, ecologists and other biologists from 14 countries convened at the University Montpellier for a symposium on Environmental Endocrinology. This meet ing was organized as a Satellite Symposium of the 27th International Congress of Physiological Sciences, Paris, 18-23 July 1977. This volume is a record of the com munications presented at the symposium. The objectives of the program were to examine the role of the endocrine system in a wide spectrum of adjustments and adaptations to changes in environmental conditions by various spe cies of animals, including man, and to promote an ex change of ideas among investigators who have approached these functions from diverse aspects. The diversity of the information and ideas communicated is great. Of necessity, they represent only an extremely modest se lection of the many facets of endocrine function in the interaction of animals with their environments. Be yond the usefulness of the communications individually, we hope that they collectively demonstrate the substan tial heuristic value of the concept of environmental endocrinology as it was perceived by the participants. We acknowledge gratefully the kindness and sympathy of Professor Jaques ROUZAUD, President of the University of Montpellier II, for his generous extension of the hospitality of the University to the Symposium. We are most grateful to Mrs. Monique VIEU who effected so well the secretarial organization of the Sympos.

Environmental Endocrinology and Endocrine Disruptors

Author : Rosario Pivonello
Publisher : Springer Nature
ISBN 13 : 3030390446
Total Pages : 532 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Environmental Endocrinology and Endocrine Disruptors by : Rosario Pivonello

Download or read book Environmental Endocrinology and Endocrine Disruptors written by Rosario Pivonello and published by Springer Nature. This book was released on 2023-04-20 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic peer-review publishing process.

Environmental Impacts on Reproductive Health and Fertility

Author : Tracey J. Woodruff
Publisher : Cambridge University Press
ISBN 13 : 9780521519526
Total Pages : 262 pages
Book Rating : 4.5/5 (195 download)

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Book Synopsis Environmental Impacts on Reproductive Health and Fertility by : Tracey J. Woodruff

Download or read book Environmental Impacts on Reproductive Health and Fertility written by Tracey J. Woodruff and published by Cambridge University Press. This book was released on 2010-01-28 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many reproductive and developmental health problems are caused by exposure to chemicals that are widely dispersed in our environment. These problems include infertility, miscarriage, poor pregnancy outcomes, abnormal fetal development, early puberty, endometriosis, and diseases and cancers of reproductive organs. The compelling nature of the collective science has resulted in recognition of a new field of environmental reproductive health. Focusing on exposures to environmental contaminants, particularly during critical periods in development and their potential effects on all aspects of future reproductive life-course, this book provides the first comprehensive source of information bringing together the arguments that are spread out among various scientific disciplines in environmental health, clinical and public health fields. It provides a review of the science in key areas of the relationship between environmental contaminants and reproductive health outcomes, and recommendations on efforts toward prevention in clinical care and public policy.

Endocrine Disruptors

Author : Rajesh K. Naz
Publisher : CRC Press
ISBN 13 : 9780849331640
Total Pages : 382 pages
Book Rating : 4.3/5 (316 download)

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Book Synopsis Endocrine Disruptors by : Rajesh K. Naz

Download or read book Endocrine Disruptors written by Rajesh K. Naz and published by CRC Press. This book was released on 1999-01-21 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruptors: Effects on Male and Female Reproductive Systems examines the epidemiology and etiology of environmental toxicants/hormone imposters, many of which act as reproductive toxicants that cause fertility problems and carcinogenic hazards. Thus far, over fifty such hormone imposters/persistent organic pollutants have been identified, the most common of which are organochlorines and dioxins. This book discusses the hazardous effects of endocrine disruptors on gonads, fertility, and sexual and reproductive function, and health hazards leading to the alarming decline in global fertility and rising incidences of breast and prostate cancer.

Endocrine Toxicology

Author : C. K. Atterwill
Publisher : Cambridge University Press
ISBN 13 : 9780521402255
Total Pages : 504 pages
Book Rating : 4.4/5 (22 download)

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Book Synopsis Endocrine Toxicology by : C. K. Atterwill

Download or read book Endocrine Toxicology written by C. K. Atterwill and published by Cambridge University Press. This book was released on 1992-04-09 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to deal comprehensively with endocrine toxicology. It covers the whole spectrum of known toxicant effects on the endocrine system ranging from small disturbances in hormonal secretion to full endocrine neoplasia. In each chapter, internationally recognised authorities have addressed basic endocrine physiology, current techniques for studying endocrine toxicity in vivo and in vitro, known xenobiotic-induced toxicity phenomena and the latest scientific advances in understanding the underlying molecular and cellular events. Consideration is given to important issues such as dietary factors which influence endocrine toxicity, species differences in sensitivity to toxicants, and the toxicity of hormones and drugs. The volume provides a sound basis for understanding the scientific aspects of this complex and important area of toxicology and will be a useful source of information for all those working in this field.

Adrenal in Toxicology

Author : Philip W. Harvey
Publisher : CRC Press
ISBN 13 : 0748403302
Total Pages : 331 pages
Book Rating : 4.7/5 (484 download)

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Book Synopsis Adrenal in Toxicology by : Philip W. Harvey

Download or read book Adrenal in Toxicology written by Philip W. Harvey and published by CRC Press. This book was released on 1996-03-28 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adrenal gland is vitally important to health and secretes hormones that control many bodily processes ranging from normal metabolism to the response to stressful circumstances. The corticosteroid hormones are the basis for anti-inflammatory medicines and are very widely prescribed. Changes in the function of the adrenal gland, either naturally through stress or disease, or through the action of drugs and chemicals, can have a major impact on the body.; This text focuses on adrenal toxicity, examining how drugs and chemicals can directly and indirectly affect this gland. Coverage includes: classification of the types of adrenal and endocrine toxicity; the mechanistic and molecular basis of toxicity; reasons why the adrenal is the most common target organ in the endocrine system; drug toxicity specific to patients with adrenal disorders; drug- corticosteroid interactions; adverse drug reactions; and how the adrenal gland is vital in tolerance to toxic insult.

Sicker, Fatter, Poorer

Author : Leonardo Trasande
Publisher : Houghton Mifflin
ISBN 13 : 1328553493
Total Pages : 245 pages
Book Rating : 4.3/5 (285 download)

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Book Synopsis Sicker, Fatter, Poorer by : Leonardo Trasande

Download or read book Sicker, Fatter, Poorer written by Leonardo Trasande and published by Houghton Mifflin. This book was released on 2019 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading voice in public health policy and top environmental medicine scientist reveals the alarming truth about how hormone-disrupting chemicals are affecting our daily lives--and what we can do to protect ourselves and fight back. Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we've turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Dr. Trasande exposes the chemicals that disrupt our hormonal systems and damage our health in irreparable ways. He shows us where these chemicals hide--in our homes, our schools, at work, in our food, and countless other places we can't control--as well as the workings of policy that protects the continued use of these chemicals in our lives. Drawing on extensive research and expertise, he outlines dramatic studies and emerging evidence about the rapid increases in neurodevelopmental, metabolic, reproductive, and immunological diseases directly related to the hundreds of thousands of chemicals that we are exposed to every day. Unfortunately, nowhere is safe. But, thanks to Dr. Trasande's work on the topic, and his commitment to effecting change, this book can help. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he shows us what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.

Principles of Endocrine Pharmacology

Author : John A. Thomas
Publisher : Springer Science & Business Media
ISBN 13 : 1468450360
Total Pages : 303 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Principles of Endocrine Pharmacology by : John A. Thomas

Download or read book Principles of Endocrine Pharmacology written by John A. Thomas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors have provided an overview of the relationships between hormones that are physiologic constituents of the body as well as their pharmacologic use in replacement therapies and related endocrine dys function. Principles of Endocrine Pharmacology concerns itself with the ther apeutic use of hormones, and hormone like substances, or drugs that can act either by suppressing or enhancing the metabolism of certain glands of internal secretion. Other drugs used for nonendocrine ther apies can likewise affect the endocrine system. Endocrine pharmacology emerged in the early 1900s with the use of crude pituitary extracts. By the mid-1900s several investigators had isolated and begun to synthesize hormones or hormonelike substances. Recognizing the limited supply of hormones that could be obtained both from animal sources and human autopsy material, the search for so called hormone substitutes also began early in the 1900s. Recently, re combinant DNA technologies have been used to provide alternative therapeutic sources of human insulin and human growth hormone. Aside from insulin, perhaps no other use of hormonally-active sub stance is better exemplified by those drugs which affect fertility. The synthesis of an orally-effective steroid represented one of the first major breakthroughs in the chemical suppression of ovulation. Since the orally active 19-norsteroids were introduced in the 1950s, several oral contra ceptive steroid preparations have been marketed. Indeed, the advent of oral contraceptives for birth control has led to a renewed interest in endocrine pharmacology.