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Author : Robert Azerad
Publisher : CRC Press
ISBN 13 : 9783718650255
Total Pages : 186 pages
Book Rating : 4.6/5 (52 download)
Download or read book Enantioselective Synthesis Using Biological Systems written by Robert Azerad and published by CRC Press. This book was released on 1990 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David John Ager
Publisher : CRC Press
ISBN 13 : 1000098494
Total Pages : 505 pages
Book Rating : 4.0/5 ( download)
Download or read book Asymmetric Synthetic Methodology written by David John Ager and published by CRC Press. This book was released on 2020-08-18 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.
Author : Maria Elizabeth Tiritan
Publisher :
ISBN 13 : 9783039362394
Total Pages : 346 pages
Book Rating : 4.3/5 (623 download)
Download or read book Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition written by Maria Elizabeth Tiritan and published by . This book was released on 2020 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes both fundamental studies and applications in a multidisciplinary research field involving a high diversity of chiral compounds, including commercial substances with industrial applications, pharmaceuticals, and new chiral compounds with promising biological activities. Recent developments and innovative approaches to producing enantiomerically pure compounds of industrial and research interest are included. Enantiomeric separation in both the analytical and preparative scale, determination of the enantiomeric purity, insights into enantioselective synthesis and many different aspects of chiral recognition, including chiral sensors, recognition in biological systems, and in analytical methods, are presented. Original research and review articles show the broad scope of chirality in diverse analytical fields and the connection to enantioselective synthesis and biological activities.
Author : Jacek Wojaczynski
Publisher : John Wiley & Sons
ISBN 13 : 3527834192
Total Pages : 692 pages
Book Rating : 4.5/5 (278 download)
Download or read book Chiral Building Blocks in Asymmetric Synthesis written by Jacek Wojaczynski and published by John Wiley & Sons. This book was released on 2022-08-05 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chiral Building Blocks in Asymmetric Synthesis A comprehensive introduction to the important classes of chiral building blocks Chirality — the asymmetric quality found in certain chemical compounds — plays an essential role in our world: chiral compounds can be found in biology, pharmaceutical compounds, agrochemicals, and fragrances. The stereoselective preparation of these complex molecular constructions constitutes a challenge. To this end, modern asymmetric synthesis utilizes a variety of valuable and efficient reagents employed as chiral auxiliaries, metal complexes and organocatalysts in stereoselective catalysis, and enantiopure reactants termed as chiral building blocks. In Chiral Building Blocks in Asymmetric Synthesis, the achievements in the fields of preparation of and applications of chiral blocks are presented. In doing so, the book comprehensively discusses the important classes of these reactants as the key for the asymmetric synthesis of chiral molecules. As such, it is an indispensable resource about synthetic methods, as well as possible modifications and transformations of important classes of chiral compounds. It also highlights the importance of their use as reactants and auxiliaries in the preparation of more sophisticated molecules or supramolecular systems. In Chiral Building Blocks in Asymmetric Synthesis readers will also find: Organization according to the most important compound classes — e.g. amino acids, BINOL and its derivatives, terpenes, and others — with an emphasis on synthesis and application A focus on the use of chiral building blocks for the preparation of bioactive compounds and supramolecular assemblies Chiral Building Blocks in Asymmetric Synthesis is a useful reference for organic chemists, catalytic chemists, chemists in industry, medicinal chemists, pharmaceutical chemists, and the libraries that support them.
Author : Ramon Rios Torres
Publisher : John Wiley & Sons
ISBN 13 : 1119567653
Total Pages : 468 pages
Book Rating : 4.1/5 (195 download)
Download or read book Spiro Compounds written by Ramon Rios Torres and published by John Wiley & Sons. This book was released on 2022-02-15 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: SPIRO COMPOUNDS A comprehensive treatment of the latest research in, and applications of, spiro compounds Spiro Compounds: Synthesis and Applications combines discussions of the latest advances in spiro compound research with the most cutting-edge, real-world applications of that knowledge. This book provides in-depth coverage of the history, significance, properties, synthetic methods, and applications of spiro compounds. As interest in spiro compounds grows due to their unique conformational features and their structural implications on biological systems, Spiro Compounds delivers fulsome treatments of advances in spiro compound synthesis (including stereoselective synthesis) methodologies. With a special focus on the mechanisms of the reactions that lead to the synthesis of spiro compounds, chapters in the book cover topics such as: The history, significance, and unique properties of spiro compounds The most important methodologies for their synthesis The applications of spiro compounds in organic chemistry, biology, drug discovery The most important syntheses of natural products bearing a spiro ring Perfect for academic and industrial chemists, this comprehensive discussion of spirocycles is an indispensable resource for those practicing in the field.
Author : Eusebio Juaristi
Publisher : John Wiley & Sons
ISBN 13 : 0471698474
Total Pages : 658 pages
Book Rating : 4.4/5 (716 download)
Download or read book Enantioselective Synthesis of Beta-Amino Acids written by Eusebio Juaristi and published by John Wiley & Sons. This book was released on 2005-05-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all facets of the synthesis of ß-amino acids As evidenced by an exponential increase in the literature published on the subject, interest in ß-amino acids has grown over the past several years. With major pharmaceutical applications, these amino acids are now studied across multiple lines of research, including combinatorial chemistry, medicinal chemistry, molecular design, proteomics, and others. This Second Edition of Enantioselective Synthesis of ß-Amino Acids updates reviews included in the First Edition while also covering new developments since its publication. The book presents detailed discussions of the most important methods for the synthesis of ß-amino acids. In most cases, the lead chemist who originally developed a method provides an authoritative description of it. In addition, Enantioselective Synthesis of ß-Amino Acids, Second Edition: * Features introductory overviews on the structural types of relevant ß-amino acid targets and salient ß-amino acids present in natural products * Dedicates several chapters to advances in the synthesis of oligomers from ß-amino acids * Includes general and practical procedures for the preparation of ß-amino acids in each chapter * Discusses the most important methods that have been recently developed for the asymmetric synthesis of cyclic and open-chain ß-amino acids * Includes a report on the preparation of libraries of enantiopure ß-amino acids using combinatorial approaches The only book of its kind available today, Enantioselective Synthesis of ß-Amino Acids, Second Edition offers upper-level students and professionals an essential resource for pharmaceutical development, medicinal chemistry, and biochemistry.
Author : J. Seyden-Penne
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 744 pages
Book Rating : 4.3/5 (91 download)
Download or read book Chiral Auxiliaries and Ligands in Asymmetric Synthesis written by J. Seyden-Penne and published by Wiley-Interscience. This book was released on 1995-10-23 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of Contents Preface Abbreviations Introduction 1 1 Enantiomerically Pure Chiral Auxiliaries 43 2 Chiral Reagents 87 3 Chiral Catalysis and Catalysts Bearing Chiral Ligands 117 4 Asymmetric Deprotonations and Protonations 143 5 Alkylations and Related Reactions 157 6 Additions to C=O and C=N Double Bonds 209 7 Additions to Carbon-Carbon Double Bonds 367 8 Additions to Double Bonds Bearing Heteroatoms. Oxidations of Sulfides and Selenides 503 9 Cycloadditions 513 10 Sigmatropic Rearrangements 593 11 Transition Metal Catalyzed Reactions 619 References 637 Index 707.
Author : David M. Hodgson
Publisher : Springer
ISBN 13 : 3540361170
Total Pages : 325 pages
Book Rating : 4.5/5 (43 download)
Download or read book Organolithiums in Enantioselective Synthesis written by David M. Hodgson and published by Springer. This book was released on 2003-09-04 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first dedicated to a comprehensive coverage of this rapidly developing transdisciplinary field. It provides a rich source of essential information on synthesizing molecules in an enantioselective manner using organolithiums, and serves as an inspiration for future developments.
Author : Dolores Badia
Publisher : Royal Society of Chemistry
ISBN 13 : 1849730245
Total Pages : 365 pages
Book Rating : 4.8/5 (497 download)
Download or read book Organocatalytic Enantioselective Conjugate Addition Reactions written by Dolores Badia and published by Royal Society of Chemistry. This book was released on 2010 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, unique in its field, is a comprehensive description of all the methodologies reported for carrying out conjugate addition reactions in a stereoselective way, using small chiral organic molecules as catalysts (organocatalysts). In the last 3-4 years, this has been a rapidly growing field in organic chemistry, and many papers have appeared reporting excellent protocols for carrying out these highly efficient transformations that compete well with other classical approachse using transition metal catalysts. A particularly attractive feature of this transformation relies upon the fact that the conjugate addition (Michael and Hetero-Michael reactions) is an extraoridinarily effective means to initiate cascade processes which result in the formation of complex molecules from very small and simple starting blocks. The book, written by noted experts, covers all recent advances in this not topic, and provides a good state-of-the-art review for organic chemists working in this field and all those who wish to start projects in this area. The Series is intended to provide an accessible reference for postgraduates and industrialists working in the field of catalysis and its applications. Books will be produced either as monographs or reference handbooks. The Series will cover research developments and applications of catalysis, in both academia and industry.
Author : Krishna C. Majumdar
Publisher : John Wiley & Sons
ISBN 13 : 3527634894
Total Pages : 648 pages
Book Rating : 4.5/5 (276 download)
Download or read book Heterocycles in Natural Product Synthesis written by Krishna C. Majumdar and published by John Wiley & Sons. This book was released on 2011-06-15 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.
Author : Maria Elizabeth Tiritan
Publisher : MDPI
ISBN 13 : 3039362380
Total Pages : 346 pages
Book Rating : 4.0/5 (393 download)
Download or read book Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition written by Maria Elizabeth Tiritan and published by MDPI. This book was released on 2020-11-13 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes both fundamental studies and applications in a multidisciplinary research field involving a high diversity of chiral compounds, including commercial substances with industrial applications, pharmaceuticals, and new chiral compounds with promising biological activities.
Author : Tse-Lok Ho
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.:/5 (319 download)
Download or read book Enantioselective Synthesis written by Tse-Lok Ho and published by Wiley-Interscience. This book was released on 1992-02-18 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the intense activities of enantioselective synthesis have been reflected in the burgeoning and ingenious applications of such natural substances as carbohydrates, -amino acids and terpenes. A comprehensive summary of terpene-based synthesis is offered, focusing on synthetic efforts using transformed chiral synthons. The author provides analysis of synthetic strategies and discusses the intricacies of reaction courses. Along with the number and variety of natural products derived from chiral terpenes, numerous flow-charts aid in clearly delineating synthetic pathways.
Author : Zackary Leland Wong
Publisher :
ISBN 13 :
Total Pages : 57 pages
Book Rating : 4.:/5 (952 download)
Download or read book Copper-catalyzed Enantioselective Stereodivergent Synthesis of Amino Alcohols written by Zackary Leland Wong and published by . This book was released on 2016 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: Different stereoisomers of bioactive molecules can have distinct activities in biological systems. For this reason, it is routine procedure in the drug discovery and development process to prepare the full matrix of possible stereoisomers of drug candidates for biological evaluation and to determine the stereochemical purity of these molecules. Despite many recent advances in asymmetric synthesis, the development of general and practical strategies that are fully divergent and give rise to all stereoisomers of products bearing multiple contiguous stereocenters remains a significant challenge. Herein we report a stereodivergent copper-based approach for the expeditious construction of amino alcohols with high levels of chemo-, regio-, diastero- and enantioselectivity. Specifically, these amino alcohol products were synthesized using the sequential copper hydride-catalyzed hydrosilylation and hydroamination of readily available enals and enones. This strategy provides a route to all possible stereoisomers of these amino alcohol products, which contain up to three contiguous stereocenters. Catalyst control and stereospecificity were simultaneously leveraged to attain exceptional control of the product stereochemistry. Beyond the utility of this protocol, the strategy demonstrated here should inspire the development of methods providing complete sets of stereoisomers for other valuable synthetic targets.
Author : Elias J. Corey
Publisher : Academic Press
ISBN 13 : 9780615395159
Total Pages : 0 pages
Book Rating : 4.3/5 (951 download)
Download or read book Enantioselective Chemical Synthesis written by Elias J. Corey and published by Academic Press. This book was released on 2013-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field's progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules
Author : Robert E. Gawley
Publisher : Elsevier
ISBN 13 : 0080914136
Total Pages : 569 pages
Book Rating : 4.0/5 (89 download)
Download or read book Principles of Asymmetric Synthesis written by Robert E. Gawley and published by Elsevier. This book was released on 2012-05-29 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis, this book presents a detailed analysis of the factors that govern stereoselectivity in organic reactions. After an explanation of the basic physical-organic principles governing stereoselective reactions, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Practical Aspects of Asymmetric Synthesis" provides a critical overview of the most common methods for the preparation of enantiomerically pure compounds, techniques for analysis of stereoisomers using chromatographic, spectroscopic, and chiroptical methods. The authors then present an overview of the most important methods in contemporary asymmetric synthesis organized by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions, one chapter on reductions, and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). This organization allows the reader to compare the leading methods for asymmetric synthesis in an appropriate context. A highlight of the book is the presentation and discussion of transition states at the current level of understanding, for important reaction types. In addition, extensive tables of examples are used to give the reader an appreciation for the scope of each reaction. Finally, leading references are provided to natural product synthesis that has been accomplished using a given reaction as a key step. - Authoritative glossary to aid understanding of stereochemical terminology - Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type - A handy reference guide to the literature of asymmetric synthesis for practitioners in the field
Author : Atta-ur- Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608051978
Total Pages : 566 pages
Book Rating : 4.6/5 (8 download)
Download or read book Advances in Organic Synthesis written by Atta-ur- Rahman and published by Bentham Science Publishers. This book was released on 2011-01-10 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating agents. It brings t"
Author : Jianxian Gong
Publisher : Springer
ISBN 13 : 3642543049
Total Pages : 146 pages
Book Rating : 4.6/5 (425 download)
Download or read book Total Synthesis of (±)-Maoecrystal V written by Jianxian Gong and published by Springer. This book was released on 2014-07-08 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
