Emerging Trends In Computational Biology Bioinformatics And Systems Biology

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Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology

Author : Hamid R Arabnia
Publisher : Morgan Kaufmann
ISBN 13 : 0128026464
Total Pages : 670 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology by : Hamid R Arabnia

Download or read book Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology written by Hamid R Arabnia and published by Morgan Kaufmann. This book was released on 2015-08-11 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology discusses the latest developments in all aspects of computational biology, bioinformatics, and systems biology and the application of data-analytics and algorithms, mathematical modeling, and simu- lation techniques. • Discusses the development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques to the study of biological and behavioral systems, including applications in cancer research, computational intelligence and drug design, high-performance computing, and biology, as well as cloud and grid computing for the storage and access of big data sets. • Presents a systematic approach for storing, retrieving, organizing, and analyzing biological data using software tools with applications to general principles of DNA/RNA structure, bioinformatics and applications, genomes, protein structure, and modeling and classification, as well as microarray analysis. • Provides a systems biology perspective, including general guidelines and techniques for obtaining, integrating, and analyzing complex data sets from multiple experimental sources using computational tools and software. Topics covered include phenomics, genomics, epigenomics/epigenetics, metabolomics, cell cycle and checkpoint control, and systems biology and vaccination research. • Explains how to effectively harness the power of Big Data tools when data sets are so large and complex that it is difficult to process them using conventional database management systems or traditional data processing applications. - Discusses the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological and behavioral systems. - Presents a systematic approach for storing, retrieving, organizing and analyzing biological data using software tools with applications. - Provides a systems biology perspective including general guidelines and techniques for obtaining, integrating and analyzing complex data sets from multiple experimental sources using computational tools and software.

Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology

Author : Hamid R Arabnia
Publisher : Morgan Kaufmann
ISBN 13 : 0128042591
Total Pages : 594 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology by : Hamid R Arabnia

Download or read book Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology written by Hamid R Arabnia and published by Morgan Kaufmann. This book was released on 2016-03-25 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology: Systems and Applications covers the latest trends in the field with special emphasis on their applications. The first part covers the major areas of computational biology, development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques for the study of biological and behavioral systems. The second part covers bioinformatics, an interdisciplinary field concerned with methods for storing, retrieving, organizing, and analyzing biological data. The book also explores the software tools used to generate useful biological knowledge. The third part, on systems biology, explores how to obtain, integrate, and analyze complex datasets from multiple experimental sources using interdisciplinary tools and techniques, with the final section focusing on big data and the collection of datasets so large and complex that it becomes difficult to process using conventional database management systems or traditional data processing applications. Explores all the latest advances in this fast-developing field from an applied perspective Provides the only coherent and comprehensive treatment of the subject available Covers the algorithm development, software design, and database applications that have been developed to foster research

Recent Trends in 'Computational Omics: Concepts and Methodology'

Author : Pramod Katara
Publisher :
ISBN 13 : 9781536179415
Total Pages : 478 pages
Book Rating : 4.1/5 (794 download)

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Book Synopsis Recent Trends in 'Computational Omics: Concepts and Methodology' by : Pramod Katara

Download or read book Recent Trends in 'Computational Omics: Concepts and Methodology' written by Pramod Katara and published by . This book was released on 2020 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last decade has witnessed various technological advances in life sciences, especially high throughput technologies. These technologies provide a way to perform parallel scientific studies in a very short period of time with low cost. High throughput techniques, mainly, next generation sequencing, microarray and mass spectrometry, have strengthened the omics vision in the last decades (study of complete system) and now resulted in well-developed branches of omics i.e., genomics, transcriptomics, proteomics and metabolomics, which deal with almost every level of central dogma of life. Practice of high throughput techniques throughout the world with different aims and objectives resulted in a voluminous data, which required computational applications, i.e., database, algorithm and software to store, process and get biological interpretation from primary raw data. Researchers from different fields are looking to analyze these raw data for different purposes, but lacking of proper information and knowledge in proper documented form creates different kinds of hurdles and raises the challenges. This book contains thirteen chapters that deal with different computational biology/bioinformatics resources and concepts which are already in practice by the scientific community or can be utilized to handle various aspects of different classes of omics data. It includes different computational concepts, algorithm, resources and recent trends belonging to the four major branches of omics (i.e., genomics, transcriptomics, proteomics and metabolomics), including integrative omics. It will help all scholars who are working in any branch of computational omics and bioinformatics field as well as those who would like to perform research at a systemic biology through computational approaches.

Kernel Methods in Computational Biology

Author : Bernhard Schölkopf
Publisher : MIT Press
ISBN 13 : 9780262195096
Total Pages : 428 pages
Book Rating : 4.1/5 (95 download)

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Book Synopsis Kernel Methods in Computational Biology by : Bernhard Schölkopf

Download or read book Kernel Methods in Computational Biology written by Bernhard Schölkopf and published by MIT Press. This book was released on 2004 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: A detailed overview of current research in kernel methods and their application to computational biology.

Computational Biology and Bioinformatics

Author : Ka-Chun Wong
Publisher : CRC Press
ISBN 13 : 1498725007
Total Pages : 439 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Computational Biology and Bioinformatics by : Ka-Chun Wong

Download or read book Computational Biology and Bioinformatics written by Ka-Chun Wong and published by CRC Press. This book was released on 2016-04-27 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advances in biotechnology such as the next generation sequencing technologies are occurring at breathtaking speed. Advances and breakthroughs give competitive advantages to those who are prepared. However, the driving force behind the positive competition is not only limited to the technological advancement, but also to the companion data analy

Systems Biology Modelling and Analysis

Author : Elisabetta De Maria
Publisher : John Wiley & Sons
ISBN 13 : 1119716586
Total Pages : 468 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Systems Biology Modelling and Analysis by : Elisabetta De Maria

Download or read book Systems Biology Modelling and Analysis written by Elisabetta De Maria and published by John Wiley & Sons. This book was released on 2022-11-18 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology Modelling and Analysis Describes important modelling and computational methods for systems biology research to enable practitioners to select and use the most suitable technique Systems Biology Modelling and Analysis provides an overview of state-of-the-art techniques and introduces related tools and practices to formalize models and automate reasoning for systems biology. The authors present and compare the main formal methods used in systems biology for modelling biological networks, including discussion of their advantages, drawbacks, and main applications. Each chapter includes an intuitive presentation of the specific formalism, a brief history of the formalism and of its applications in systems biology, a formal description of the formalism and its variants, at least one realistic case study, some applications of formal techniques to validate and make deep analysis of models encoded with the formalism, and a discussion on the kind of biological systems for which the formalism is suited, along with concrete ideas on its possible evolution. Edited by a highly qualified expert with significant experience in the field, some of the methods and techniques covered in Systems Biology Modelling and Analysis include: Petri nets, an important tool for studying different aspects of biological systems, ranging from simple signaling pathways to metabolic networks and beyond Pathway Logic, a formal, rule-based system and interactive viewer for developing executable models of cellular processes Boolean networks, a mathematical model which has been widely used for decades in the context of biological regulation networks Answer Set Programming (ASP), which has proven to be a strong logic programming paradigm to deal with the inherent complexity of biological models For systems biologists, biochemists, bioinformaticians, molecular biologists, pharmacologists, and computer scientists, Systems Biology Modelling and Analysis is a comprehensive all-in-one resource to understand and harness the field’s current models and techniques while also preparing for their potential developments in coming years with the help of the author’s expert insight.

Biomolecular Networks

Author : Luonan Chen
Publisher : John Wiley & Sons
ISBN 13 : 9780470488058
Total Pages : 416 pages
Book Rating : 4.4/5 (88 download)

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Book Synopsis Biomolecular Networks by : Luonan Chen

Download or read book Biomolecular Networks written by Luonan Chen and published by John Wiley & Sons. This book was released on 2009-06-29 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alternative techniques and tools for analyzing biomolecular networks With the recent rapid advances in molecular biology, high-throughput experimental methods have resulted in enormous amounts of data that can be used to study biomolecular networks in living organisms. With this development has come recognition of the fact that a complicated living organism cannot be fully understood by merely analyzing individual components. Rather, it is the interactions of components or biomolecular networks that are ultimately responsible for an organism's form and function. This book addresses the important need for a new set of computational tools to reveal essential biological mechanisms from a systems biology approach. Readers will get comprehensive coverage of analyzing biomolecular networks in cellular systems based on available experimental data with an emphasis on the aspects of network, system, integration, and engineering. Each topic is treated in depth with specific biological problems and novel computational methods: GENE NETWORKS—Transcriptional regulation; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networks PROTEIN INTERACTION NETWORKS—Prediction of protein-protein interactions; topological structure of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein function METABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and applications of metabolic networks; modeling and inference of signaling networks; and other topics and new trends In addition to theoretical results and methods, many computational software tools are referenced and available from the authors' Web sites. Biomolecular Networks is an indispensable reference for researchers and graduate students in bioinformatics, computational biology, systems biology, computer science, and applied mathematics.

Roll with the Times, or the Times Roll Over You

Author : Beth R. Bernhardt
Publisher : Purdue University Press
ISBN 13 : 1941269117
Total Pages : 512 pages
Book Rating : 4.9/5 (412 download)

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Book Synopsis Roll with the Times, or the Times Roll Over You by : Beth R. Bernhardt

Download or read book Roll with the Times, or the Times Roll Over You written by Beth R. Bernhardt and published by Purdue University Press. This book was released on 2017-10-15 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over one hundred presentations from the 36th annual Charleston Library Conference (held November 1-5, 2016) are included in this annual proceedings volume. Major themes of the meeting included data visualization, streaming video, analysis and assessment, demand-driven acquisition, and open access publishing. While the Charleston meeting remains a core one for acquisitions librarians in dialog with publishers and vendors, the breadth of coverage of this volume reflects the fact that this conference is now one of the major venues for leaders in the publishing and library communities to shape strategy and prepare for the future. Almost 2,000 delegates attended the 2016 meeting, ranging from the staff of small public library systems to the CEOs of major corporations. This fully indexed, copyedited volume provides a rich source for the latest evidence-based research and lessons from practice in a range of information science fields. Contributors comprise leaders in the library, publishing, and vendor communities.

Molecular Docking for Computer-Aided Drug Design

Author : Mohane S. Coumar
Publisher : Academic Press
ISBN 13 : 0128223138
Total Pages : 522 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Molecular Docking for Computer-Aided Drug Design by : Mohane S. Coumar

Download or read book Molecular Docking for Computer-Aided Drug Design written by Mohane S. Coumar and published by Academic Press. This book was released on 2021-02-17 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. - Covers the latest information and state-of-the-art trends in structure-based drug design methodologies - Includes case studies that complement learning - Consolidates fundamental concepts and current practice of molecular docking into one convenient resource

Computational and Analytic Methods in Biological Sciences

Author : Akshara Makrariya
Publisher : CRC Press
ISBN 13 : 1000879879
Total Pages : 325 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Computational and Analytic Methods in Biological Sciences by : Akshara Makrariya

Download or read book Computational and Analytic Methods in Biological Sciences written by Akshara Makrariya and published by CRC Press. This book was released on 2023-05-31 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite major advances in healthcare over the past century, the successful treatment of cancer has remained a significant challenge, and cancers are the second leading cause of death worldwide behind cardiovascular disease. Early detection and survival are important issues to control cancer. The development of quantitative methods and computer technology has facilitated the formation of new models in medical and biological sciences. The application of mathematical modelling in solving many real-world problems in medicine and biology has yielded fruitful results. In spite of advancements in instrumentations technology and biomedical equipment, it is not always possible to perform experiments in medicine and biology for various reasons. Thus, mathematical modelling and simulation are viewed as viable alternatives in such situations, and are discussed in this book. The conventional diagnostic techniques of cancer are not always effective as they rely on the physical and morphological appearance of the tumour. Early stage prediction and diagnosis is very difficult with conventional techniques. It is well known that cancers are involved in genome level changes. As of now, the prognosis of various types of cancer depends upon findings related to the data generated through different experiments. Several machine learning techniques exist in analysing the data of expressed genes; however, the recent results related with deep learning algorithms are more accurate and accommodative, as they are effective in selecting and classifying informative genes. This book explores the probabilistic computational deep learning model for cancer classification and prediction.

Omics Applications for Systems Biology

Author : Wan Mohd Aizat
Publisher : Springer
ISBN 13 : 3319987585
Total Pages : 111 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Omics Applications for Systems Biology by : Wan Mohd Aizat

Download or read book Omics Applications for Systems Biology written by Wan Mohd Aizat and published by Springer. This book was released on 2018-10-31 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains omics at the most basic level, including how this new concept can be properly utilized in molecular and systems biology research. Most reviews and books on this topic have mainly focused on the technicalities and complexity of each omics’ platform, impeding readers to wholly understand its fundamentals and applications. This book tackles such gap and will be most beneficial to novice in this area, university students and even researchers. Basic workflow and practical guidance in each omics are also described, such that scientists can properly design their experimentation effectively. Furthermore, how each omics platform has been conducted in our institute (INBIOSIS) is also detailed, a comprehensive example on this topic to further enhance readers’ understanding. The contributors of each chapter have utilized the platforms in various manner within their own research and beyond. The contributors have also been interactively integrated and combined these different omics approaches in their research, being able to systematically write each chapter with the conscious knowledge of other inter-relating topics of omics. The potential readers and audience of this book can come from undergraduate and postgraduate students who wish to extend their comprehension in the topics of molecular biology and big data analysis using omics platforms. Furthermore, researchers and scientists whom may have expertise in basic molecular biology can extend their experimentation using the omics technologies and workflow outlined in this book, benefiting their research in the long run.

Computational Immunology

Author : Josep Bassaganya-Riera
Publisher : Academic Press
ISBN 13 : 0128037156
Total Pages : 212 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Computational Immunology by : Josep Bassaganya-Riera

Download or read book Computational Immunology written by Josep Bassaganya-Riera and published by Academic Press. This book was released on 2015-10-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Immunology: Models and Tools encompasses the methodological framework and application of cutting-edge tools and techniques to study immunological processes at a systems level, along with the concept of multi-scale modeling. The book's emphasis is on selected cases studies and application of the most updated technologies in computational modeling, discussing topics such as computational modeling and its usage in immunological research, bioinformatics infrastructure, ODE based modeling, agent based modeling, and high performance computing, data analytics, and multiscale modeling. There are also modeling exercises using recent tools and models which lead the readers to a thorough comprehension and applicability. The book is a valuable resource for immunologists, computational biologists, bioinformaticians, biotechnologists, and computer scientists, as well as all those who wish to broaden their knowledge in systems modeling. - Offers case studies with different levels of complexity - Provides a detailed view on cutting-edge tools for modeling that are useful to experimentalists with limited computational skills - Explores the usage of simulation for hypothesis generation, helping the reader to understand the most valuable points on experimental setting

Computational Drug Discovery and Design

Author : Mohini Gore
Publisher : Springer Nature
ISBN 13 : 1071634410
Total Pages : 357 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Computational Drug Discovery and Design by : Mohini Gore

Download or read book Computational Drug Discovery and Design written by Mohini Gore and published by Springer Nature. This book was released on 2023-10-09 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Drug Discovery and Design, Second Edition aims to effectively utilize computational methodologies in discovery and design of novel drugs.

Antibacterial Drug Discovery to Combat MDR

Author : Iqbal Ahmad
Publisher : Springer Nature
ISBN 13 : 9811398712
Total Pages : 673 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Antibacterial Drug Discovery to Combat MDR by : Iqbal Ahmad

Download or read book Antibacterial Drug Discovery to Combat MDR written by Iqbal Ahmad and published by Springer Nature. This book was released on 2019-11-09 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Natural Flavours, Fragrances, and Perfumes

Author : Sreeraj Gopi
Publisher : John Wiley & Sons
ISBN 13 : 3527824804
Total Pages : 261 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Natural Flavours, Fragrances, and Perfumes by : Sreeraj Gopi

Download or read book Natural Flavours, Fragrances, and Perfumes written by Sreeraj Gopi and published by John Wiley & Sons. This book was released on 2023-02-14 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Flavours, Fragrances, and Perfumes Explore this one-stop resource on every relevant aspect of natural flavors and fragrances The use of sensory science has the potential to give scientists, researchers, and industry specialists a way to overcome the challenges in nutraceuticals and, more generally, in the functional food industry. Flavor and fragrance have the potential to significantly influence consumer satisfaction with products and its success in the marketplace. In order to effectively produce and optimize a customer’s experience in both food and household products, it is essential to have a strong understanding of the fundamentals of chemistry and physicochemical processes. Natural Flavours, Fragrances and Perfumes offers a comprehensive look at the sensory sciences necessary to produce the most appealing olfactory responses derived from natural resources for consumers – from the analysis and biomolecular aspects of natural products to the processing and isolation of desired products, from the perceptual properties to regulatory aspects. Specifically, the book presents novel approaches to the processes involved in producing plant-derived functional products by examining how characteristic flavors arise due to complex interactions between hundreds of molecules, as well as studying the physiological variables that affect flavor perception. Natural Flavours, Fragrances, and Perfumes readers will also find: Insights into the identification and characterization of plant volatiles, as well as chromatography techniques for sensory fingerprints Chapters devoted to biosynthesis and metabolic pathways for the development of household products composed of organic materials Additional chapters on the advances in flavor science, on technological advances in the effective delivery of flavor, and challenges in the retention and release of flavor Natural Flavours, Fragrances, and Perfumes is a useful reference for chemists of all kinds, food scientists, biotechnologists, and perfumers, as well as those studying in these fields.

Application of Clinical Bioinformatics

Author : Xiangdong Wang
Publisher : Springer
ISBN 13 : 9401775435
Total Pages : 395 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Application of Clinical Bioinformatics by : Xiangdong Wang

Download or read book Application of Clinical Bioinformatics written by Xiangdong Wang and published by Springer. This book was released on 2016-03-31 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elucidates how genetic, biological and medical information can be applied to the development of personalized healthcare, medication and therapies. Focusing on aspects of the development of evidence-based approaches in bioinformatics and computational medicine, including data integration, methodologies, tools and models for clinical and translational medicine, it offers an essential introduction to clinical bioinformatics for clinical researchers and physicians, medical students and teachers, and scientists working with human disease-based omics and bioinformatics. Dr. Xiangdong Wang is a distinguished Professor of Medicine. He is Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Deputy Director of Shanghai Respiratory Research Institute, Director of Biomedical Research Center, Fudan University Zhongshan Hospital, Shanghai, China; Dr. Christian Baumgartner is a Professor of Health Care and Biomedical Engineering at Institute of Health Care Engineering with European Notified Body of Medical Devices, Graz University of Technology, Graz, Austria; Dr. Denis Shields is a Professor of Clinical Bioinformatics at Conway Institute, Belfield, Dublin, Ireland; Dr. Hong-Wen Deng is a Professor at Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, USA; Dr. Jacques S Beckmann is a Professor and Director of Section of Clinical Bioinformatics, Swiss Institute of Bioinformatics, Switzerland.

Epi-Informatics

Author : Jose Medina-Franco
Publisher : Academic Press
ISBN 13 : 0128028092
Total Pages : 446 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Epi-Informatics by : Jose Medina-Franco

Download or read book Epi-Informatics written by Jose Medina-Franco and published by Academic Press. This book was released on 2016-02-24 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes. - Focuses on the discovery of epi-drugs as candidates to be used in therapy including combined therapies - Describes new computational methodologies and screening assays utilizing recent and emerging novel structural data - Highlights the discovery, development and optimization of epi-probes, which are molecular probes that elucidate epigenetic mechanisms - Includes important topics such as computational-guided optimization of epi-hits, virtual screening to identify novel compounds for epigenetic targets, development and mining of epigenetic molecular databases, SAR modeling of screening data and much more