Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Electrochemical Biosensor Point Of Care For Early Detection Of Bone Loss
Download Electrochemical Biosensor Point Of Care For Early Detection Of Bone Loss full books in PDF, epub, and Kindle. Read online Electrochemical Biosensor Point Of Care For Early Detection Of Bone Loss ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Electrochemical Biosensor: Point-of-Care for Early Detection of Bone Loss by : Nasrin Afsarimanesh
Download or read book Electrochemical Biosensor: Point-of-Care for Early Detection of Bone Loss written by Nasrin Afsarimanesh and published by Springer. This book was released on 2018-12-13 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the design of a robust, portable and low-cost PoC sensing system for the early detection of bone loss. The device can measure the level of CTx-I – one of the most sensitive biochemical markers of bone resorption – in serum and transmit the measured value to an IoT-based cloud server. The selectivity of the sensing system to CTx-I has been achieved by coating the sensor with artificial antibodies, prepared by means of molecular imprinting technology. Explaining all aspects of the system’s development in detail, the book will be of great interest to all engineers, researchers and scientists whose work involves the development of electrochemical sensors and PoC devices.
Book Synopsis MEMS Sensors and Resonators by : Frederic Nabki
Download or read book MEMS Sensors and Resonators written by Frederic Nabki and published by MDPI. This book was released on 2020-05-27 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microelectromechanical systems (MEMS) have had a profound impact on a wide range of applications. The degree of miniaturization made possible by MEMS technology has significantly improved the functionalities of many systems, and the performance of MEMS has steadily improved as its uses augment. Notably, MEMS sensors have been prevalent in motion sensing applications for decades, and the sensing mechanisms leveraged by MEMS have been continuously extended to applications spanning the detection of gases, magnetic fields, electromagnetic radiation, and more. In parallel, MEMS resonators have become an emerging field of MEMS and affected subfields such as electronic timing and filtering, and energy harvesting. They have, in addition, enabled a wide range of resonant sensors. For many years now, MEMS have been the basis of various industrial successes, often building on novel academic research. Accordingly, this Special Issue explores many research innovations in MEMS sensors and resonators, from biomedical applications to energy harvesting, gas sensing, resonant sensing, and timing.
Book Synopsis Electrochemical Biosensors for Whole Blood Analysis by : Fan Xia
Download or read book Electrochemical Biosensors for Whole Blood Analysis written by Fan Xia and published by Springer Nature. This book was released on 2023-10-02 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates recent advances in developing sensitive and selective electrochemical biosensors for their whole blood application. Known to be a cutting-edge and fast-growing technology, electrochemical biosensors demonstrate their potential in laboratories, industries, and healthcare to achieve specific and direct target detection in complex media, and have become an emerging technology for guiding personalized medicine. The book first demonstrates methods and models to cover the detection of a variety of target molecules in whole blood, including ions, small molecules, nucleic acids, proteins, cells, etc. Then, it provides comments on various detection strategies employed to improve sensors' sensitivity, specificity, selectivity, and reproducibility as well as presenting the laws and principles. In addition, it summarizes achievements and challenges from recent years. Finally, it provides future perspectives and opportunities in electrochemical biosensors including point of care detection, molecular diagnostics and the integration of this sensor platform with multidisciplinary technologies, towards the ultimate goal of personalized medicine. The book integrates abundant viewpoints from multiple sciences and is helpful and valuable to a wide readership in the various fields of biochemistry, biophysics, bioengineering, and pharmaceutics.
Book Synopsis Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics by : Gorachand Dutta
Download or read book Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics written by Gorachand Dutta and published by Springer. This book was released on 2022-12-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare.
Book Synopsis Medical Imaging and Computer-Aided Diagnosis by : Ruidan Su
Download or read book Medical Imaging and Computer-Aided Diagnosis written by Ruidan Su and published by Springer Nature. This book was released on 2020-07-02 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers virtually all aspects of image formation in medical imaging, including systems based on ionizing radiation (x-rays, gamma rays) and non-ionizing techniques (ultrasound, optical, thermal, magnetic resonance, and magnetic particle imaging) alike. In addition, it discusses the development and application of computer-aided detection and diagnosis (CAD) systems in medical imaging. Given its coverage, the book provides both a forum and valuable resource for researchers involved in image formation, experimental methods, image performance, segmentation, pattern recognition, feature extraction, classifier design, machine learning / deep learning, radiomics, CAD workstation design, human–computer interaction, databases, and performance evaluation.
Book Synopsis Electrochemical Biosensors for Point-of-care Medical Diagnostics by : Aaron Alexander Rowe
Download or read book Electrochemical Biosensors for Point-of-care Medical Diagnostics written by Aaron Alexander Rowe and published by . This book was released on 2011 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrochemical biosensors could become the key components of many point-of-care medical diagnostics. These reusable devices can make rapid measurements in untreated samples, providing information that could allow doctors to make better decisions or change their course of action to avert clinical mishaps. This dissertation describes a variety of molecular architectures, and a device for using them to make measurements in the field. In short, we have developed a sensor that can rapidly test for aminoglycoside antibiotic overdoses in whole blood. Another sensor that was developed during the course of this dissertation can detect single-stranded DNA within two minutes. Finally, our laboratory has developed an inexpensive handheld potentiostat that can be used in conjunction with the aforementioned biosensors.
Book Synopsis Nanostructured Electrochemical Biosensors by : Brian Lam
Download or read book Nanostructured Electrochemical Biosensors written by Brian Lam and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development and Characterization of an Iridium-Modified Electrochemical Biosensor for Potential Diabetic Patient Management by : Lei Fang
Download or read book Development and Characterization of an Iridium-Modified Electrochemical Biosensor for Potential Diabetic Patient Management written by Lei Fang and published by . This book was released on 2008 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this research was to apply thick-film screen printing technology to produce a single-use, disposable, cost-effective electrochemical biosensor prototype in large scale. Iridium nanoparticles supported by carbon were selected to modify the electrode of the biosensor for its excellent catalytic effect towards the commonly detected electrochemical active species, i.e., hydrogen peroxide, nicotinamide adenine dinucleotide (reduced form, NADH), and nicotinamide adenine dinucleotide (oxidized form, NAD+). The development of this electrochemical biosensor prototype can establish a platform technology for various analytes of clinical importance. This study focused on the biosensing of the following analytes related to diabetes, i.e., 3-hydroxybutyrate (3HB), fructosyl valine, and the HbA1c, providing an analytical tool for diabetic patient management. The first part of this study discusses the importance of developing a point-of-care amperometric biosensor to detect 3-hydroxybutyrate (3HB) for diabetic patient management. Current electrochemical detection methods for 3HB require at least two stepwise reactions or a mediator. The detection method in this study only requires a single reaction step without any mediator, which can potentially also be more accurate, sensitive, cost-effective and stable over the long term. In this detection method, the enzyme D-3-hydroxybutyrate dehydrogenase (3HBDH, EC 1.1.1.30) was immobilized on the iridium0́3modified sensor prototypes which detect the NADH produced by the reaction of 3HB with NAD+ in the presence of 3HBDH. This microelectrode quantified the NADH electrochemically, which produced an electrical current that would then be used to quantify the concentration of 3HB. The interferences from uric acid, NAD+, and serum were measured. It was concluded that the level of 3HB could still be quantified well in the presence of these interfering species. Spectrometric measurements of NADH and 3HB were performed in both PBS and bovine serum and correlated very well with the electrochemical measurements of 3HB, using our biosensor prototype. The relationship between the sensing performance of this 3HB biosensor and the element properties in fabrication and the characterization parameters were assessed. As a result, the value for the element properties in fabrication and the parameters in the characterization were determined based on the experimental results together with the requirements for practical applications. Finally, inkjet printing technology was applied for the enzyme ink deposition for the mass-production of this biosensor. The biosensors from inkjet printing were characterized in both PBS and bovine serum. In the next part of this study, this biosensor prototype was used for the detection of NAD+, in order to quantify the interference from AcAc on the 3HB detection, and to quantify numerous biomarkers related to NAD+. This biosensor operated in the reduction mode at a relatively low electrochemical potential ( -0.4V vs Ag/AgCl reference electrode) in both buffer solution and bovine serum. The biosensor outputs showed high sensitivity, high linearity, and high reproducibility. The temperature effect and the interference from NADH were also assessed. The temperature effect and the interference from NADH were also assessed. As a separate study, the measurement of glycosylated hemoglobin (HbA1c) was considered to be most important for the long-term management of diabetic patients. Electrochemical detection of HbA1c was proposed involving multi-step decomposition of HbA1c to small molecules proportional to the concentration of HbA1c, then detection of the produced molecules amperometricly. This biosensor prototype was used for the detection of both HbA1c, and fructosyl valine (FV), one of the produced small molecules as a model compound for the HbA1c detection. Consequently, electrochemical biosensors for the detection of FV and HbA1c were developed. Quantifications of FV and HbA1c were carried out at a relatively low electrochemical potential (+0.25V vs Ag/AgCl) at an ambient temperature to detect the enzymatically produced H2O2. The enzymes, e.g., fructosyl amine oxidase (E.C. 1.5.3.x, FAO) and the lysis buffer were then co-immobilized onto the iridium-modified disposable sensor for HbA1c detection in whole human blood. This reagent-free electrochemical biosensor detected HbA1c in the physiological range with practical sensitivity and good linearity. Finally, a diffusion-reaction model was developed for the electrochemical detection of 3HB in solution which achieved reasonable agreement with the experimental results.
Book Synopsis Electrochemical Biosensors for Point-of-care Diagnostics Whole Human Fluids by : Cho Rok Christiana Oh
Download or read book Electrochemical Biosensors for Point-of-care Diagnostics Whole Human Fluids written by Cho Rok Christiana Oh and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Developing Electrochemical Biosensors for Point-of-care Diagnostics of Cardiovascular Biomarkers by : Yang Cheng (M.Sc.)
Download or read book Developing Electrochemical Biosensors for Point-of-care Diagnostics of Cardiovascular Biomarkers written by Yang Cheng (M.Sc.) and published by . This book was released on 2013 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Troponin is known as a type of reliable biomarker for the detection of cardiac disorders. Cardiac troponin I (cTnI), as a subunit of troponin, is highly sensitive to cardiac injury; therefore, the cTnI level is used as an index to diagnose myocardial damage, particularly acute myocardial infarction. It can be also used in cardiospecific diagnosis, risk stratification therapeutic treatment and post risk management. In this research, an amperometric immunosensor was developed based on planar electrode and sandwich ELISA format. The electrical response corresponding to biological information was obtained via four main procedures, including electrode modification, immunoreaction, signal amplifications and amperometric detection. Enzyme labels such as horseradish peroxide (HRP) and alkaline phosphatase (ALP) were used for signals amplification. Since alkaline phosphatase works better in low background current levels and has great reproducibility, it was used for nanomaterials, chitosan, gold nanoparticle, carbon nanotube as electrode modification investigation. The anti-cTnI antibody is detectable by electrochemical technology. Necessary conditions and interferences of the experiment were examined. Detection range was from 0.001 ng ml-1 to 300 ng ml-1 on PDDA-MWCNT sensor, and from 0.02 ng ml-1 to 200 ng ml-1 on chitosan-AuNPs sensor. The detection range was investigated using cyclic voltammetry. The signal behavior recorded was linear to cTnI concentration. This behavior makes the developed biosensor be able to widely use in clinical practice. Likewise, two liquid substrates were catalyzed by hydroquinone and 3, 3', 5, 5'-teteramethylbenzidine respectively. Hydrogen peroxide (H2O2) is a product of glucose oxidizes catalyzing the oxidation of -D-glucose by oxygen. It is also used as an oxidizing agent in catalyzing HRP. Hence, an HRP-based immunosensor is important in integrating an immunosensor and an enzyme sensor for the purpose of achieving multianalyte detection compacted on one chip. The cTnI immunosensor developed here is rapid, easy-to-use, cost-efficient and robust.
Book Synopsis Electrochemical DNA Biosensors by : Mehmet Sengun Ozsoz
Download or read book Electrochemical DNA Biosensors written by Mehmet Sengun Ozsoz and published by CRC Press. This book was released on 2012-04-23 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the basic electrochemical applications of DNA in various areas, from basic principles to the most recent discoveries. The book comprises theoretical and experimental analysis of various properties of nucleic acids, research methods, and some promising applications. The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticle and nanotubes; nanomaterial-based electrochemical DNA detection; electrochemical detection of microorganism-based DNA biosensors; gold nanoparticle-based electrochemical DNA biosensors; electrochemical detection of the aptamer-target interaction; nanoparticle-induced catalysis for DNA biosensing; basic terms regarding electrochemical DNA (nucleic acids) biosensors; screen-printed electrodes for electrochemical DNA detection; application of field-effect transistors to label free electrical DNA biosensor arrays; and electrochemical detection of nucleic acids using branched DNA amplifiers.
Book Synopsis Development of a Novel Electrochemical Lab-on-a-disc, Bio-sensors and Bio-assays for Pathogen Capture and Detection by : Eadaoin Carthy
Download or read book Development of a Novel Electrochemical Lab-on-a-disc, Bio-sensors and Bio-assays for Pathogen Capture and Detection written by Eadaoin Carthy and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of rapid pathogenic detection continues to be at the forefront of the greatest challenges of our clinical settings to date. Sepsis is a serious systematic inflammatory response which is triggered by bacterial, viral, or fungal infections. It persists to be a primary cause of patient death despite the medical advances made in therapeutics and antibiotics development. The non-specific symptoms of sepsis are the utmost limitation of diagnosis of the condition. Delays in detection therefore leads to an increase in patient mortality. Current gold standards within microbiology laboratories are too slow, therefore a huge demand exists for a reliable method for early stage detection of sepsis. In this work, the development of biosensors and point-of-care systems for use with electrochemical, centrifugal lab-on-a-disc, Enzyme Linked Oligonucleotide Assay (ELONA), Polymerase Chain Reaction (PCR) and Recombinase Polymerase Amplification (RPA) techniques are demonstrated. A novel integrated point-of-care LoaD system has allowed a real-life application of the sensors to be studied for hospital samples. This innovative system allows pre-loading of reagents and samples which are systematically triggered using spin-frequencies where EIS techniques are adopted to give a sample to answer in under 15 minutes. These devices are single use, therefore are ideal for quick, infectious sample testing. A full optimisation of the device was required as fluid manipulation of various samples is a key-feature where samples ranging from buffer to whole blood can be tested within the same device without the need for sample pre-treatment. A label-free electrochemical biosensor, capable of capture and detection of pathogens, was produced by using a self-assembled monolayer and antibody capture layer was fabricated and characterised to compare with the single use biosensor developed for this work. Real-cultured samples from a microbiological clinic were studied to determine the capabilities of the device for real point-of-care settings. The device, which is capable of detecting the presence of pathogens, and furthermore the category in which they lie in, has proved to be an exciting and critical step-forward in early stage sepsis detection. Further analysis allowed a specific threshold to be determined, where a change in 300 Ohms to the system signifies the presence of a pathogen on the capture surface due to changes in the interfacial capacitance of the biosensor. Using confocal microscopy, the surface coverage of the captured pathogens was determined, where a directly proportional relationship exists between the number of pathogens captured and the change in the impedance response. This highly novel system is unlike any other commercially available technology for pathogen detection. Other methods have been explored, such as ELONA and DNA amplification. With very low detection limits of 23 CFU/ml for the ELONA, 5 CFU/ml for the PCR assay and finally 9 CFU/ml for the RPA assay. With varying assay times of 195-103 minutes, the assays were highly capable of detecting extremely low counts of E. coli in clean buffer samples. Although laborious they have also been proved to be able to detect specific E. coli pathogens which may lead the way for the development of a secondary analysis tool to specifically identify the causative pathogen for a highly precise diagnosis for patients.
Book Synopsis Hypersensitive Electrochemical Biosensors Based on Nanowell Array Structures for Point of Care Technology by : JuKyung Lee
Download or read book Hypersensitive Electrochemical Biosensors Based on Nanowell Array Structures for Point of Care Technology written by JuKyung Lee and published by . This book was released on 2016 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers are sensitive indicators of pathogenic processes and pharmaceutical responses. Most of these biomarkers are present in the body with extremely low concentration and should be accurately and continually monitored to evaluate the dynamic physiological responses upon exposure to pathogens or drugs. However, conventional assays such as Enzyme linked immuno-sorbent assay (ELISA) and mass spectrometry can only take static and one time measurements, the process is long, expensive, and requires specialist equipment. Therefore, there is need for an advanced sensing system that is cost-effective, portable, and capable of simultaneously detecting very low levels of specific biomarkers with stable and reusable point of care technology (POCT). The goal of this thesis is to develop hyper sensitive biosensors based on electrochemical detection to recognize analytes a using nanowell array (NWA) electrode technology. NWA electrodes have been shown to enable faster detection of biomolecules with reproducibility much better than other approaches. In this thesis, I used fabricated a NWA on a 6-inch Si wafer by krypton-fluoride (KrF) stepper semiconductor process in order to develop NWA sensor through a combination of low cost and high throughput nano-pattern. Finally 57 uniform and homogeneous NWA electrodes were obtained on a 6-inch wafer. Second, to validate this NWA as a biosensor, several biomarkers were detected and monitored. In this part, first, NWA as immunosensor, antibody was immobilized on the NWA, and alkaline phosphatase (ALP) for bone monitoring and stress induced protein 1 (STIP-1) as ovarian cancer monitoring were used as antigen. Specific current and impedance were measured to quantify these analytes binding to the electrode. The Limit of detection (LOD) and the sensitivity & selectivity is highly increased compared with conventional micro-sized electrodes with reducing non-specific binding. Finally, these results suggest that wafer-scale NWA biosensor is useful for sensing application field for point of care technology because their structure provides for an advantage for detecting molecular binding events.
Book Synopsis Low-cost Point-of-care Electrochemical Sensors for Rapid Detection of Target Biological Analytes by : Meredith Q. Lee
Download or read book Low-cost Point-of-care Electrochemical Sensors for Rapid Detection of Target Biological Analytes written by Meredith Q. Lee and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Sensing Technology by : Nagender Kumar Suryadevara
Download or read book Sensing Technology written by Nagender Kumar Suryadevara and published by Springer Nature. This book was released on 2022-06-07 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers the latest advances, innovations, and applications in the field of sensing technology, as presented by international researchers and engineers at the 14th International Conference on Sensing Technology (ICST), held in Chennai, India on January 17-19, 2022. Contributions include a wide range of topics such as: vision sensing, sensor signal processing, sensors phenomena and modelling, sensor characterization, smart sensors and sensor fusion, electromagnetic, chemical and physical sensors, electronic nose technology, biosensors, nano sensors, wireless sensors and WSN, Internet of Things, optical sensors, sensor arrays, intelligent sensing, Internet-based and remote data acquisition. The contributions, which were selected by means of a rigorous international peer-review process, present a wealth of exciting ideas that will open novel research directions and foster multidisciplinary collaboration among different specialists.
Book Synopsis Point-of-Care Solution for Osteoporosis Management by : Patricia Khashayar
Download or read book Point-of-Care Solution for Osteoporosis Management written by Patricia Khashayar and published by Springer. This book was released on 2018-05-13 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamber to measure serum levels of different biomarkers, creating a microfluidic proteomic platform that can easily be translated into a biomarker diagnostic. The Osteokit System, a result of the integration of electrochemical system and microfluidic chips, is a unique design that offers the potential for greater sensitivity. The implementation, feasibility, and specificity of the Osteokit platform is demonstrated in this book, which is appropriate for researchers working on bone biology and mechanics, as well as clinicians.
Book Synopsis Interdigital Sensors by : Subhas Chandra Mukhopadhyay
Download or read book Interdigital Sensors written by Subhas Chandra Mukhopadhyay and published by Springer Nature. This book was released on 2021-02-15 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book highlights the research contributions of the interdigitated (IDT) sensors over a period of two decades in the field of sensing technology. It presents theory, design, and practical realization of the IDT sensors working over wide frequency rage for scientific, industrial, and consumer applications. The IDT sensors have been widely investigated for wide range of sensing applications including agriculture, environmental monitoring, structural health monitoring, health care, food and beverage testing, testing of dielectric material, proximity sensing, microfluidic application, automatic dispensing system etc. Hence, importance of IDT sensors is growing continuously for future applications. As such, it offers a key reference guide on IDT sensors for students, applied physicists, material scientists, engineers, sensors designers and technicians.
