Effect Of Omega 3 Fatty Acids On T10 C12 Conjugated Linoleic Acid Induced Insulin Resistance Non Alcoholic Fatty Liver Disease And Tissue Fatty Acid Composition

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Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition

Author : Madhuri Vemuri
Publisher :
ISBN 13 : 9781109662306
Total Pages : pages
Book Rating : 4.6/5 (623 download)

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Book Synopsis Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition by : Madhuri Vemuri

Download or read book Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition written by Madhuri Vemuri and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Conjugated linoleic acid (CLA) refers to all the positional and geometric isomers of linoleic acid. The two most studied isomers are cis9, trans11-CLA and trans10, cis12-CLA. CLA supplements, often a mixture of the two isomers, have been popularly used for weight loss and other claimed health benefits. However supplementing CLA isomers, especially trans10, cis12-CLA has been shown to cause non alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) in several animal models. Here we have confirmed that supplementing 0.5% trans10, cis12-CLA to C57BL/6 mice for 8 weeks causes NAFLD and IR. When CLA diets were concomitantly supplemented with omega-3 fatty acids docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) at 1.5% (w/w) for 8 weeks, DHA prevented CLA induced IR, while EPA was ineffective. Both EPA and DHA prevented CLA induced fatty liver. CLA also reduced the plasma leptin and adiponectin concentrations, and both EPA and DHA partially restored plasma leptin, but only DHA partially restored the plasma adiponectin. In another experiment, concomitant supplementation of CLA diets with 0.5% of flaxseed oil (rich in alpha linolenic acid) also prevented IR and decreased liver weights and lipids compared with those in CLA group. CLA supplementation also altered lipid profile in liver, decreasing n-6 and n-3 wt% and increasing n-6:n-3 ratio. Concomitant supplementation with flaxseed oil increased n-6 and n-3 polyunsaturated (PUFA) in liver lipids and decreased the n-6:n-3 ratio compared to that in CLA group. Supplementing 0.5% (w/w) of purified c9, t11- or trans10, cis12-CLA to mice for 8 weeks altered fatty acid profile of tissues differently. c9, t11-CLA diet reduced MUFA wt% in liver, adipose tissue, and spleen, and reduced the spleen n-3 PUFAs significantly while increasing the n-6 PUFA wt% in all tissues except heart. In contrast, trans10, cis12-CLA reduced both the n-6 and n-3 PUFA wt% in liver and heart however increased the wt% of n-3 PUFAs in spleen. Considering the adverse health effects of trans10, cis12-CLA and of mixtures of CLA isomers on NAFLD, IR and tissue fatty acids, human use of CLA supplements should not be recommended.

Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice

Author : Dawn Fedor
Publisher :
ISBN 13 : 9781303442483
Total Pages : pages
Book Rating : 4.4/5 (424 download)

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Book Synopsis Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice by : Dawn Fedor

Download or read book Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice written by Dawn Fedor and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin resistance (IR) is a condition in which normal amounts of insulin fail to maintain normal blood glucose because of decreased responsiveness of muscle (glucose uptake), liver (inhibition of gluconeogenesis) and adipocytes (inhibition of lipolysis). IR is often associated with nonalcoholic fatty liver disease (NAFLD), the most common liver disease in adults and children in the Western world. Results from human epidemiological studies indicate that n-3 PUFA reduce the development of IR and NAFLD although the mechanisms involved are poorly understood. Our lab previously showed that concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12- conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced NAFLD and IR. The effective dose of DHA, the mechanisms involved and the effect of CLA on fatty acid compositions of adipose tissue and muscle, and whether DHA can prevent those CLA-induced changes in fatty acid composition is not known. In the first study, we examined the ability of DHA (0.5 and 1.5%) to prevent increases in NAFLD and homeostatic model assessment of insulin resistance (HOMA-IR) induced by CLA (0.5%) when fed concomitantly for 4 weeks to C57BL/6N female mice. We also examined changes in expression of hepatic genes involved in fatty acid synthesis and oxidation. CLA supplementation increased liver triglycerides (TG) and HOMA-IR by 221 and 547%, respectively, and decreased mass of adipose depots by 65-90%. When fed concomitantly, 0.5% and 1.5% DHA prevented CLA-induced increases in liver TG and circulating insulin with varying efficiency, but neither dose of DHA prevented the loss in adipose tissue mass. In CLA + DHA 0.5 % group the liver TG did not differ from those in the control group, but circulating insulin and HOMA-IR were 285 and 264 %, respectively, greater than those in the control group. In the CLA + DHA 1.5% group liver TG were 54% lower than those in the control group, but circulating insulin concentration and HOMA-IR did not differ between these two groups. CLA increased the expression of hepatic genes involved in fatty acid synthesis and decreased the expression of genes involved in fatty acid oxidation. 1.5% DHA prevented changes in the expression of hepatic genes caused by CLA, which may be a possible mechanism contributing to the prevention of TG accumulating in the liver. Based on these results, we further studied the 1.5% DHA diet. We investigated the effects of 1.5% DHA concomitantly fed with CLA on fatty acid compositions of liver, adipose, and muscle lipids in the same mice, as well as expression of genes involved in adipose fatty acid metabolism. CLA supplementation decreased total hepatic n-3 PUFA concentration. DHA not only prevented the CLA-induced changes in liver fat, but also increased n-3 PUFA by >350% as compared with the control group. CLA decreased adipose weight and the expression of genes involved in fatty acid synthesis, oxidation, and uptake, and increased that of UCP2 in the adipose. Supplementing DHA along with CLA increased adipose n-3 PUFA by >1000% compared with control group, but did not prevent the CLA-induced changes in mass or gene expression. Both CLA and DHA were incorporated into muscle lipids, but had minor effects on FA composition. In conclusion, liver, adipose tissue, and muscle responded differently to CLA and DHA supplementation. CLA was more potent than DHA in altering depot fat and insulin concentration. DHA prevented CLA-induced increase in liver fat but not loss of adipose mass. CLA and DHA were preferentially incorporated into adipose tissue lipids, but they had only modest effects on the overall fatty acid composition of the adipose tissue. The largest changes in fatty acid composition were seen in the liver and smallest in muscle lipids.

Modern Dietary Fat Intakes in Disease Promotion

Author : Fabien De Meester
Publisher : Springer Science & Business Media
ISBN 13 : 1603275711
Total Pages : 475 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Modern Dietary Fat Intakes in Disease Promotion by : Fabien De Meester

Download or read book Modern Dietary Fat Intakes in Disease Promotion written by Fabien De Meester and published by Springer Science & Business Media. This book was released on 2010-06-07 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nutrition and Health series of books have had great success because each volume has the consistent overriding mission of providing health professionals with texts that are essential because each includes (1) a synthesis of the state of the science, (2) timely, in-depth reviews by the leading researchers in their respective ?elds, (3) extensive, up-to-date fully annotated ref- ence lists, (4) a detailed index, (5) relevant tables and ?gures, (6) identi?cation of paradigm shifts and the consequences, (7) virtually no overlap of information between chapters, but targeted, inter-chapter referrals, (8) suggestions of areas for future research, and (9) balanced, data-driven answers to patient as well as health professionals questions which are based upon the totality of evidence rather than the ?ndings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter and in the choice of chapter authors. The editor(s), whose training(s) is (are) both research and practice oriented, has(ve) the opportunity to develop a primary objective for their book, de?ne the scope and focus, and then invite the leading authorities to be part of their initiative. The authors are encouraged to provide an overview of the ?eld, discuss their own research, and relate the research ?ndings to potential human health consequences.

Omega-6/omega-3 Essential Fatty Acid Ratio

Author : Artemis P. Simopoulos
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805576404
Total Pages : 188 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Omega-6/omega-3 Essential Fatty Acid Ratio by : Artemis P. Simopoulos

Download or read book Omega-6/omega-3 Essential Fatty Acid Ratio written by Artemis P. Simopoulos and published by Karger Medical and Scientific Publishers. This book was released on 2003-01-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on the evolutionary aspects of diet and molecular studies included in this volume indicate that human beings evolved on a diet that was balanced in the essential fatty acids (EFA). In fact, the ratio of omega-6/omega-3 EFA was 1/1 whereas present day diets in both developed and developing countries have a much higher ratio, between 5/1 and 50/1. Additional studies show that a high ratio of omega-6/omega-3 EFA is detrimental to health and may lead to the development of chronic diseases. Improving the dietary ratio by decreasing the omega-6 fatty acids and increasing the omega-3 fatty acids is essential for brain function and for the management of cardiovascular disease, arthritis and cancer. A ratio of 4/1 or less leads to lower dosage and to the reduction of adverse effects of drugs. This volume should be of interest to a large and varied audience of researchers in academia, industry, and government; cardiologists, geneticists, immunologists, neuroscientists, and cancer specialists; as well as nutritionists, dietitians, food scientists, agriculturists, economists and regulators.

Omega-3 Fatty Acids in Health and Disease

Author : Lindsay Brown
Publisher : MDPI
ISBN 13 : 303842272X
Total Pages : 325 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Omega-3 Fatty Acids in Health and Disease by : Lindsay Brown

Download or read book Omega-3 Fatty Acids in Health and Disease written by Lindsay Brown and published by MDPI. This book was released on 2018-09-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Omega-3 Fatty Acids in Health and Disease" that was published in JCM

Omega-3 Fatty Acids in Health and Disease

Author : Lees
Publisher : CRC Press
ISBN 13 : 9780824782924
Total Pages : 262 pages
Book Rating : 4.7/5 (829 download)

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Book Synopsis Omega-3 Fatty Acids in Health and Disease by : Lees

Download or read book Omega-3 Fatty Acids in Health and Disease written by Lees and published by CRC Press. This book was released on 1990-02-09 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: A report from research in the MIT Sea Grant College Program. Discusses the relationship between particular fatty acids found only in fish oil, and human health. Presents and evaluates information on the health effects of dietary fats generally; evidence that fish oil consumption affects the incidenc

Effect of Omega-3 Fatty Acids on Non-alcoholic Fatty Liver Disease

Author : Eleonora Scorletti
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (111 download)

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Book Synopsis Effect of Omega-3 Fatty Acids on Non-alcoholic Fatty Liver Disease by : Eleonora Scorletti

Download or read book Effect of Omega-3 Fatty Acids on Non-alcoholic Fatty Liver Disease written by Eleonora Scorletti and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Effects of Abomasal Lipid Infusion on Liver Triglyceride Accumulation During Fatty Liver Induction

Author : Amy E. Kulick
Publisher :
ISBN 13 :
Total Pages : 168 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Effects of Abomasal Lipid Infusion on Liver Triglyceride Accumulation During Fatty Liver Induction by : Amy E. Kulick

Download or read book Effects of Abomasal Lipid Infusion on Liver Triglyceride Accumulation During Fatty Liver Induction written by Amy E. Kulick and published by . This book was released on 2006 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Proceedings from the Scientific Conference on Omega-3 Fatty Acids in Nutrition, Vascular Biology, and Medicine

Author : Henry J. Pownall
Publisher :
ISBN 13 :
Total Pages : 276 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Proceedings from the Scientific Conference on Omega-3 Fatty Acids in Nutrition, Vascular Biology, and Medicine by : Henry J. Pownall

Download or read book Proceedings from the Scientific Conference on Omega-3 Fatty Acids in Nutrition, Vascular Biology, and Medicine written by Henry J. Pownall and published by . This book was released on 1995 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of the conference was on the cardiovascular effects of omega-3 fatty acids. Papers address the evolutionary role of omega-3 fatty acids; nutrition; lipoproteins; biophysical properties and peroxidation; cell biology; syntheses and interconversion; and clinical atherosclerosis and thrombosis.

Do Dietary Fats Contribute to Fatty Liver

Author : Connor Andrew Mahler
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)

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Book Synopsis Do Dietary Fats Contribute to Fatty Liver by : Connor Andrew Mahler

Download or read book Do Dietary Fats Contribute to Fatty Liver written by Connor Andrew Mahler and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-alcoholic fatty liver disease (NAFLD) is a common occurrence in people with insulin resistance and NAFLD increases the risk of developing liver disease. Although the pathogenesis of NAFLD is not well understood, recent evidence suggests that mitochondria dysfunction is critical in its development. A dominant species of cardiolipin in the inner mitochondria membrane is tetra-linoleoyl-cardiolipin (LA4CL), a phospholipid with molecules of linoleic acid (LA). Reduced levels of LA4CL are linked with mitochondrial dysfunction. The hepatic phospholipid fatty acid profiles may reflect both the disease of NAFLD as well as dietary fat composition. The overall hypothesis of my thesis is: consumption of a linoleic acid (LA) rich oil will alleviate progression of fatty liver in mice by increased incorporation of LA into hepatic phospholipids. To test this hypothesis, we fed mice two different high fat diets, one containing a LA rich safflower oil and the other diet containing lard. To determine any changes in hepatic fat accumulation we measured triglyceride (TG), and total lipid content. Phospholipid fatty acid composition was assessed as well to determine any changes in phospholipid fatty acids. C57BL6/J male mice (N=24) were assigned to a high fat diet of 24% wt fat containing either LA-rich safflower oil or lard which is rich in saturated fat, for 130 days. Body composition, blood glucose and insulin sensitivity measurements were assessed. Solid phase extraction (SPE) and gas chromatography were used to analyze the fatty acid composition of the hepatic phospholipids; HPLC/MS in collaboration with Dr. Genevieve Sparagna (University of Colorado) was used to determine cardiolipin speciation. An insulin tolerance test revealed that blood glucose remained lower at 90 min and 120 min after the insulin injection in the SO diet compared to the LD diet. The SO diet had increased the percent of LA4CL compared to the LD diet of total cardiolipin species. No differences in total lipids or TG in the liver between diets. Of the phospholipid fractions extracted, the fatty acid compositions reflected major species of fatty acids found in their respective diets in the phospholipid fractions reported. This study indicates that dietary fat altered fatty acid compositions of phospholipids, and consumption of a high fat LA-rich safflower oil does not alleviate fatty liver accumulation in mice fed a high fat diet.

Metabolic Benefits of Plant-based N-3 Polyunsaturated Fatty Acids on Brown Thermogenesis

Author : Kyung Ho Park
Publisher :
ISBN 13 :
Total Pages : 90 pages
Book Rating : 4.:/5 (127 download)

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Book Synopsis Metabolic Benefits of Plant-based N-3 Polyunsaturated Fatty Acids on Brown Thermogenesis by : Kyung Ho Park

Download or read book Metabolic Benefits of Plant-based N-3 Polyunsaturated Fatty Acids on Brown Thermogenesis written by Kyung Ho Park and published by . This book was released on 2020 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are two essential fatty acids for humans, a-linolenic acid (ALA) and linoleic acid (LA), which should be taken from foods to maintain health. Once incorporated into cells, ALA and LA, which are omega-3 poly unsaturated fatty acid (n-3 PUFA) and n-6 PUFA respectively, undergo elongation and desaturation to generate longer and more unsaturated fatty acids influencing inflammation and immunological responses. Numerous studies showed a dietary reduction of n-6/n-3 PUFA ratio improves cardiovascular health, inflammation, and insulin resistance. Fish oil, the main resource for n-3 PUFA, is shown to increase these health benefits. In our lab, we investigated the efficacy of ALA-enriched butter (n3Bu) as an alternative to fish oil for n-3 PUFA. n3Bufed mice showed increased bioconversion of ALA to long-chain n-3 PUFA (LC n-3 PUFA) and attenuated high fat (HF) diet-induced insulin resistance and inflammation. Besides, these health benefits, n-3 PUFA is shown to improve obesity and its related diseases by regulating lipid metabolism in both white adipose tissue (WAT) and brown adipose tissue (BAT). Fish oil abundant with n-3 PUFA promotes BAT formation and increases its thermogenic activity in cold acclimation. However, the impact of ALAenriched agricultural products on the BAT function is unknown. In this study, we investigated the effect of ALA-biofortified butter (n3Bu) on lipid metabolism and thermogenic functions in BAT. Intake of n3Bu significantly reduced the whitening of BAT and increased the thermogenesis in response to acute-cold treatment. Consumption of n3Bu promoted bioconversion of LC n-3 PUFA, fatty acid elongation and desaturation, and mitochondrial biogenesis. Taken together, our results support that ALA-biofortified butter is a novel source of n-3 PUFA that potentiates the BAT thermogenic function.

Effects of Dietary Linoleic Acid on Conversion of Omega-3 Fatty Acids to Long Chain Fatty Acids

Author : Elizabeth Flaherty
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Effects of Dietary Linoleic Acid on Conversion of Omega-3 Fatty Acids to Long Chain Fatty Acids by : Elizabeth Flaherty

Download or read book Effects of Dietary Linoleic Acid on Conversion of Omega-3 Fatty Acids to Long Chain Fatty Acids written by Elizabeth Flaherty and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: With the modern diet that is high in total fats, high in omega-6 fatty acids (FA), and low in omega-3 FA, there is a high prevalence of metabolic and cardiovascular disease. Certain dietary acids are beneficial, while others may contribute to these disease processes. Eggs are an important part of the human diet as they are protein and nutrient dense and are a good source of vitamins and minerals. It is possible to manipulate the nutrients and composition of FA in the eggs by modifying the balance of the hens diets. This makes them a good target for experiments with fatty acids (FA). A diet high in omega-3 (n-3) FA has many beneficial effects including plasma lipid reduction, reduction in some types of cancer mortality, anti-inflammatory effects, antiarrhythmic effects, antithrombotic effects, antiatheromatous effects, and less severe manifestations of autoimmune diseases and inflammatory diseases. Due to the benefits of n-3 FA, it is important to understand the effects of oleic acid and linoleic acid (LA; C18:2n-6) on the deposition of n-3 FA in egg yolks. The goals of the experiment are to determine the effect of these FA on deposition of ALA and VLC n-3 FA in yolks. It is hypothesized that LA will have a negative impact on the deposition of ALA in yolks as they compete for elongase and desaturase enzymes. Additionally, it is expected that oleic acid will also have a negative effect on n-3 deposition in yolks.Fifty hens were randomly assigned to one of five dietary treatments that included a control, two levels of high oleic safflower oil (HOSO; 2% and 4%), and two levels of high linoleic safflower oil (HLSO; 2% or 4%). All diets contained 4% flaxseed oil (FLAX) to provide -linolenic acid (ALA; C18:3n-3) as a substrate for synthesis of the very long chain omega-3(VLC n-3) FA. Egg samples were collected on day 0 and day 28 of the experiment and were analyzed for yolk weights and FA composition. Samples of adipose and liver tissue were collected on day 28 for FA analysis.Increasing dietary oleic acid (18:1n-9), provided by HOSO, had a positive effect on deposition of oleic acid in the yolk. Increased dietary linoleic acid (LA; C18:3n-6), provided by HLSO, had a negative effect on oleic acid deposition. HOSO and HLSO also negatively affected the deposition of ALA and VLC n-3 FA in yolks. This supports previous experiments that showed dietary n-6 FA had a negative effect on deposition of n-3 FA in yolks as a result of competition for the elongase and desaturase enzymes. The diet that is most conducive to developing a high n-3 fatty acid egg is a diet with a high level of ALA and a low level of oleic and linoleic acid.

Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA)

Author : Wan Shen
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (919 download)

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Book Synopsis Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA) by : Wan Shen

Download or read book Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA) written by Wan Shen and published by . This book was released on 2015 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Overweight and obesity are the most widespread nutritional diseases in the U.S., which greatly increase chronic disease risks and mortality. Therefore, it is urgent to develop a relatively efficacious and safe strategy for the weight management. Consumption of conjugated linoleic acid (CLA) supplements or one of its isomers, trans-10, cis-12 (10,12) CLA, has consistently demonstrated reductions in body weight or body fat in human and animal studies. Our lab has demonstrated that 10,12 CLA triggered calcium release from endoplasmic reticulum in human primary adipocytes, which activated downstream inflammatory signaling, resulting in impaired uptake of glucose and fatty acid, and delipidation. However, the upstream signals responsible for these actions are unknown. Therefore, my Aim 1 investigated the upstream mechanism by which 10,12 CLA increases intracellular calcium and inflammatory signaling in human primary adipocytes. The results indicated that phospholipase C plays an important role in 10,12 CLA-mediated activation of intracellular calcium accumulation, inflammatory signaling, delipidation, and insulin resistance in human primary adipocytes. It has been demonstrated that 10,12 CLA increased mRNA levels and protein levels of cyclooxygenase-2 (COX-2) and pro-inflammatory prostaglandins, which have been linked to increased energy expenditure associated with white adipose tissue (WAT) browning and uncoupling of ATP synthesis. It also has been shown that relatively high doses of 10,12 CLA lead to more significant reductions in body fat, but cause a greater level of inflammation, insulin resistance, and steatosis in animals. Therefore, Aims 2 and Aim 3 determined the extent to which a relative low dose of 10,12 CLA or a CLA isomer mixture increases markers of browning in mice and its dependence in inflammatory signaling. In Aim 2, a low threshold dose of 10,12 CLA was found that prevented body fat accumulation with minimum metabolic side-effects in non-obese mice. It was also found that 10,12 CLA-induced browning in WAT was accompanied by increases in mRNA levels of COX-2 and other markers of inflammation. In Aim 3, a relatively low dose of 10,12 CLA reduced body fat and increased browning of WAT in overweight mice, which were independent of inflammatory signaling. Collectively, these findings provide critical insights for the development of reliable dietary strategies for people who take CLA as method to lose weight. However, we still do not know (i) if 10,12 CLA supplementation would effectively reduce body fat in overweight mice when they are continuously fed an American-type, high-fat diet; (ii) potential risks of impaired regulation of body temperature, inflammation, and steatosis due to 10,12 CLA consumption in high fat-fed mice; and (iii) potential mechanisms by which 10,12 CLA reduces body fat in high fat-fed mice."--Abstract from author supplied metadata.

Effect of Omega-6 and Omega-3 Oxylipins on HNF4[alpha] Protein Stability and Function

Author : Hannah E. Navarrete
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Effect of Omega-6 and Omega-3 Oxylipins on HNF4[alpha] Protein Stability and Function by : Hannah E. Navarrete

Download or read book Effect of Omega-6 and Omega-3 Oxylipins on HNF4[alpha] Protein Stability and Function written by Hannah E. Navarrete and published by . This book was released on 2019 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocyte nuclear factor 4[alpha] (HNF4[alpha]) is a highly conserved nuclear receptor and has been implicated in many human diseases such as diabetes, hemophilia, and atherosclerosis. Previous unpublished research suggests that soybean oil, a popular cooking oil, may lead to decreased levels of HNF4[alpha] in the nuclei of hepatocytes. Soybean oil is rich in unsaturated fats, especially linoleic acid (C18:2), and assumed to be healthy, yet it induces obesity, diabetes, insulin resistance, and fatty liver in mice. Metabolomic analysis of the liver showed positive correlation between obesity and hepatic C18 oxylipin metabolites of omega-3 and omega-6 fatty acids ([alpha]-linoleic and linoleic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway. Studies also indicate that linoleic acid is an endogenous ligand for HNF4[alpha], and computer modeling has suggested that it may be possible for oxylipins to bind HNF4[alpha]. Here, experiments utilizing cell culture and immunoblot analysis examined whether the presence of omega-3 and omega-6 oxylipins in cell culture destabilize HNF4[alpha] protein. The results suggest that the presence of oxylipins in media may destabilize HNF4[alpha].

The Omega Solution

Author : Jonathan Goodman
Publisher : Prima Lifestyles
ISBN 13 :
Total Pages : 262 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis The Omega Solution by : Jonathan Goodman

Download or read book The Omega Solution written by Jonathan Goodman and published by Prima Lifestyles. This book was released on 2001 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tap Into the Proven, Potent Healing Powers of Essential Fatty Acids Think of essential fatty acids (EFAs)--both omega-3 and omega-6--as nature's own miracle drug. Research has proven that a proper balance of these nutrients promotes a healthy heart, influences how you think, look, and feel, and enhances your body's ability to fight disease. EFAs even influence how long you live. Yet they are the number one nutritional deficiency in the United States! The good news is that with nutritional supplements or through your regular diet you can begin to reap the profound health benefits of EFAs today! This complete resource shows you how. "A well-written, highly practical guide for understanding the importance of essential fatty acids in health and disease."--Michael T. Murray, N.D., co-author, "Encyclopedia of Natural Medicine "Timely, well-researched, and easy to read--a must for everyone interested in optimizing their health and reducing disease."--Joseph Pizzorno, N.D., co-author, "Encyclopedia of Natural Medicine, member, White House Commission on Complementary and Alternative Medicine "From cancer and heart disease to women's health issues, essential fatty acids play a major role in health promotion and the amelioration of disease. This book imparts the knowledge of necessary to properly utilize EFAs to enhance our own health and healing."--Joel M. Evans, M.D., director, "The Center for Women's Health

Bioactive Fatty Acid Supplementation and Risk Factors for the Metabolic Syndrome

Author : Patricia Mitchell
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (812 download)

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Book Synopsis Bioactive Fatty Acid Supplementation and Risk Factors for the Metabolic Syndrome by : Patricia Mitchell

Download or read book Bioactive Fatty Acid Supplementation and Risk Factors for the Metabolic Syndrome written by Patricia Mitchell and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Omega-3 Fatty Acids and Health

Author : Joyce A. Nettleton
Publisher : Springer
ISBN 13 : 9781461358602
Total Pages : 0 pages
Book Rating : 4.3/5 (586 download)

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Book Synopsis Omega-3 Fatty Acids and Health by : Joyce A. Nettleton

Download or read book Omega-3 Fatty Acids and Health written by Joyce A. Nettleton and published by Springer. This book was released on 2012-09-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evidence that omega-3 fatty acids are essential for human development and most helpful to achieve good health throughout life is clearly documented by Dr. Joyce Nettleton in her new book Omega-3 Fatty Acids and Health. Omega 3 fatty acids are produced by the plants of the land and sea. The tissues of the body require the omega-3 fatty acids for their proper functioning just as they also need the omega-6 essential fatty acids. It is probable in man's evolutionary development that there has always been the proper balance between these two groups of essential fatty acids, but in the modern era with the provision of inexpensive vegetable oils it is possible that the pendulum for increased dietary omega-6 fatty acids in the form of linoleic acid has swung too far and the intake ofomega-3 fatty acids has actualIy declined. In particular, the 22 carbon omega 3 fatty acid, docosahexaenoic acid, which has six double bonds, is important in the membranes of brain cells, heart muscle cells, the rods and cones of the retina and spermatozoa. Docosahexaenoic acid is found only in foods such as fish and other sea life, having been synthesized by the phytoplankton of the waters. An outright deficiency of omega-3 fatty acids has led to a number of distur bances in animals and human infants such as impaired vision, abnormalities of the electroretinogram, of the eye and various behavioral aberrations.