Drug Receptor Interactions In Antimicrobial Chemotherapy

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Drug Receptor Interactions in Antimicrobial Chemotherapy

Author : J. Drews
Publisher : Springer Science & Business Media
ISBN 13 : 3709184053
Total Pages : 331 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Drug Receptor Interactions in Antimicrobial Chemotherapy by : J. Drews

Download or read book Drug Receptor Interactions in Antimicrobial Chemotherapy written by J. Drews and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of chemotherapy as originated by Paul Ehrlich is based on the premise that antiparasitic drugs must have two properties: they must first bind to specific structures of the parasite which Ehrlich called chemoreceptors. Subsequent to their attachment to the chemoreceptor and by virtue of this binding they must possess the capacity to kill the parasite. Since the host which is to be cured of an invading parasite also contains a large number of chemoreceptors, that have the potential to bind toxic compounds, the task of the chemo therapist is to identify chemoreceptors of the parasite which are . not represented in the host and to design drugs which bind selectively to them~ In this context, Ehrlich called· for "the complete and exhaustive knowledge of all the different chemoreceptors of a certain parasite" as a "sine qua non for success in chemotherapy". Paradoxically and in spite of the fact that chemotherapy has become a very advanced and successful therapeutic discipline, few of its tri umphs have been achieved by following Ehrlich's original precepts. On the contrary, in the overwhelming majority of cases, effective drugs have been discovered without any knowledge of their chemoreceptors, and these drugs themselves have conversely been used as tools to study the nature of the chemoreceptors involved. In other words: chemother apy, notably antibacterial chemotherapy, has been successful without ever living up to the fundamental standards put forward by Paul Ehr lich.

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1174 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1982 with total page 1174 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

The Antimicrobial Drugs

Author : Eric Michael Scholar
Publisher :
ISBN 13 : 9780195125283
Total Pages : 632 pages
Book Rating : 4.1/5 (252 download)

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Book Synopsis The Antimicrobial Drugs by : Eric Michael Scholar

Download or read book The Antimicrobial Drugs written by Eric Michael Scholar and published by . This book was released on 2000 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.

Modes and Mechanisms of Microbial Growth Inhibitors

Author : Fred E. Hahn
Publisher : Springer Science & Business Media
ISBN 13 : 3642689469
Total Pages : 355 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Modes and Mechanisms of Microbial Growth Inhibitors by : Fred E. Hahn

Download or read book Modes and Mechanisms of Microbial Growth Inhibitors written by Fred E. Hahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is not certain that the editors of Antibiotics I (1967), Drs. GOTTLffiB and SHAW, fully realized that they were laying the foundation for an entire series of which we present here Vol. VI. For some time to come, this will be the last volume of the Antibiotics series. There are several reasons for this. Firstly, the discovery of medicinally useful antibiotics has leveled off, because the number of microbiological products with antimicrobial properties is not infinite. In 1972 some 2500 antibiotic substances were known, of which approximately one per cent are clinically useful. Further search for antibiotics has led to increasing frequency of rediscoveries and drasti cally decreasing frequency of discoveries of new antibiotics. As the search for antibiotics with a standard methodology in conventional ecological niches has exhausted itself, there is a paucity of new and interesting substances on which to undertake modes/mechanisms of action studies. Secondly, the mechanism of action field has come of age and its results are now academic knowledge. This also holds true for synthetic chemothera peutic drugs and becomes the case rapidly for toxic substances with anti-eukar yotic action. The study of mechanisms of action was undertaken for two reasons: one was the basic scientific desire to know how antimicrobial substances inter fered with microbial biochemistry; the second one was the hope that such infor mation would be useful in the premeditated design of synthetic antimicrobials.

Drug Action at the Molecular Level

Author : G.C.K. Roberts
Publisher : Springer
ISBN 13 : 1349032301
Total Pages : 296 pages
Book Rating : 4.3/5 (49 download)

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Book Synopsis Drug Action at the Molecular Level by : G.C.K. Roberts

Download or read book Drug Action at the Molecular Level written by G.C.K. Roberts and published by Springer. This book was released on 1977-06-17 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Catalog of Copyright Entries. Third Series

Author : Library of Congress. Copyright Office
Publisher : Copyright Office, Library of Congress
ISBN 13 :
Total Pages : 1482 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Catalog of Copyright Entries. Third Series by : Library of Congress. Copyright Office

Download or read book Catalog of Copyright Entries. Third Series written by Library of Congress. Copyright Office and published by Copyright Office, Library of Congress. This book was released on 1977 with total page 1482 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanism of Action of Antieukaryotic and Antiviral Compounds

Author : Fred E. Hahn
Publisher : Springer Science & Business Media
ISBN 13 : 3642464076
Total Pages : 484 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Mechanism of Action of Antieukaryotic and Antiviral Compounds by : Fred E. Hahn

Download or read book Mechanism of Action of Antieukaryotic and Antiviral Compounds written by Fred E. Hahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.

Antimicrobial Chemotherapy

Author : Peter Davey
Publisher : OUP Oxford
ISBN 13 : 0191004014
Total Pages : 482 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Antimicrobial Chemotherapy by : Peter Davey

Download or read book Antimicrobial Chemotherapy written by Peter Davey and published by OUP Oxford. This book was released on 2015-05-07 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. The fully revised and updated seventh edition of Antimicrobial Chemotherapy is an essential guide to the principles of antimicrobial chemotherapy, the problem of resistance and its control through policies, antimicrobial stewardship and surveillance. The book provides an aid to informed, rational prescribing for common bacterial, fungal, parasitic and viral infections. Divided in five parts, the book cover issues specific to both the developed and developing world. Part 1 'General property of antimicrobial agents' discusses mechanisms of action and resistance to antibacterial, antifungal antiprotozoal, antiviral, and antiviral agents. Part 2 'Resistance to antimicrobial agents' provides guidance about the problem of resistance, mechanisms of acquired resistance and genetics of resistance. Part 3 'General principles of usage of antimicrobial agents' analyses the use of the laboratory, general principles of the treatment of infection, dosing in special groups (extremes of age, pregnancy, obesity), safe prescribing, prophylaxis and the role of policies in antimicrobial stewardship. Part 4 'Therapeutic use of antimicrobial agents' provides advice about the treatment of common infections which are described by anatomical. There are also chapters on the management of mycobacterial disease, viral infections, HIV/AIDS and parasitic infections. The final part of the book analyses the development and marketing of antimicrobial drugs. This seventh edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs.

Mechanism of Action of Antibacterial Agents

Author : Fred E. Hahn
Publisher : Springer Science & Business Media
ISBN 13 : 3642464033
Total Pages : 389 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Mechanism of Action of Antibacterial Agents by : Fred E. Hahn

Download or read book Mechanism of Action of Antibacterial Agents written by Fred E. Hahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume of Antibiotics was published in 1967 and contained a series of review papers on antibiotic actions. The editors, Drs. GOTTLIEB and SHAW, were aware of the rapid development of this field of study and provided a number of addenda in an effort to keep knowledge up to date while the book was in production. One year after the publication of Antibiotics I, this editor had a conference with Dr. KONRAD F. SPRINGER in which it became clear that another volume on actions of antibiotics would be necessary. For a variety of reasons, this was delayed until 1975 and became Antibiotics III. It did not contain addenda since it was recognized by the editors, Drs. CORCORAN and HAHN, that still another volume would have to follow and that in a moving field, such as the study of the actions of antibacterial drugs, no publication can be definitive or remain current, except for a limited period of time. The editors of Volume III grouped the contributions into sections: 1. Inter ference with nucleic acid biosyntheses, 2. Interference with protein biosynthesis, and 3. Interference with cell wall/membrane biosynthesis, specific enzyme sys tems, and those in which the mode of action was not known with certainty.

Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques

Author : Norman K. Hollenberg
Publisher : Birkhäuser
ISBN 13 : 3034889968
Total Pages : 326 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques by : Norman K. Hollenberg

Download or read book Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques written by Norman K. Hollenberg and published by Birkhäuser. This book was released on 2013-03-07 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 46 of this well-established and acclaimed book series contains seven comprehensive reviews by internationally recognized experts. They will provide the reader with up-to-date information. Contents: N.K. Hollenberg and S.W. Graves: Endogenous sodium pump inhibition: Current Status • R.B. McCall: Neurotransmitters involved in the central regulation of the cardivascular system • W.T. Jackson and J.H. Fleisch: Development of novel anti- inflammatory agents: A pharmacologic perspective on leukotrienes and their receptors • M. Margaglione, E. Grandone, F.P. Mancini and G. Di Minno: Drugs affecting plasma fibrinogen levels. Implications for new antithrombotic strategies • N. Seiler, A. Hardy and J.P. Moulinoux: Aminoglycosides and polyamines: Targets and effects in the mammalian organism of two important groups of natural aliphatic polycations • J. Claghorn and M.D. Lesem: Recent developments in antidepressant agents • E.J. Lien, A. Das and L.L. Lien: Immunopharmacological and biochemical bases of Chinese herbal medicine • Index Vol. 46 • Index of titles Vols. 1-46 • Author and paper index Vols. 1-46.

Quinolone Antibacterials

Author : Jochen Kuhlmann
Publisher : Springer
ISBN 13 : 9783642803666
Total Pages : 0 pages
Book Rating : 4.8/5 (36 download)

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Book Synopsis Quinolone Antibacterials by : Jochen Kuhlmann

Download or read book Quinolone Antibacterials written by Jochen Kuhlmann and published by Springer. This book was released on 2012-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been over 30 years since the first clinically important member of the quinolone class, nalidixic acid, was introduced into medical practice. The modification produced in the quinolone nucleus by introducing a fluorine at the 6-position led to the discovery of the newer fluoroquinolones with enhanced antibacterial activities as compared to nalidixic acid. By now a great deal of preclinical and clinical experience has been obtained with these agents. The intense interest in this class of antibacterial agents by chemists, micro biologists, toxicologists, pharmacologists, clinical pharmacologists, and clini cians in various disciplines encouraged us to summarize the information on the history, chemistry, mode of action and in vitro properties, kinetics and efficacy in animals, mechanisms of resistance, toxicity, clinical pharmacology, clinical experience, and future prospects in one volume of the Handbook of Experimental Pharmacology. As this series deals predominantly with "experimental" characteristics of drugs, our volume is dedicated specifically to quinolones and emphasizes principally their preclinical and clinical phar macological characteristics, despite the existence of several summaries on quinolones. The chemistry of the quinolones is described in detail. The chapter on the mode of action of quinolones reports the conclusive evidence that gyrase is the intracellular target of the quinolones; however, another enzyme, topoisomerase IV, may also be a target for quinolones, and the exact mechanisms by which quinolones act bactericidally are far from being understood.

Progress in Molecular and Subcellular Biology

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642666264
Total Pages : 188 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Progress in Molecular and Subcellular Biology by :

Download or read book Progress in Molecular and Subcellular Biology written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Toxinology

Author : W. T. Shier
Publisher : CRC Press
ISBN 13 : 1000147673
Total Pages : 828 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Handbook of Toxinology by : W. T. Shier

Download or read book Handbook of Toxinology written by W. T. Shier and published by CRC Press. This book was released on 2020-08-26 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized primarily around the mechanisms of action of the toxins at the biochemical, physiological and pathological level, rather than by source, the handbook covers most toxins which have been clearly identified and characterized, but emphasizes toxins that are more important by virtue of the sign

Annual Reports in Medicinal Chemistry

Author :
Publisher : Academic Press
ISBN 13 : 008058358X
Total Pages : 370 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Annual Reports in Medicinal Chemistry by :

Download or read book Annual Reports in Medicinal Chemistry written by and published by Academic Press. This book was released on 1979-11-14 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry

Treating Infectious Diseases in a Microbial World

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Infectious Diseases

Author : Sherwood L. Gorbach
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 0781733715
Total Pages : 2546 pages
Book Rating : 4.7/5 (817 download)

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Book Synopsis Infectious Diseases by : Sherwood L. Gorbach

Download or read book Infectious Diseases written by Sherwood L. Gorbach and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 2546 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of this definitive reference provides comprehensive guidelines on the diagnosis, treatment, and prevention of every infectious disease seen in current clinical practice. More than 300 world-class practitioners detail the full range of clinical infections, microorganisms, diagnostic tests, and antimicrobial therapies. Coverage includes chapters on surgical infections written by preeminent surgeons and up-to-the-minute information on HIV infection. A comprehensive antimicrobial drugs section includes tables that provide at-a-glance prescribing information. New Third Edition chapters cover bioterrorism, hospital infections, emerging infections, human herpesvirus-8, West Nile virus, food safety, linezolid and quinupristin/dalfopristin, molecular diagnostics, and diagnostic significance of nonspecific laboratory abnormalities.

Molecular Mechanisms of Protein Biosynthesis

Author : Herbert Weissbach
Publisher : Elsevier
ISBN 13 : 0323141706
Total Pages : 739 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Molecular Mechanisms of Protein Biosynthesis by : Herbert Weissbach

Download or read book Molecular Mechanisms of Protein Biosynthesis written by Herbert Weissbach and published by Elsevier. This book was released on 2012-12-02 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Mechanisms of Protein Biosynthesis is a collection of papers dealing with cell-free systems at the molecular level, including transfer RNA; the initiation, elongation, and termination processes; ribosome structure and function; mRNA translation; and DNA-directed in vitro protein synthesis. A couple of papers review tRNA, aminoacyl-tRNA synthetases, and aspects of ribosome structure. One paper discusses affinity labeling in the study of binding and catalytic sites of large complex and heterogeneous systems such as the ribosome. The investigator should be aware of the chemically reactive or photoactivatible analogue reacting specifically with one or more ribosomal components. This reaction should be determined if it is dependent on the correct binding of the affinity label at the functional site. Another paper describes the series of reactions in protein synthesis as the process by which the ribosome moves relative to the messenger RNA. Other papers discuss messenger RNA and its translation, DNA-dependent cell-free protein synthesis, as well as the genetics of the translational apparatus. The collection will benefit microbiologists, biotechnologists, and academicians connected with the biological sciences.