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Drug Design And Action
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Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications
Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Academic Press. This book was released on 2014-03-29 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Download or read book Drug Design written by Gerhard Klebe and published by Springer. This book was released on 2013-07-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.
Book Synopsis Smith and Williams' Introduction to the Principles of Drug Design and Action by : H. John Smith
Download or read book Smith and Williams' Introduction to the Principles of Drug Design and Action written by H. John Smith and published by CRC Press. This book was released on 2005-10-10 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
Book Synopsis Drug Design and Action by : Joaquín M. Campos Rosa
Download or read book Drug Design and Action written by Joaquín M. Campos Rosa and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-12-18 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: A slow and consistent study of the approaches for drug design can help the foundation for a good scientific intuition. This edition includes over 30 new illustrations, numerous new mechanistic schemes and enhanced original figures. In addition, the use of color makes its study more pleasant and impressive. The Second Edition has been thoroughly revised with a modern look. The chapters on QSAR and Drug Metabolism have been extended, emphasizing concepts, such as the hyperconjugative effect or the anomeric effect, in which the student normally finds it difficult to understand. Stereoelectronic effects are essential to explain the mechanism of action of drugs and therefore, its agile and intuitive handling will allow the student access to both chemical and biological mechanisms, in a more rational way. The text is illustrated with hundreds of formulas and many tables that facilitate the understanding of this interesting discipline, which is halfway between Organic Chemistry, Biochemistry and Pharmacology. This Volume is aimed at building basis principles on drug design and it is likely to be of interest to students reading, pharmacy, pharmacology, and pharmaceutical chemistry. This book emphasizes general principles of drug design and drug action from an organic chemical perspective, rather than from the overview of specific classes of drugs, allowing the reader to extrapolate information to many related classes of drug molecules. This volume presents an organic chemistry’s perspective of how drug are designed and assuming no prior knowledge of biochemistry, and pharmacology. It is written in an informal, clear style so that undergraduates can easily understand the concepts presented.
Book Synopsis The Ups and Downs in Drug Design by : Victor E. Marquez
Download or read book The Ups and Downs in Drug Design written by Victor E. Marquez and published by CRC Press. This book was released on 2021-11-15 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ups and Downs in Drug Design: Adventures in Medicinal Chemistry highlights the necessity for an integrative approach in medicinal chemistry and chemical biology. As medicinal chemistry is not a monolithic science, it is important to emphasize the other various disciplines that are required for successful drug design. This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery. It is an excellent companion text for graduate and postgraduate students who would like further insight into the parameters of drug design, including the challenges that come with the project. Key Features Illustrates "real-life" examples in medicinal chemistry Integrates the use of physical, chemical, and biological concepts that are important in drug design Highlights the "ups" and "downs" that come with drug discovery Aims to inspire students who may be struggling with the challenges and thought process in drug design Intends to be an excellent companion text for graduate and postgraduate students
Book Synopsis Drug Design by : Everhardus Jacobus Ariëns
Download or read book Drug Design written by Everhardus Jacobus Ariëns and published by . This book was released on 1971 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Successful Drug Discovery, Volume 1 by : János Fischer
Download or read book Successful Drug Discovery, Volume 1 written by János Fischer and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Academic Press. This book was released on 2005-01-19 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases
Book Synopsis Drug Design and Action by : Joaquín M. Campos Rosa
Download or read book Drug Design and Action written by Joaquín M. Campos Rosa and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-12-18 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: A slow and consistent study of the approaches for drug design can help the foundation for a good scientific intuition. This edition includes over 30 new illustrations, numerous new mechanistic schemes and enhanced original figures. In addition, the use of color makes its study more pleasant and impressive. The Second Edition has been thoroughly revised with a modern look. The chapters on QSAR and Drug Metabolism have been extended, emphasizing concepts, such as the hyperconjugative effect or the anomeric effect, in which the student normally finds it difficult to understand. Stereoelectronic effects are essential to explain the mechanism of action of drugs and therefore, its agile and intuitive handling will allow the student access to both chemical and biological mechanisms, in a more rational way. The text is illustrated with hundreds of formulas and many tables that facilitate the understanding of this interesting discipline, which is halfway between Organic Chemistry, Biochemistry and Pharmacology. This Volume is aimed at building basis principles on drug design and it is likely to be of interest to students reading, pharmacy, pharmacology, and pharmaceutical chemistry. This book emphasizes general principles of drug design and drug action from an organic chemical perspective, rather than from the overview of specific classes of drugs, allowing the reader to extrapolate information to many related classes of drug molecules. This volume presents an organic chemistry’s perspective of how drug are designed and assuming no prior knowledge of biochemistry, and pharmacology. It is written in an informal, clear style so that undergraduates can easily understand the concepts presented.
Book Synopsis Introduction to the Principles of Drug Design by : H. J. Smith
Download or read book Introduction to the Principles of Drug Design written by H. J. Smith and published by Elsevier. This book was released on 2016-06-14 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.
Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di
Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Book Synopsis Chemistry and Molecular Aspects of Drug Design and Action by : E. A. Rekka
Download or read book Chemistry and Molecular Aspects of Drug Design and Action written by E. A. Rekka and published by CRC Press. This book was released on 2008-04-28 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to deve
Book Synopsis Smith and Williams' Introduction to the Principles of Drug Design and Action by : H. Jphn Smith
Download or read book Smith and Williams' Introduction to the Principles of Drug Design and Action written by H. Jphn Smith and published by CRC Press. This book was released on 2005-10-10 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
Book Synopsis Textbook of Drug Design and Discovery, Third Edition by : Tommy Liljefors
Download or read book Textbook of Drug Design and Discovery, Third Edition written by Tommy Liljefors and published by CRC Press. This book was released on 2002-07-25 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.
Book Synopsis Basic Principles of Drug Discovery and Development by : Benjamin E. Blass
Download or read book Basic Principles of Drug Discovery and Development written by Benjamin E. Blass and published by Academic Press. This book was released on 2021-03-30 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry
