Drug Delivery Applications Of Noninvasive Imaging

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Drug Delivery Applications of Noninvasive Imaging

Author : Chun Li
Publisher : John Wiley & Sons
ISBN 13 : 1118356837
Total Pages : 422 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Drug Delivery Applications of Noninvasive Imaging by : Chun Li

Download or read book Drug Delivery Applications of Noninvasive Imaging written by Chun Li and published by John Wiley & Sons. This book was released on 2013-10-14 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

Pre-clinical in Vivo Studies of Parenteral Drug Delivery Systems Using Non-invasive Multispectral Fluorescence Imaging

Author : Andreas Schädlich
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (935 download)

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Book Synopsis Pre-clinical in Vivo Studies of Parenteral Drug Delivery Systems Using Non-invasive Multispectral Fluorescence Imaging by : Andreas Schädlich

Download or read book Pre-clinical in Vivo Studies of Parenteral Drug Delivery Systems Using Non-invasive Multispectral Fluorescence Imaging written by Andreas Schädlich and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pre-clinical studies; in vivo imaging; in vivo studies; optical imaging; fluorescence imaging; multispectral; parenteral; drug delivery system; nano

Handbook of Non-Invasive Drug Delivery Systems

Author : Vitthal S. Kulkarni
Publisher : Elsevier
ISBN 13 : 0815520263
Total Pages : 328 pages
Book Rating : 4.8/5 (155 download)

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Book Synopsis Handbook of Non-Invasive Drug Delivery Systems by : Vitthal S. Kulkarni

Download or read book Handbook of Non-Invasive Drug Delivery Systems written by Vitthal S. Kulkarni and published by Elsevier. This book was released on 2009-12-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.

Nanomedicine for Deep-Tissue High-Resolution Bio-Imaging and Non-Invasive Therapy

Author : Michael Ming-Yuan Wei
Publisher : Frontiers Media SA
ISBN 13 : 288966113X
Total Pages : 223 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Nanomedicine for Deep-Tissue High-Resolution Bio-Imaging and Non-Invasive Therapy by : Michael Ming-Yuan Wei

Download or read book Nanomedicine for Deep-Tissue High-Resolution Bio-Imaging and Non-Invasive Therapy written by Michael Ming-Yuan Wei and published by Frontiers Media SA. This book was released on 2020-11-12 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr Ming-Yuan Wei currently holds a pending U.S. Patent Application entitled “Systems and Methods for High-Resolution Imaging”. All other Guest Editors have no other competing interests to declare with regards to the Topic subject.

Magnetic Nanoparticles in Human Health and Medicine

Author : Costica Caizer
Publisher : John Wiley & Sons
ISBN 13 : 1119754674
Total Pages : 516 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Magnetic Nanoparticles in Human Health and Medicine by : Costica Caizer

Download or read book Magnetic Nanoparticles in Human Health and Medicine written by Costica Caizer and published by John Wiley & Sons. This book was released on 2021-11-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

Non-Invasive Monitoring of Transdermal Drug Delivery

Author : Pasquale Arpaia
Publisher : CRC Press
ISBN 13 : 1000544850
Total Pages : 192 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Non-Invasive Monitoring of Transdermal Drug Delivery by : Pasquale Arpaia

Download or read book Non-Invasive Monitoring of Transdermal Drug Delivery written by Pasquale Arpaia and published by CRC Press. This book was released on 2022-03-23 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging

Author : Dara L. Kraitchman
Publisher : CRC Press
ISBN 13 : 1439807523
Total Pages : 473 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging by : Dara L. Kraitchman

Download or read book Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging written by Dara L. Kraitchman and published by CRC Press. This book was released on 2011-11-18 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging provides a comprehensive overview of cell therapy imaging, ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. It emphasizes the use of medical imaging for therapeutic delivery/targeting, cell tracking, and det

Non-Invasive Monitoring of Transdermal Drug Delivery

Author : Pasquale Arpaia
Publisher : CRC Press
ISBN 13 : 1000544842
Total Pages : 203 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Non-Invasive Monitoring of Transdermal Drug Delivery by : Pasquale Arpaia

Download or read book Non-Invasive Monitoring of Transdermal Drug Delivery written by Pasquale Arpaia and published by CRC Press. This book was released on 2022-03-23 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Author : Kakoli Bose
Publisher : Springer Nature
ISBN 13 : 9813298162
Total Pages : 587 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach by : Kakoli Bose

Download or read book Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach written by Kakoli Bose and published by Springer Nature. This book was released on 2019-11-25 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.

Pre-clinical in Vivo Studies of Parenteral Drug Delivery Systems Using Non-invasive Multispectral Fluorescence Imaging

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (935 download)

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Book Synopsis Pre-clinical in Vivo Studies of Parenteral Drug Delivery Systems Using Non-invasive Multispectral Fluorescence Imaging by :

Download or read book Pre-clinical in Vivo Studies of Parenteral Drug Delivery Systems Using Non-invasive Multispectral Fluorescence Imaging written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Pre-clinical studies; in vivo imaging; in vivo studies; optical imaging; fluorescence imaging; multispectral; parenteral; drug delivery system; nano

Image-guided Therapy, Surgery, and Drug Delivery

Author : Keyvan Farahani
Publisher :
ISBN 13 : 9781498764896
Total Pages : pages
Book Rating : 4.7/5 (648 download)

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Book Synopsis Image-guided Therapy, Surgery, and Drug Delivery by : Keyvan Farahani

Download or read book Image-guided Therapy, Surgery, and Drug Delivery written by Keyvan Farahani and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Potentials and Perspectives of Ultrasound Responsive Drug Delivery System

Author : Winwar Study Expert
Publisher : Independently Published
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.3/5 (564 download)

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Book Synopsis Potentials and Perspectives of Ultrasound Responsive Drug Delivery System by : Winwar Study Expert

Download or read book Potentials and Perspectives of Ultrasound Responsive Drug Delivery System written by Winwar Study Expert and published by Independently Published. This book was released on 2022-10-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound is a multi-directional and cost-effective technique used in various clinical applications because of the wide-ranging interactions with biological systems. It has been used in diagnostic imaging for more than 50 years, until continuing its progress in the development of real-time, three-dimensional (3-D) systems, and functional imaging techniques. It is a noninvasive, nonionizing technology that can be designed in versatile device of configurations, enabling its use for a multiple applications. Different approaches of URDDS include microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles are clinically used in different types of ailments. However, the development of microbubbles contrast agents has opened many new opportunities, including new functional imaging, and the possibility of molecular targeting.

Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications

Author : Wing-Fu Lai
Publisher : Springer Nature
ISBN 13 : 3030544907
Total Pages : 511 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications by : Wing-Fu Lai

Download or read book Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications written by Wing-Fu Lai and published by Springer Nature. This book was released on 2020-10-19 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.

Nanotheranostics for Cancer Applications

Author : Prakash Rai
Publisher : Springer
ISBN 13 : 3030017753
Total Pages : 484 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Nanotheranostics for Cancer Applications by : Prakash Rai

Download or read book Nanotheranostics for Cancer Applications written by Prakash Rai and published by Springer. This book was released on 2018-11-12 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.

Magnetic Particle Imaging

Author : Tobias Knopp
Publisher : Springer Science & Business Media
ISBN 13 : 364204199X
Total Pages : 211 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Magnetic Particle Imaging by : Tobias Knopp

Download or read book Magnetic Particle Imaging written by Tobias Knopp and published by Springer Science & Business Media. This book was released on 2012-05-04 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.

Neuroimaging in Addiction

Author : Bryon Adinoff
Publisher : John Wiley & Sons
ISBN 13 : 1119972701
Total Pages : 539 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Neuroimaging in Addiction by : Bryon Adinoff

Download or read book Neuroimaging in Addiction written by Bryon Adinoff and published by John Wiley & Sons. This book was released on 2011-11-02 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimaging in Addiction presents an up-to-date, comprehensive review of the functional and structural imaging human studies that have greatly advanced our understanding of this complex disorder. Approaching addiction from a conceptual rather than a substance-specific perspective, this book integrates broad neuropsychological constructs that consider addiction as a neuroplastic process with genetic, developmental, and substance-induced contributions. The internationally recognized contributors to this volume are leaders in clinical imaging with expertise that spans the addiction spectrum. Following a general introduction, an overview of neural circuitry and modern non-invasive imaging techniques provides the framework for subsequent chapters on reward salience, craving, stress, impulsivity and cognition. Additional topics include the use of neuroimaging for the assessment of acute drug effects, drug-induced neurotoxicity, non-substance addictive behaviors, and the application of imaging genetics to identify unique intermediate phenotypes. The book concludes with an exploration of the future promise for functional imaging as guide to the diagnosis and treatment of addictive disorders. Scientists and clinicians will find the material in this volume invaluable in their work towards understanding the addicted brain, with the overall goal of improved prevention and treatment outcomes for patients. Features a Foreword by Edythe London, Director of the Center for Addictive Behaviors, University of California at Los Angeles.

Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors

Author : Karel Pacak
Publisher : Humana Press
ISBN 13 : 3319460382
Total Pages : 483 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors by : Karel Pacak

Download or read book Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors written by Karel Pacak and published by Humana Press. This book was released on 2016-12-26 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists, nuclear physicians, oncologists, surgeons, physicists, radio-pharmacists and geneticists. It begins with the embryology, classification and molecular genetics of gastroenteropancreatic neuroendocrine tumors and carcinoids, chromaffin cell tumors, and MEN1- and MEN2-related tumors. Following a chapter on radiopharmaceuticals in neuroendocrine imaging, it turns to the physics and technology of current and cutting-edge radiology, including SPECT/CT and PET/CT and PET/MR. Discussing of radionuclide imaging covers the tumors mentioned above, as well as pulmonary and thymic neuroendocrine tumors and medullary thyroid carcinoma. A presentation of radionuclide therapies follows, including 131I-MIBG therapy, somatostatin receptor-based therapy, and alpha radionuclide therapy, as well as the role of nanoparticles. Comprehensive and up-to-date, Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors will assist and guide physicians who encounter patients with these conditions, either from a diagnostic or therapeutic standpoint, and particularly emphasizes the current and emerging medical devices and imaging and therapeutic options.