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Drosphila Zinc Finger Protein Schnurri Recruits Multiple Transcriptional Corepressors To Repress Transcription
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Book Synopsis Drosphila Zinc Finger Protein Schnurri Recruits Multiple Transcriptional Corepressors to Repress Transcription by : Yi Cai
Download or read book Drosphila Zinc Finger Protein Schnurri Recruits Multiple Transcriptional Corepressors to Repress Transcription written by Yi Cai and published by . This book was released on 2007 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Zinc Finger Proteins by : Shiro Iuchi
Download or read book Zinc Finger Proteins written by Shiro Iuchi and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.
Book Synopsis Principles of Bone Regeneration by : Jona J. Sela
Download or read book Principles of Bone Regeneration written by Jona J. Sela and published by Springer Science & Business Media. This book was released on 2012-03-13 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions. Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.
Book Synopsis Inborn Errors of Development by : Charles J. Epstein
Download or read book Inborn Errors of Development written by Charles J. Epstein and published by Oxford University Press, USA. This book was released on 2004 with total page 1110 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
Book Synopsis Stem Cell Biology by : Daniel R. Marshak
Download or read book Stem Cell Biology written by Daniel R. Marshak and published by CSHL Press. This book was released on 2001 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells are the focus of intense interest from a growing, multidisciplinary community of investigators with new tools for isolating and characterizing these elusive cell types. This volume, which features contributions from many of the world's leading laboratories, provides a uniquely broad and authoritative basis for understanding the biology of stem cells and the current excitement about their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their collaborators in the emerging field of regenerative medicine.
Book Synopsis Invertebrate Cytokines and the Phylogeny of Immunity by : Alain Beschin
Download or read book Invertebrate Cytokines and the Phylogeny of Immunity written by Alain Beschin and published by Springer. This book was released on 2012-11-22 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated. In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2001 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Physical Basis of Heredity by : Thomas Hunt Morgan
Download or read book The Physical Basis of Heredity written by Thomas Hunt Morgan and published by . This book was released on 1919 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tgf-beta Family written by Rik Derynck and published by . This book was released on 2017-04-30 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Members of the transforming growth factor β (TGFβ) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. This book provides a comprehensive view of the different members of the TGFβ family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer"--
Download or read book Unraveled written by Emily Regan and published by . This book was released on 2011-10 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this collection, Unraveled, Emily Regan has spanned the generations, from the very young to the very old, to present characters in the midst of loss. Again and again, her characters' tethers are coming loose, and even breaking, sending some adrift, while others try to find their grasp once more. The losses in some of these stories are devastating because they mostly deal with a loved one's leaving, either intentionally or unintentionally. In our time, to lose something is nothing new: a job, a foreclosed house, or a repossessed car. But Regan delves into how the psyche responds to the real emotional extremes of loss. The death of a loved one is life changing. But when a character simply leaves out of selfishness or self-preservation, abandoning a child out in the yard on a swing set, the ramification can be life destroying.Some of these stories I've read in earlier incarnations and some are new to me, as they will be to the fortunate readers of this collection. "Squirrels" shows a widow becoming undone, heralding the end of her freedom of living alone. Her longing for her dead husband has driven her to attack, in funny and crazed ways, an unseen army of squirrels. She is convinced the squirrels want her out of her house. But her real evictor, her daughter, is more difficult to conquer. In "Visiting Day" we witness a vital elderly woman, who is strong and confident at the start, lose her way. All because the old sometimes have a way of reverting to acting like school children, and the simple action of sitting down at a table can have debilitating consequences. "Mirror, Mirror" is a nice reboot of a fairy tale, but there is no happily ever after for Mariella. The flash fiction, "Five", is one of my favorites in this collection. Regan is pitch-perfect in showing, through actions and dialogue, this emotional moment. A young child's birthday is set aside because of a down deep hurt. And more escapes ensue.In the longest piece in this collection, "Loose Threads", Anne navigates through the coming apart of her family after the death of her brother. Addictions sever the many ties between characters throughout this novella: from drugs, to abusive relationships, to victimization. In the end, though, there comes finally a kind of redemption by way of a baby's birth. Anne is reconnecting with a tether that may bring her back to where she deserves to be.This is Emily Regan's first book. And I'm certain it will not be her last. She has done something here that calls for attention. She has opened familiar wounds that we need to consider, but will not be able to readily heal. And, as many of us may admit, sometimes running away from what hurts us seems the easiest way out. Although, I must acknowledge that Regan, once a student of mine, is now instructing me with her wonderful writing and vivid characters that easiest may work for a moment, but the many moments, days, weeks, and years that follow tend to have a way of making life more and more difficult. Good writing, in my opinion, should present this outcome, and Emily Regan is a very good writer.-- Dan Crawley (from the Preface)
Book Synopsis Arteriogenesis by : Wolfgang Schaper
Download or read book Arteriogenesis written by Wolfgang Schaper and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizes the research activities of Germany’s Nauheim Institute of the Max Planck Society and its group of investigators both past and present, in the field of collateral artery growth. Incorporates a multidisciplinary in vivo approach to the study of arteriogenesis that includes molecular approaches with classical physiology and immunohistochemistry. Full color throughout and well illustrated.
Book Synopsis Smad Signal Transduction by : Peter Dijke
Download or read book Smad Signal Transduction written by Peter Dijke and published by Springer Science & Business Media. This book was released on 2007-05-10 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.
Book Synopsis Stem Cells Handbook by : Stewart Sell
Download or read book Stem Cells Handbook written by Stewart Sell and published by Springer Science & Business Media. This book was released on 2013-08-16 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.
Book Synopsis Crusader's Cross by : James Lee Burke
Download or read book Crusader's Cross written by James Lee Burke and published by Simon and Schuster. This book was released on 2006-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: After hearing an old schoolmate's deathbed confession, Dave Robicheaux searches for a prostitute with ties to the mob that he had met decades earlier, an endeavor that proves dangerous in the wake of a series of murders.
Book Synopsis Chromatin Signaling and Diseases by : Olivier Binda
Download or read book Chromatin Signaling and Diseases written by Olivier Binda and published by Academic Press. This book was released on 2016-08-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling
Book Synopsis Bone Diseases by : Claus-Peter Adler
Download or read book Bone Diseases written by Claus-Peter Adler and published by Springer Science & Business Media. This book was released on 1999-12-09 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive description of macroscopic, microscopic, and radiological methods for the diagnosis of bone diseases. The book presents all the procedures involved in diagnosis, using not only radiological and histological techniques, but also modern immunohistochemical and scintigraphic methods. Succinct and well-structured therapeutic recommendations are provided for an array of bone diseases, making this a practice-oriented reference work for pathologists, radiologists, rheumatologists, and orthopedists.
Book Synopsis Genetics of Bone Biology and Skeletal Disease by : Rajesh V. Thakker
Download or read book Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker and published by Academic Press. This book was released on 2017-10-31 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
