Dopamine Receptor Subtypes

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Author :
Publisher : IOS Press
ISBN 13 : 9789051992915
Total Pages : 200 pages
Book Rating : 4.9/5 (929 download)

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Book Synopsis Dopamine Receptor Subtypes by : Peter Jenner

Download or read book Dopamine Receptor Subtypes written by Peter Jenner and published by IOS Press. This book was released on 1998 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple subtypes of dopamine receptors exist in the brain. This volume reviews the characteristics of D-1, D-2, D-3 and D-4 receptors and describes the current concepts of their involvement in motor disorders and in the control of schizophrenia. Readers: the book will be of great interest to professionals in pharmacology, medicinal chemistry, neuroscience, cell biology and therapeutic applications in clinical medicine as antipsychotics, anti-Parkinson's disease and related areas.

Encyclopedia of Movement Disorders

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Author :
Publisher : Academic Press
ISBN 13 : 012374105X
Total Pages : 1633 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Encyclopedia of Movement Disorders by :

Download or read book Encyclopedia of Movement Disorders written by and published by Academic Press. This book was released on 2010-02-26 with total page 1633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Movement Disorders is a comprehensive reference work on movement disorders, encompassing a wide variety of topics in neurology, neurosurgery, psychiatry and pharmacology. This compilation will feature more than 300 focused entries, including sections on different disease states, pathophysiology, epidemiology, genetics, clinical presentation, diagnostic tools, as well as discussions on relevant basic science topics. This Encyclopedia is an essential addition to any collection, written to be accessible for both the clinical and non-clinical reader. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in the laboratory to the clinical features, pathophysiology and treatment of movement disorders. The Encyclopedia targets a broad readership, ranging from students to general physicians, basic scientists and Movement Disorder specialists. Published both in print and via Elsevier’s online platform of Science Direct, this Encyclopedia will have the enhanced option of integrating traditional print with online multimedia. Connects experimental findings made in the laboratory to the clinical features, pathophysiology, and treatment of movement disorders Encompasses a wide variety of topics in neurology neurosurgery, psychiatry, and pharmacology Written for a broad readership ranging from students to general physicians, basic scientists, and movement disorder specialists

Dopamine in the CNS I

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642560512
Total Pages : 355 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Dopamine in the CNS I by : Gaetano Di Chiara

Download or read book Dopamine in the CNS I written by Gaetano Di Chiara and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Biology of the NMDA Receptor

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Author :
Publisher : CRC Press
ISBN 13 : 142004415X
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

Dopamine Receptors and Transporters

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Author :
Publisher : CRC Press
ISBN 13 : 0824747429
Total Pages : 663 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Dopamine Receptors and Transporters by : Anita Sidhu

Download or read book Dopamine Receptors and Transporters written by Anita Sidhu and published by CRC Press. This book was released on 2003-01-31 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management."

Receptor-Receptor Interactions

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468454153
Total Pages : 577 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Receptor-Receptor Interactions by : Kjell Fuxe

Download or read book Receptor-Receptor Interactions written by Kjell Fuxe and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Dopamine Receptors

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 147572635X
Total Pages : 555 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis The Dopamine Receptors by : Kim Neve

Download or read book The Dopamine Receptors written by Kim Neve and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seven years after the cloning of the rat dopamine D receptor, and four 2 years after the cloning of the last mammalian dopamine receptor identified to date, this seems to be an excellent time to put together the present The Dopamine Receptors volume ofthis series, The Receptors. There has been time for considerable characterization of the novel receptor subtypes, and new, exciting lines of research from the molecular to the behavioral levels are taking shape. We asked the contributors to The Dopamine Receptors to follow the superb example set by the previous volumes in this series by writing compre hensive, historical reviews that will comprise an essential resource for nonspe cialists and newcomers to the dopamine receptor field, while at the same time providing up-to-date summaries of the most active areas of research. It is difficult these days to write about receptors without addressing the issue of receptor nomenclature. For dopamine receptors, valid arguments can be made for a system in which the subtypes are classified as belonging to the Dl or D2 classes, with letters assigned in the order of cloning (D A, D , D A, 1 18 2 D , Dc). We decided, however, that common usage counts for something, and 28 2 chose to use D , D , and D for the D2-like receptors because these names are 2 3 4 nearly unanimously used in the literature.

Dopamine Receptors and Transporters

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Author :
Publisher : CRC Press
ISBN 13 :
Total Pages : 720 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Dopamine Receptors and Transporters by : Hyman B. Niznik

Download or read book Dopamine Receptors and Transporters written by Hyman B. Niznik and published by CRC Press. This book was released on 1994 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management."

Successful Drug Discovery, Volume 4

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527344683
Total Pages : 270 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Successful Drug Discovery, Volume 4 by : J¿nos Fischer

Download or read book Successful Drug Discovery, Volume 4 written by J¿nos Fischer and published by John Wiley & Sons. This book was released on 2019-11-11 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort. Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more. -Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2 -Features personal experiences of successful drug developers from industry and academia -Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.

Central D1 Dopamine Receptors

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Author :
Publisher : Springer
ISBN 13 : 1489927239
Total Pages : 184 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Central D1 Dopamine Receptors by : M. J. Goldstein

Download or read book Central D1 Dopamine Receptors written by M. J. Goldstein and published by Springer. This book was released on 2013-11-21 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.

Serotonin Receptors in Neurobiology

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Author :
Publisher : CRC Press
ISBN 13 : 1420005758
Total Pages : 230 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Serotonin Receptors in Neurobiology by : Amitabha Chattopadhyay

Download or read book Serotonin Receptors in Neurobiology written by Amitabha Chattopadhyay and published by CRC Press. This book was released on 2007-05-17 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l

Neurobiology of Central D1-Dopamine Receptors

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 146845191X
Total Pages : 223 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Neurobiology of Central D1-Dopamine Receptors by : George Breese

Download or read book Neurobiology of Central D1-Dopamine Receptors written by George Breese and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.

Peripheral Dopamine Pathophysiology

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Author :
Publisher : CRC Press
ISBN 13 : 1000013138
Total Pages : 492 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Peripheral Dopamine Pathophysiology by : Francesco Amenta

Download or read book Peripheral Dopamine Pathophysiology written by Francesco Amenta and published by CRC Press. This book was released on 2019-06-04 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1989, this book offers a full, comprehensive guide into the role of Dopamine in the Periphery. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.

Primer on the Autonomic Nervous System

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Author :
Publisher : Elsevier
ISBN 13 : 0080473962
Total Pages : 489 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Primer on the Autonomic Nervous System by : Phillip A. Low

Download or read book Primer on the Autonomic Nervous System written by Phillip A. Low and published by Elsevier. This book was released on 2004-06-02 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist's bookshelf! - Greatly amplified and updated from previous edition including the latest developments in the field of autonomic cardiovascular regulation and neuroscience - Provides key information about all aspects of autonomic physiology and pathology - Discusses stress and how its effects on the body are mediated - Compiles contributions by over 140 experts on the autonomic nervous system

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

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Author :
Publisher : National Academies Press
ISBN 13 : 0309212219
Total Pages : 74 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Medical Biochemistry

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Publisher : Academic Press
ISBN 13 : 0120954400
Total Pages : 1068 pages
Book Rating : 4.1/5 (29 download)

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Book Synopsis Medical Biochemistry by : N. V. Bhagavan

Download or read book Medical Biochemistry written by N. V. Bhagavan and published by Academic Press. This book was released on 2002 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the fundamentals of biochemistry and related topics for all those pursuing medical or other health-related fields such as clinical chemistry, medical technology, or pharmacology.

Peripheral Actions of Dopamine

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Author :
Publisher :
ISBN 13 : 9780333441312
Total Pages : 227 pages
Book Rating : 4.4/5 (413 download)

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Book Synopsis Peripheral Actions of Dopamine by : Christopher Bell

Download or read book Peripheral Actions of Dopamine written by Christopher Bell and published by . This book was released on 1988 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proceedings of a Satellite Symposium of the 9th IUPHAR congress in 1987, this work reviews three main areas concerning the actions and significance of dopamine in the periphery: current research, sources and effects, classification and distribution.