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Discovery Of Novel G Protein Coupled Receptor Genes Including Human Galr3 Receptor Gene
Download Discovery Of Novel G Protein Coupled Receptor Genes Including Human Galr3 Receptor Gene full books in PDF, epub, and Kindle. Read online Discovery Of Novel G Protein Coupled Receptor Genes Including Human Galr3 Receptor Gene ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Download or read book Galanin written by Tomas Hökfelt and published by Springer Science & Business Media. This book was released on 2010-08-18 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.
Book Synopsis Fmoc Solid Phase Peptide Synthesis by : W. Chan
Download or read book Fmoc Solid Phase Peptide Synthesis written by W. Chan and published by OUP Oxford. This book was released on 1999-12-16 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1808 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Comparative Survey of the RF-amide Peptide Superfamily by : Karine Rousseau
Download or read book A Comparative Survey of the RF-amide Peptide Superfamily written by Karine Rousseau and published by Frontiers Media SA. This book was released on 2015-12-16 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery, twelve years ago, that the RF-amide peptide kisspeptin, acting via GPR54, is essential for the onset of puberty and reproduction, has been a major breakthrough in reproductive physiology. It has also put in front of the spotlights RF-amide peptides and allowed to revive research on this superfamily. The first member of this family to be characterized, in 1977, was the cardioexcitatory peptide, FMRFamide, isolated from the ganglia of the clam Macrocallista nimbosa. Since then, a large number of these peptides, designated after their C-terminal arginine (R) and amidated phenylalaline (F) residues, have been identified in representative species of all major phyla. By means of phylogenetic analyses, the superfamily of RFamide peptides has been divided into five families in vertebrates: kisspeptin, QFRP (including 26RFa), LPXRFa (including GnIH and RFRP), PQRFa (including NPFF) and PrRP. Recent data reveal that SIFamide-type neuropeptides in protostomian invertebrates and SALMFamide-type neuropeptides in deuterostomian invertebrates share a common evolutionary origin with vertebrate LPXRFa and PQRFa. Interestingly, in invertebrates as in vertebrates, multiple genes, as well as multiple mature peptides, are often present in a single species, questioning the need for such diversity in term of function. Comparative studies on non-mammalian vertebrates and invertebrates allow major advances in the knowledge of the evolutionary history of the RF-amide peptide superfamily. Such phylogenetical studies also contribute to improve classification and nomenclature of both peptides and receptors. RF-amide peptides from different families have major evolutionary conserved roles in the control of reproduction, but also of food intake, metabolism, energy expenditure, cardiovascular function, nociception and stress. They are also involved in the integration of environmental signals, notably the photoperiod, to regulate reproduction. For instance, in most vertebrate species and especially in seasonal mammals, kisspeptin and GnIH/RFRP have complementary but opposite effects in the control of reproductive function. In addition, recent data show cross-activities between the members of the RF-amide peptide superfamily and their receptors. For example, PrRP, kisspeptin and 26RFa are able to modulate nociception via NPFF receptors. Comparative studies have the potential to reveal novel regulatory mechanisms that could give a better comprehension of physiological functions and lead to new therapeutic treatments for related human pathologies. Thus, kisspeptin antagonists have been developed as novel tools for treatment of hormone-dependent disorders of reproduction such as precocious puberty and endometriosis or kisspeptin agonists for treatment of infertility, in humans. Studies on lower vertebrate models can also contribute to the discovery of new roles of these peptides, as seen recently with kisspeptin being involved in the early development of the medaka. This research topic will aim at gathering major advances achieved through comparative studies in (mammalian and non-mammalian) vertebrates and invertebrates, in the knowledge of RF-amide peptides in term of evolutionary history and physiological roles.
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2540 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Sturkie's Avian Physiology by : Colin G. Scanes
Download or read book Sturkie's Avian Physiology written by Colin G. Scanes and published by Elsevier. This book was released on 2014-06-30 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sturkie's Avian Physiology is the classic comprehensive single volume on the physiology of domestic as well as wild birds. The Sixth Edition is thoroughly revised and updated, and features several new chapters with entirely new content on such topics as migration, genomics and epigenetics. Chapters throughout have been greatly expanded due to the many recent advances in the field. The text also covers the physiology of flight, reproduction in both male and female birds, and the immunophysiology of birds. The Sixth Edition, like the earlier editions, is a must for anyone interested in comparative physiology, poultry science, veterinary medicine, and related fields. This volume establishes the standard for those who need the latest and best information on the physiology of birds. - Includes new chapters on endocrine disruptors, magnetoreception, genomics, proteomics, mitochondria, control of food intake, molting, stress, the avian endocrine system, bone, the metabolic demands of migration, behavior and control of body temperature - Features extensively revised chapters on the cardiovascular system, pancreatic hormones, respiration, pineal gland, pituitary gland, thyroid, adrenal gland, muscle, gastro-intestinal physiology, incubation, circadian rhythms, annual cycles, flight, the avian immune system, embryo physiology and control of calcium - Stands out as the only comprehensive, single volume devoted to bird physiology - Offers a full consideration of both blood and avian metabolism on the companion website (http://booksite.elsevier.com/ 9780124071605). Tables feature hematological and serum biochemical parameters together with circulating concentrations of glucose in more than 200 different species of wild birds
Book Synopsis Receptor-Receptor Interactions by : Kjell Fuxe
Download or read book Receptor-Receptor Interactions written by Kjell Fuxe and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Biologically Active Peptides by : Abba Kastin
Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Elsevier. This book was released on 2011-04-28 with total page 1682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Book Synopsis Handbook of Stress and the Brain Part 1: The Neurobiology of Stress by : Thomas Steckler
Download or read book Handbook of Stress and the Brain Part 1: The Neurobiology of Stress written by Thomas Steckler and published by Elsevier. This book was released on 2005-03-24 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry. Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality. * Provides an overview of recent advances made in stress research * Includes timely discussion of stress and its effect on the immune system * Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanisms
Book Synopsis Pharmacoepigenetics by : Ramón Cacabelos
Download or read book Pharmacoepigenetics written by Ramón Cacabelos and published by Academic Press. This book was released on 2019-06-04 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. - Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development - Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry - Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety - Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine
Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Download or read book Genetics Abstracts written by and published by . This book was released on 1998 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genes, brain, and emotions by : Andrei C. Miu
Download or read book Genes, brain, and emotions written by Andrei C. Miu and published by Oxford University Press. This book was released on 2019-04-04 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of emotions has rapidly expanded in recent decades, incorporating interdisciplinary research on the genetic underpinnings and neural mechanisms of emotion. This has involved a wide range of methods from as varied fields as behavioral genetics, molecular biology, and cognitive neuroscience, and has allowed researchers to start addressing complex multi-level questions such as: what is the role of genes in individual differences in emotions and emotional vulnerability to psychopathology, and what are the neural mechanisms through which genes and experience shape these emotion? Genes, Brain, and Emotions: Interdisciplinary and translational perspectives offers a comprehensive account of this interdisciplinary field of research, bridging psychology, genetics, and neuroscience, with rich sections dedicated to methods, cognitive and biological mechanisms, and psychopathology. Written by leading researchers who have each inspired new research directions and innovated methods and concepts, this book will be of interest to anyone working or studying in the field of affective science, whether they be behavioural geneticists, psychologists and psychiatrists, or cognitive neuroscientists.
Book Synopsis Leptin and Reproduction by : Michael C. Henson
Download or read book Leptin and Reproduction written by Michael C. Henson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The isolation of leptin in 1994 and its characterization as a factor influencing appetite, energy balance, and adiposity, immediately thrust the polypeptide into the rapidly growing body of literature centered on the physiology of obesity. The growing clinical awareness of obesity as a major health risk in developed societies dovetailed perfectly with any of a number of roles that leptin might play in this abenant physiological condition. Almost unnoticed amidst the excitement generated by early leptin publications was the suggestion that the "fat hormone" might also regulate a wide range of systems and events important to reproduction, including pubertal development, gonadal endocrinology, fettility, and pregnancy. Recognizing this potential, a relatively small cadre of researchers began to examine leptin specifically as a reproductive hormone, thus creating a new and fertile field of investigation. Interest in this area has since gained momentum and an increased number of participants have now made significant contributions to our understanding of many leptin-related mechanisms that are relevant to reproductive biology. Leptin and Reproduction is the first major volume to specifically address leptin as a reproductive hormone and closely examines the advances made in the short time since this field of interest developed. Preeminent researchers ti'om many of the subdisciplines working within this area present a welcomed compendium of the wealth of related literature and voice novel interpretations of cun'ent advances.
Book Synopsis Pain and Neurogenic Inflammation by : Susan Brain
Download or read book Pain and Neurogenic Inflammation written by Susan Brain and published by Springer Science & Business Media. This book was released on 1999 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is intended to bring together recent advances in the often separate fields of pain and neurogenic inflammation. To this end, eminent researchers from both domains have contributed in-depth discussion of the mechanisms underlying these processes. Individual chapters focus on important recent discoveries such as the cloning of the capsaicin receptor and the discovery of RAMP proteins for CGRP receptors. This book provides an integrated account of recent advances in the fields of pain and neurogenic inflammation. The volume is intended to bring together studies from eminent researchers in the often separate research fields of pain and inflammation. "Pain and Neurogenic Inflammation" is aimed primarily at postgraduate researchers as well as academic and industrial researchers in pain and inflammation but is also likely to be of interest to undergraduate students seeking a firm grounding in the mechanisms underlying these important clinical conditions.
Book Synopsis Oxidative Stress and Neurodegenerative Disorders by : G. Ali Qureshi
Download or read book Oxidative Stress and Neurodegenerative Disorders written by G. Ali Qureshi and published by Elsevier. This book was released on 2007-03-22 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Book Synopsis Frontiers in Psychiatry by : Yong-Ku Kim
Download or read book Frontiers in Psychiatry written by Yong-Ku Kim and published by Springer Nature. This book was released on 2019-11-09 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews key recent advances and new frontiers within psychiatric research and clinical practice. These advances either represent or are enabling paradigm shifts in the discipline and are influencing how we observe, derive and test hypotheses, and intervene. Progress in information technology is allowing the collection of scattered, fragmented data and the discovery of hidden meanings from stored data, and the impacts on psychiatry are fully explored. Detailed attention is also paid to the applications of artificial intelligence, machine learning, and data science technology in psychiatry and to their role in the development of new hypotheses, which in turn promise to lead to new discoveries and treatments. Emerging research methods for precision medicine are discussed, as are a variety of novel theoretical frameworks for research, such as theoretical psychiatry, the developmental approach to the definition of psychopathology, and the theory of constructed emotion. The concluding section considers novel interventions and treatment avenues, including psychobiotics, the use of neuromodulation to augment cognitive control of emotion, and the role of the telomere-telomerase system in psychopharmacological interventions.
