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Author : Michael Charles Konopka
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (89 download)
Download or read book Diffusion in Crowded Environment of Live Cells written by Michael Charles Konopka and published by . This book was released on 2006 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Apratim Dhar
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (774 download)
Download or read book Protein Folding in Crowded Environments and Living Cells written by Apratim Dhar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomolecular dynamics and stability are predominantly investigated in vitro, and extrapolated to explain function in the living cell. In this thesis, we attempt to bridge this divide by performing studies of protein folding in in vitro crowded environments and in living cells. We begin by investigating the thermodynamic and kinetic behavior of the proteins in protein/carbohydrate matrices, and find significant differences compared to dilute, buffer solutions. We then develop Fast Relaxation Imaging (FReI) as a novel imaging technique to investigate protein folding dynamics inside living cells with millisecond temporal resolution and micrometer spatial resolution. We study the folding of the metabolic enzyme phosphoglycerate kinase (PGK) in U2OS (human osteosarcoma) cells and observe variations in folding kinetics within a single cell. FReI experiments carried out on an ensemble of 30 cells reveal large variations in folding time from cell to cell, which are analyzed to estimate the folding diffusion coefficient in vivo. Finally, we use short peptide tags to target PGK to the nucleus and endoplasmic reticulum of live cells and discern differential folding stability and kinetics in these organelles compared to protein folding in the cytoplasm.
Author : Luiz Roberto Evangelista
Publisher : Springer Nature
ISBN 13 : 3031181506
Total Pages : 411 pages
Book Rating : 4.0/5 (311 download)
Download or read book An Introduction to Anomalous Diffusion and Relaxation written by Luiz Roberto Evangelista and published by Springer Nature. This book was released on 2023-01-01 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a contemporary treatment of the problems related to anomalous diffusion and anomalous relaxation. It collects and promotes unprecedented applications dealing with diffusion problems and surface effects, adsorption-desorption phenomena, memory effects, reaction-diffusion equations, and relaxation in constrained structures of classical and quantum processes. The topics covered by the book are of current interest and comprehensive range, including concepts in diffusion and stochastic physics, random walks, and elements of fractional calculus. They are accompanied by a detailed exposition of the mathematical techniques intended to serve the reader as a tool to handle modern boundary value problems. This self-contained text can be used as a reference source for graduates and researchers working in applied mathematics, physics of complex systems and fluids, condensed matter physics, statistical physics, chemistry, chemical and electrical engineering, biology, and many others.
Author : Ron Milo
Publisher : Garland Science
ISBN 13 : 1317230698
Total Pages : 400 pages
Book Rating : 4.3/5 (172 download)
Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
Author : Alexander Shekhtman
Publisher :
ISBN 13 : 9783039282555
Total Pages : 152 pages
Book Rating : 4.2/5 (825 download)
Download or read book In-Cell NMR Spectroscopy: Biomolecular Structure and Function written by Alexander Shekhtman and published by . This book was released on 2020 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.].
Author :
Publisher : Academic Press
ISBN 13 : 0123918693
Total Pages : 573 pages
Book Rating : 4.1/5 (239 download)
Download or read book Imaging and Spectroscopic Analysis of Living Cells written by and published by Academic Press. This book was released on 2012-01-25 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology is the first of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. - Expert authors who are leaders in the field - Extensively referenced and useful figures and tables - Provides hints and tricks to facilitate reproduction of methods
Author : Swomitra Palit
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (131 download)
Download or read book Macromolecular Dynamics and Structure in Crowded and Confined Environments written by Swomitra Palit and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Macromolecular crowding and confinement, the effects caused by high concentrations of macromolecules in solution and/or in small compartments, are believed to influence diffusion processes, intermolecular interactions, protein folding, and intracellular transport in living cells. Understanding mechanisms of transport in biological systems (such as living cells) is complex and challenging. We construct cell mimetic environments in which the artificial macromolecules (e.g. polyethylene glycol, Ficoll70) are compartmentalized not in cells but in concentrated environments and agarose gel networks. In this work we have established a system to generate stable and monodisperse droplets of hierarchical confinement. The goal of this study is to measure translational diffusion in crowded and confined geometries of varying concentrations of different macromolecules on diffusion. We have combined the use of pulsed-fieldgradient nuclear magnetic resonance (PFG NMR) with small-angle neutron scattering (SANS) in order to obtain new insights in simple model systems of macromolecular crowding. The NMR and SANS techniques complement each other. Using PFG NMR technique, we have monitored the dynamics of synthetic macromolecules with multiple chemical components in complex environments. SANS, on the other hand, yields structure (size) of macromolecules. Our experimental findings in cell mimetic environments provide an important step towards gaining further insights into the effects of macromolecular crowding on diffusion and conformation.
Author : Yutaka Ito
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160934
Total Pages : 322 pages
Book Rating : 4.8/5 (391 download)
Download or read book In-cell NMR Spectroscopy written by Yutaka Ito and published by Royal Society of Chemistry. This book was released on 2019-12-09 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-cell NMR spectroscopy is a relatively new field. Despite its short history, recent in-cell NMR-related publications in major journals indicate that this method is receiving significant general attention. This book provides the first informative work specifically focused on in-cell NMR. It details the historical background of in-cell NMR, host cells for in-cell NMR studies, methods for in-cell biological techniques and NMR spectroscopy, applications, and future perspectives. Researchers in biochemistry, biophysics, molecular biology, cell biology, structural biology as well as NMR analysts interested in biological applications will all find this book valuable reading.
Author : Peter Schuck
Publisher : Springer Science & Business Media
ISBN 13 : 0387359664
Total Pages : 537 pages
Book Rating : 4.3/5 (873 download)
Download or read book Protein Interactions written by Peter Schuck and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume successfully and clearly examines how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It deals with the methodology behind the research and shows how to synergistically incorporate several methodologies for use. Each chapter treats and introduces the reader to different biological systems, includes a brief summary of the physical principles, and mentions practical requirements.
Author : Daniel ben-Avraham
Publisher : Cambridge University Press
ISBN 13 : 0521622786
Total Pages : 334 pages
Book Rating : 4.5/5 (216 download)
Download or read book Diffusion and Reactions in Fractals and Disordered Systems written by Daniel ben-Avraham and published by Cambridge University Press. This book was released on 2000-11-02 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes diffusion and transport in disordered media such as fractals and random resistor networks.
Author : Luiz Roberto Evangelista
Publisher : Cambridge University Press
ISBN 13 : 1107143551
Total Pages : 361 pages
Book Rating : 4.1/5 (71 download)
Download or read book Fractional Diffusion Equations and Anomalous Diffusion written by Luiz Roberto Evangelista and published by Cambridge University Press. This book was released on 2018-01-25 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a unified treatment of anomalous diffusion problems using fractional calculus in a wide range of applications across scientific and technological disciplines.
Author : Robert L. Ellis
Publisher : Elsevier
ISBN 13 : 0080528880
Total Pages : 339 pages
Book Rating : 4.0/5 (85 download)
Download or read book The Chaperonins written by Robert L. Ellis and published by Elsevier. This book was released on 1996-04-01 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations. - Origins of the new view of protein folding - Prokaryotic chaperonins - Eukaryotic chaperonins - Evolution of the chaperonins - Refolding of denatured proteins - Organelle biosynthesis - Biomedical aspects
Author : Gandhimohan M Viswanathan
Publisher : World Scientific
ISBN 13 : 9814590150
Total Pages : 346 pages
Book Rating : 4.8/5 (145 download)
Download or read book Perspectives And Challenges In Statistical Physics And Complex Systems For The Next Decade written by Gandhimohan M Viswanathan and published by World Scientific. This book was released on 2014-04-03 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Physics (SP) has followed an unusual evolutionary path in science. Originally aiming to provide a fundamental basis for another important branch of Physics, namely Thermodynamics, SP gradually became an independent field of research in its own right. But despite more than a century of steady progress, there are still plenty of challenges and open questions in the SP realm.In fact, the area is still rapidly evolving, in contrast to other branches of science, which already have well defined scopes and borderlines of applicability. This difference is due to the steadily expanding number of applications, as well as ongoing improvements and revisions of concepts and methods in SP. Such particular aspects of SP lend further significance and timeliness to this book about perspectives and trends within the field.Here, the aim is to present the state-of-the-art vision of expert researchers who study SP and Complex Systems. Although a comprehensive treatment is well beyond what can be treated in a single volume, the book provides a snapshot of the field today, as well as a glimpse of where the field may be heading during the next decade.The book is aimed at graduate and advanced undergraduate physics students, as well as researchers who work with SP, Complex Systems, Computational Physics, Biological Physics and related topics. It addresses questions such as: What insights can be gained from recent advances in the study of traditional problems in SP? How can SP help us understand problems that arise in the biological sciences and in the study of complex systems? How can new problems be formulated using the ‘language’ of SP? In this way, it attempts to document partial progress in answering these and related questions.The book also commemorates the occasion of the 70th anniversary in 2011 of two important physicists and friends who dedicated their lives to the understanding of nature in general and to the development of Statistical Physics and the science of Complexity in particular: Liacir Lucena and H Eugene Stanley.
Author : Ronald Hancock
Publisher : Academic Press
ISBN 13 : 0128002522
Total Pages : 511 pages
Book Rating : 4.1/5 (28 download)
Download or read book New Models of the Cell Nucleus: Crowding, Entropic Forces, Phase Separation, and Fractals written by Ronald Hancock and published by Academic Press. This book was released on 2013-12-27 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2012: 4.973. Ideas from the fields of biophysics, physical chemistry, of polymer and colloid, and soft matter science have helped clarify the structure and functions of the cell nucleus. The development of powerful methods for modeling conformations and interactions of macromolecules has also contributed. The book aims to encourage cell and molecular biologists to become more familiar with and understand these new concepts and methods, and the crucial contributions they are making to our perception of the nucleus. This is the first volume to present a comprehensive review of New Models of the Cell Nucleus
Author :
Publisher : Academic Press
ISBN 13 : 0128033274
Total Pages : 393 pages
Book Rating : 4.1/5 (28 download)
Download or read book Lipid Domains written by and published by Academic Press. This book was released on 2015-06-08 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. - Written by leading experts - Contains original material, both textual and illustrative, that should become a very relevant reference material - The material is presented in a very comprehensive manner - Both researchers in the field and general readers should find relevant and up-to-date information
Author : Brandy Grove
Publisher :
ISBN 13 :
Total Pages : 33 pages
Book Rating : 4.:/5 (944 download)
Download or read book Monte Carlo Studies of Diffusion in Crowded Environments written by Brandy Grove and published by . This book was released on 2014 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a mixture with multiple dissolved solutes, the diffusivity depends on the density of all components. Interactions among species may give rise to phase separation; the resulting microstructure affects diffusive transport. This mechanism may play an important role in diffusion within cell membranes. We explore this via Monte Carlo simulation of the two-dimensional lattice gas. A grid is populated by "blocker" particles. "Tracer" particles are released on one side of the grid and diffuse via nearest-neighbor hops; particles that reach the opposite side exit the system. Ising-like interactions of all particles are taken into account via the Metropolis algorithm. The interactions cause blocker particles to attract, aggregating into clusters at low temperature; tracer is miscible with the surrounding solution. At high temperature, both species are miscible. We examine how flux affects microstructure, and how microstructure affects transport. These results yield insight into fundamental mechanisms affecting transport in crowded mixtures.
Author : R. Rigler
Publisher : Springer Science & Business Media
ISBN 13 : 3642595421
Total Pages : 503 pages
Book Rating : 4.6/5 (425 download)
Download or read book Fluorescence Correlation Spectroscopy written by R. Rigler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book-length treatment of both the theoretical background to fluorescence correlation spectroscopy (FCS) and a variety of applications in various fields of science. The high spatial and temporal resolution of FCS has made it a powerful tool for the analysis of molecular interactions and kinetics, transport properties due to thermal motion, and flow. It contains an essential contribution from Nobel Prize winner M. Eigen, who is credited with inventing FCS.
