Differential Metabolic Effects In White And Brown Adipose Tissue By Conjugated Linoleic Acid Elicit Lipodystrophy Associated Hepatic Insulin Resistance

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Differential Metabolic Effects in White and Brown Adipose Tissue by Conjugated Linoleic Acid Elicit Lipodystrophy-associated Hepatic Insulin Resistance

Author : Michael B. Stout
Publisher :
ISBN 13 :
Total Pages : 138 pages
Book Rating : 4.:/5 (745 download)

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Book Synopsis Differential Metabolic Effects in White and Brown Adipose Tissue by Conjugated Linoleic Acid Elicit Lipodystrophy-associated Hepatic Insulin Resistance by : Michael B. Stout

Download or read book Differential Metabolic Effects in White and Brown Adipose Tissue by Conjugated Linoleic Acid Elicit Lipodystrophy-associated Hepatic Insulin Resistance written by Michael B. Stout and published by . This book was released on 2011 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The prevalence of obesity has risen substantially throughout the world in recent decades. Nonsurgical treatments for reducing adiposity remain paramount to diminishing obesity and its associated comorbidities. Conjugated linoleic acid has received considerable attention due to its ability to reduce body weight and adiposity in a number of species. The mechanisms responsible for adipose depletion by conjugated linoleic acid remain controversial and are not completely understood. The first objective of this research was to determine if conjugated linoleic acid altered adipose phenotype by inducing adaptive thermogenesis and increasing oxidative capacity. In this study, conjugated linoleic acid dramatically reduced weight gain and adipose mass. Additionally, conjugated linoleic acid induced the expression of numerous genes involved in adaptive thermogenesis in epididymal white adipose tissue. Lipid droplet morphology was unchanged by conjugated linoleic acid treatment, although mitochondrial density was increased in epididymal white adipose tissue. Unexpectedly, whole body oxygen consumption and body temperatures were reduced and unchanged by conjugated linoleic acid treatment, respectively. We attributed these observations to a significant reduction in brown adipose tissue with a concomitant compensatory response in epididymal white adipose tissue. Our data suggest that significant reductions in brown adipose tissue by conjugated linoleic acid initiates white adipose adaptive thermogenesis as a means to maintain body temperature.

Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity

Author : Angela Ann Wendel
Publisher :
ISBN 13 : 9780549000204
Total Pages : 216 pages
Book Rating : 4.0/5 (2 download)

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Book Synopsis Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity by : Angela Ann Wendel

Download or read book Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity written by Angela Ann Wendel and published by . This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The significant depletion of adipose in mice by CLA may contribute to the lipodystrophic-like effects that accompany. The final objective of this research was to determine mechanisms by which CLA reduces adipose mass. Six-week old, male ob/ob mice were fed either a control diet (CON) or a diet supplemented with 1.5% mixed isomer CLA (CLA) for 4 weeks. A third group of mice (LEPTIN) were fed the control diet and received daily, intraperitoneal injections of 1 mg/kg BW recombinant leptin as a positive control for adipose depletion in ob/ob mice. The depletion of adipose tissue by CLA was accompanied by the acquirement of brown adipose-like characteristics, such as increased CPT-1b, PGC-1alpha, and UCP-1, in the white adipose of CLA-fed mice. This alteration may facilitate the reduction of adipose mass by increasing mitochondrial oxidation and energy dissipation. However, it appears that CLA does not increase UCP-1 through beta3AR signaling.

Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA)

Author : Wan Shen
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (919 download)

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Book Synopsis Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA) by : Wan Shen

Download or read book Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA) written by Wan Shen and published by . This book was released on 2015 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Overweight and obesity are the most widespread nutritional diseases in the U.S., which greatly increase chronic disease risks and mortality. Therefore, it is urgent to develop a relatively efficacious and safe strategy for the weight management. Consumption of conjugated linoleic acid (CLA) supplements or one of its isomers, trans-10, cis-12 (10,12) CLA, has consistently demonstrated reductions in body weight or body fat in human and animal studies. Our lab has demonstrated that 10,12 CLA triggered calcium release from endoplasmic reticulum in human primary adipocytes, which activated downstream inflammatory signaling, resulting in impaired uptake of glucose and fatty acid, and delipidation. However, the upstream signals responsible for these actions are unknown. Therefore, my Aim 1 investigated the upstream mechanism by which 10,12 CLA increases intracellular calcium and inflammatory signaling in human primary adipocytes. The results indicated that phospholipase C plays an important role in 10,12 CLA-mediated activation of intracellular calcium accumulation, inflammatory signaling, delipidation, and insulin resistance in human primary adipocytes. It has been demonstrated that 10,12 CLA increased mRNA levels and protein levels of cyclooxygenase-2 (COX-2) and pro-inflammatory prostaglandins, which have been linked to increased energy expenditure associated with white adipose tissue (WAT) browning and uncoupling of ATP synthesis. It also has been shown that relatively high doses of 10,12 CLA lead to more significant reductions in body fat, but cause a greater level of inflammation, insulin resistance, and steatosis in animals. Therefore, Aims 2 and Aim 3 determined the extent to which a relative low dose of 10,12 CLA or a CLA isomer mixture increases markers of browning in mice and its dependence in inflammatory signaling. In Aim 2, a low threshold dose of 10,12 CLA was found that prevented body fat accumulation with minimum metabolic side-effects in non-obese mice. It was also found that 10,12 CLA-induced browning in WAT was accompanied by increases in mRNA levels of COX-2 and other markers of inflammation. In Aim 3, a relatively low dose of 10,12 CLA reduced body fat and increased browning of WAT in overweight mice, which were independent of inflammatory signaling. Collectively, these findings provide critical insights for the development of reliable dietary strategies for people who take CLA as method to lose weight. However, we still do not know (i) if 10,12 CLA supplementation would effectively reduce body fat in overweight mice when they are continuously fed an American-type, high-fat diet; (ii) potential risks of impaired regulation of body temperature, inflammation, and steatosis due to 10,12 CLA consumption in high fat-fed mice; and (iii) potential mechanisms by which 10,12 CLA reduces body fat in high fat-fed mice."--Abstract from author supplied metadata.

Fatty Acid and Lipotoxicity in Obesity and Diabetes

Author : Gregory R. Bock
Publisher : John Wiley & Sons
ISBN 13 : 9780470985564
Total Pages : 222 pages
Book Rating : 4.9/5 (855 download)

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Book Synopsis Fatty Acid and Lipotoxicity in Obesity and Diabetes by : Gregory R. Bock

Download or read book Fatty Acid and Lipotoxicity in Obesity and Diabetes written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-03-11 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism

Author : Amy Dianne Noto
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (184 download)

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Book Synopsis Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism by : Amy Dianne Noto

Download or read book Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism written by Amy Dianne Noto and published by . This book was released on 2005 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Regulation of Adiposity by Dietary Conjugated Linoleic Acid

Author : Xiaofang Xu
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Regulation of Adiposity by Dietary Conjugated Linoleic Acid by : Xiaofang Xu

Download or read book Regulation of Adiposity by Dietary Conjugated Linoleic Acid written by Xiaofang Xu and published by . This book was released on 2002 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice

Author : Dawn Fedor
Publisher :
ISBN 13 : 9781303442483
Total Pages : pages
Book Rating : 4.4/5 (424 download)

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Book Synopsis Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice by : Dawn Fedor

Download or read book Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice written by Dawn Fedor and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin resistance (IR) is a condition in which normal amounts of insulin fail to maintain normal blood glucose because of decreased responsiveness of muscle (glucose uptake), liver (inhibition of gluconeogenesis) and adipocytes (inhibition of lipolysis). IR is often associated with nonalcoholic fatty liver disease (NAFLD), the most common liver disease in adults and children in the Western world. Results from human epidemiological studies indicate that n-3 PUFA reduce the development of IR and NAFLD although the mechanisms involved are poorly understood. Our lab previously showed that concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12- conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced NAFLD and IR. The effective dose of DHA, the mechanisms involved and the effect of CLA on fatty acid compositions of adipose tissue and muscle, and whether DHA can prevent those CLA-induced changes in fatty acid composition is not known. In the first study, we examined the ability of DHA (0.5 and 1.5%) to prevent increases in NAFLD and homeostatic model assessment of insulin resistance (HOMA-IR) induced by CLA (0.5%) when fed concomitantly for 4 weeks to C57BL/6N female mice. We also examined changes in expression of hepatic genes involved in fatty acid synthesis and oxidation. CLA supplementation increased liver triglycerides (TG) and HOMA-IR by 221 and 547%, respectively, and decreased mass of adipose depots by 65-90%. When fed concomitantly, 0.5% and 1.5% DHA prevented CLA-induced increases in liver TG and circulating insulin with varying efficiency, but neither dose of DHA prevented the loss in adipose tissue mass. In CLA + DHA 0.5 % group the liver TG did not differ from those in the control group, but circulating insulin and HOMA-IR were 285 and 264 %, respectively, greater than those in the control group. In the CLA + DHA 1.5% group liver TG were 54% lower than those in the control group, but circulating insulin concentration and HOMA-IR did not differ between these two groups. CLA increased the expression of hepatic genes involved in fatty acid synthesis and decreased the expression of genes involved in fatty acid oxidation. 1.5% DHA prevented changes in the expression of hepatic genes caused by CLA, which may be a possible mechanism contributing to the prevention of TG accumulating in the liver. Based on these results, we further studied the 1.5% DHA diet. We investigated the effects of 1.5% DHA concomitantly fed with CLA on fatty acid compositions of liver, adipose, and muscle lipids in the same mice, as well as expression of genes involved in adipose fatty acid metabolism. CLA supplementation decreased total hepatic n-3 PUFA concentration. DHA not only prevented the CLA-induced changes in liver fat, but also increased n-3 PUFA by >350% as compared with the control group. CLA decreased adipose weight and the expression of genes involved in fatty acid synthesis, oxidation, and uptake, and increased that of UCP2 in the adipose. Supplementing DHA along with CLA increased adipose n-3 PUFA by >1000% compared with control group, but did not prevent the CLA-induced changes in mass or gene expression. Both CLA and DHA were incorporated into muscle lipids, but had minor effects on FA composition. In conclusion, liver, adipose tissue, and muscle responded differently to CLA and DHA supplementation. CLA was more potent than DHA in altering depot fat and insulin concentration. DHA prevented CLA-induced increase in liver fat but not loss of adipose mass. CLA and DHA were preferentially incorporated into adipose tissue lipids, but they had only modest effects on the overall fatty acid composition of the adipose tissue. The largest changes in fatty acid composition were seen in the liver and smallest in muscle lipids.

Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition

Download Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition PDF Online Free

Author : Madhuri Vemuri
Publisher :
ISBN 13 : 9781109662306
Total Pages : pages
Book Rating : 4.6/5 (623 download)

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Book Synopsis Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition by : Madhuri Vemuri

Download or read book Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition written by Madhuri Vemuri and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Conjugated linoleic acid (CLA) refers to all the positional and geometric isomers of linoleic acid. The two most studied isomers are cis9, trans11-CLA and trans10, cis12-CLA. CLA supplements, often a mixture of the two isomers, have been popularly used for weight loss and other claimed health benefits. However supplementing CLA isomers, especially trans10, cis12-CLA has been shown to cause non alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) in several animal models. Here we have confirmed that supplementing 0.5% trans10, cis12-CLA to C57BL/6 mice for 8 weeks causes NAFLD and IR. When CLA diets were concomitantly supplemented with omega-3 fatty acids docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) at 1.5% (w/w) for 8 weeks, DHA prevented CLA induced IR, while EPA was ineffective. Both EPA and DHA prevented CLA induced fatty liver. CLA also reduced the plasma leptin and adiponectin concentrations, and both EPA and DHA partially restored plasma leptin, but only DHA partially restored the plasma adiponectin. In another experiment, concomitant supplementation of CLA diets with 0.5% of flaxseed oil (rich in alpha linolenic acid) also prevented IR and decreased liver weights and lipids compared with those in CLA group. CLA supplementation also altered lipid profile in liver, decreasing n-6 and n-3 wt% and increasing n-6:n-3 ratio. Concomitant supplementation with flaxseed oil increased n-6 and n-3 polyunsaturated (PUFA) in liver lipids and decreased the n-6:n-3 ratio compared to that in CLA group. Supplementing 0.5% (w/w) of purified c9, t11- or trans10, cis12-CLA to mice for 8 weeks altered fatty acid profile of tissues differently. c9, t11-CLA diet reduced MUFA wt% in liver, adipose tissue, and spleen, and reduced the spleen n-3 PUFAs significantly while increasing the n-6 PUFA wt% in all tissues except heart. In contrast, trans10, cis12-CLA reduced both the n-6 and n-3 PUFA wt% in liver and heart however increased the wt% of n-3 PUFAs in spleen. Considering the adverse health effects of trans10, cis12-CLA and of mixtures of CLA isomers on NAFLD, IR and tissue fatty acids, human use of CLA supplements should not be recommended.

Advances in Conjugated Linoleic Acid Research, Volume 3

Author : Martin P. Yurawecz
Publisher : The American Oil Chemists Society
ISBN 13 : 9781893997875
Total Pages : 284 pages
Book Rating : 4.9/5 (978 download)

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Book Synopsis Advances in Conjugated Linoleic Acid Research, Volume 3 by : Martin P. Yurawecz

Download or read book Advances in Conjugated Linoleic Acid Research, Volume 3 written by Martin P. Yurawecz and published by The American Oil Chemists Society. This book was released on 2006-09-29 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the chemistry, biological properties and healthful benefits of conjugated linoleic acid (CLA) continues to grow. The number of peer reviewed publications produced on CLA since the 2003 publication of Advances in Conjugated Linoleic Acid Research, Volume 2, has more than doubled. It is likely that CLA will be used in the future in many more studies related to diseases such as cancer, atherosclerosis, and diabetes. This text provides comprehensive coverage of this area of research. Sections include material on biosynthesis and metabolic processes, techniques of determination of individual isomers, diversity of CLA, and effects of CLA isomers in humans.

Trends in Elevated Triglyceride in Adults: United States, 2001-2012

Author : Margaret D. Carroll
Publisher :
ISBN 13 :
Total Pages : 12 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Trends in Elevated Triglyceride in Adults: United States, 2001-2012 by : Margaret D. Carroll

Download or read book Trends in Elevated Triglyceride in Adults: United States, 2001-2012 written by Margaret D. Carroll and published by . This book was released on 2015 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cellular and Biochemical Mechanisms of Obesity

Author : Paramjit S. Tappia
Publisher : Springer Nature
ISBN 13 : 3030847632
Total Pages : 420 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Cellular and Biochemical Mechanisms of Obesity by : Paramjit S. Tappia

Download or read book Cellular and Biochemical Mechanisms of Obesity written by Paramjit S. Tappia and published by Springer Nature. This book was released on 2021-12-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood. Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.

Drug Metabolism in Diseases

Author : Wen Xie
Publisher : Academic Press
ISBN 13 : 0128029633
Total Pages : 296 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Drug Metabolism in Diseases by : Wen Xie

Download or read book Drug Metabolism in Diseases written by Wen Xie and published by Academic Press. This book was released on 2016-09-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Medical Biochemistry

Author : Miriam D. Rosenthal
Publisher : John Wiley & Sons
ISBN 13 : 1118210298
Total Pages : 455 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Medical Biochemistry by : Miriam D. Rosenthal

Download or read book Medical Biochemistry written by Miriam D. Rosenthal and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism includes various pathways of chemical reactions; understanding these pathways leads to an improved knowledge of the causes, preventions, and cures for human diseases. Medical Biochemistry: Human Metabolism in Health and Disease provides a concise yet thorough explanation of human metabolism and its role in health and diseases. Focusing on the physiological context of human metabolism without extensive consideration of the mechanistic principles of underlying enzymology, the books serves as both a primary text and resource for students and professional in medical, dental, and allied health programs.

Cosmetic Dermatology

Author : Leslie Baumann
Publisher : McGraw Hill Professional
ISBN 13 : 9780071362818
Total Pages : 252 pages
Book Rating : 4.3/5 (628 download)

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Book Synopsis Cosmetic Dermatology by : Leslie Baumann

Download or read book Cosmetic Dermatology written by Leslie Baumann and published by McGraw Hill Professional. This book was released on 2002 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: -- Provides physicians with scientific answers to everyday cosmetic problems.

Dermatology

Author : Sima Jain
Publisher : Springer Science & Business Media
ISBN 13 : 1441905243
Total Pages : 375 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Dermatology by : Sima Jain

Download or read book Dermatology written by Sima Jain and published by Springer Science & Business Media. This book was released on 2012-03-29 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully-illustrated, note-packed volume of information, Dermatology: Illustrated Study Guide and Comprehensive Board Review fulfills a real need for a single study guide for the Dermatology Board Exam. Written by a previous Chief Resident of Dermatology at the University of Illinois at Chicago Medical Center, the text focuses on presenting comprehensive information in an easy-to-understand, easy-to-remember format. Tips, tricks, short lists, and tables fill every inch of this book—a must-have for any dermatology resident. Features: Acts as a concise go-to review book for the Dermatology Board Exam Hundreds of author notes pinpointing important information presented in an easy-to-read format Scores of mnemonics and memory tricks to mentally organize information Over 500 high-quality images placed parallel to the represented skin disorder Life after Boards—essential tips on coding and documentation

Pediatric Endocrinology

Author : M. Sperling
Publisher :
ISBN 13 :
Total Pages : 826 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Pediatric Endocrinology by : M. Sperling

Download or read book Pediatric Endocrinology written by M. Sperling and published by . This book was released on 2002 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: This New Edition is today's most comprehensive, definitive reference in the field, incorporating all of today's explosive discoveries in basic and clinical endocrinology. Its reliable, cutting-edge guidance for a full range of problems is combined with a wealth of information on the physiological, biochemical, and genetic basis at the molecular biological level. Dr. Mark A. Sperling and 33 contributing experts bring readers the benefits of discovery at the bench and its application at the bedside. New chapters, extensive revisions, and compelling updates will keep readers at the forefront of the diagnosis and management of endocrine disease in children. Incorporates the explosive growth in molecular biology as it relates to developmental and pediatric endocrinology. Extensively revised and updated chapters throughout reflect the latest information. Coverage of up-to-the-minute topics in the field, including molecular, biochemical, and clinical basis of hyperinsulinemic hypoglycemia of infancy and childhood diabetes mellitus energy balance/obesity growth hormone paradigms of mechanisms of hormone action, and others Contributions from new authors from distinguished institutions Numerous brand-new illustrations depict the most current information, particularly the basic science/genetic basis of certain entities

Oxidative Stress in Heart Diseases

Author : Sajal Chakraborti
Publisher : Springer Nature
ISBN 13 : 9811382735
Total Pages : 596 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Oxidative Stress in Heart Diseases by : Sajal Chakraborti

Download or read book Oxidative Stress in Heart Diseases written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-06 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.