Diagnostic Pathology Genitourinary

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Diagnostic Pathology: Genitourinary E-Book

Author : Mahul B. Amin
Publisher : Elsevier Health Sciences
ISBN 13 : 0323442994
Total Pages : 1070 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Diagnostic Pathology: Genitourinary E-Book by : Mahul B. Amin

Download or read book Diagnostic Pathology: Genitourinary E-Book written by Mahul B. Amin and published by Elsevier Health Sciences. This book was released on 2016-06-17 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the highly regarded Diagnostic Pathology series, this updated volume by Drs. Mahul B. Amin and Satish K. Tickoo is a visually stunning, easy-to-use reference covering all aspects of genitourinary pathology. Outstanding images – including gross pathology, a wide range of stains, and detailed medical illustrations – make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This 2nd Edition incorporates the most recent clinical, pathological, staging, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Nearly 200 diagnoses, richly illustrated and extensively annotated, cover diseases of the kidney, prostate, bladder, testis, and penis. High-quality, carefully annotated images provide clinically and diagnostically important information, including difficult issues of grading and staging, and diagnostic dilemmas not covered in depth elsewhere. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, and annotated images. State-of-the-art coverage of kidney tumors associated with familial disorders, kidney tumors with papillary architecture, new terminology for precursor and invasive tumors of testicular and penile tumors, new variants in bladder cancer, and grading of inverted lesions of the urinary bladder. For each anatomical site, you'll find CAP Cancer Staging and specimen handling protocols, plus detailed immunohistochemistry panels to accompany the images. New molecular knowledge, the latest concepts and nomenclature, incorporation of best practices in immunohistochemistry , and new precision medicine for urologic cancer based on recent data from The Cancer Genome Atlas (TCGA).

Diagnostic Pathology: Genitourinary E-Book

Author : Mahul B. Amin
Publisher : Elsevier Health Sciences
ISBN 13 : 0323763332
Total Pages : 1100 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Diagnostic Pathology: Genitourinary E-Book by : Mahul B. Amin

Download or read book Diagnostic Pathology: Genitourinary E-Book written by Mahul B. Amin and published by Elsevier Health Sciences. This book was released on 2022-07-22 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering complete, practical guidance on the evaluation of the surgical pathology specimen, the Manual of Surgical Pathology concentrates decades of experience from the faculty and staff of one of the busiest and most respected pathology departments in the world. From a specimen’s arrival in the department to preparation of the final report, you’ll find step-by-step instructions on specimen processing, tissue handling, gross dissection technique, histological examination, application of special stains, development of a differential diagnosis, and more. The fully revised 4th Edition is an invaluable reference for practicing pathologists, residents, and pathology assistants as a practical, everyday resource for learning and applying optimal specimen evaluation as well as an excellent guide for board review. Helps you find information quickly with a user-friendly design, concise paragraphs, numbered lists, and bulleted material throughout the text. Reflects the latest AJCC staging information, as well as updates throughout on reporting procedures, protocols, and safety. Offers detailed instructions on the dissection, description, and sampling of specimens, and explains the application of pathology reports to patient management. Provides procedures for new types of specimens including pulmonary image guided resections, endoscopic mucosal resection, endoscopic submucosal dissection, laparoscopic hysterectomy, or nephrectomy morcellation, vertical sleeve gastrectomy, and evaluation of breast implant capsules with a clinical suspicion of lymphoma Features dozens of illustrations that demonstrate the gross appearance of common pathologic lesions, and more than 150 tables that examine the interpretation of histochemical stains, immunohistochemical studies, electron microscopy findings, cytogenetic changes, and much more. Examines the specimens from every organ and system as well as bullets, medical devices, and foreign materials. Includes a new chapter on occupational hazards for pathologists ranging from visual and musculoskeletal problems to exposure and prevention of workplace acquired infection and cancer.

Diagnostic Pathology

Author : Mahul B. Amin
Publisher :
ISBN 13 : 9780323395342
Total Pages : 0 pages
Book Rating : 4.3/5 (953 download)

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Book Synopsis Diagnostic Pathology by : Mahul B. Amin

Download or read book Diagnostic Pathology written by Mahul B. Amin and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diagnostic Pathology: Genitourinary

Author : Mahul B. Amin
Publisher : Saunders
ISBN 13 : 9780323377140
Total Pages : 0 pages
Book Rating : 4.3/5 (771 download)

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Book Synopsis Diagnostic Pathology: Genitourinary by : Mahul B. Amin

Download or read book Diagnostic Pathology: Genitourinary written by Mahul B. Amin and published by Saunders. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the highly regarded Diagnostic Pathology series, this updated volume by Drs. Mahul B. Amin and Satish K. Tickoo is a visually stunning, easy-to-use reference covering all aspects of genitourinary pathology. Outstanding images - including gross pathology, a wide range of stains, and detailed medical illustrations - make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This 2nd Edition incorporates the most recent clinical, pathological, staging, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Nearly 200 diagnoses, richly illustrated and extensively annotated, cover diseases of the kidney, prostate, bladder, testis, and penis. High-quality, carefully annotated images provide clinically and diagnostically important information, including difficult issues of grading and staging, and diagnostic dilemmas not covered in depth elsewhere. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index. State-of-the-art coverage of kidney tumors associated with familial disorders, kidney tumors with papillary architecture, new terminology for precursor and invasive tumors of testicular and penile tumors, new variants in bladder cancer, and grading of inverted lesions of the urinary bladder. For each anatomical site, you'll find CAP Cancer Staging and specimen handling protocols, plus detailed immunohistochemistry panels to accompany the images. New molecular knowledge, the latest concepts and nomenclature, incorporation of best practices in immunohistochemistry, and new precision medicine for urologic cancer based on recent data from The Cancer Genome Atlas (TCGA).

Genitourinary Pathology E-Book

Author : Ming Zhou
Publisher : Elsevier Health Sciences
ISBN 13 : 0323188338
Total Pages : 723 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Genitourinary Pathology E-Book by : Ming Zhou

Download or read book Genitourinary Pathology E-Book written by Ming Zhou and published by Elsevier Health Sciences. This book was released on 2014-10-20 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genitourinary Pathology, by Drs. Ming Zhou and Cristina Magi-Galluzzi, a volume in the Foundations in Diagnostic Pathology Series, packs all of today's most essential information on genitourinary pathology into a compact, high-yield format! Well-organized and segmented by type of infectious organism, the book's pragmatic approach complemented by abundant full-color, high-quality photomicrographs and clinical photos, and at-a-glance tables makes it easy to access the information you need to quickly and accurately detect and identify molecular and genetic mechanisms of disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Easily review normal histology before examining abnormal findings so you can avoid false positives. Gain a superb visual understanding of important histologic features with hundreds of full-color illustrations representing a wide variety of pathologic lesions. Benefit from the same highly practical format as other titles in this series: consistent headings throughout, summary boxes for pathologic and clinical features, high quality photomicrographs and clinical photos, and a logical organization by type of infectious organism. Avoid incorrect diagnoses with a separate section on artifacts and pitfalls that highlights common problems you may encounter. Get up-to-date, comprehensive coverage of the field, including new renal cell carcinoma subtypes and intraductal carcinoma of the prostate; newer immunohistochemical and molecular markers; and updates to the Gleason Grading system for prostate cancer, Fuhrman Grading system for renal cell carcinoma, and TNM classification for GU malignancies.

Genitourinary

Author : Mahul B. Amin
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9781931884280
Total Pages : 0 pages
Book Rating : 4.8/5 (842 download)

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Book Synopsis Genitourinary by : Mahul B. Amin

Download or read book Genitourinary written by Mahul B. Amin and published by Lippincott Williams & Wilkins. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed as an easy-to-use and comprehensive reference for the practicing pathologist, "Diagnostic Pathology: Genitourinary" will guide readers through the intricacies of genitourinary pathology and the diagnosis of genitourinary-related diseases. Includes more than 3,000 images.

Atlas of Genitourinary Pathology

Author : Sara E. Wobker
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496397673
Total Pages : 1653 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Atlas of Genitourinary Pathology by : Sara E. Wobker

Download or read book Atlas of Genitourinary Pathology written by Sara E. Wobker and published by Lippincott Williams & Wilkins. This book was released on 2020-10-12 with total page 1653 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closely mirroring the daily sign-out process, Atlas of Genitourinary Pathology: A Pattern Based Approach is a highly illustrated, efficient guide to accurate diagnosis. This practical reference uses a proven, pattern-based approach to clearly explain how to interpret challenging cases by highlighting red flags in the clinical presentation and locating hidden clues in the slides. Useful as a daily “scope-side guide,” it features numerous clinical and educational features that help you find pertinent information, reach a correct diagnosis, and assemble a thorough and streamlined pathology report.

Diagnostic Pathology of Infectious Disease E-Book

Author : Richard L. Kradin
Publisher : Elsevier Health Sciences
ISBN 13 : 0323508677
Total Pages : 715 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Diagnostic Pathology of Infectious Disease E-Book by : Richard L. Kradin

Download or read book Diagnostic Pathology of Infectious Disease E-Book written by Richard L. Kradin and published by Elsevier Health Sciences. This book was released on 2017-04-26 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and up to date, the Second Edition of Diagnostic Pathology: Infectious Disease, by Dr. Richard Kradin, is an invaluable tool for the accurate diagnosis of any infectious disease?from the common to the most challenging. The organ-based format makes it an especially useful tool for surgical pathologists' daily diagnostic and management issues. High-quality, full-color illustrations and differential diagnosis tables accompany each lesion, clearly depicting how to recognize the morphology of organisms and the spectrum of histological responses that they may cause. - Addresses the most difficult diagnostic issues that practicing or trainee surgical pathologists face when handling infectious disease tissue specimens. - Highlights morphological characteristics and landmarks of tissue samples for easy access to information necessary for signing out a specimen. - Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection. - Completely revised with the latest diagnostic support and hot topics in the field: - A new chapter on novel techniques in microbiology - A new chapter on eye infections - New coverage of immunohistochemical staining and other molecular diagnostic techniques - New discussions of human papillomavirus, a critical tool in predictive cancer screening - New information on infections in the immunocompromised host and related special considerations - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Atlas of Genitourinary Pathology

Author : Gregory T. MacLennan
Publisher : Springer Science & Business Media
ISBN 13 : 1848823959
Total Pages : 425 pages
Book Rating : 4.8/5 (488 download)

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Book Synopsis Atlas of Genitourinary Pathology by : Gregory T. MacLennan

Download or read book Atlas of Genitourinary Pathology written by Gregory T. MacLennan and published by Springer Science & Business Media. This book was released on 2010-12-02 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single source of information about pathologic lesions of the adrenal, the urinary tract, and the male genital system, minimizing the need to consult numerous texts of limited scope, this book contains gross photos and photomicrographs of virtually every pathologic entity, and variants of those entities. The book is lavishly illustrated with images accompanied by text that explains the visual images, highlighting key diagnostic features and providing brief but helpful discussions of the differential diagnosis. This book is designed for practicing pathologists and pathologists in training as well as urologists, GU radiologists, GU radiation oncologists, and GU medical oncologists.

Genitourinary Pathology

Author : Ming Zhou (Pathologist)
Publisher :
ISBN 13 :
Total Pages : 688 pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Genitourinary Pathology by : Ming Zhou (Pathologist)

Download or read book Genitourinary Pathology written by Ming Zhou (Pathologist) and published by . This book was released on 2007 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diagnostic Pathology: Kidney Diseases E-Book

Author : Robert B. Colvin
Publisher : Elsevier Health Sciences
ISBN 13 : 0443109230
Total Pages : 1267 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Diagnostic Pathology: Kidney Diseases E-Book by : Robert B. Colvin

Download or read book Diagnostic Pathology: Kidney Diseases E-Book written by Robert B. Colvin and published by Elsevier Health Sciences. This book was released on 2023-08-16 with total page 1267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of common and rare nonneoplastic renal diseases, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Kidney Diseases, fourth edition, is a visually stunning, one-stop resource for every practicing pathologist, nephrologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. Provides a comprehensive source for key pathologies and clinical features of more than 265 kidney diseases Features two dozen new chapters on a variety of timely topics, including COVID-19 nephropathies, xenografts, artificial intelligence (AI), digital pathology analysis, harmonized nephropathology terminology, newly identified types of amyloidosis, common artifacts and pitfalls on kidney biopsy, vaccination-associated renal disease, crystal nephropathies, and much more Includes updates from the International Kidney and Monoclonal Gammopathy (IKMG) research group, the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for IgG4-related disease, Banff Foundation for Allograft Pathology, and others Details updated genetic causes of nephrotic syndromes and antinephrin antibodies in podocytopathies—by the investigator who discovered it Discusses the newly identified variant IgG nephropathy and novel membranous autoantigens Contains chapters on techniques, including immunofluorescence on paraffin sections, C4d staining, and polyomavirus detection in tissue Contains more than 4,300 print and online images, including high-resolution photographs and histologic images, full-color medical illustrations, radiologic images, and more Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care Shares the expertise of internationally recognized authors who provide fresh perspectives on multiple topics, with a particular emphasis on practical information that directly assists in making and supporting a diagnosis

Diagnostic Pathology: Normal Histology - E-Book

Author : Matthew R Lindberg
Publisher : Elsevier Health Sciences
ISBN 13 : 0323548059
Total Pages : 500 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Diagnostic Pathology: Normal Histology - E-Book by : Matthew R Lindberg

Download or read book Diagnostic Pathology: Normal Histology - E-Book written by Matthew R Lindberg and published by Elsevier Health Sciences. This book was released on 2017-08-18 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Visually stunning and easy to use, this volume in the highly regarded Diagnostic Pathology series covers the normal histology of every organ system. This edition incorporates the most recent scientific and technological knowledge in the field to provide a comprehensive overview of all areas of normal histology, including introductory chapters on electron microscopy, immunofluorescence, immunohistochemistry and histochemistry, the cell, and the basic organization of tissues. With nearly 1,800 outstanding images, this reference is an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. Unparalleled visual coverage with carefully annotated photomicrographs, spectacular gross images, electron micrographs, and medical illustrations Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index Thoroughly updated content throughout, with all-new chapters on synovium and histologic artifacts, a thoroughly revised skeletal muscle chapter that now addresses normal histology in the setting of neuromuscular biopsy, and coverage of additional histologic variations that cause diagnostic confusion New content on immunohistochemistry; more image examples of newly recognized normal variations, mimics, and pitfalls; and expanded text in many sections for greater clarity and ease of reference

Diagnostic Pathology: Thoracic E-Book

Author : Saul Suster
Publisher : Elsevier Health Sciences
ISBN 13 : 0323443052
Total Pages : 950 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Diagnostic Pathology: Thoracic E-Book by : Saul Suster

Download or read book Diagnostic Pathology: Thoracic E-Book written by Saul Suster and published by Elsevier Health Sciences. This book was released on 2017-01-24 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of thoracic pathology. Outstanding images make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Unsurpassed visual coverage, with carefully annotated gross pathology, histopathology, special stains, and correlative radiologic images that provide clinically and diagnostically important information. Designed to help you identify crucial elements of each diagnosis along with associated differential diagnoses and pitfalls to more quickly resolve problems during routine sign out of cases. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index. Thoroughly updated content throughout, reflecting new WHO classifications of adenocarcinoma of the lung and a proliferation of molecular markers. New coverage of targeted therapies in molecular testing that determine why, when, and where these precisely classified lung cancers are found and their biologic behavior.

Clinical Genitourinary Pathology

Author : Andreas C. Lazaris
Publisher : Springer
ISBN 13 : 3319721941
Total Pages : 542 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Clinical Genitourinary Pathology by : Andreas C. Lazaris

Download or read book Clinical Genitourinary Pathology written by Andreas C. Lazaris and published by Springer. This book was released on 2018-07-13 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents clinicopathological insights into common genitourinary diseases, especially those of neoplastic nature, and introduces experiential learning based on case presentations (case-based learning). One of the tasks that trainees face is converting the extensive amount of data into medical experience. Using successive microscopic images, the book gradually and analytically presents diagnostic procedures for the genitourinary system (kidney, urinary bladder, prostate gland and testis). Characteristic cases are presented for each organ, each ending with a clinical commentary and key messages. This form of presentation helps readers acquire the valuable skill of effective diagnostic thinking, focusing their attention on the essential microscopic findings and disregarding insubstantial findings. Although clinical applications are frequently based on pathological findings which therefore need to be clearly described and recorded, the importance of this in everyday medical practice is often ignored by medical students and downplayed by clinicians. Demonstrating how knowledge can be practically applied, the book is a valuable resource mainly for residents in pathology, urology and oncology but also for medical students with a special interest in histopathology.

Differential Diagnosis in Surgical Pathology

Author : Vijaya B. Reddy
Publisher : Elsevier Health Sciences
ISBN 13 : 0323261973
Total Pages : 1087 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Differential Diagnosis in Surgical Pathology by : Vijaya B. Reddy

Download or read book Differential Diagnosis in Surgical Pathology written by Vijaya B. Reddy and published by Elsevier Health Sciences. This book was released on 2014-10-20 with total page 1087 pages. Available in PDF, EPUB and Kindle. Book excerpt: Confidently sign out your most complex and challenging cases with the updated edition of Differential Diagnosis in Surgical Pathology. Widely used by residents and practicing pathologists alike, this comprehensive medical reference provides brief, bulleted descriptions of both common and rare disorders, integrating excellent illustrative examples of the pathology with selected references. It's the perfect go-to resource to have by your microscope! Quickly access essential information through concise, bulleted text; a consistent approach to diagnosis and interpretation; and a comprehensive yet manageable size. Formulate an accurate diagnosis with coverage of all of the relevant ancillary diagnostic techniques, and ensure every diagnostic possibility is explored with help from quick checklists throughout. Make informed decisions when delineating one disease from another with discussions covering all of the major organ systems. Understand what diagnostic criteria to consider or exclude with expert "pearls" and practical tips throughout. Take advantage of extensive updates on tumor classifications and diseases, as well as expanded coverage of medical renal pathology. Stay abreast of the latest developments in molecular testing, including diagnostics, biomarkers, and targeted therapies, for entities such as the breast, lung, gastrointestinal tract, and melanoma. View over 1,350 full-color macro and microphotographs that provide a realistic basis for comparison to what you see under the microscope. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

Differential Diagnoses in Surgical Pathology: Genitourinary System

Author : Jonathan Epstein
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975162927
Total Pages : 1866 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Differential Diagnoses in Surgical Pathology: Genitourinary System by : Jonathan Epstein

Download or read book Differential Diagnoses in Surgical Pathology: Genitourinary System written by Jonathan Epstein and published by Lippincott Williams & Wilkins. This book was released on 2021-07-20 with total page 1866 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering expert, practical guidance through the decision-making process, Differential Diagnoses in Surgical Pathology: Genitourinary System, by Drs. Jonathan I. Epstein and George J. Netto, covers more than 175 differential diagnoses, ranging from the most common to the less frequently seen. In every chapter of this new second edition, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the authors emphasize atypical features that can complicate diagnoses.

Practical Genitourinary Pathology

Author : Ximing J. Yang
Publisher : Springer Nature
ISBN 13 : 3030571416
Total Pages : 302 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Practical Genitourinary Pathology by : Ximing J. Yang

Download or read book Practical Genitourinary Pathology written by Ximing J. Yang and published by Springer Nature. This book was released on 2020-10-29 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a practical guide and provides updates in Genitourinary (GU) Pathology. By using a “Questions and Answers” format, it addresses frequently encountered diagnostic challenges in daily practice for pathologists. Emphasis is placed on diagnosis and differential diagnosis based on morphological characteristics, clinicopathologic correlation, and interpretation of immunohistochemical and other ancillary tests. Concise answers to each question are provided by experts in the field accompanied by ample high quality illustrations and updated references. This book includes common and rare benign and malignant conditions in the GU system, covering the entire genitourinary system including the prostate, kidney, bladder, testis, urethra, ureter, penis and adrenal. It also reviews current topics, controversies and diagnostic dilemmas in diagnostic GU pathology. Practical Genitourinary Pathology serves as a quick reference for busy practicing pathologists, pathologists in training, urologists, medical students, and other physicians with questions of genitourinary conditions.