Development of Polylactide-based Reduction-responsive Degradable Nanomaterials for Multifunctional Biomedical Applications

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ISBN 13 :
Total Pages : 158 pages
Book Rating : 4.:/5 (111 download)

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Book Synopsis Development of Polylactide-based Reduction-responsive Degradable Nanomaterials for Multifunctional Biomedical Applications by : Na Re Ko

Download or read book Development of Polylactide-based Reduction-responsive Degradable Nanomaterials for Multifunctional Biomedical Applications written by Na Re Ko and published by . This book was released on 2015 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polylactide (PLA)-based nanomaterials have been extensively explored in biomedical applications due to their biocompatibility and biodegradability. However, PLA has two main limitations: hydrophobicity and slow degradation rate. My Ph.D. research focuses on the exploration of potential approaches to circumvent these challenges by synthesis of PLA-based amphiphilic block copolymers (ABPs) with stimuli-responsive degradation (SRD) and these ABPs are used to fabricate novel PLA-based nanomaterials. SRD is highly desirable in the design of multi-functional polymer-based drug delivery systems. SRD involves the incorporation of dynamic covalent bonds into nanomaterials that can be cleaved in response to external stimuli such as light, ultrasound, low pH, and enzymes. This process leads to chemical or physical changes of nanomaterials to enhance the release of therapeutics or tune the morphologies. Reduction-responsive degradation uses disulfide-thiol chemistry. Disulfide linkages are cleaved either in response to a reductive environment or a disulfide-thiol exchange reaction in the presence of thiols. Using this unique system, PLA-based nanomaterials with disulfide linkages can be developed for tumor-targeting drug delivery. Amphiphilic micellar aggregates have attracted much interest as a promising candidate for effective polymeric drug delivery. Micelles are formed through aqueous self-assembly of ABPs consisting of both hydrophilic and hydrophobic blocks. Hydrophobic cores encapsulate hydrophobic therapeutics and the surrounding hydrophilic coronas enhance colloidal stability. Adjusting this unique structure of ABP is a promising strategy for circumventing the hydrophobicity of PLA. Uniformed micelles in the nanoscale size range can prolong the blood residence and minimize side effects, and possess multiple cargos into a single vehicle, allowing multi-functional drug delivery. In this thesis, several reduction-responsive degradable PLA-based ABPs have been reported. They were further used to fabricate various nanomaterials including micellar drug carriers; polyplexes; and nanofibers. These ABPs were synthesized by a combination method of ring opening polymerization and atom transfer radical polymerization. Due to their amphiphilic nature, ABPs can be self-assembled to form the micellar platforms possessing hydrophobic therapeutics in the core, which is surrounded with hydrophilic coronas. ABPs with positively charged hydrophilic blocks enable the formation of cationic micellar aggregates. These cationic micelles have subsequently been used as dual delivery carriers of drugs and genes. Furthermore, incorporating dual-located disulfide linkages at both the hydrophobic PLA core and the interface leads to a synergistically enhanced release of encapsulated drugs in cellular environments. Moreover, PLA nanofibers were fabricated via air-spinning technique of high-molecular weight PLAs. Their hydrophobic surface was modified with hydrophilic polymers via facile surface-initiated ATRP. The resulting surface-modified PLA fibers exhibit enhanced hydrophilicity and thermal stability, as well as tunable surface properties upon the cleavage of disulfide linkages. Under a reductive environment, these novel PLA-based nanomaterials are rapidly degraded upon the cleavage of disulfides, leading to controlled release of drugs and genes, as well as change of surface properties. These results suggest the disulfide-labeled PLA-based nanomaterials offer great potential and versatility in biomedical applications.

Development of Dual Stimuli-responsive Degradable Polylactide-based Multifunctional Materials for Drug Delivery

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Development of Dual Stimuli-responsive Degradable Polylactide-based Multifunctional Materials for Drug Delivery by : Kamaljeet Kaur Bawa

Download or read book Development of Dual Stimuli-responsive Degradable Polylactide-based Multifunctional Materials for Drug Delivery written by Kamaljeet Kaur Bawa and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in the synthesis of amphiphilic block copolymers has contributed to promising advances in the construction of smart nanocarriers for anticancer drug delivery systems. Their excellent features such as biodegradability through enzymatic hydrolysis and biocompatibility have led to tremendous applications in the biomedical field. Polylactide (PLA) is a biocompatible and FDA-approved polymer which has been used as hydrophobic core-forming block in drug delivery vehicles. However, hydrophobicity and slow degradation are the two main drawbacks that limits its usage in drug delivery systems. An introduction of stimuli-responsive degradable (SRD) platform into the design of PLA-based polymeric drug delivery systems can overcome these challenges as they can precisely tune drug release kinetics to fit the therapeutic window of the encapsulated drug. However, most of the smart PLA-based block copolymers are designed to respond to a single stimulus and therefore, multi-stimuli responsive degradable systems in which the location, number and type of degradable linkages can be varied needs to be developed. My PhD research was focused on the studies of dual stimuli-responsive degradation (DSRD) platform to synthesize advanced PLA-based nanomaterials. They were featured with different types and location of labile linkages, that cleaved in response to biological stimuli found in cancer cells and tumor tissues. In this thesis, I had developed robust strategies that allowed for the synthesis of three novel PLA-based SRD copolymers designed with a) reduction-responsive disulfide linkage and b) an acid-labile linkage. These synthetic strategies utilized a combination of ring opening polymerization (ROP), atom transfer radical polymerization (ATRP) and facile coupling reactions. The results demonstrated the feasibility to design and synthesize smart DSRD-based block copolymers which self-assemble to form colloidally-stable micellar aggregates and encapsulate hydrophobic dyes or drugs in the hydrophobic cores. Furthermore, the SRD-driven enhanced/controlled release of loaded cargoes suggested that DSRD strategy can offer the versatility and hold great potential in the development of intracellular drug delivery nanocarriers.

Development of Reduction-responsive Degradable Polylactide-based Amphiphilic Block Copolymers for Drug-delivery Applications

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Development of Reduction-responsive Degradable Polylactide-based Amphiphilic Block Copolymers for Drug-delivery Applications by : Alexander Cunningham

Download or read book Development of Reduction-responsive Degradable Polylactide-based Amphiphilic Block Copolymers for Drug-delivery Applications written by Alexander Cunningham and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Poly(lactide)-containing Multifunctional Nanoparticles: Synthesis, Domain-selective Degradation and Therapeutic Applicability

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ISBN 13 :
Total Pages : pages
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Book Synopsis Poly(lactide)-containing Multifunctional Nanoparticles: Synthesis, Domain-selective Degradation and Therapeutic Applicability by : Sandani Samarajeewa

Download or read book Poly(lactide)-containing Multifunctional Nanoparticles: Synthesis, Domain-selective Degradation and Therapeutic Applicability written by Sandani Samarajeewa and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Construction of nanoassemblies from degradable components is desired for packaging and controlled release of active therapeutics, and eventual biodegradability in vivo. In this study, shell crosslinked micelles composed of biodegradable poly(lactide) (PLA) core were prepared by the self-assembly of an amphiphilic diblock copolymer synthesized by a combination of ring opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization. Enzymatic degradation of the PLA cores of the nanoparticles was achieved upon the addition of proteinase K (PK). Kinetic analyses and comparison of the properties of the nanomaterials as a function of degradation extent will be discussed. Building upon our findings from selective-excavation of the PLA core, enzyme- and redox-responsive nanoparticles were constructed for the encapsulation and stimuli-responsive release of an antitumor drug. This potent chemotherapeutic, otherwise poorly soluble in water was dispersed into aqueous solution by the supramolecular co-assembly with an amphiphilic block copolymer, and the release from within the core of these nanoparticles were gated by crosslinking the hydrophilic shell region with a reduction-responsive crosslinker. Enzyme- and reduction-triggered release behavior of the antitumor drug was demonstrated along with their remarkably high in vitro efficacy. As cationic nanoparticles are a promising class of transfection agents for nucleic acid delivery, in the next part of the study, synthetic methodologies were developed for the conversion of the negatively-charged shell of the enzymatically-degradable shell crosslinked micelles to positively-charged cationic nanoparticles for the complexation of nucleic acids. These degradable cationic nanoparticles were found to efficiently deliver and transfect plasmid DNA in vitro. The hydrolysis of the PLA core and crosslinkers of the nanocarriers may provide a mechanism for their programmed disassembly within endosomes, which would in-turn promote endosomal disruption by osmotic swelling, and release of active therapeutics from the polymeric assemblies. In the last part, a comparative degradation study was performed between the anionic and cationic micellar assemblies in the presence of two model enzymes, and electrostatic interaction-mediated preferential hydrolysis was demonstrated between the oppositely-charged enzyme-micelle pairs. These findings may be of potential significance toward the design of charge-mediated enzyme-responsive nanomaterials that are capable of undergoing environmentally-triggered therapeutic release, disassembly or morphological alterations under selective enzyme conditions. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/149300

Biodegradable and Biobased Polymers for Environmental and Biomedical Applications

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Publisher : John Wiley & Sons
ISBN 13 : 1119117356
Total Pages : 448 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Biodegradable and Biobased Polymers for Environmental and Biomedical Applications by : Susheel Kalia

Download or read book Biodegradable and Biobased Polymers for Environmental and Biomedical Applications written by Susheel Kalia and published by John Wiley & Sons. This book was released on 2016-01-29 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume incorporates 13 contributions from renowned experts from the relevant research fields that are related biodegradable and biobased polymers and their environmental and biomedical applications. Specifically, the book highlights: Developments in polyhydroxyalkanoates applications in agriculture, biodegradable packaging material and biomedical field like drug delivery systems, implants, tissue engineering and scaffolds The synthesis and elaboration of cellulose microfibrils from sisal fibres for high performance engineering applications in various sectors such as the automotive and aerospace industries, or for building and construction The different classes and chemical modifications of tannins Electro-activity and applications of Jatropha latex and seed The synthesis, properties and applications of poly(lactic acid) The synthesis, processing and properties of poly(butylene succinate), its copolymers, composites and nanocomposites The different routes for preparation polymers from vegetable oil and the effects of reinforcement and nano-reinforcement on the physical properties of such biobased polymers The different types of modified drug delivery systems together with the concept of the drug delivery matrix for controlled release of drugs and for antitumor drugs The use of nanocellulose as sustainable adsorbents for the removal of water pollutants mainly heavy metal ions, organic molecules, dyes, oil and CO2 The main extraction techniques, structure, properties and different chemical modifications of lignins Proteins and nucleic acids based biopolymers The role of tamarind seed polysaccharide-based multiple-unit systems in sustained drug release

Biodegradable Poly (Lactic Acid)

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Publisher : Springer Science & Business Media
ISBN 13 : 3642175961
Total Pages : 314 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Biodegradable Poly (Lactic Acid) by : Jie Ren

Download or read book Biodegradable Poly (Lactic Acid) written by Jie Ren and published by Springer Science & Business Media. This book was released on 2011-04-05 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Biodegradable Poly (Lactic Acid): Synthesis, Modification, Processing and Applications" describes the preparation, modification, processing, and the research and applications of biodegradable poly (lactic acid), which belong to the biomedical and environment-friendly materials. Highly illustrated, the book introduces systematically the synthesis, physical and chemical modifications, and the latest developments of research and applications of poly (lactic acid) in biomedical materials. The book is intended for researchers and graduate students in the fields of materials science and engineering, polymer science and engineering, biomedicine, chemistry, environmental sciences, textile science and engineering, package materials, and so on. Dr. Jie Ren is a professor at the Institute of Nano and Bio-Polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai, China.

Advances in Polymeric Nanomaterials for Biomedical Applications

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Publisher : Elsevier
ISBN 13 : 0128146575
Total Pages : 388 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Advances in Polymeric Nanomaterials for Biomedical Applications by : Anil Kumar Bajpai

Download or read book Advances in Polymeric Nanomaterials for Biomedical Applications written by Anil Kumar Bajpai and published by Elsevier. This book was released on 2021-03-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Polymeric Nanomaterials for Biomedical Applications examines advanced polymer synthetic strategies for developing novel biomaterials for use in medicine. With a strong focus on fundamentals and structure, the authors also explore their fabrication, along with their current and potential biomedical applications. The book begins with a look at the fundamentals of polymeric nanomaterials and their properties and then discusses the design of biomaterials and their applications in drug delivery. Further chapters explore important applications, such as imaging and regenerative medicine, including current challenges and future trends. This valuable resource is especially useful for materials and polymer scientists, and bioengineers wishing to broaden their knowledge of polymeric nanobiomaterials. Covers the complete spectrum of polymer nanomaterials used in biomedical applications Includes various applications, such as drug delivery, gene delivery, bio-imaging, tissue engineering and regenerative medicine, anti-microbial agents, and neuroscience Explores fundamental correlations between structures, properties and applications, as well as synthetic strategies for polymer nanomaterials

Solid State Polymerization

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Publisher : John Wiley & Sons
ISBN 13 : 0470451823
Total Pages : 314 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Solid State Polymerization by : Constantine D. Papaspyrides

Download or read book Solid State Polymerization written by Constantine D. Papaspyrides and published by John Wiley & Sons. This book was released on 2009-04-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most current guide to solid state polymerization Solid State Polymerization (SSP)is an indispensable tool in the design, manufacture, and study of polymers, plastics, and fibers. SSP presents significant advantages over other polymerization techniques due to low operating temperatures, inexpensive equipment, and simple and environmentally sound procedures. Combining fundamentals of polymer science, chemistry, physical chemistry, and engineering, SSP also offers many research applications for a wide range of students and investigators. Gathering and filtering the latest literature on SSP, Solid Solid State Polymerization offers a unique, one-stop resource on this important process. With chapters contributed by leaders in the field, this text summarizes SSP, and provides essential coverage that includes: An introduction to SSP, with chemical and physical steps, apparatus, advantages, and parameters SSP physical chemistry and mechanisms Kinetic aspects of polyesters and polyamides SSP Catalysis in SSP processes Application of SSP under high pressure conditions in the laboratory Engineering aspects regarding process modeling and industrial application Recent developments and future possibilities Solid State Polymerization provides the most up-to-date coverage of this constantly developing field to academic and industry professionals, as well as graduate and postgraduate-level students in chemical engineering, materials science and engineering, polymer chemistry, polymer processing and polymer engineering.

Rapid, Efficient and Versatile Strategies for Functionally Sophisticated Polymers and Nanoparticles

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (865 download)

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Book Synopsis Rapid, Efficient and Versatile Strategies for Functionally Sophisticated Polymers and Nanoparticles by : Shiyi Zhang

Download or read book Rapid, Efficient and Versatile Strategies for Functionally Sophisticated Polymers and Nanoparticles written by Shiyi Zhang and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall emphasis of this dissertation research included two kinds of asymmetrically-functionalized nanoparticles with anisotropic distributions of chemical functionalities, three degradable polymers synthesized by organocatalyzed ring-opening polymerizations, and two polyphosphoester-based nanoparticle systems for various biomedical applications. Inspired by the many hierarchical assembly processes that afford complex materials in Nature, the construction of asymmetrically-functionalized nanoparticles with efficient surface chemistries and the directional organization of those building blocks into complex structures have attracted much attention. The first method generated a Janus-faced polymer nanoparticle that presented two orthogonally click-reactive surface chemistries, thiol and azido. This robust method involved reactive functional group transfer by templating against gold nanoparticle substrates. The second method produced nanoparticles with sandwich-like distribution of crown ether functionalities through a stepwise self-assembly process that utilized crown ether-ammonium supramolecular interactions to mediate inter-particle association and the local intra-particle phase separation of unlike hydrophobic polymers. With the goal to improve the efficiency of the production of degradable polymers with tunable chemical and physical properties, a new type of reactive polyphosphoester was synthesized bearing alkynyl groups by an organocatalyzed ring-opening polymerization, the chemical availability of the alkyne groups was investigated by employing "click" type azide-alkyne Huisgen cycloaddition and thiol-yne radical-mediated reactions. Based on this alkyne-functionalized polyphosphoester polymer and its two available "click" type reactions, two degradable nanoparticle systems were developed. To develop the first system, the well defined poly(ethylene oxide)-block-polyphosphester diblock copolymer was transformed into a multifunctional Paclitaxel drug conjugate by densely attaching the polyphosphoester block with azide-functionalized Paclitaxel by azide-alkyne Huisgen cycloaddition. This Paclitaxel drug conjugate provides a powerful platform for combinational cancer therapy and bioimaging due to its ultra-high Paclitaxel loading (> 65 wt%), high water solubility (>6.2 mg/mL for PTX) and easy functionalization. Another polyphosphoester-based nanoparticle system has been developed by a programmable process for the rapid and facile preparation of a family of nanoparticles with different surface charges and functionalities. The non-ionic, anionic, cationic and zwitterionic nanoparticles with hydrodynamic diameters between 13 nm to 21 nm and great size uniformity could be rapidly prepared from small molecules in 6 h or 2 days. The anionic and zwitterionic nanoparticles were designed to load silver ions to treat pulmonary infections, while the cationic nanoparticles are being applied to regulate lung injuries by serving as a degradable iNOS inhibitor conjugates. In addition, a direct synthesis of acid-labile polyphosphoramidate by organobase-catalyzed ring-opening polymerization and an improved two-step preparation of polyphosphoester ionomer by acid-assisted cleavage of phosphoramidate bonds on polyphosphoramidate were developed. Polyphosphoramidate and polyphosphoester ionomers may be applied to many applications, due to their unique chemical and physical properties

Multifunctional Polymeric Nanocomposites Based on Cellulosic Reinforcements

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Publisher : William Andrew
ISBN 13 : 0323417396
Total Pages : 410 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Multifunctional Polymeric Nanocomposites Based on Cellulosic Reinforcements by : Debora Puglia

Download or read book Multifunctional Polymeric Nanocomposites Based on Cellulosic Reinforcements written by Debora Puglia and published by William Andrew. This book was released on 2016-07-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Polymeric Nanocomposites Based on Cellulosic Reinforcements introduces the innovative applications of polymeric materials based on nanocellulose, and covers extraction methods, functionalization approaches, and assembly methods to enable these applications. The book presents the state-of-the-art of this novel nano-filler and how it enables new applications in many different sectors, beyond existing products. With a focus on application of nano-cellulose based polymers with multifunctional activity, the book explains the methodology of nano-cellulose extraction and production and shows the potential performance benefits of these particular nanostructured polymers, for applications across different sectors, including food active packaging, energy-photovoltaics, biomedical, and filtration. The book describes how the different methodologies, functionalization, and organization at the nano-scale level could contribute to the design of required properties at macro level. The book studies the interactions between the main nano-filler with other active systems and how this interaction enables multi-functionality in the produced materials. The book is an indispensable resource for the growing number of scientists and engineers interested in the preparation and novel applications of nano-cellulose, and for industrial scientists active in formulation and fabrication of polymer products based on renewable resources. - Provides insight into nanostructure formation science, and processing of polymeric materials and their characterization - Offers a strong analysis of real industry needs for designing the materials - Provides a well-balanced structure, including a light introduction of basic knowledge on extraction methods, functionalization approaches, and assembling focused to applications - Describes how different methodologies, functionalization, and organization at the nano-scale level could contribute to the design of required properties at macro level

Cross-linkable Surfactant-stabilized Polylactide-based Nanoparticles by Thiol-ene Reactions in Transparent Miniemulsion

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ISBN 13 :
Total Pages : 46 pages
Book Rating : 4.:/5 (769 download)

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Book Synopsis Cross-linkable Surfactant-stabilized Polylactide-based Nanoparticles by Thiol-ene Reactions in Transparent Miniemulsion by : Lu Yu

Download or read book Cross-linkable Surfactant-stabilized Polylactide-based Nanoparticles by Thiol-ene Reactions in Transparent Miniemulsion written by Lu Yu and published by . This book was released on 2011 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biodegradable nanomaterials have attracted broad interests because of their significant biomedical applications. However, it remains a challenge to develop simple and robust approaches for the preparation of biodegradable nanomaterials with well-controlled structures and optimal properties. Nanoparticles typically have high tendency to aggregate, but such aggregation behavior may impair their performance as drug delivery scaffolds. Our research group recently demonstrated an efficient synthesis of well-defined biodegradable nanoparticles by thiol-ene cross-linking in transparent miniemulsion. However, the resulting polylactide-based nanoparticles can easily aggregate in various liquid media. This thesis research is to achieve nanoparticles with minimal aggregation tendency by covalent stabilization of surfactants on the surface of nanoparticles. Reactive surfactants were designed, prepared, and used in the preparation of nanoparticles. The nanoparticles with fixed surfactant moieties on surface exhibited remarkably high colloidal stability.

Multifunctional Polydopamine Nanomaterials for Biomedical and Environmental Applications

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)

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Book Synopsis Multifunctional Polydopamine Nanomaterials for Biomedical and Environmental Applications by : Hamed Gholami Derami

Download or read book Multifunctional Polydopamine Nanomaterials for Biomedical and Environmental Applications written by Hamed Gholami Derami and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polydopamine (PDA), a synthetic and organic material, has emerged as a promising materialplatform for various applications in energy, environmental, and biomedical fields. PDA, formed by self-polymerization of dopamine, is rich in catechol and amine groups, which facilitate covalent conjugation and/or other non-covalent interactions with organic and inorganic materials. It is highly biocompatible, biodegradable, has broadband light absorption spectrum and excellent light-to-heat conversion efficiency. Also, it is easy to synthesize and functionalize. The combination of excellent characteristics of polydopamine-based nanomaterials, make them a promising adsorbent agent for environmental wastewater treatment and photothermal agent for biomedical applications. In the first half of thesis, we utilize the surface chemical functionality of polydopamine nanoparticles and their affinity to heavy metal ions and organic dyes to realize multifunctional filtration membranes that remove heavy metal ions and organic dyes from water through adsorption and catalytic degradation. Polydopamine exhibits high adsorption capacity toward heavy metal ions and organic dyes. Adsorption-based membrane technologies can be ideal for continuous flow water purification and have been extensively employed at industrial scale forxxiii water reclamation. By introducing polydopamine nanoparticles during bacteria-mediated cellulose growth, we fabricated a composite foam and membrane to study the adsorption behavior of the nanocomposites in different environmentally relevant pH and concentrations. The PDA/BNC membrane was used to investigate the removal efficiency of toxic heavy metals ions such as Pb (II) and Cd (II) and organic pollutants such as rhodamine 6G and methylene blue. Furthermore, to improve the range of pH in which the composite membrane is effective for dye removal, we fabricated another novel polydopamine/nanocellulose membrane, which is decorated with palladium (Pd) nanoparticles to remove organic dyes from contaminated water through catalytic dye degradation. In the second part of thesis, we develop polydopamine-based nanomaterials and experimental setups to be used in biomedical applications such as drug delivery and photothermal stimulation of cells. Using mesoporous silica-coated PDA nanoparticles as drug carrier and tetradecanol (TD) as gate keeper, we demonstrated that we could enhance the immune system response toward Melanoma cancer in mouse model through combination of photothermal and immunotherapy. Polydopamine core works as a photothermal agent to cause localized release of gardiquimod and tumor cell death upon NIR laser irradiation, hence, release of tumor associated antigens. Antigen presenting cells (APCs) including the dendritic cells and macrophages uptake these antigens and be activated around tumor site in response to these signals. Furthermore, these activated APCs, present the antigen to CD8+ cytotoxic T cells to actuate anti-tumor immune response. We have shown that this treatment is effective in reducing the tumor size and eliminating it in majority of cases. Also, the treatment created a memory effect in immune system toward melanoma cancer when second cancer event happened in mice that were treated before. Finally, we investigated the possibility of controlling the excitable cells' activity through nanoheating. This was made possible by using polydopamine nanoparticles to localize the heat on cell membrane. We demonstrated that by using polydopamine nanoparticle and polydopamine/collagen 3D foam, and by applying NIR laser light, we can reversibly modulate the activity of in vitro cultured neurons and cardiomyocytes. A reduction in firing rate of neurons and an increase in beating rate of cardiomyocytes with different degree of inhibition and excitation was observed. Effect of different parameters on the quality of modulation was investigated.

Bionanocomposites

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Publisher : John Wiley & Sons
ISBN 13 : 1118942221
Total Pages : 390 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Bionanocomposites by : Carole Aimé

Download or read book Bionanocomposites written by Carole Aimé and published by John Wiley & Sons. This book was released on 2017-09-05 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning with a general overview of nanocomposites, Bionanocomposites: Integrating Biological Processes for Bio-inspired Nanotechnologies details the systems available in nature (nucleic acids, proteins, carbohydrates, lipids) that can be integrated within suitable inorganic matrices for specific applications. Describing the relationship between architecture, hierarchy and function, this book aims at pointing out how bio-systems can be key components of nanocomposites. The text then reviews the design principles, structures, functions and applications of bionanocomposites. It also includes a section presenting related technical methods to help readers identify and understand the most widely used analytical tools such as mass spectrometry, calorimetry, and impedance spectroscopy, among others.

Applications of Multifunctional Nanomaterials

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Publisher : Elsevier
ISBN 13 : 0128208821
Total Pages : 834 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Applications of Multifunctional Nanomaterials by : Sabu Thomas

Download or read book Applications of Multifunctional Nanomaterials written by Sabu Thomas and published by Elsevier. This book was released on 2023-03-30 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of Multifunctional Nanomaterials showcases the major applications of highly correlated nanosystems that highlight the multifunctionality of nanomaterials. This includes applications of nanomaterials in spintronics, information storage, magnetic data storage and memory device applications, energy harvesting applications using nanomultiferroics with piezoelectric polymers, nonlinear optical limiting applications using graphene or ferrite nanoparticles, soft tissues applications, EMI shielding applications and even applications in sunscreen lotions, cosmetics and food packaging will be discussed. In addition, nanoparticle incorporation in animal nutrition intended for increased productivity is an innovative and groundbreaking theme of the book. Finally, functionalized magnetic nanoparticles for drug delivery, magnetic hyperthermia, sutures, cancer therapy, dentistry and other biomedical and bio-engineering applications using nanoparticles are discussed in detail. - Explains the major design and fabrication techniques and processes for a range of multifunctional nanomaterials and nanotechnologies - Demonstrates how ferromagnetics, multiferroics and carbon nanomaterials are designed for electronic and optical applications - Assesses the major challenges of using multifunctional nanomaterials on a mass scale

Biopolymers from Renewable Resources

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Publisher : Springer Science & Business Media
ISBN 13 : 3662036800
Total Pages : 438 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Biopolymers from Renewable Resources by : David L. Kaplan

Download or read book Biopolymers from Renewable Resources written by David L. Kaplan and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopolymers from Renewable Resources is a compilation of information on the diverse and useful polymers derived from agricultural, animal, and microbial sources. The volume provides insight into the diversity of polymers obtained directly from, or derived from, renewable resources. The beneficial aspects of utilizing polymers from renewable resources, when considering synthesis, pro cessing, disposal, biodegradability, and overall material life-cycle issues, suggests that this will continue to be an important and growing area of interest. The individual chapters provide information on synthesis, processing and properties for a variety of polyamides, polysaccharides, polyesters and polyphenols. The reader will have a single volume that provides a resource from which to gain initial insights into this diverse field and from which key references and contacts can be drawn. Aspects of biology, biotechnology, polymer synthesis, polymer processing and engineering, mechanical properties and biophysics are addressed to varying degrees for the specific biopolymers. The volume can be used as a reference book or as a teaching text. At the more practical level, the range of important materials derived from renewable resources is both extensive and impressive. Gels, additives, fibers, coatings and films are generated from a variety of the biopolymers reviewed in this volume. These polymers are used in commodity materials in our everyday lives, as well as in specialty products.

Encyclopedia of Polymer Applications, 3 Volume Set

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Publisher : CRC Press
ISBN 13 : 1351019414
Total Pages : 2954 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Encyclopedia of Polymer Applications, 3 Volume Set by : Munmaya Mishra

Download or read book Encyclopedia of Polymer Applications, 3 Volume Set written by Munmaya Mishra and published by CRC Press. This book was released on 2018-12-17 with total page 2954 pages. Available in PDF, EPUB and Kindle. Book excerpt: Undoubtedly the applications of polymers are rapidly evolving. Technology is continually changing and quickly advancing as polymers are needed to solve a variety of day-to-day challenges leading to improvements in quality of life. The Encyclopedia of Polymer Applications presents state-of-the-art research and development on the applications of polymers. This groundbreaking work provides important overviews to help stimulate further advancements in all areas of polymers. This comprehensive multi-volume reference includes articles contributed from a diverse and global team of renowned researchers. It offers a broad-based perspective on a multitude of topics in a variety of applications, as well as detailed research information, figures, tables, illustrations, and references. The encyclopedia provides introductions, classifications, properties, selection, types, technologies, shelf-life, recycling, testing and applications for each of the entries where applicable. It features critical content for both novices and experts including, engineers, scientists (polymer scientists, materials scientists, biomedical engineers, macromolecular chemists), researchers, and students, as well as interested readers in academia, industry, and research institutions.

Biodegradable polymers for biomedical applications - volume II

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Publisher : Frontiers Media SA
ISBN 13 : 2832528821
Total Pages : 167 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Biodegradable polymers for biomedical applications - volume II by : Liqun Yang

Download or read book Biodegradable polymers for biomedical applications - volume II written by Liqun Yang and published by Frontiers Media SA. This book was released on 2023-07-04 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: