Development Of Innovative Drugs Via Modeling With Matlab

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Development of Innovative Drugs via Modeling with MATLAB

Author : Ronald Gieschke
Publisher : Springer Science & Business Media
ISBN 13 : 3642397654
Total Pages : 407 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Development of Innovative Drugs via Modeling with MATLAB by : Ronald Gieschke

Download or read book Development of Innovative Drugs via Modeling with MATLAB written by Ronald Gieschke and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: - Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs - Guidance for exploration and modification of these programs to enhance the understanding of key principles - Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature - A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.

Introduction to Modeling and Simulation with MATLAB® and Python

Author : Steven I. Gordon
Publisher : CRC Press
ISBN 13 : 1498773907
Total Pages : 140 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Introduction to Modeling and Simulation with MATLAB® and Python by : Steven I. Gordon

Download or read book Introduction to Modeling and Simulation with MATLAB® and Python written by Steven I. Gordon and published by CRC Press. This book was released on 2017-07-12 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Modeling and Simulation with MATLAB and Python is intended for students and professionals in science, social science, and engineering that wish to learn the principles of computer modeling, as well as basic programming skills. The book content focuses on meeting a set of basic modeling and simulation competencies that were developed as part of several National Science Foundation grants. Even though computer science students are much more expert programmers, they are not often given the opportunity to see how those skills are being applied to solve complex science and engineering problems and may also not be aware of the libraries used by scientists to create those models. The book interleaves chapters on modeling concepts and related exercises with programming concepts and exercises. The authors start with an introduction to modeling and its importance to current practices in the sciences and engineering. They introduce each of the programming environments and the syntax used to represent variables and compute mathematical equations and functions. As students gain more programming expertise, the authors return to modeling concepts, providing starting code for a variety of exercises where students add additional code to solve the problem and provide an analysis of the outcomes. In this way, the book builds both modeling and programming expertise with a "just-in-time" approach so that by the end of the book, students can take on relatively simple modeling example on their own. Each chapter is supplemented with references to additional reading, tutorials, and exercises that guide students to additional help and allows them to practice both their programming and analytical modeling skills. In addition, each of the programming related chapters is divided into two parts – one for MATLAB and one for Python. In these chapters, the authors also refer to additional online tutorials that students can use if they are having difficulty with any of the topics. The book culminates with a set of final project exercise suggestions that incorporate both the modeling and programming skills provided in the rest of the volume. Those projects could be undertaken by individuals or small groups of students. The companion website at http://www.intromodeling.com provides updates to instructions when there are substantial changes in software versions, as well as electronic copies of exercises and the related code. The website also offers a space where people can suggest additional projects they are willing to share as well as comments on the existing projects and exercises throughout the book. Solutions and lecture notes will also be available for qualifying instructors.

Developing Solid Oral Dosage Forms

Author : Yihong Qiu
Publisher : Academic Press
ISBN 13 : 0128026375
Total Pages : 1178 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Developing Solid Oral Dosage Forms by : Yihong Qiu

Download or read book Developing Solid Oral Dosage Forms written by Yihong Qiu and published by Academic Press. This book was released on 2016-11-08 with total page 1178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more. - Written and edited by an international team of leading experts with experience and knowledge across industry, academia, and regulatory settings - Includes new chapters covering the pharmaceutical applications of surface phenomenon, predictive biopharmaceutics and pharmacokinetics, the development of formulations for drug discovery support, and much more - Presents new case studies throughout, and a section completely devoted to regulatory aspects, including global product regulation and international perspectives

New Insights into Toxicity and Drug Testing

Author : Sivakumar Joghi Thatha Gowder
Publisher : BoD – Books on Demand
ISBN 13 : 9535109464
Total Pages : 255 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis New Insights into Toxicity and Drug Testing by : Sivakumar Joghi Thatha Gowder

Download or read book New Insights into Toxicity and Drug Testing written by Sivakumar Joghi Thatha Gowder and published by BoD – Books on Demand. This book was released on 2013-01-23 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book "New Insights into Toxicity and Drug Testing" covers all emerging technologies (profiling technologies, 3D cultures, next generation sequencing etc.), available methods and models to evaluate candidate drugs and medicinal plants with reference to toxicity, drug testing and development. This book is an original contribution of experts from different parts of the globe and the in-depth information will be a significant resource for scientists and physicians who are directly dealing with drugs / medicines and human life.

Predictive Analytics using MATLAB(R) for Biomedical Applications

Author : L. Ashok Kumar
Publisher : Elsevier
ISBN 13 : 0443298890
Total Pages : 109 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Predictive Analytics using MATLAB(R) for Biomedical Applications by : L. Ashok Kumar

Download or read book Predictive Analytics using MATLAB(R) for Biomedical Applications written by L. Ashok Kumar and published by Elsevier. This book was released on 2024-10-03 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predictive Analytics using MATLAB(R) for Biomedical Applications is a comprehensive and practical guide for biomedical engineers, data scientists, and researchers on how to use predictive analytics techniques in MATLAB(R) for solving real-world biomedical problems. The book offers a technical overview of various predictive analytics methods and covers the utilization of MATLAB(R) for implementing these techniques. It includes several case studies that demonstrate how predictive analytics can be applied to real-world biomedical problems, such as predicting disease progression, analyzing medical imaging data, and optimizing treatment outcomes.With a plethora of examples and exercises, this book is the ultimate tool for reinforcing one's knowledge and skills. - Covers various predictive analytics methods, including regression analysis, time series analysis, and machine learning algorithms, providing readers with a comprehensive understanding of the field - Provides a hands-on approach to learning predictive analytics, with a focus on practical applications in biomedical engineering - Includes several case studies that demonstrate the practical application of predictive analytics in real-world biomedical problems, such as disease progression prediction, medical imaging analysis, and treatment optimization

Optimal Control of Nonlinear Processes

Author : Dieter Grass
Publisher : Springer Science & Business Media
ISBN 13 : 3540776478
Total Pages : 552 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Optimal Control of Nonlinear Processes by : Dieter Grass

Download or read book Optimal Control of Nonlinear Processes written by Dieter Grass and published by Springer Science & Business Media. This book was released on 2008-07-24 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic optimization is rocket science – and more. This volume teaches researchers and students alike to harness the modern theory of dynamic optimization to solve practical problems. These problems not only cover those in space flight, but also in emerging social applications such as the control of drugs, corruption, and terror. This volume is designed to be a lively introduction to the mathematics and a bridge to these hot topics in the economics of crime for current scholars. The authors celebrate Pontryagin’s Maximum Principle – that crowning intellectual achievement of human understanding. The rich theory explored here is complemented by numerical methods available through a companion web site.

Early Drug Development

Author : Fabrizio Giordanetto
Publisher : John Wiley & Sons
ISBN 13 : 3527801774
Total Pages : 872 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Early Drug Development by : Fabrizio Giordanetto

Download or read book Early Drug Development written by Fabrizio Giordanetto and published by John Wiley & Sons. This book was released on 2018-06-15 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.

Computer Aided Pharmaceutics and Drug Delivery

Author : Vikas Anand Saharan
Publisher : Springer Nature
ISBN 13 : 9811651809
Total Pages : 767 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Computer Aided Pharmaceutics and Drug Delivery by : Vikas Anand Saharan

Download or read book Computer Aided Pharmaceutics and Drug Delivery written by Vikas Anand Saharan and published by Springer Nature. This book was released on 2022-05-30 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics. This book provides abundant applications of computers in formulation designing and characterization are provided as examples, case studies and illustrations. Short reviews of software, databases and expert systems have also been added to culminate the interest of readers for novel applications in formulation development and drug delivery. Computer-aided pharmaceutics and drug delivery is an authoritative reference source for all the latest scholarly update on emerging developments in computed assisted techniques for drug designing and development. The book is ideally designed for pharmacists, medical practitioners, students and researchers.

Applied Pharmacometrics

Author : Stephan Schmidt
Publisher : Springer
ISBN 13 : 1493913042
Total Pages : 570 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Applied Pharmacometrics by : Stephan Schmidt

Download or read book Applied Pharmacometrics written by Stephan Schmidt and published by Springer. This book was released on 2014-12-01 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer’s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.

NASA Tech Briefs

Author :
Publisher :
ISBN 13 :
Total Pages : 986 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis NASA Tech Briefs by :

Download or read book NASA Tech Briefs written by and published by . This book was released on 2001 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Engineering Drug Delivery Systems

Author : Ali Seyfoddin
Publisher : Woodhead Publishing
ISBN 13 : 0081025491
Total Pages : 252 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Engineering Drug Delivery Systems by : Ali Seyfoddin

Download or read book Engineering Drug Delivery Systems written by Ali Seyfoddin and published by Woodhead Publishing. This book was released on 2019-11-15 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering Drug Delivery Systems is an essential resource on a variety of biomaterials engineering approaches for creating drug delivery systems that have market and therapeutic potential. The book comprehensively discusses recent advances in the fields of biomaterials and biomedical sciences in relation to drug delivery. Chapters provide a detailed introduction to various engineering approaches in designing drug delivery systems, delve into the engineering of body functions, cover the selection, design and evaluation of biomaterials, and discuss the engineering of colloids as drug carriers. The book's final chapters address the engineering of implantable drug delivery systems and advances in drug delivery technology. This book is an invaluable resource for drug delivery, materials scientists and bioengineers within the pharmaceutical industry. - Examines the properties and synthesis of biomaterials for successful drug delivery - Discusses the important connection between drug delivery and tissue engineering - Includes techniques and approaches applicable to a wide range of users - Reviews innovative technologies in drug delivery systems such as 3-D printed devices for drug delivery

Biopharmaceutical Applied Statistics Symposium

Author : Karl E. Peace
Publisher : Springer
ISBN 13 : 9811078297
Total Pages : 414 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Biopharmaceutical Applied Statistics Symposium by : Karl E. Peace

Download or read book Biopharmaceutical Applied Statistics Symposium written by Karl E. Peace and published by Springer. This book was released on 2018-08-20 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter.The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. This book is the first of the 3-volume book series. The topics covered include: A Statistical Approach to Clinical Trial Simulations, Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design, Adaptive Trial Design in Clinical Research, Best Practices and Recommendations for Trial Simulations in the Context of Designing Adaptive Clinical Trials, Designing and Analyzing Recurrent Event Data Trials, Bayesian Methodologies for Response-Adaptive Allocation, Addressing High Placebo Response in Neuroscience Clinical Trials, Phase I Cancer Clinical Trial Design: Single and Combination Agents, Sample Size and Power for the Mixed Linear Model, Crossover Designs in Clinical Trials, Data Monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures, Design and Data Analysis for Multiregional Clinical Trials – Theory and Practice, Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines, Development and Validation of Patient-reported Outcomes, Interim Analysis of Survival Trials: Group Sequential Analyses, and Conditional Power – A Non-proportional Hazards Perspective.

Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

Author : Panos Macheras
Publisher : Springer
ISBN 13 : 3319275984
Total Pages : 498 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics by : Panos Macheras

Download or read book Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics written by Panos Macheras and published by Springer. This book was released on 2016-03-30 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology. Reviews of the first edition: "This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007) "These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)

Computational Pharmaceutics

Author : Defang Ouyang
Publisher : John Wiley & Sons
ISBN 13 : 1118573978
Total Pages : 350 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Computational Pharmaceutics by : Defang Ouyang

Download or read book Computational Pharmaceutics written by Defang Ouyang and published by John Wiley & Sons. This book was released on 2015-05-19 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.

Modeling and Control of Economic Systems 2001

Author : R. Neck
Publisher : Elsevier
ISBN 13 : 008053659X
Total Pages : 443 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Modeling and Control of Economic Systems 2001 by : R. Neck

Download or read book Modeling and Control of Economic Systems 2001 written by R. Neck and published by Elsevier. This book was released on 2003-05-21 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers presented at the IFAC symposium on Modeling and control of Economic Systems (SME 2001), which was held at the university of Klagenfurt, Austria. The symposium brought together scientists and users to explore current theoretical developments of modeling techniques for economic systems. It contains a section of plenary, invited and contributed papers presented at the SME 2001 symposium. The papers presented in this volume reflect advances both in methodology and in applications in the area of modeling and control of economic systems.

Mathematical Modeling the Life Sciences

Author : N. G. Cogan
Publisher : CRC Press
ISBN 13 : 1000646955
Total Pages : 209 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Mathematical Modeling the Life Sciences by : N. G. Cogan

Download or read book Mathematical Modeling the Life Sciences written by N. G. Cogan and published by CRC Press. This book was released on 2022-09-09 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this unique textbook is to bridge the gap between the need for numerical solutions to modeling techniques through computer simulations to develop skill in employing sensitivity analysis to biological and life sciences applications. The underpinning mathematics is minimalized. The focus is on the consequences, implementation, and application. Historical context motivates the models. An understanding of the earliest models provides insight into more complicated ones. While the text avoids getting mired in the details of numerical analysis, it demonstrates how to use numerical methods and provides core codes that can be readily altered to fit a variety of situations. Numerical scripts in both Python and MATLAB® are included. Python is compiled in Jupyter Notebook to aid classroom use. Additionally, codes are organized and available online. One of the most important skills requiring the use of computer simulations is sensitivity analysis. Sensitivity analysis is increasingly used in biomathematics. There are numerous pitfalls to using sensitivity analysis and therefore a need for exposure to worked examples in order to successfully transfer their use from mathematicians to biologists. The interconnections between mathematics and the life sciences have an extensive history. This book offers a new approach to using mathematics to model applications using computers, to employ numerical methods, and takes students a step further into the realm of sensitivity analysis. With some guidance and practice, the reader will have a new and incredibly powerful tool to use. https://www.math.fsu.edu/~cogan/Book/Codes/Codes.html

Modeling and Control of Infectious Diseases in the Host

Author : Esteban A. Hernandez-Vargas
Publisher : Academic Press
ISBN 13 : 012813111X
Total Pages : 258 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Modeling and Control of Infectious Diseases in the Host by : Esteban A. Hernandez-Vargas

Download or read book Modeling and Control of Infectious Diseases in the Host written by Esteban A. Hernandez-Vargas and published by Academic Press. This book was released on 2019-02-14 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. - Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases - Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases - Presents a theoretic approach to schedule drug treatments