Development Of Genomic Methods And Tools For An Equine Model

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Development of Genomic Methods and Tools for an Equine Model

Author : Mohammed Ali Al Abri
Publisher :
ISBN 13 :
Total Pages : 290 pages
Book Rating : 4.:/5 (932 download)

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Book Synopsis Development of Genomic Methods and Tools for an Equine Model by : Mohammed Ali Al Abri

Download or read book Development of Genomic Methods and Tools for an Equine Model written by Mohammed Ali Al Abri and published by . This book was released on 2015 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of genomic analysis has identified regions of functional significance in several mammalian species. However, for horses, relatively little such work was done compared to other farm animals. The current archive of genetic variations in the horse is mostly based on the Thoroughbred mare upon which the reference sequence (EquCab2.0) was generated. Thus, more investigation of the equine genomic architecture is critical to better understand the equine genome. Chapter 2 of this dissertation represents an analyses of next generation sequencing data of six horses from a diverse genetic background. I have utilized the most advanced techniques to identify, and annotate genetic variants including single nucleotide polymorphism, copy number variations and structural variations pertaining to these horse breeds. The analysis discovered thousands of novel SNPs and INDELs and hundreds of CNVs and SVs in each of the horses. These newly identified variants where formatted as online tracks and should provide a foundational database for future studies in horse genomics. Chapter three of the thesis discusses a genome wide association study aimed at the discovery of QTLs affecting body size variation in horses. I used the Illumina Equine SNP50 BeadChip to genotype 48 horses from diverse breeds and representing the extremes in body size in horses. Unlike most association studies, I have utilized a dominant model to identify these QTLs. The analysis revealed an association in chromosome one at the ANKRD1 gene (involved in muscle myocytes and cardiomyocyte growth and differentiation). In chapter four, I represent the results of a genomic study in which 36 Egyptian Arabian horses were genotyped using the Illumina Equine SNP70 BeadChip. The study was conducted to elucidate the genetic background of the herd, relatedness within the herd and to estimate genomic inbreeding values. I was able to re-establish the genetic links between the horses and to confirm their Egyptian ancestry among other Arabian horse bloodlines. Genomic inbreeding values were highly correlated with the pedigree estimated ones. Altogether, our results signify the benefit of using this BeadChip technology to infer relationships within herds and ancestry of herds and to estimate inbreeding in herds lacking pedigree recording.

Equine Genomics

Author : Bhanu P. Chowdhary
Publisher : John Wiley & Sons
ISBN 13 : 0813815630
Total Pages : 349 pages
Book Rating : 4.8/5 (138 download)

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Book Synopsis Equine Genomics by : Bhanu P. Chowdhary

Download or read book Equine Genomics written by Bhanu P. Chowdhary and published by John Wiley & Sons. This book was released on 2013-04-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analysis of the equine genome began just over a decade ago, culminating in the recent complete sequencing of the horse genome. The availability of the equine whole genome sequence represents the successful completion of an important era of equine genome analysis, and the beginning of a new era where the sequence information will catalyze the development of new tools and resources that will permit study of a range of traits that are economically important and are significant to equine health and welfare. Equine Genomics provides a timely comprehensive overview of equine genomic research. Chapters detail key accomplishments and the current state of research, as well as looking forward to possible applications of genomic technologies to horse breeding, health, and welfare. Equine Genomics delivers a global overview of the topic and is seamlessly edited by a leading equine genomics researcher. Equine Genomics is an indispensible source of information for anyone with an interest in this increasingly important field of study, including equine genomic researchers, clinicians, animal science professionals and equine field veterinarians.

Leveraging Emerging Genomic Technologies for the Benefit of the Domestic Horse

Author : Heather Marie Holl
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.:/5 (892 download)

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Book Synopsis Leveraging Emerging Genomic Technologies for the Benefit of the Domestic Horse by : Heather Marie Holl

Download or read book Leveraging Emerging Genomic Technologies for the Benefit of the Domestic Horse written by Heather Marie Holl and published by . This book was released on 2014 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The domestic horse has played an important role in human history and serves as a valuable model organism for genetic studies. Generations of selective breeding have created several key population and genomic advantages for study. The completion of the horse reference genome sequence in 2009 further strengthened the utility of the horse as a genetic model. However, in order to continue deriving the maximum benefit from research, it is vital to incorporate novel genomic technologies. We applied three such methodologies in the following projects. Chromosomal aberrations can lead to congenital abnormalities, embryonic loss, and infertility. Detection of small deviations - such as aneuploidy in the acrocentric chromosomes, mosaicisms, or partial chromosomal structural variation can be difficult with typical cytogenetics techniques. The Illumina Equine SNP50 BeadChip was utilized for molecular karyotyping, assessing copy number variation at fifty thousand loci simultaneously throughout the genome. This method successfully diagnosed aberrations in three cases where the traditional FISH was not possible. Laminitis is a devastating disease of the hoof that is the second leading cause of both lameness and euthanasia in the horse. The etiology is poorly understood, and published research has focused on a small number of known gene targets. Due to the poor quality of current equine gene annotation, RNA-seq of lamellar tissue was undertaken to provide a more robust set of targets. De novo transcriptome assembly generated a valuable gene annotation resource for the future study of laminitis. Leopard complex spotting is a unique collection of pigmentation patterns in which a single autosomal allele (LP) allows for the expression of other modifying loci. RNA-seq was used to supplement typical gene mapping approaches for characterizing PATN1, a major effect modifier of LP. A targeted set of variants was produced for finemapping a 16 Mbp region associated with the phenotype. These genotypes identified a SNP in the 3'UTR of RFWD3 that may be utilized by horse breeders for the identification of non-LP horses that carry PATN1. These three projects demonstrate the benefit of next-generation technologies. High-throughput methods facilitate rapid high-resolution evaluation of the entire genome, providing a comprehensive tool for future research.

Genome Editing in Animals

Author : Izuho Hatada
Publisher : Springer Nature
ISBN 13 : 1071630164
Total Pages : 396 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Genome Editing in Animals by : Izuho Hatada

Download or read book Genome Editing in Animals written by Izuho Hatada and published by Springer Nature. This book was released on 2023-02-11 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides new and updated protocols that can be used for generation of knockout animals. Chapters guide the reader through basic protocols for three genome editing technologies, target design tools, and specific protocols for each animal. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Editing in Animals: Methods and Protocols, Second Edition aims to be a useful practical guide to researches to help further their study in this field.

Paleogenomics

Author : Charlotte Lindqvist
Publisher : Springer
ISBN 13 : 3030047539
Total Pages : 427 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Paleogenomics by : Charlotte Lindqvist

Download or read book Paleogenomics written by Charlotte Lindqvist and published by Springer. This book was released on 2019-01-07 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genome-scale DNA sequencing technologies have revolutionized genetic research on ancient organisms, extinct species, and past environments. When it is recoverable after hundreds or thousands of years of unintended preservation, “ancient DNA” (or aDNA) is often highly degraded, necessitating specialized handling and analytical approaches. Paleogenomics defines the field of reconstructing and analyzing the genomes of historic or long-dead organisms, most often through comparison with modern representatives of the same or similar species. The opportunity to isolate and study paleogenomes has radically transformed many fields, spanning biology, anthropology, agriculture, and medicine. Examples include understanding evolutionary relationships of extinct species known only from fossils, the domestication of plants and animals, and the evolution and geographical spread of certain pathogens. This pioneering book presents a snapshot view of the history, current status, and future prospects of paleogenomics, taking a broad viewpoint that covers a range of topics and organisms to provide an up-to-date status of the applications, challenges, and promise of the field. This book is intended for a variety of readerships, including upper-level undergraduate and graduate students, professionals and experts in the field, as well as anyone excited by the extraordinary insights that paleogenomics offers.

Genomic and Phenomic Tools for Livestock Genome Analysis

Author : Satpal Dixit
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659284182
Total Pages : 212 pages
Book Rating : 4.2/5 (841 download)

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Book Synopsis Genomic and Phenomic Tools for Livestock Genome Analysis by : Satpal Dixit

Download or read book Genomic and Phenomic Tools for Livestock Genome Analysis written by Satpal Dixit and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the era of genomic revolution the benefit can be reaped by successful integration of livestock genomics & phenomics to improve the productivity. This book covers various aspects of surveying, performance recording & breed descriptor development. It also includes: Phenotypic scoring-function for breed Identification; Genetic diversity analysis by STR; Breed registration in India; Analysis of milk quality traits by HPLC & GLC; Milk cells as indicator of mastitis; Application of linear & non-linear models in animal breeding; Data analysis using SYSTAT & HARVEY'S software; Estimation of breeding values for animal selections; Molecular markers for goat fecundity; Next generation sequencing; SNP chip development & genome wide association studies; Breed DNA signature by computational approach; Neural computation; Proteomics & its application; SNP discovery & association studies; In silico modeling of non-synonymous SNPs & prediction of protein structure & function; Microarrays in livestock research, Molecular modeling & drug designing; Stem cell & cloning of animal. This book is rare of its kind for beginners of research & future livestock molecular breeders for conceptualization.

Animal production and animal science worldwide

Author : A. Rosati
Publisher : BRILL
ISBN 13 : 908686564X
Total Pages : 370 pages
Book Rating : 4.0/5 (868 download)

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Book Synopsis Animal production and animal science worldwide by : A. Rosati

Download or read book Animal production and animal science worldwide written by A. Rosati and published by BRILL. This book was released on 2023-08-28 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the experience of the first volume, The World Association for Animal Production (WAAP) continues the publication of the Book of the Year series for the benefit of animal scientists and policy makers in the field of livestock systems. The WAAP asked the best known and significant animal scientists in the world to contribute to the preparation of this book. Following the success of the first volume of the series, the WAAP Book of the Year 2003, many authors from the six continents are contributing to this 2nd volume. The importance of this publication is to have already established a worldwide reference for the animal science and production sectors. There are the usual four sections that raised much interest in the previous volume of the series. The first section has six articles, describing the changing conditions of livestock systems in each of the six continents. The second section has more than twenty papers, describing the development of the many sectors in which the animal science field has been divided. The third section, dealing with contemporary issues, is declared by our readers to be the most interesting. It allows participating authors to describe current and significant issues important in these last years for the animal science and production sectors. The statistics produced in the previous volume are updated and enhanced with new figures in this book to form the fourth section. The papers included in this book speak clearly of the development in the last twelve months in the livestock systems worldwide. Major space is also devoted to the list of references from where every author can start to deepen his knowledge. This book is essential for libraries that want their readers to be easily updated. Also scientists, policy makers and scientific writers, who need, to enhance their competence, to have the most practical way of knowing what is going on in the world in the field of livestock science and production will find this book of great value.

Horse Genetics

Author : Ernest Bailey
Publisher : CABI
ISBN 13 : 1786392585
Total Pages : 240 pages
Book Rating : 4.7/5 (863 download)

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Book Synopsis Horse Genetics by : Ernest Bailey

Download or read book Horse Genetics written by Ernest Bailey and published by CABI. This book was released on 2020-04-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely updated and revised, the third edition of this essential textbook describes the basic genetics of the horse including coat colour, parentage, medical and population genetics, cytogenetics, performance, breeding systems and genetic conservation, as well as the many recent advances in genomics.

High-Resolution Functional Mapping of the Venezuelan Equine Encephalitis Virus Genome by Insertional Mutagenesis and Massively Parallel Sequencing

Download High-Resolution Functional Mapping of the Venezuelan Equine Encephalitis Virus Genome by Insertional Mutagenesis and Massively Parallel Sequencing PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 15 pages
Book Rating : 4.:/5 (713 download)

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Book Synopsis High-Resolution Functional Mapping of the Venezuelan Equine Encephalitis Virus Genome by Insertional Mutagenesis and Massively Parallel Sequencing by :

Download or read book High-Resolution Functional Mapping of the Venezuelan Equine Encephalitis Virus Genome by Insertional Mutagenesis and Massively Parallel Sequencing written by and published by . This book was released on 2010 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis or massively parallel sequencing to identify functionally important regions of the Venezuelan equine encephalitis virus (VEEV) genome. We initially used a capillary electrophoresis method to gain insight into the role of the VEEV nonstructural protein 3 (nsP3) in viral replication. We identified several regions in nsP3 that are intolerant to small (15 bp) insertions, and thus are presumably functionally important. We also identified nine separate regions in nsP3 that will tolerate small insertions at low temperatures (30 deg C), but not at higher temperatures (37 deg C, and 40 deg C). Because we found this method to be extremely effective at identifying temperature sensitive (ts) mutations, but limited by capillary electrophoresis capacity, we replaced the capillary electrophoresis with massively parallel sequencing and used the improved method to generate a functional map of the entire VEEV genome. We identified several hundred potential ts mutations throughout the genome and we validated several of the mutations in nsP2, nsP3, E3, E2, E1 and capsid using single-cycle growth curve experiments with virus generated through reverse genetics. We further demonstrated that two of the nsP3 ts mutants were attenuated for virulence in mice but could elicit protective immunity against challenge with wild-type VEEV. The recombinant ts mutants will be valuable tools for further studies of VEEV replication and virulence. Moreover, the method that we developed is applicable for generating such tools for any virus with a robust reverse genetics system.

Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries

Author : Yashpal Singh Malik
Publisher : Academic Press
ISBN 13 : 0128163534
Total Pages : 564 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries by : Yashpal Singh Malik

Download or read book Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries written by Yashpal Singh Malik and published by Academic Press. This book was released on 2019-09-14 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries is a comprehensive reference for animal biotechnologists, veterinary clinicians, fishery scientists, and anyone who needs to understand the latest advances in the field of next generation sequencing and genomic editing in animals and fish. This essential reference provides information on genomics and the advanced technologies used to enhance the production and management of farm and pet animals, commercial and non-commercial birds, and aquatic animals used for food and research purposes. This resource will help the animal biotechnology research community understand the latest knowledge and trends in this field. Presents biological applications of cattle, poultry, marine and animal pathogen genomics Discusses the relevance of biomarkers to improve farm animals and fishery Includes recent approaches in cloning and transgenic cattle, poultry and fish production

Equine Sports Medicine and Surgery - E-Book

Author : Kenneth W Hinchcliff
Publisher : Elsevier Health Sciences
ISBN 13 : 0443105944
Total Pages : 1442 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Equine Sports Medicine and Surgery - E-Book by : Kenneth W Hinchcliff

Download or read book Equine Sports Medicine and Surgery - E-Book written by Kenneth W Hinchcliff and published by Elsevier Health Sciences. This book was released on 2023-12-15 with total page 1442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get evidence-based guidelines to keeping athletic horses healthy and physically fit! Equine Sports Medicine and Surgery, 3rd Edition provides a comprehensive guide to exercise physiology and training within a clinical context, along with a detailed review of all diseases affecting horses participating in racing and competition. Not only does this text discuss the physiological responses of each body system to exercise, but it covers nutritional support, the prevention of exercise-induced disorders and lameness, and modification of training regimens. New to this edition are topics such as drug effects on performance and the use of cloud-based technologies for monitoring performance, as well as new content on exercise physiology, welfare, conditioning, farriery, behavior, and vision. Written by an expert team of international authors, each print purchase of this this authoritative, all-in-one resource comes with an ebook! NEW! Chapters in this edition include: History of Equine Exercise Physiology Welfare of Equine Athletes in Sport and the Social License to Operate The Connected Horse (focusing on innovative, cloud-based technologies used to monitor athletic horses) Conditioning of the Equine Athlete Principles of Sport Horse Farriery Epidemiology and Control of Infectious Respiratory Disease in Populations of Athletic Horses Behavior and Behavioral Abnormalities in Athletic Horses Vision and Disorders of Vision in Performance Horses Detection of Drug Use in Athletic Horses Drug Effects on Performance of the Equine Athlete Comprehensive coverage is based on sound research and evidence-based practice and provides an understanding of the physiologic processes underlying the responses of horses to exercise and physical conditioning — from musculoskeletal and respiratory disorders to nutrition and physical rehabilitation. International perspective on equine athletics includes guidelines pertinent to different geographic areas and racing jurisdictions. More than 1,000 images include medical illustrations and clinical photos depicting equine anatomy, testing, and treatment scenarios, as well as radiographic, ultrasonographic, CAT, and MRI imaging to support understanding and diagnosis. Coverage of abnormalities of the upper airway is now divided into two chapters: Disease of the Nasopharynx and Diseases of the Larynx and Trachea. Coverage of diseases of the heart is divided into two chapters: Arrhythmias and Abnormalities of the Cardiac Conduction System and Structural Heart Disease, Cardiomyopathy, and Diseases of Large Vessels. eBook version, included with print purchase, gives you the power to access all the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Equine Breeding Management and Artificial Insemination

Author : Juan C. Samper
Publisher : Elsevier Health Sciences
ISBN 13 : 1437711227
Total Pages : 336 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Equine Breeding Management and Artificial Insemination by : Juan C. Samper

Download or read book Equine Breeding Management and Artificial Insemination written by Juan C. Samper and published by Elsevier Health Sciences. This book was released on 2008-12-22 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Put the principles of good breeding management into practice with Equine Breeding Management and Artificial Insemination, 2nd Edition for reproductive success! Practical information on the reproductive management of both thoroughbred and warmblood breeding operations prepares you to effectively breed even problem mares and stallions. Plus, detailed content on techniques, procedures, reproductive physiology, and more help you increase reproductive efficiency as well as track and improve your results throughout each breeding season. A section on reproduction efficiency evaluation includes a worksheet to evaluate the performance of both mares and stallions during each breeding season, and helps you compare reproductive performance with previous breeding seasons. Detailed descriptions of procedures and techniques including embryo transfer, artificial insemination, and more enable you to implement the methods for better breeding results. Practical information on reproductive management of both thoroughbred and warmblood breeding operations enhance the fertility of problem mares and stallions. World-renowned authors and contributors with years of practical knowledge and experience provide cutting-edge information. Vibrant full-color design and photographs show accurate representations of clinical appearance. Chapters covering the latest reproductive techniques improve chances of successful breeding, and improve survival rates after the birth of the foal. Vital chapters with information on recognizing potential problems help you quickly identify warning signs before fertility is negatively affected.

Textbook of Animal Biotechnology

Author : B Singh
Publisher : The Energy and Resources Institute (TERI)
ISBN 13 : 817993327X
Total Pages : 715 pages
Book Rating : 4.1/5 (799 download)

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Book Synopsis Textbook of Animal Biotechnology by : B Singh

Download or read book Textbook of Animal Biotechnology written by B Singh and published by The Energy and Resources Institute (TERI). This book was released on 2005-01-01 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal biotechnology is an integral component of agriculture. Supported with over 50 figures and more than 30 tables, this textbook is a must have for undergraduates and postgraduates of various agriculture and animal husbandry academia, teachers, professionals, and researchers in basic as well as applied animal sciences including biotechnology, nutrition, physiology and reproduction. The book covers various topics, including economically important livestock breeds, paradigm shifts in livestock production, biotechnology in animal nutrition and in livestock-assisted reproduction, and genomics and genetic engineering tools in livestock production and management.

Engineering the Jerbouse

Author : Hannah Ariel Grunwald
Publisher :
ISBN 13 :
Total Pages : 175 pages
Book Rating : 4.:/5 (123 download)

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Book Synopsis Engineering the Jerbouse by : Hannah Ariel Grunwald

Download or read book Engineering the Jerbouse written by Hannah Ariel Grunwald and published by . This book was released on 2020 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the course of millions of years, modifications in mammalian genomes have produced an incredible variety of phenotypes, from the antlers of deer, to the breathing capacity of whales, to the dexterous fingers of a human. This remarkable diversity is perhaps nowhere more evident than in the limb of the mammal, which, despite its underlying structural similarities, exhibits specialized morphologies that look strikingly different in different species. Thus the hands typing this abstract are structurally similar but morphologically and functionally divergent from the fins of a manatee, the wings of a bat, or the legs of a horse. Comparing the genetic and regulatory underpinnings of this divergence (and indeed, of the similarities between species) allows us to simultaneously reconstruct genomic evolution and delve into the developmental mechanisms that produce limbs. The lesser Egyptian jerboa, Jaculus jaculus, is genomically similar to the common laboratory mouse, Mus musculus, but has highly divergent derived characteristics in the hindlimb. The hindlimb of the jerboa features a striking elongation of metatarsals and tibia, the loss of two digits, and the fusing of metatarsals into one central bone. By engineering 'jerboanized' mouse models, where regions of the mouse genome are replaced with their jerboa homologues to produce animals with jerboa-esque phenotypes, we can elucidate the mechanisms of divergence and development in the jerboa in a well-established and highly manipulable model system. Here, I present work on two genetic engineering techniques that promise to transform interspecies comparisons in rodent systems. First, I introduce a large interspecies conversion that simultaneously deletes a ~26kb region of the mouse genome and replaces it with ~31kb of homologous sequence from the jerboa. Second, I present the first demonstration of active genetics, a technique that makes use of the CRISPR Cas9 system to convert genotypes, in a rodent model. Active genetics in the rodent may be used to increase the rate of inheritance of an allele, which has profound implications the future of genetic engineering in both laboratory and applied settings. Together these tools may be used to develop complex mouse models of jerboanized phenotypes to probe the specific genomic changes responsible for the evolution of the development of the jerboa morphology.

Development of Computational Techniques for Genomic Data Analysis and Visualisation in Model and Non-model Organisms

Author : Anil Thanki
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)

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Book Synopsis Development of Computational Techniques for Genomic Data Analysis and Visualisation in Model and Non-model Organisms by : Anil Thanki

Download or read book Development of Computational Techniques for Genomic Data Analysis and Visualisation in Model and Non-model Organisms written by Anil Thanki and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Equine Viruses

Author : Romain Paillot
Publisher : MDPI
ISBN 13 : 3039283200
Total Pages : 230 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Equine Viruses by : Romain Paillot

Download or read book Equine Viruses written by Romain Paillot and published by MDPI. This book was released on 2020-04-30 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Food and Agriculture Organization of the United Nations has recently estimated that the world equid population exceeds 110 million. Working equids (horses, ponies, donkeys, and mules) remain essential to ensure the livelihood of poor communities around the world. In many developed countries, the equine industry has significant economical weight, with around 7 million horses in Europe alone. The close relationship between humans and equids and the fact that the athlete horse is the terrestrial mammal that travels the most worldwide after humans are important elements to consider in the transmission of pathogens and diseases, amongst equids and to other species. The potential effect of climate change on vector ecology and vector-borne diseases is also of concern for both human and animal health. In this Special Issue, we intend to explore our understanding of a panel of equine viruses, looking at their pathogenicity, their importance in terms of welfare and potential association with diseases, their economic importance and impact on performance, and how their identification can be helped by new technologies and methods.

Genetic Analysis

Author : Philip Meneely
Publisher : Oxford University Press, USA
ISBN 13 : 0198809905
Total Pages : 491 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Genetic Analysis by : Philip Meneely

Download or read book Genetic Analysis written by Philip Meneely and published by Oxford University Press, USA. This book was released on 2020-02-11 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks? With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the interactions of genes during suppression, synthetic enhancement, and epistasis follows, which is then expanded into a consideration of genetic networks and personal genomics. Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight. We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.