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Development Of Dopaminergic Neurons
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Book Synopsis Development of Dopaminergic Neurons by : Umberto Di Porzio
Download or read book Development of Dopaminergic Neurons written by Umberto Di Porzio and published by Landes Bioscience. This book was released on 1999 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development and Engineering of Dopamine Neurons by : Jeroen Pasterkamp
Download or read book Development and Engineering of Dopamine Neurons written by Jeroen Pasterkamp and published by Springer Science & Business Media. This book was released on 2009-12-16 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
Book Synopsis Dopaminergic System Function and Dysfunction: Experimental Approaches by : José Antonio Fuentealba-Evans
Download or read book Dopaminergic System Function and Dysfunction: Experimental Approaches written by José Antonio Fuentealba-Evans and published by Springer Nature. This book was released on 2022-12-07 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving animals, multi-recording devices for in vivo simultaneous single cell and population activity, in silico modeling of dopamine neurons activity, neuroanatomical approaches, unbiased stereology, ultrastructural analyses of dopaminergic neurons, and axonal innervation. Additionally, chapters also incorporate pharmacological tools to model neuropsychiatric diseases, novel behavioral paradigms to dissect dopamine's role in behavior, and functional imaging to follow human dopamine system development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Dopamine Neurotransmission aims to be a valuable resource for researchers in various disciplines.
Book Synopsis Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS by : S.R.W. Stott
Download or read book Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS written by S.R.W. Stott and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Dopaminergic Neurons from Neural Stem Cells and Transplantation Into a Neonatal and Adult Animal Model of Parkinson's Disease by : Torben Scholz
Download or read book Development of Dopaminergic Neurons from Neural Stem Cells and Transplantation Into a Neonatal and Adult Animal Model of Parkinson's Disease written by Torben Scholz and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dopamine Handbook by : Leslie L. Iversen
Download or read book Dopamine Handbook written by Leslie L. Iversen and published by . This book was released on 2010 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.
Download or read book Wiring Up Diversity written by and published by . This book was released on 2018 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Book Synopsis Dopamine Handbook by : Leslie Iversen
Download or read book Dopamine Handbook written by Leslie Iversen and published by Oxford University Press. This book was released on 2009-11-13 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.
Book Synopsis Trophic Regulation of the Basal Ganglia by : K. Fuxe
Download or read book Trophic Regulation of the Basal Ganglia written by K. Fuxe and published by Elsevier. This book was released on 2013-10-22 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trophic Regulation of the Basal Ganglia: Focus on Dopamine Neurons examines neurotransmitters. The book first discusses the role of fibroblast growth factor-2 (FGF-2) and ganglioside GM1 and the trophic regulation of the basal ganglia. Biochemical and histochemical studies on the cellular localization of FGF-2; mapping of FGF-2 and its receptors in the basal ganglia postnatally and adulthood; and mapping of the ganglioside GM1 distribution in the basal ganglia are presented. The text also explains glucocorticoid and estrogen effects on the nigrostriatal and mesolimbic dopaminergic systems; factors associated to dopaminergic cell death in Parkinson's disease; and compensatory mechanisms at dopamine D-2 receptors. The book also describes the effects of brain-derived neurotrophic factor on injured dopaminergic neurons; role of gangliosides and trophic factors in brain repair; and features of the trophic action of polyamines. The text also underscores the presence of interleukin-1 in the central nervous system; neuropeptides synthesis in astrocytes; and astrocytic kynurenines as modulators of dopaminergic function in the rat basal ganglia. The selection is a good source of information for readers wanting to study neurotransmitters.
Book Synopsis Investigating the Development of Midbrain Dopaminergic Neurons Using Mouse Embryonic Stem Cell Reporter Lines by : Colin Tze En Su
Download or read book Investigating the Development of Midbrain Dopaminergic Neurons Using Mouse Embryonic Stem Cell Reporter Lines written by Colin Tze En Su and published by . This book was released on 2012 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Embryonic stem (ES) cells possess the capability to self-renew indefinitely and are capable of generating any cell of the three primary germ layers, making them an attractive source of material to investigate both basic physiological properties and neurodegenerative processes. Although ES cells can be directed into specific cell lineages, the differentiation of ES cells results in heterogenous cultures. To date, there are few differentiation protocols that produce homogenous populations of any desired cell type. Many methods have been used in an effort to obtain homogenous populations of cells; from forced expression of genes involved in developmental pathways, to FACS isolation of cells expressing markers of interest. There has been a considerable focus on generating homogenous populations of midbrain dopaminergic progenitors (or neurons) for Parkinson's disease which involves the degeneration of a specific population of midbrain dopaminergic neurons. In this thesis, I investigate the development of mouse embryonic stem cells into midbrain dopaminergic neurons using reporter cell lines. In the first experimental chapter, I investigate the expression of Lmx1a and Msx1; two key transcription factors implicated in dopaminergic neuronal development. I also examine the impact of the BMP, Shh and Wnt signalling pathways on dopaminergic neural differentiation. Activation of the BMP and Wnt pathways resulted in inhibition of neural induction and the expression of both Lmx1a and Msx1. In contrast, antagonising these signalling pathways increased the yield of tyrosine hydroxylase (TH) expressing neurons. Activating or inhibiting the Shh pathway did not affect Lmx1a, Msx1 or TH expression. These experiments show that early Lmx1a expression is not indicative of the number of dopaminergic neurons produced. Furthermore, many of the TH positive neurons derived from monolayer cultures were not of midbrain origin. In the following experimental chapter, I used immunocytochemistry and qPCR to characterise the population of cells expressing Lmx1a. The downstream targets of Lmx1a, Msx1 and Wnt1, and midbrain dopaminergic neuron markers, Lmx1b and En1, were significantly upregulated in Lmx1a positive cells. The Lmx1a positive fraction was enriched with neural progenitors, and give rise to highly neural cultures. However, the majority of neurons in the terminally differentiated cultures derived from Lmx1a positive cells were GABAergic. Immunocytochemistry identified these cells as forebrain GABAergic neurons with upper-layer identity. Furthermore, the isolated Lmx1a positive cells were not responsive to patterning cues, indicating that they were already committed towards a GABAergic neuron fate. To show that these Lmx1a+ progenitors could generate dopaminergic neurons I used an alternative differentiation paradigm, the PA6 co-culture method. Expression of Lmx1a in PA6 co-cultures was different from monolayer cultures; the percentage of Lmx1a positive cells increased throughout the differentiation period. In addition, PA6 co-culture derived TH positive cells were found to co-express Lmx1a, an occurrence that was uncommon in monolayer cultures.The ionotropic glutamate receptors on neurons derived on adherent monolayer and PA6 co-cultures were functionally characterised in the final experimental chapter. Previously, antagonism of ionotropic glutamate receptors has been reported to improve behavioural assay scores in Parkinsonian animal models (Johnson et al., 2009). Terminally differentiated monolayer cultures and PA6 co-cultures responded differently to stimulation with glutamate, AMPA kainate and NMDA. The ionotropic glutamate receptors of midbrain dopaminergic and GABAergic neurons derived from both culture systems were further investigated. An initial characterisation indicates distinct differences between the glutamate receptor populations in monolayer and PA6 co-cultures. It appears that monolayer differentiation generates AMPA expressing midbrain dopaminergic neurons in comparison to the NMDA receptors evident following PA6 differentiation. Interestingly, these differences in receptor expression appear restricted by culture method, rather than neuronal subtype, i.e. monolayer neurons expressed AMPA receptors, regardless of whether they were TH+ or GAD67+. Similarly both TH+ and GAD67+ neurons appeared to express NMDA receptors following PA6 differentiation. At present the significance of these findings is unknown. In addition, the effect of Wnt5a on cell responses to glutamate agonists was examined. Wnt5a was able to potentiate cell responses to sub-maximal concentrations of certain glutamate agonists depending on the differentiation paradigm performed.
Book Synopsis Dopamine in the CNS I by : Gaetano Di Chiara
Download or read book Dopamine in the CNS I written by Gaetano Di Chiara and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Book Synopsis Essential Current Concepts in Stem Cell Biology by : Beate Brand-Saberi
Download or read book Essential Current Concepts in Stem Cell Biology written by Beate Brand-Saberi and published by Springer Nature. This book was released on 2020-01-03 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the biology of different adult stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal and cord blood stem cells and also covers induced pluripotent stem cells. Further, it includes a chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on the international masters program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and Tongji University Shanghai, the book is a valuable source for postdocs and researchers working with stems cells and also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.
Book Synopsis Factors Influencing the Survival and Development of Midbrain Dopaminergic Neurons in Vitro by : Catherine Holmes
Download or read book Factors Influencing the Survival and Development of Midbrain Dopaminergic Neurons in Vitro written by Catherine Holmes and published by . This book was released on 1996 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis In Situ Hybridization by : D. G. Wilkinson
Download or read book In Situ Hybridization written by D. G. Wilkinson and published by Oxford University Press, USA. This book was released on 1998 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: In situ hybridization is used to reveal the location of specific nucleic acids sequences on chromosomes or in tissues. Visualization of the location of genes on chromosomes or of specific mRNAs or viruses in tissues is crucial for understanding the organization, regulation, and function of genes. It is a therefore a core technique in all areas of biomedical research. In Situ Hybridization: A Practical Approach 2/e is the second edition of one of the most successful Practical Approach books, published in 1992. Since the first edition was published, a number of important technical advances have been made. The new edition has been thoroughly updated to contain protocols detailing the major techniques of in situ hybridization currently in use: in situ hybridization to mRNA with oligonucleotide and RNA probes (radiolabelled and hapten labelled); analysis using light and electron microscopes; whole mount in situ hybridization; double detection of RNAs, and RNA plus protein; and fluorescent in situ hybridization to detect chromosomal sequences. The protocols are complemented by advice on strategies for successful results, descriptions of the theoretical basis of in situ hybridization and important new developments in gene expression databases. The procedures described are widely applicable to many systems. The use of in situ hybridization in PCR is covered in a separate volume: Herrington and O'Leary (Eds) PCR 3 - PCR in situ hybridization: A Practical Approach (OUP, 1997). All the authors have extensive practical experience of establishing reliable techniques of in situ hybridization. This book will be useful to all researchers at all levels who use in situ hybridization.
Book Synopsis Dopaminergic System by : Liana Bolis
Download or read book Dopaminergic System written by Liana Bolis and published by . This book was released on 2001 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume an international, multidisciplinary group of experts reviews the latest findings on the biology of dopaminergic neurotransmission and the role of dopamine in the pathophysiology and treatment of disorders such as schizophrenia, depression, dysthymia, and motor diseases. The book integrates current knowledge on dopaminergic function from diverse areas of basic science and clinical research, including molecular biology, transgenic studies, biochemistry, genetics, brain imaging, neurology, and psychiatry.
Book Synopsis Development of Midbrain Dopaminergic Neurons in the Chick Embryo by : Phillip Michael Garfin
Download or read book Development of Midbrain Dopaminergic Neurons in the Chick Embryo written by Phillip Michael Garfin and published by . This book was released on 2004 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: