Development Of A Novel Gastro Retentive Delivery System Using Alfuzosin Hcl As A Model Drug

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Development of a Novel Gastro-retentive Delivery System Using Alfuzosin HCl as a Model Drug

Author : Quan Liu
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (128 download)

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Book Synopsis Development of a Novel Gastro-retentive Delivery System Using Alfuzosin HCl as a Model Drug by : Quan Liu

Download or read book Development of a Novel Gastro-retentive Delivery System Using Alfuzosin HCl as a Model Drug written by Quan Liu and published by . This book was released on 2010 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gastro-retentive dosage forms have been the topic of interest in recent years as a practical approach in drug deliveries to the upper GI tract or for release prolongation and absorption. These dosage forms are particularly suitable for drugs that have local effects on the gastric mucosa in the stomach. Other candidates include drugs that are likely to be absorbed in the upper small intestine, or drugs that are unstable in basic environment of distal intestine and colon or those with low solubility at elevated pH conditions (i.e. weak bases). To develop a gastro-retentive delivery system the following steps were taken. First, to investigate the possible incompatibility issues between the model drug and excipients to be used for the delivery system. Stability and physicochemical properties of the active agent and its mixture with excipients were studied using analytical techniques such as Raman spectroscopy and Differential scanning calorimetry (DSC). No incompatibility issues were detected. Second, Kollidon SR as a relatively new release-rate controlling polymer was incorporated in the final formulation. For solid dosage form the ability of the final powder mix to flow well during manufacturing and the intrinsic characteristics that make it compressible are critical. The in-depth compaction study of Kollidon SR was assessed with the help of a compaction simulator. The flowability, swelling and erosion behavior together with release-rate retarding properties of Kollidon SR were also assessed. The final oral delivery system was based on Kollidon SR and Polyethylene Oxide (PEO) 303 as a monolithic matrix system. The noneffervescent monolithic matrix was made by direct compression. In vitro evaluation of the designed system released the active content in a near zero manner. The dosage form was bouyant in pH 2.0 acidic buffer with no floatation lag time which minimizes the possibility of early gastric emptying.

A Statistical Approach to Design of Floating Drug Delivery System

Author : Venkata Srikanth Meka
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659583346
Total Pages : 52 pages
Book Rating : 4.5/5 (833 download)

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Book Synopsis A Statistical Approach to Design of Floating Drug Delivery System by : Venkata Srikanth Meka

Download or read book A Statistical Approach to Design of Floating Drug Delivery System written by Venkata Srikanth Meka and published by LAP Lambert Academic Publishing. This book was released on 2014-08-01 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a statistical approach to design and optimization of monolithic gastric floating drug delivery system of anticancer drug, Alfuzosin. Drug delivery system has its main aim to administered appropriate amount of drugs to the target site of the body in order to achieve and maintain the desired therapeutic drug concentration that elicits the desired pharmacological action. Drug absorption of oral route could be inadequate and highly variable in individuals due to physiological variabilities. This can be overcome by developing a suitable gastroretentive drug delivery system, which can prolong the gastric residence time of dosage form thereby improve the drug bio-availability. Floating drug delivery system is considerably easy and logical approach in the development of gastroretentive dosage forms. The oral delivery of anticancer alfuzosin was facilitated by preparing a gastric floating dosage form which could increase its absorption in the gastric region of the stomach by prolonging the gastric residence time of the drug. In the present work, gastric floating tablets were optimized by conventional process and further optimized by statistical methods.

Drug Delivery

Author : Yitzhak Rosen
Publisher : CRC Press
ISBN 13 : 1466565950
Total Pages : 602 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Drug Delivery by : Yitzhak Rosen

Download or read book Drug Delivery written by Yitzhak Rosen and published by CRC Press. This book was released on 2017-09-19 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.

Aulton's Pharmaceutics

Author : Michael E. Aulton
Publisher : Elsevier Health Sciences
ISBN 13 : 0702042900
Total Pages : 909 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Aulton's Pharmaceutics by : Michael E. Aulton

Download or read book Aulton's Pharmaceutics written by Michael E. Aulton and published by Elsevier Health Sciences. This book was released on 2013 with total page 909 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.

Hydrophilic Matrix Tablets for Oral Controlled Release

Author : Peter Timmins
Publisher : Springer
ISBN 13 : 1493915193
Total Pages : 328 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Hydrophilic Matrix Tablets for Oral Controlled Release by : Peter Timmins

Download or read book Hydrophilic Matrix Tablets for Oral Controlled Release written by Peter Timmins and published by Springer. This book was released on 2014-10-11 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.

Polysaccharides

Author : Severian Dumitriu
Publisher : CRC Press
ISBN 13 : 1420030825
Total Pages : 1210 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Polysaccharides by : Severian Dumitriu

Download or read book Polysaccharides written by Severian Dumitriu and published by CRC Press. This book was released on 2004-11-30 with total page 1210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and expanded to reflect the latest advancements in the field, Polysaccharides: Structural Diversity and Functional Versatility, Second Edition outlines fundamental concepts in the structure, function, chemistry, and stability of polysaccharides and reveals new analytical techniques and applications currently impacting the cosmeti

Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms

Author : Linda A. Felton
Publisher : CRC Press
ISBN 13 : 1315352923
Total Pages : 668 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms by : Linda A. Felton

Download or read book Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms written by Linda A. Felton and published by CRC Press. This book was released on 2016-09-19 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aqueous-based film coating has become routine in the pharmaceutical industry. This process eliminates the use of organic solvents and thus avoids economic, environmental, and toxicological issues related to residual solvents and solvent recovery. Aqueous-based coating, however, is complex and many variables may impact the final product and its performance. This fourth edition of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms aims to provide insight into the factors and parameters that should be considered and controlled for the successful development and commercialization of a coated product. The fourth edition has been revised and expanded to reflect the most recent scientific advancements from the literature. The contributing authors explain in detail, using illustrated examples, appropriate steps to solve and ideally avoid formulation, processing, and stability problems and to achieve an optimized dosage form. Trade names and chemical names of commercially marketed coatings are used throughout the text to help familiarize the reader with the various materials available for pharmaceutical applications. This book will be a valuable resource for anyone in the pharmaceutical industry working in the area of aqueous-based film coating.

Handbook of Drug Administration via Enteral Feeding Tubes, 3rd edition

Author : Rebecca White
Publisher : Pharmaceutical Press
ISBN 13 : 0857111620
Total Pages : 753 pages
Book Rating : 4.8/5 (571 download)

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Book Synopsis Handbook of Drug Administration via Enteral Feeding Tubes, 3rd edition by : Rebecca White

Download or read book Handbook of Drug Administration via Enteral Feeding Tubes, 3rd edition written by Rebecca White and published by Pharmaceutical Press. This book was released on 2015-03-11 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over 400 drug monographs, this book covers the technical, practical and legal aspects that you should consider before prescribing or administering drugs via enteral feeding tubes.

Color Atlas of Pharmacology

Author : Heinz Lüllmann
Publisher :
ISBN 13 : 9783137817024
Total Pages : 404 pages
Book Rating : 4.8/5 (17 download)

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Book Synopsis Color Atlas of Pharmacology by : Heinz Lüllmann

Download or read book Color Atlas of Pharmacology written by Heinz Lüllmann and published by . This book was released on 2000 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacology in 7 Days for Medical Students

Author : Fazal-I-Akbar Danish
Publisher : CRC Press
ISBN 13 : 1138031143
Total Pages : 160 pages
Book Rating : 4.1/5 (38 download)

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Book Synopsis Pharmacology in 7 Days for Medical Students by : Fazal-I-Akbar Danish

Download or read book Pharmacology in 7 Days for Medical Students written by Fazal-I-Akbar Danish and published by CRC Press. This book was released on 2018-05-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacological knowledge among medical students can have a very short 'half life': students often fail not because they have failed to study, but because they have been unable to retain key knowledge and reproduce it in an exam setting. This book takes an alternative route to the conventional approach of comprehensively exploring each individual drug and its features: not only can such an approach overwhelm and make knowledge retention difficult, but the current exam format makes questions structured in this way unlikely anyway. Instead of aiming to be completely comprehensive, it examines drugs systematically by classifications, mechanisms of action, therapeutic uses and side effects, enabling students to gain the distilled, functional grasp of pharmacology that their exams actually demand quickly and clearly.

The Renal Drug Handbook

Author : Caroline Ashley
Publisher : CRC Press
ISBN 13 : 0429863640
Total Pages : 1108 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis The Renal Drug Handbook by : Caroline Ashley

Download or read book The Renal Drug Handbook written by Caroline Ashley and published by CRC Press. This book was released on 2018-05-24 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable guide, endorsed by the UKMi and reflecting the extensive experience of the UK Renal Pharmacy Group, features drug monographs guiding physicians in how to prescribe, prepare, and administer drugs to patients with different levels of kidney function and when undergoing renal replacement therapy. It has been fully updated for this fifth edition to include up to 100 additional drugs, while maintaining the clear structure and format that is easy to use and simple to follow in the busy clinical setting. It continues to offer support and guidance to health care professionals enabling them to prescribe medications to their renal patients appropriately and safely.

ADME Processes in Pharmaceutical Sciences

Author : Alan Talevi
Publisher : Springer
ISBN 13 : 3319995936
Total Pages : 364 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis ADME Processes in Pharmaceutical Sciences by : Alan Talevi

Download or read book ADME Processes in Pharmaceutical Sciences written by Alan Talevi and published by Springer. This book was released on 2018-11-30 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.

Fundamentals of Anaesthesia

Author : Colin Pinnock
Publisher : Cambridge University Press
ISBN 13 : 9780521690799
Total Pages : 990 pages
Book Rating : 4.6/5 (97 download)

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Book Synopsis Fundamentals of Anaesthesia by : Colin Pinnock

Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.

Handbook of Drug Interactions

Author : Ashraf Mozayani
Publisher : Springer Science & Business Media
ISBN 13 : 1592596541
Total Pages : 662 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Handbook of Drug Interactions by : Ashraf Mozayani

Download or read book Handbook of Drug Interactions written by Ashraf Mozayani and published by Springer Science & Business Media. This book was released on 2003-10-15 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcohol drug interactions, nicotine and tobacco, and anabolic doping agents. Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.

Modified-release Drug Delivery Technology

Author :
Publisher :
ISBN 13 :
Total Pages : 696 pages
Book Rating : 4.:/5 (92 download)

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Book Synopsis Modified-release Drug Delivery Technology by :

Download or read book Modified-release Drug Delivery Technology written by and published by . This book was released on 2008 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:

2011 Nurse's Drug Handbook

Author : Jones Learning,
Publisher : Jones & Bartlett Learning
ISBN 13 : 0763792381
Total Pages : 1266 pages
Book Rating : 4.7/5 (637 download)

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Book Synopsis 2011 Nurse's Drug Handbook by : Jones Learning,

Download or read book 2011 Nurse's Drug Handbook written by Jones Learning, and published by Jones & Bartlett Learning. This book was released on 2010-06-29 with total page 1266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jones and Bartlett Publishers 2011 Nurses Drug Handbook is the most up-to-date, practical, and easy-to-use nursing drug reference! It provides accurate, timely facts on hundreds of drugs from abacavir sulfate to Zyvox; concise, consistently formatted drug entries organized alphabetically; no-nonsense writing style that speaks your language in terms you use everyday; index of all generic, trade, and alternate drug names for quick reference

Pharmacology Clear & Simple

Author : Cynthia J Watkins
Publisher : F.A. Davis
ISBN 13 : 0803689888
Total Pages : 530 pages
Book Rating : 4.8/5 (36 download)

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Book Synopsis Pharmacology Clear & Simple by : Cynthia J Watkins

Download or read book Pharmacology Clear & Simple written by Cynthia J Watkins and published by F.A. Davis. This book was released on 2018-04-18 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here’s the must-have knowledge and guidance you need to gain a solid understanding of pharmacology and the safe administration of medications in one text. A body systems approach to pharmacology with a basic math review and a focus on drug classifications prepare you for administering specific drugs in the clinical setting.