Development And Application Of The Geant4 Dna Toolkit For The Simulation Of Radiobiological Effects At The Sub Cellular Scale

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Development and Application of the Geant4-DNA Toolkit for the Simulation of Radiobiological Effects at the Sub-cellular Scale

Author : Wook Geun Shin
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (124 download)

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Book Synopsis Development and Application of the Geant4-DNA Toolkit for the Simulation of Radiobiological Effects at the Sub-cellular Scale by : Wook Geun Shin

Download or read book Development and Application of the Geant4-DNA Toolkit for the Simulation of Radiobiological Effects at the Sub-cellular Scale written by Wook Geun Shin and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predicting the biological effects induced by ionizing radiation is a major scientific challenge of current radiobiology, in particular to try to better understand the effects of low doses on living beings as well as carcinogenesis. The computational approach based on codes to simulate trace structures in the biological medium using the Monte Carlo technique is today the most reliable method to calculate the early effects of ionizing radiation on DNA, the main cellular target of radiation effects. Among the existing codes, the Geant4-DNA extension of the Geant4 general purpose simulation toolkit is the first one fully open and freely available to the community. Geant4-DNA can simulate not only the physical but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of DNA to assess direct and indirect early DNA damage. In this thesis, I propose (1) to improve in Geant4-DNA the modeling of the elastic scattering of electrons in liquid water in order to simulate more precisely the spatial distribution of energy deposits and radical species. Then, (2) the physico-chemical stage of water radiolysis is also improved based on approaches described in the literature (modeling, measurements), this step strongly affecting the chemical stage by modifying the initial yields and the concentration of radical species. (3) In addition, the Independent Reaction Time (IRT) method is implemented in Geant4-DNA to reduce the computational time to simulate the chemical kinetics of water radiolysis. Finally, I evaluate (4) the biological damage induced at the subcellular scale using a cellular DNA geometry developed in a previous study, including in the simulation all the improvements developed during this thesis, up to the repair of early DNA damage. These developments are grouped in a complete simulation chain for users of the Geant4-DNA extension of Geant4.

KDD-96

Author : Evangelos Simoudis
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis KDD-96 by : Evangelos Simoudis

Download or read book KDD-96 written by Evangelos Simoudis and published by . This book was released on 1996 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Microdosimetry

Author : Lennart Lindborg
Publisher : CRC Press
ISBN 13 : 9780367868925
Total Pages : 204 pages
Book Rating : 4.8/5 (689 download)

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Book Synopsis Microdosimetry by : Lennart Lindborg

Download or read book Microdosimetry written by Lennart Lindborg and published by CRC Press. This book was released on 2020-10-02 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting biological effects, and the appropriate quantities to be used in characterizing and quantifying radiation quality. Although many reviews and contributions to the field have been published over the past fifty years, this new book is the first to provide a single, up to date, and easily accessible account of experimental microdosimetry. This book is designed to be used in medical, radiation, and health physics courses and by Master's and PhD students. In addition to serving as an introductory text to the field for graduate students, this book will also be of interest as a teaching and reference resource for graduate supervisors and established researchers. Drs. Lennart Lindborg and Anthony Waker have spent a life-time career in experimental microdosimetry research in academic, industrial and regulatory environments and have observed the development of the field from its early days as a recognized discipline; they bring to this book particular knowledge and experience in the design, construction, operation and use of tissue equivalent gas ionization counters and chambers.

Proton Therapy Physics

Author : Harald Paganetti
Publisher : CRC Press
ISBN 13 : 1439836450
Total Pages : 691 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Proton Therapy Physics by : Harald Paganetti

Download or read book Proton Therapy Physics written by Harald Paganetti and published by CRC Press. This book was released on 2016-04-19 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.

2004 IEEE Nuclear Science Symposium Conference Record

Author :
Publisher :
ISBN 13 :
Total Pages : 758 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis 2004 IEEE Nuclear Science Symposium Conference Record by :

Download or read book 2004 IEEE Nuclear Science Symposium Conference Record written by and published by . This book was released on 2004 with total page 758 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Single-Cell-Based Models in Biology and Medicine

Author : Alexander Anderson
Publisher : Springer Science & Business Media
ISBN 13 : 376438123X
Total Pages : 346 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Single-Cell-Based Models in Biology and Medicine by : Alexander Anderson

Download or read book Single-Cell-Based Models in Biology and Medicine written by Alexander Anderson and published by Springer Science & Business Media. This book was released on 2007-08-08 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.

The Hydrated Electron

Author : Edwin James Hart
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.3/5 (97 download)

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Book Synopsis The Hydrated Electron by : Edwin James Hart

Download or read book The Hydrated Electron written by Edwin James Hart and published by John Wiley & Sons. This book was released on 1970 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Laser-Driven Sources of High Energy Particles and Radiation

Author : Leonida Antonio Gizzi
Publisher : Springer Nature
ISBN 13 : 3030258505
Total Pages : 254 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Laser-Driven Sources of High Energy Particles and Radiation by : Leonida Antonio Gizzi

Download or read book Laser-Driven Sources of High Energy Particles and Radiation written by Leonida Antonio Gizzi and published by Springer Nature. This book was released on 2019-09-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a selection of articles based on inspiring lectures held at the “Capri” Advanced Summer School, an original event conceived and promoted by Leonida Antonio Gizzi and Ralph Assmann that focuses on novel schemes for plasma-based particle acceleration and radiation sources, and which brings together researchers from the conventional accelerator community and from the high-intensity laser-matter interaction research fields. Training in these fields is highly relevant for ultra-intense lasers and applications, which have enjoyed dramatic growth following the development of major European infrastructures like the Extreme Light Infrastructure (ELI) and the EuPRAXIA project. The articles preserve the tutorial character of the lectures and reflect the latest advances in their respective fields. The volume is mainly intended for PhD students and young researchers getting started in this area, but also for scientists from other fields who are interested in the latest developments. The content will also appeal to radiobiologists and medical physicists, as it includes contributions on potential applications of laser-based particle accelerators.

Cell Biology by the Numbers

Author : Ron Milo
Publisher : Garland Science
ISBN 13 : 1317230698
Total Pages : 400 pages
Book Rating : 4.3/5 (172 download)

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Book Synopsis Cell Biology by the Numbers by : Ron Milo

Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

X-ray Nanochemistry

Author : Ting Guo
Publisher : Springer
ISBN 13 : 3319780042
Total Pages : 521 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis X-ray Nanochemistry by : Ting Guo

Download or read book X-ray Nanochemistry written by Ting Guo and published by Springer. This book was released on 2018-06-01 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the latest developments in the new research discipline of X-ray nanochemistry, which uses nanomaterials to enhance the effectiveness of X-ray irradiation. Nanomaterials now can be synthesized in such a way as to meet the demand for complex functions that enhance the X-ray effect. Innovative methods of delivering the X-rays, which can interact with those nanomaterials much more strongly than energetic electrons and gamma rays, also create new opportunities to enhance the X-ray effect. As a result, new concepts are conceived and new developments are made in the last decade, which are discussed and summarized in this book. This book will help define the discipline and encourage more students and scientists to work in this discipline. These efforts will eventually lead to formation of a full set of physical, chemical and materials principles for this new research field.

Microdosimetry and Its Applications

Author : H.H. Rossi
Publisher : Springer Science & Business Media
ISBN 13 : 3642851843
Total Pages : 333 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Microdosimetry and Its Applications by : H.H. Rossi

Download or read book Microdosimetry and Its Applications written by H.H. Rossi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microdosimetry and Its Applications is an advanced textbook presenting the fundamental concepts and numerical aspects of the absorption of energy by matter exposed to ionizing radiation. It is the only comprehensive work on the subject that can be considered definitive. It provides a deeper understanding of the initial phase of the interaction of ionizing radiation with matter, especially biological matter, and its consequences.

Monte Carlo Techniques in Radiation Therapy

Author : Frank Verhaegen
Publisher : CRC Press
ISBN 13 : 1000455556
Total Pages : 291 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Monte Carlo Techniques in Radiation Therapy by : Frank Verhaegen

Download or read book Monte Carlo Techniques in Radiation Therapy written by Frank Verhaegen and published by CRC Press. This book was released on 2021-11-29 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: About ten years after the first edition comes this second edition of Monte Carlo Techniques in Radiation Therapy: Introduction, Source Modelling, and Patient Dose Calculations, thoroughly updated and extended with the latest topics, edited by Frank Verhaegen and Joao Seco. This book aims to provide a brief introduction to the history and basics of Monte Carlo simulation, but again has a strong focus on applications in radiotherapy. Since the first edition, Monte Carlo simulation has found many new applications, which are included in detail. The applications sections in this book cover the following: Modelling transport of photons, electrons, protons, and ions Modelling radiation sources for external beam radiotherapy Modelling radiation sources for brachytherapy Design of radiation sources Modelling dynamic beam delivery Patient dose calculations in external beam radiotherapy Patient dose calculations in brachytherapy Use of artificial intelligence in Monte Carlo simulations This book is intended for both students and professionals, both novice and experienced, in medical radiotherapy physics. It combines overviews of development, methods, and references to facilitate Monte Carlo studies.

MIRD: Radionuclide Data and Decay Schemes

Author : Keith F. Eckerman
Publisher : Snmmi
ISBN 13 : 9780932004802
Total Pages : 684 pages
Book Rating : 4.0/5 (48 download)

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Book Synopsis MIRD: Radionuclide Data and Decay Schemes by : Keith F. Eckerman

Download or read book MIRD: Radionuclide Data and Decay Schemes written by Keith F. Eckerman and published by Snmmi. This book was released on 2007 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nanoparticle Enhanced Radiation Therapy

Author : Erno Sajo
Publisher :
ISBN 13 : 9780750323956
Total Pages : pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Nanoparticle Enhanced Radiation Therapy by : Erno Sajo

Download or read book Nanoparticle Enhanced Radiation Therapy written by Erno Sajo and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose in Nanoparticle-Enhanced Radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target and control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Part of IOP Series in Global Health and Radiation Oncology.

Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?

Author : Kulmira Nurgali
Publisher : Frontiers Media SA
ISBN 13 : 2889454827
Total Pages : 245 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? by : Kulmira Nurgali

Download or read book Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? written by Kulmira Nurgali and published by Frontiers Media SA. This book was released on 2018-06-12 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.

Carbon-Ion Radiotherapy

Author : Hirohiko Tsujii
Publisher : Springer Science & Business Media
ISBN 13 : 4431544577
Total Pages : 284 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Carbon-Ion Radiotherapy by : Hirohiko Tsujii

Download or read book Carbon-Ion Radiotherapy written by Hirohiko Tsujii and published by Springer Science & Business Media. This book was released on 2013-12-25 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

Handbook of Image-Guided Brachytherapy

Author : Jyoti Mayadev
Publisher : Springer
ISBN 13 : 3319448277
Total Pages : 630 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Handbook of Image-Guided Brachytherapy by : Jyoti Mayadev

Download or read book Handbook of Image-Guided Brachytherapy written by Jyoti Mayadev and published by Springer. This book was released on 2017-03-21 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a clinically relevant, succinct, and comprehensive overview of image-guided brachytherapy. Throughout the last decade, the utility of image guidance in brachytherapy has increased to enhance procedural development, treatment planning, and radiation delivery in an effort to optimize safety and clinical outcomes. Organized into two parts, the book discusses physics and radiobiology principles of brachytherapy as well as clinical applications of image-guided brachytherapy for various disease sites (central nervous system, eye, head and neck, breast, lung, gastrointestinal, genitourinary, gynecologic, sarcoma, and skin). It also describes the incorporation of imaging techniques such as CT, MRI, and ultrasound into brachytherapy procedures and planning. Featuring procedural and anesthesia care, extensive images, contouring examples, treatment planning techniques, and dosimetry for the comprehensive treatment for each disease site, Handbook of Image-Guided Brachytherapy is a valuable resource for practicing radiation oncologists, physicists, dosimetrists, residents, and medical students.