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Detecting Tissue Optical And Mechanical Properties With An Ultrasound Modulated Optical Imaging System
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Book Synopsis Detecting Tissue Optical and Mechanical Properties with an Ultrasound-modulated Optical Imaging System by : Yi Cheng
Download or read book Detecting Tissue Optical and Mechanical Properties with an Ultrasound-modulated Optical Imaging System written by Yi Cheng and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Nonlinear Optics and Quantum Optics Approaches for Ultrasound-modulated Optical Tomography in Soft Biological Tissue by : Huiliang Zhang
Download or read book Novel Nonlinear Optics and Quantum Optics Approaches for Ultrasound-modulated Optical Tomography in Soft Biological Tissue written by Huiliang Zhang and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging of soft biological tissue is highly desirable since it is nonionizing and provides sensitive contrast information which enables the detection of physiological functions and abnormalities, including potentially early cancer detection. However, due to the diffusive nature of light in soft biological tissue, it is difficult to achieve simultaneously good spatial resolution and good imaging depth with pure optical imaging modalities. This work focuses on the ultrasound-modulated optical tomography (UOT): a hybrid technique which combines the advantages of ultrasonic resolution and optical contrast. In this technique, focused ultrasound and optical radiation of high temporal coherence are simultaneously applied to soft biological tissue. The intensity of the sideband, or ultrasound "tagged" photons depends on the optical absorption in the region of interest where the ultrasound is focused. Demodulation of the optical speckle pattern yields the intensity of tagged photons for each location of the ultrasonic focal spot. Thus UOT yields an image with spatial resolution of the focused ultrasound -- typically submillimeter -- whose contrast is related to local optical absorption and the diffusive properties of light in the organ. Thus it extends all the advantages of optical imaging deep into highly scattering tissue. However lack of efficient tagged light detection techniques has so far prevented ultrasound-modulated optical tomography from achieving maturity. The signal-to-noise ratio (SNR) and imaging speed are two of the most important figures of merit and need further improvement for UOT to become widely applicable. In the first part of this work, nonlinear optics detection methods have been implemented to demodulate the "tagged" photons. The most common of these is photorefractive (PR) two wave mixing (TWM) interferometry, which is a time-domain filtering technique. When used for UOT, it is found that this approach extracts not only optical properties but also mechanical properties for the area of interest. To improve on TWM, PR four wave mixing (FWM) experiments were performed to read out only the modulated light and at the same time strongly suppressing the "untagged" light. Spectral-hole burning (SHB) in a rare-earth-ion-doped crystal has been developed for UOT more recently. Experiments in Tm3 :Y3Al5O12 (Tm:YAG) show the outstanding features of SHB: large angle acceptance (etendue), light speckle processing in parallel (insensitive to the diffusive light nature) and real-time signal collection (immune to light speckle decorrelation). With the help of advanced laser stabilization techniques, two orders of magnitude improvement of SNR have been achieved in a persistent SHB material (Pr3 :Y2SiO5) compared to Tm:YAG. Also slow light with PSHB further reduces noise in Pr:YSO UOT that is caused by polarization leakage by performing time-domain filtering.
Download or read book El Tirano de Lombardia written by and published by . This book was released on 1790* with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Tissue Optical Clearing by : Valery V. Tuchin
Download or read book Handbook of Tissue Optical Clearing written by Valery V. Tuchin and published by CRC Press. This book was released on 2022-02-04 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical photonics is currently one of the fastest growing fields, connecting research in physics, optics, and electrical engineering coupled with medical and biological applications. It allows for the structural and functional analysis of tissues and cells with resolution and contrast unattainable by any other methods. However, the major challenges of many biophotonics techniques are associated with the need to enhance imaging resolution even further to the sub-cellular level as well as translate them for in vivo studies. The tissue optical clearing method uses immersion of tissues into optical clearing agents (OCAs) that reduces the scattering of tissue and makes tissue more transparent and this method has been successfully used ever since. This book is a self-contained introduction to tissue optical clearing, including the basic principles and in vitro biological applications, from in vitro to in vivo tissue optical clearing methods, and combination of tissue optical clearing and various optical imaging for diagnosis. The chapters cover a wide range of issues related to the field of tissue optical clearing: mechanisms of tissue optical clearing in vitro and in vivo; traditional and innovative optical clearing agents; recent achievements in optical clearing of different tissues (including pathological tissues) and blood for optical imaging diagnosis and therapy. This book provides a comprehensive account of the latest research and possibilities of utilising optical clearing as an instrument for improving the diagnostic effectiveness of modern optical diagnostic methods. The book is addressed to biophysicist researchers, graduate students and postdocs of biomedical specialties, as well as biomedical engineers and physicians interested in the development and application of optical methods in medicine. Key features: The first collective reference to collate all known knowledge on this topic Edited by experts in the field with chapter contributions from subject area specialists Brings together the two main approaches in immersion optical clearing into one cohesive book
Book Synopsis Ultrasound Modulated Optical Tomography in Optical Diffuse Medium Using Acoustic Radiation Force by : Rui Li
Download or read book Ultrasound Modulated Optical Tomography in Optical Diffuse Medium Using Acoustic Radiation Force written by Rui Li and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Deep Imaging in Tissue and Biomedical Materials by : Lingyan Shi
Download or read book Deep Imaging in Tissue and Biomedical Materials written by Lingyan Shi and published by CRC Press. This book was released on 2017-03-16 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.
Book Synopsis Ultrasound-encoded Optical Tomography and Time-reversed Ultrasonically Encoded Optical Focusing by : Xiao Xu
Download or read book Ultrasound-encoded Optical Tomography and Time-reversed Ultrasonically Encoded Optical Focusing written by Xiao Xu and published by . This book was released on 2011 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound modulated optical tomography is a developing hybrid imaging modality that combines high optical contrast and good ultrasonic resolution to image soft biological tissue. We developed a photorefractive crystal-based, time-resolved detection scheme with the use of a millisecond long ultrasound burst to image both the optical and mechanical properties of biological tissues, with improved detection efficiency of ultrasound-tagged photons. We also applied spectral-hole burning (SHB) aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB was improved by using a Tm3+: YAG crystal of higher doping concentration (2.0-atomic%) and a double-pass pumping configuration. With the improved SHB-UOT system, we imaged absorbing, scattering, and phase contrast objects that were embedded in the middle plane of a 30-mm thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also imaged two absorbing objects embedded in the middle plane of a 32-mm thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to a practical optical imaging application in biological and clinical studies. Light focusing plays a central role in biomedical imaging, manipulation, and therapy. In optical scattering media such as biological tissue, light propagation is randomized by multiple scattering. Beyond one transport mean free path, where photon propagation is in the diffusive regime, direct light focusing becomes infeasible. Although various methods have been developed to overcome this optical diffusion limit, all are limited by the lack of a practical internal "guide star." Here we proposed and experimentally validated a novel concept, called Time-Reversed Ultrasonically Encoded (TRUE) optical focusing, to deliver light dynamically into any predefined location inside a scattering medium. First, diffused coherent light is encoded by an ultrasonic wave focused to a predefined location; then, the encoded component of the diffused light is time-reversed and consequently converges back to the ultrasonic focus. The ultrasonic encoding noninvasively provides a virtual internal "guide star" for the time reversal. The TRUE optical focus--dynamically defined by the ultrasonic focus--is unaffected by multiple scattering of light, which is especially desirable in biological tissue where ultrasonic scattering is ~1000 times weaker than optical scattering. Various fields, such as biomedical, colloidal, atmospheric, and ocean optics, can benefit from TRUE optical focusing. Further, the concept can be generalized for non-optical waves.
Book Synopsis Optics and Ultrasound in Biomedicine: Sensing, Imaging and Therapy by : Chao Tian
Download or read book Optics and Ultrasound in Biomedicine: Sensing, Imaging and Therapy written by Chao Tian and published by Frontiers Media SA. This book was released on 2021-07-22 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Quantitative Ultrasound in Soft Tissues by : Jonathan Mamou
Download or read book Quantitative Ultrasound in Soft Tissues written by Jonathan Mamou and published by Springer Science & Business Media. This book was released on 2013-09-26 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to parallel advances in signal processing and computer hardware in the last 15 years, quantitative ultrasound techniques have reached maturity, allowing for the construction of quantitative maps or images of soft tissues. This book will focus on 5 modern research topics related to quantitative ultrasound of soft tissues: - Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc.; - Envelope statistics analysis as a means of quantifying and imaging tissue properties; - Ultrasound elastography for quantifying elastic properties of tissues (several clinical ultrasound scanners now display elastography images); - Scanning acoustic microscopy for forming images of mechanical properties of soft tissues with micron resolution (desktop size scanners are now available); and - Ultrasound computer tomography for breast cancer imaging (new ultrasound tomography systems have been developed and are currently under evaluation clinically).
Book Synopsis Parametric Imaging of Tissue Microstructure Using Optical Coherence Tomography by : Lixin Chin
Download or read book Parametric Imaging of Tissue Microstructure Using Optical Coherence Tomography written by Lixin Chin and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: [Truncated] Biological tissue has intrinsic optical and mechanical properties that are linked to its structure and function, and are altered by pathologies such as cancer. Techniques for imaging these properties could, thus, aid in the detection, diagnosis, and understanding of disease. Birefringence is one such optical property, arising from structural and molecular anisotropies in tissue and, thus, a measure of the tissue microstructure. Similarly, many pathologies lead to a stiffening or softening of tissues, and, in principle, can be detected from changes in mechanical elasticity. Optical coherence tomography (OCT) is a minimally invasive optical imaging modality, with micrometre-scale resolution and millimetre-scale depth penetration, which can be extended to measure these tissue properties. This research combines three-dimensional OCT imaging with parametric modelling to develop signal processing methods for spatially resolved micro-scale measurements of tissue birefringence and elasticity, an approach referred to as parametric OCT.
Download or read book Dīwān ši'r Baššār b. Burd written by and published by . This book was released on 1964 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Britton Chance Publisher :SPIE-International Society for Optical Engineering ISBN 13 :9780819465474 Total Pages :468 pages Book Rating :4.4/5 (654 download)
Book Synopsis Optical Tomography and Spectroscopy of Tissue VII by : Britton Chance
Download or read book Optical Tomography and Spectroscopy of Tissue VII written by Britton Chance and published by SPIE-International Society for Optical Engineering. This book was released on 2007 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory/Algorithm/Modeling; Instrumentation and Technology I; Fluorescence Imaging/Spectroscopy (algorithm/model/tomography); Fluorescence Imaging/Image Reconstruction (Experimental); Instrumentation and Technology II; Fluorescence Imaging Technology I; Fluorescence Imaging Technology II; Fluorescence Imaging Technology III; Network for Translational Research in Optical Imaging: Breast Cancer Diffuse Optical Imaging; Breast II - Instrumentation & New Analysis Method; Breast III - Clinical Study; Pre-Clinical/Animal; Instrumentation and Technology III; Clinical/Human Subject Studies.
Book Synopsis Ultrasound-modulated Fluorescence Techniques by : Yuan Liu
Download or read book Ultrasound-modulated Fluorescence Techniques written by Yuan Liu and published by . This book was released on 2014 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound-modulated fluorescence (UMF) imaging has been proposed as a novel imaging modality by combining ultrasound and optical imaging techniques for early cancer detection. In UMF, a focused ultrasound beam is used to modulate the diffused fluorescence photons in the acoustic focal region, and by specifically analyzing the modulated photons, one can isolate and quantify the fluorescence properties within the ultrasonic focal area. Therefore, UMF is able to provide fluorescence contrast while maintaining ultrasound resolution in tissue. The major challenge of UMF is to extract the weakly modulated fluorescence signal from a bright and unmodulated background, i.e. the low modulation efficiency. This work is focused on investigating and developing novel UMF contrast agents and imaging systems, to improve the modulation efficiency of UMF for biological applications. This work can be categorized into two major parts: the contrast agent and the imaging system. In the contrast agent part, firstly four different fluorescent probes, ranging from 5 nm to 1 micron in diameter, were used to study the size effect of fluorescent probes on UMF modulation efficiency. Next, two novel microbubble-based UMF contrast agents (single fluorophore labeled microbubbles and donor-acceptor labeled microbubbles) were developed to further improve the modulation efficiency. These designs take advantage of the microbubbles' oscillations in size in response to ultrasound to modulate the inter-fluorophore distance and the quenching efficiency. As a result, the fluorescence emissions were modulated, presented as UMF signal. In the imaging technique part, a novel optical system consists of a confocal microscopic system and a gated and intensified charge-coupled device (ICCD) camera system was developed first in order to characterize the contrast agents. The high-speed oscillations of microbubbles in 3-dimensions were characterized, and their modulation efficiencies were evaluated and optimized. After that, those contrast agents were utilized for UMF imaging in water and scattering mediums using a sensitive ultrasound combined optical imaging system. Results showed that the modulation efficiency was improved by approximately a factor of two when the size of the fluorescent particles was increased from 5 nm to 1 micron. However, this improvement was still not sufficient for UMF imaging in biomedical applications. Excitingly, the microbubble-based contrast agents were successfully developed and demonstrated UMF signal with high modulation efficiency. The dynamics of the microbubbles under various ultrasound pressures were clearly observed along both horizontal plane (x-y plane) and vertical direction (z direction) using the developed optical imaging system. It was shown that the UMF strength were highly dependent on the microbubbles' oscillation amplitude and the initial surface fluorophore-quenching status. A UMF modulation efficiency of ~40% was detected corresponding to a size change of ~33% from individual microbubbles of both types, thought the donor-acceptor labeling scheme presented more complex quenching mechanisms compared to the single-fluorophore labeling scheme. In the end, UMF signals from a 500-micron tube filled with both microbubble-based contrast agents were detected in water and a scattering medium using the UMF imaging system. These results indicate that fluorescent microbubbles can be used as promising UMF contrast agents. When combined with the developed UMF system, they can potentially be used for fluorescence-based molecular imaging in future.
Download or read book Optics Letters written by and published by . This book was released on 2007 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Biomedical Optics by : David A. Boas
Download or read book Handbook of Biomedical Optics written by David A. Boas and published by CRC Press. This book was released on 2016-04-19 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental
Book Synopsis Magnetic Resonance Elastography by : Sudhakar K. Venkatesh
Download or read book Magnetic Resonance Elastography written by Sudhakar K. Venkatesh and published by Springer. This book was released on 2014-10-01 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
