Design, Synthesis and Characterization of New Coordination Compounds with Biologically Active Ligands

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)

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Book Synopsis Design, Synthesis and Characterization of New Coordination Compounds with Biologically Active Ligands by : Suneel Lanka

Download or read book Design, Synthesis and Characterization of New Coordination Compounds with Biologically Active Ligands written by Suneel Lanka and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ligands

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Publisher : Nova Science Publishers
ISBN 13 : 9781631171437
Total Pages : 0 pages
Book Rating : 4.1/5 (714 download)

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Book Synopsis Ligands by : Paula Gawryszewska

Download or read book Ligands written by Paula Gawryszewska and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: To meet the search for new therapeutic compounds this book summarises the research on biologically active organic molecules (chapters 1, 2 and 3), metal complexes with biological activity (chapter 4), and shows the possibilities for co-ordination chemistry in the planning of metal complexes with interesting properties for application (chapters 5, 6, 7, 8, and 9). It should be remembered that in the design of a new potentially active metallodrug, beyond the nature of the metal, the choice of appropriate ligands which affect the thermodynamic and kinetic stability, as well as the solubility and lipophilicity of the complexes is of paramount importance. The information contained in the book concerns: 1) the interactions involving the members of the Nuclear Receptor superfamily and their ligands; 2) the role of chemokine ligands and their receptors in normal and disease processes, and the emerging therapeutic approaches of using chemokine antagonists for appropriately targeted therapy; 3) the inhibition of alkaline phosphatases by calix[4]arenes functionalysed at the macrocyclic upper rim by one or two methylenebisphosphonic acid fragments; 4) the main biological applications, enzyme modelling and antiproliferative and antimicrobial activity of such scorpionate-type complexes, which are classified by ligand and also by transition metal; 5) the silver(I) discrete and polymeric coordination compounds bearing 1,3,5-triaza-7-phosphaadamantane or its derivatives towards engineering functional silver-organic frameworks (MOFs); 6) arylhydrazones of methylene active nitriles and their use as starting materials for the generation of new organic and coordination compounds; 7) amidophosphate ligands as promising sensitisers of lanthanide ions emission; 8) N-acetylsalicylhydrazidate as a versatile ligand for the synthesis of higher nuclearity metal complexes, which are illustrated herein along with their applications; 9) the chemistry and some applications of formazans which can be used for the simultaneous selective determination of several metal cations. All chapters were compiled by renowned scientists, providing both beginners in the field and advanced researchers with comprehensive information on the subject.

Catalytic Enzymes: the Design, Synthesis, and Characterization of Ligands that Provide a Controlled Catalytic Environment

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ISBN 13 :
Total Pages : 77 pages
Book Rating : 4.:/5 (483 download)

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Book Synopsis Catalytic Enzymes: the Design, Synthesis, and Characterization of Ligands that Provide a Controlled Catalytic Environment by : Mark D. Wathen

Download or read book Catalytic Enzymes: the Design, Synthesis, and Characterization of Ligands that Provide a Controlled Catalytic Environment written by Mark D. Wathen and published by . This book was released on 2000 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Design, Synthesis, and Characterization of Coordination Compounds and Coordination Polymers Based on 1,2,3-triazolate Ligands

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ISBN 13 :
Total Pages : 195 pages
Book Rating : 4.:/5 (76 download)

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Book Synopsis Design, Synthesis, and Characterization of Coordination Compounds and Coordination Polymers Based on 1,2,3-triazolate Ligands by : Shyam Biswas

Download or read book Design, Synthesis, and Characterization of Coordination Compounds and Coordination Polymers Based on 1,2,3-triazolate Ligands written by Shyam Biswas and published by . This book was released on 2010 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structure Determination from Powder Diffraction Data

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Publisher : OUP Oxford
ISBN 13 : 0198500912
Total Pages : 358 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Structure Determination from Powder Diffraction Data by : William I. F. David

Download or read book Structure Determination from Powder Diffraction Data written by William I. F. David and published by OUP Oxford. This book was released on 2002 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the properties of materials, from drugs and proteins to catalysts and ceramics, is almost always based on structural information. This book describes the new developments in the realm of powder diffraction which make it possible for scientists to obtain such information even from polycrystalline materials. Written and edited by experts active in the field, and covering both the fundamental and applied aspects of structure solution from powder diffraction data, this book guides both novices and experienced practitioners alike through the maze of possibilities.

Ligand Design in Medicinal Inorganic Chemistry

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Publisher : John Wiley & Sons
ISBN 13 : 1118697898
Total Pages : 650 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Ligand Design in Medicinal Inorganic Chemistry by : Tim Storr

Download or read book Ligand Design in Medicinal Inorganic Chemistry written by Tim Storr and published by John Wiley & Sons. This book was released on 2014-06-12 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.

Concepts and Models in Bioinorganic Chemistry

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Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 480 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Concepts and Models in Bioinorganic Chemistry by : Heinz-Bernhard Kraatz

Download or read book Concepts and Models in Bioinorganic Chemistry written by Heinz-Bernhard Kraatz and published by Wiley-VCH. This book was released on 2006-07-21 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Destined to set the standard, this book meets the need for a didactic textbook focusing on the role of model systems in bioinorganic chemistry. The first part features concepts in bioinorganic chemistry such as electron transfer, medicinal inorganic chemistry, bioorganometallics and metal DNA complexes, while the second part presents inorganic model chemistry on metallo-enzymes, organized by metal ion. Experts in the pertinent fields provide a didactically well-organized background on relevant biological systems, as well as on their structural, functional and spectroscopic properties. All chapters are similarly structured, each one beginning with a timeline featuring the most important historical facts on the subject, followed by a table of the most significant enzymes. The authors also summarize key developments and open questions within the respective model systems. This book is aimed at senior undergraduate and graduate students in chemistry, biochemistry, life science and related fields.

Design of Redox-active Ligands

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)

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Book Synopsis Design of Redox-active Ligands by : Nico Matteo Bonanno

Download or read book Design of Redox-active Ligands written by Nico Matteo Bonanno and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the design, synthesis, properties, and coordination chemistry of redoxactive ligands. This thesis also explores new ways of expanding our ligand systems, in order to improve their binding capacities. We accomplished this by utilizing familiar redox-active moieties and structures to those published previously in our group, but with enhanced topological capacities and predictable structural outcomes. Chapter 1 begins with a general outline of the fundamental principles that govern organic radicals including; their reactivity, their properties and applications, and how these can be applied to the design of ligands for polynuclear assembly. Chapter 2 starts with a brief overview of arylazo ligands and the synthesis of a new hydrazone substituted phenalenol ligand (2.1). In the following section (2.2) we use this ligand to produce homoleptic ligand mixed-valence complexes featuring trivalent cobalt and iron metals. The chapter is concluded (2.3) with the synthesis of a new ditopic aryl-azo ligand and its cobalt coordination chemistry involving a neutral tetra-radical/tetra-nuclear molecular grid featuring valence tautomerism. Chapter 3 begins with the design and synthesis of a new ditopic diamino phenol ligand, which was found to oxidize to a neutral stable phenoxyl radical (3.1-3.2). The solution properties, which include reversible pi-dimerization of this stable radical are also described (3.3), and later the substitution chemistry of this new ligand is explored (3.4). In chapter 4, we describe the coordination chemistry of this new ditopic aminophenol ligand, which includes assembly into several coordination clusters involving copper (4.2), iron (4.3), nickel (4.4), and zinc (4.5). These coordination clusters feature the ligand in a variety of oxidation states; including rare examples of dianion "aminyl" radical clusters. In chapter 5, we begin with a description of a new synthetic derivative which can be used for the construction of larger tetratopic or asymmetric diamino phenol ligands. In 5.2 we describe the synthesis of a tetratopic aminophenol ligand along with its reactivity and aerial oxidation to a tri-phenoxyl radical. In 5.3, we conclude the thesis with the use of an asymmetric diamino phenol ligand and it's Cu(II/III) coordination chemistry, which displayed unique reactivity with molecular oxygen.

Design, Synthesis, Structure Characterization and Properties of Inorganic-organic Hybrid Coordination Compounds

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ISBN 13 :
Total Pages : 174 pages
Book Rating : 4.:/5 (213 download)

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Book Synopsis Design, Synthesis, Structure Characterization and Properties of Inorganic-organic Hybrid Coordination Compounds by : Aihua Fu

Download or read book Design, Synthesis, Structure Characterization and Properties of Inorganic-organic Hybrid Coordination Compounds written by Aihua Fu and published by . This book was released on 2001 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Closer Look at Coordination Complexes

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Publisher : Nova Science Publishers
ISBN 13 : 9781685071998
Total Pages : 438 pages
Book Rating : 4.0/5 (719 download)

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Book Synopsis A Closer Look at Coordination Complexes by : Sandeep Kaur-Ghumaan

Download or read book A Closer Look at Coordination Complexes written by Sandeep Kaur-Ghumaan and published by Nova Science Publishers. This book was released on 2021 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Coordination chemistry plays an important role in the designing of inorganic metal complexes, materials, organo-synthesis, biological systems and catalysis. In A Closer Look at Coordination Complexes, novel and evolving developments in the field have been described. The book includes chapters on the synthesis of coordination compounds using different ligand combinations (Schiff base ligands, phosphines, thiolates, ligands with N- and S-donors and so on), biological relevance and catalytic applications of the reported metal complexes. Different aspects of metal complexes, viz. structural and coordination properties of the ligands and complexes and applications viz., asymmetric organic transformations, potential anticancer agents, antibacterial-antioxidant-antifungal properties, alkenes epoxidation, olefins polymerization, nitrogen reduction, hydrogen evolution and oxidation and mercury poisoning treatment reviewed by the authors have been delineated in the eight chapters of the book"--

Stability and Applications of Coordination Compounds

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Publisher : BoD – Books on Demand
ISBN 13 : 1838800573
Total Pages : 178 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Stability and Applications of Coordination Compounds by : Abhay Nanda Srivastva

Download or read book Stability and Applications of Coordination Compounds written by Abhay Nanda Srivastva and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the current era of incessant developing needs for the betterment and ease in living style for humans, technology is seeking upgraded, well structured materials for utilization in various fields of human-wellness such as medication, energy, environment protection and cleaning, food security etc. In the same direction, chemists are doing very well at synthesizing compounds and materials from different groups of chemicals. Among them, coordination compounds also play a key role in serving humanity as these compounds have a wide range of applications in health care from antimicrobial to anticancer, bioengineering, bio-mimetic models, catalysis, photosensitized materials etc. Along with development of stable coordination compounds, their extensive structural studies are also in the main line of work for researchers. Twenty-nine authors from different countries have contributed their scientific views and work in magnifying the importance and scope of coordination compounds in the present book entitled “Stability and Applications of Coordination Compounds”. I hope that the book will achieve its target of supplementing the community of researchers and readers working in the field of coordination chemistry.

Modern Green Chemistry and Heterocyclic Compounds

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Publisher : CRC Press
ISBN 13 : 1000029174
Total Pages : 302 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Modern Green Chemistry and Heterocyclic Compounds by : Ravindra S. Shinde

Download or read book Modern Green Chemistry and Heterocyclic Compounds written by Ravindra S. Shinde and published by CRC Press. This book was released on 2020-03-31 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the general properties of heterocyclic compounds and methods for their preparation to use in applications of green chemistry. Heterocyclic compounds are an important class of molecules in organic chemistry due to their presence in natural products and their use in pharmaceuticals and new materials. They also play a vital role in the metabolism of living cells. Heterocyclic compounds have a wide range of applications in agrochemicals, pharmaceuticals, veterinary products, etc. This research-oriented volume is ideal for readers who want to fully realize the almost limitless potential of heterocyclic compounds and to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features several case studies and step-by-step descriptions of synthetic methods and practical techniques. It also serves as a guide for chemists, offering them new insights and new paths to explore for effective drug discovery.

Emerging Trends in Synthesis and Catalysis in Chemistry

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Publisher : Springer Nature
ISBN 13 : 9819751691
Total Pages : 342 pages
Book Rating : 4.8/5 (197 download)

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Book Synopsis Emerging Trends in Synthesis and Catalysis in Chemistry by : Sunita Rattan

Download or read book Emerging Trends in Synthesis and Catalysis in Chemistry written by Sunita Rattan and published by Springer Nature. This book was released on with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis and Characterization of Hetero- and Homobimetallic Complexes of New Hard-soft Binucleating Ligands

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ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis Synthesis and Characterization of Hetero- and Homobimetallic Complexes of New Hard-soft Binucleating Ligands by : Debra Ann Wrobleski

Download or read book Synthesis and Characterization of Hetero- and Homobimetallic Complexes of New Hard-soft Binucleating Ligands written by Debra Ann Wrobleski and published by . This book was released on 1983 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis, Characterization, and Catalytic and Biological Activities of a Mixed-ligand Cobalt(ii) Bipyridyl/diphenylazodioxide Complex

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ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 (126 download)

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Book Synopsis Synthesis, Characterization, and Catalytic and Biological Activities of a Mixed-ligand Cobalt(ii) Bipyridyl/diphenylazodioxide Complex by : Kylin Alice Emhoff

Download or read book Synthesis, Characterization, and Catalytic and Biological Activities of a Mixed-ligand Cobalt(ii) Bipyridyl/diphenylazodioxide Complex written by Kylin Alice Emhoff and published by . This book was released on 2021 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transition metal complexes have immense importance in the pharmaceutical industry. These types of complexes can be useful catalysts in the synthesis of medicinal compounds and can act as anticancer drugs. In these pharmaceutical applications, 1st-row transition metal-containing complexes offer certain advantages compared to their 2nd and 3rd-row transition metal counterparts. Our motivation was to investigate pharmaceutical applications of transition metal complexes containing both a 1st-row transition metal and unusual ligands to expand the knowledge of a class of complexes that could potentially be beneficial in the pharmaceutical industry. A class of rare ligands that piqued our interest was that of the diaryl azodioxides, cis-Ar(O)NN(O)Ar, which belong to the wider class of organic derivatives of nitric oxide (NO). Our synthesis and pharmaceutical applications of the azodioxide complex salt [Co(bpy){Ph(O)NN(O)Ph}2](PF6)2 have been able to significantly expand the knowledge of azodioxide complexes by displaying an unusual trigonal prismatic coordination geometry for cobalt(II) with only bidentate ligands, showing evidence of ligand-based redox activity, acting as an active catalyst in allylic amination/C0́2C double-bond transposition reactions, and selectively inducing apoptosis in SK-HEP-1 human liver adenocarcinoma cells. Importantly, catalytic and biological studies of [Co(bpy){Ph(O)NN(O)Ph}2](PF6)2 are ongoing, and focused on its potential for use in the pharmaceutical industry as a drug or catalyst for drug synthesis. Future work will involve comparing the catalytic and biological activities of [Co(bpy){Ph(O)NN(O)Ph}2](PF6)2 with other azodioxide complexes prepared by our group to identify structure-activity relationships and inform the design of more efficient catalysts and anti-cancer, pro-apoptotic agents.

Synthesis, Characterization and Reactions of Complexes Containing New Ligands with Carbon-phosphorus Multiple Bonds

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Publisher :
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.:/5 (393 download)

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Book Synopsis Synthesis, Characterization and Reactions of Complexes Containing New Ligands with Carbon-phosphorus Multiple Bonds by : Wayde Vincent Konze

Download or read book Synthesis, Characterization and Reactions of Complexes Containing New Ligands with Carbon-phosphorus Multiple Bonds written by Wayde Vincent Konze and published by . This book was released on 1997 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Design, Synthesis, and Characterization of Catalytically Functional Galactose Oxidase Model Complexes

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ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Design, Synthesis, and Characterization of Catalytically Functional Galactose Oxidase Model Complexes by : Yadong Wang

Download or read book Design, Synthesis, and Characterization of Catalytically Functional Galactose Oxidase Model Complexes written by Yadong Wang and published by . This book was released on 1999 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: