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Design And Synthesis Of Hydroxyethylamines As Inhibitors Of Peptidoglycan Biosynthesis
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Book Synopsis Design and synthesis of hydroxyethylamines as inhibitors of peptidoglycan biosynthesis by : Matej Sova (farmacevt.)
Download or read book Design and synthesis of hydroxyethylamines as inhibitors of peptidoglycan biosynthesis written by Matej Sova (farmacevt.) and published by . This book was released on 2009 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structure-based design, synthesis and evaluation of new inhibitors of peptidoglycan biosynthesis by : Kaja Rožman (farmacevtka.)
Download or read book Structure-based design, synthesis and evaluation of new inhibitors of peptidoglycan biosynthesis written by Kaja Rožman (farmacevtka.) and published by . This book was released on 2018 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enzymes: Advances in Research and Application: 2011 Edition by :
Download or read book Enzymes: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Enzymes and Coenzymes. The editors have built Enzymes: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Enzymes and Coenzymes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Enzymes: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Metalloenzymes by : Claudiu T. Supuran
Download or read book Metalloenzymes written by Claudiu T. Supuran and published by Elsevier. This book was released on 2023-08-30 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications. Examines a range of metalloenzymes, from biochemistry to pharmacology and drug design Each chapter examines enzyme structure and function, physiologic and pathologic roles, inhibitors and activators, and clinical application Features chapter contributions from international experts in the field
Book Synopsis Rising Stars in Comparative and Clinical Medicine: 2022 by : Md. Masudur Rahman
Download or read book Rising Stars in Comparative and Clinical Medicine: 2022 written by Md. Masudur Rahman and published by Frontiers Media SA. This book was released on 2024-01-18 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognising the future leaders of Comparative and Clinical Medicine is fundamental to safeguarding tomorrow's driving force in innovation. This collection will showcase the high-quality work of internationally recognized researchers in the early stages of their careers. We aim to highlight research by leading scientists of the future across the entire breadth of Comparative and Clinical Medicine and present advances in theory, experiment, and methodology with applications to compelling problems.
Book Synopsis Virtual Screening: An Alternative or Complement to High Throughput Screening? by : Gerhard Klebe
Download or read book Virtual Screening: An Alternative or Complement to High Throughput Screening? written by Gerhard Klebe and published by Springer. This book was released on 2010-12-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this request which is summarized in this publication.
Book Synopsis Polypharmacology in Drug Discovery by : Jens-Uwe Peters
Download or read book Polypharmacology in Drug Discovery written by Jens-Uwe Peters and published by John Wiley & Sons. This book was released on 2012-03-13 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.
Book Synopsis Cambridge Scientific Biochemistry Abstracts by :
Download or read book Cambridge Scientific Biochemistry Abstracts written by and published by . This book was released on 1993-07 with total page 1498 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antibacterial Drug Discovery to Combat MDR by : Iqbal Ahmad
Download or read book Antibacterial Drug Discovery to Combat MDR written by Iqbal Ahmad and published by Springer Nature. This book was released on 2019-11-09 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.
Download or read book Virology & Aids Abstracts written by and published by . This book was released on 1993 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Botanical Leads for Drug Discovery by : Bikarma Singh
Download or read book Botanical Leads for Drug Discovery written by Bikarma Singh and published by Springer Nature. This book was released on 2020-10-05 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.
Book Synopsis Molecular Advancements in Tropical Diseases Drug Discovery by : Gauri Misra
Download or read book Molecular Advancements in Tropical Diseases Drug Discovery written by Gauri Misra and published by Academic Press. This book was released on 2020-05-12 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Advancements in Tropical Diseases Drug Discovery presents in-depth knowledge relating to the detection of infection, epidemiology, drugs against various tropical diseases, new target sites for drug discovery and multidrug resistance issues using bioinformatics tools and approaches. The book's chapters are written by experts in their respective fields so that each disease is covered in a rational manner and with a solid foundation on existing facts and prospective research ideas. Updates knowledge about tropical diseases with recent advancements in the field Presents an overview of new research covering detection, infection, epidemiology and risk factors of the most common tropical diseases using bioinformatics tools Encompasses a detailed description of developments in drug discovery, new drugs and their molecular mechanisms of action
Download or read book Phytopharmacy written by Sarah E. Edwards and published by John Wiley & Sons. This book was released on 2015-02-17 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare professionals, including doctors, pharmacists and nurses, are often confronted with patients who use over-the-counter (OTC) herbal medicinal products and food supplements. While taking responsibility for one’s own health and treatment options is encouraged, many patients use these products based on limited (and sometimes inaccurate) information from non-scientific sources, such as the popular press and internet. There is a clear need to offer balanced, well-informed advice to patients, yet a number of studies have shown that, generally, conventionally trained health practitioners consider their knowledge about herbal medicinal products and supplements to be weak. Phytopharmacy fills this knowledge gap, and is intended for use by the busy pharmacist, nurse, or doctor, as well as the ‘expert patient’ and students of pharmacy and herbal medicine. It presents clear, practical and concise monographs on over a hundred popular herbal medicines and plant-based food supplements. Information provided in each monograph includes: • Indications • Summary and appraisal of clinical and pre-clinical evidence • Potential interactions • Contraindications • Possible adverse effects An overview of the current regulatory framework is also outlined, notably the EU Traditional Herbal Medicinal Products Directive. This stipulates that only licensed products or registered traditional herbal medicinal products (THRs), which have assured quality and safety, can now legally be sold OTC. Monographs are included of most of the major herbal ingredients found in THRs, and also some plant-based food supplements, which while not strictly medicines, may also have the potential to exert a physiological effect.
Book Synopsis Pro-drugs as Novel Drug Delivery Systems by : Takeru Higuchi
Download or read book Pro-drugs as Novel Drug Delivery Systems written by Takeru Higuchi and published by . This book was released on 1975 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Subject Coverage and Arrangement of Abstracts by Sections in Chemical Abstracts by : American Chemical Society. Chemical Abstracts Service
Download or read book Subject Coverage and Arrangement of Abstracts by Sections in Chemical Abstracts written by American Chemical Society. Chemical Abstracts Service and published by . This book was released on 1972 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Research in Complementary Therapies E-Book by : George Thomas Lewith
Download or read book Clinical Research in Complementary Therapies E-Book written by George Thomas Lewith and published by Elsevier Health Sciences. This book was released on 2010-11-23 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of complementary therapies is exploding, increasing the pressure to establish a rigorous science to support its practice. Clinical Research in Complementary Therapies: Principles, Problems and Solutions provides students with the tools they need to research complementary and integrative medicine (CIM) and so fill this gap. Essential for both undergraduate and postgraduate students, this second edition is significantly updated and enhanced. Part 1 deals with research strategies and methods, explaining the major types of clinical research in CIM and how these inter-relate. New chapters are included on whole systems research, qualitative research and questionnaire development. Not all therapies can be treated the same way nor channeled through the signal process of randomized controlled trials. Therefore, detailed description of mixed methods approaches including observational, qualitative, cost-benefit and comparative effectiveness research are described. Part 2 deals with specific complementary therapies and how they are invested by experts in each field. The book analyses the key questions asked and the controversies debated in complementary medicine research and offers clear and innovative guidance for answering these questions. FEATURES • Provides an overarching synthesis of methods in CIM and how they are to be used collectively including the role of comparative effectiveness research • Suggests both general and specific factors which need to be considered in assessing or planning complementary therapy research • Pinpoints aspects of research which are different in orthodox research and complementary therapy research • Reviews the types of research carried out in specific complementary therapies and analyses issues which arise • Includes information on measuring the economic cost and benefits of complementary medicine, clinical audit and the role of placebos use • Builds upon recent research results, looks at the lessons these provide for all complementary therapies and suggests key issues to address in future research. • Provides an overarching synthesis of methods in CIM and how they are to be used collectively including the role of comparative effectiveness research • Suggests both general and specific factors which need to be considered in assessing or planning complementary therapy research • Pinpoints aspects of research which are different in orthodox research and complementary therapy research • Reviews the types of research carried out in specific complementary therapies and analyses issues which arise • Includes information on measuring the economic cost and benefits of complementary medicine, clinical audit and the role of placebos use • Builds upon recent research results, looks at the lessons these provide for all complementary therapies and suggests key issues to address in future research.
Book Synopsis Indigenous Herbal Medicines by : Deepak Acharya
Download or read book Indigenous Herbal Medicines written by Deepak Acharya and published by . This book was released on 2008 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Indian context.
