Dermal Drug Selection And Development

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Dermal Drug Selection and Development

Author : Lionel Trottet
Publisher : Springer
ISBN 13 : 3319595040
Total Pages : 154 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Dermal Drug Selection and Development by : Lionel Trottet

Download or read book Dermal Drug Selection and Development written by Lionel Trottet and published by Springer. This book was released on 2017-08-07 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.

Dermal Drug Delivery

Author : Tapash K. Ghosh
Publisher : CRC Press
ISBN 13 : 1315356643
Total Pages : 432 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Dermal Drug Delivery by : Tapash K. Ghosh

Download or read book Dermal Drug Delivery written by Tapash K. Ghosh and published by CRC Press. This book was released on 2020-01-21 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the continued advancement of better-quality control and patient outcome reporting systems, changes in the development, control, and regulation of all pharmaceutical delivery systems including transdermal and topical products have been happening on a continuous basis. In light of various quality issues that have been reported by patients and practitioners resulting in the recall or removal of products from the market, both the pharmaceutical industries and regulatory agencies have been adopting new measures to address these issues. With chapters written by experts in this field, this book takes a 21st century multidisciplinary and cross-functional look at these dosage forms to improve the development, design, manufacturing, quality, clinical performance, safety, and regulation of these products. This book offers a wealth of up-to-date information organized in a logical sequence corresponding to various stages of research, development, and commercialization of dermal drug delivery products. The authors have been carefully selected from different sectors of pharmaceutical science for their expertise in their selected areas to present objectively a balanced view of the current state of these products development and commercialization via regulatory approval. Their insights will provide useful information to others to ensure the successful development of the next generation dermal drug products. Key Features: Presents current advancements including new technologies of transdermal and topical dosage forms. Presents challenges in the development of the new generation of transdermal and topical dosage forms. Introduces new technologies and QbD (quality by design) aspects of manufacturing and control strategies. Includes new perspectives on pre-clinical and clinical development, regulatory considerations, safety and quality. Discusses regulatory challenges, gaps, and future considerations for dermal drug delivery systems.

Fundamentals of Drug Delivery

Author : Heather A. E. Benson
Publisher : John Wiley & Sons
ISBN 13 : 1119769604
Total Pages : 580 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Fundamentals of Drug Delivery by : Heather A. E. Benson

Download or read book Fundamentals of Drug Delivery written by Heather A. E. Benson and published by John Wiley & Sons. This book was released on 2021-10-12 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Transdermal Drug Delivery

Author : Kevin Ita
Publisher : Academic Press
ISBN 13 : 0128225513
Total Pages : 325 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Transdermal Drug Delivery by : Kevin Ita

Download or read book Transdermal Drug Delivery written by Kevin Ita and published by Academic Press. This book was released on 2020-06-12 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transdermal Drug Delivery: Concepts and Application provides comprehensive background knowledge and documents the most recent advances made in the field of transdermal drug delivery. It provides comprehensive and updated information regarding most technologies and formulation strategies used for transdermal drug delivery. There has been recent growth in the number of research articles, reviews, and other types of publications in the field of transdermal drug delivery. Research in this area is active both in the academic and industry settings. Ironically, only about 40 transdermal products with distinct active pharmaceutical ingredients are in the market indicating that more needs to be done to chronicle recent advances made in this area and to elucidate the mechanisms involved. This book will be helpful to researchers in the pharmaceutical and biotechnological industries as well as academics and graduate students working in the field of transdermal drug delivery and professionals working in the field of regulatory affairs focusing on topical and transdermal drug delivery systems. Researchers in the cosmetic and cosmeceutical industries, as well as those in chemical and biological engineering, will also find this book useful. - Captures the most recent advancements and challenges in the field of transdermal drug delivery - Covers both passive and active transdermal drug delivery strategies - Explores a selection of state-of-the-art transdermal drug delivery systems

The Art and Science of Dermal Formulation Development

Author : Marc B. Brown
Publisher : CRC Press
ISBN 13 : 0429596065
Total Pages : 241 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis The Art and Science of Dermal Formulation Development by : Marc B. Brown

Download or read book The Art and Science of Dermal Formulation Development written by Marc B. Brown and published by CRC Press. This book was released on 2019-03-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes. Key Features: Presents a practical guide for both industry and academia Focuses on and draws together the fundamental principles behind transdermal and topical drug delivery Illustrates the practicalities of formulation design using key case studies Gives an understanding of the skin as a route of delivery and how formulation development for such application differs from that for other administration routes

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

Author : Ali S. Faqi
Publisher : Academic Press
ISBN 13 : 0128036214
Total Pages : 988 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis A Comprehensive Guide to Toxicology in Nonclinical Drug Development by : Ali S. Faqi

Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2016-11-03 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. - Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more - Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules - Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Compounded Topical Pain Creams

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030967218X
Total Pages : 353 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Compounded Topical Pain Creams by : National Academies of Sciences, Engineering, and Medicine

Download or read book Compounded Topical Pain Creams written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-21 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is both a symptom and a disease. It manifests in multiple forms and its treatment is complex. Physical, social, economic, and emotional consequences of pain can impair an individual's overall health, well-being, productivity, and relationships in myriad ways. The impact of pain at a population level is vast and, while estimates differ, the Centers for Disease Control and Prevention reported that 50 million U.S. adults are living in pain. In terms of pain's global impact, estimates suggest the problem affects approximately 1 in 5 adults across the world, with nearly 1 in 10 adults newly diagnosed with chronic pain each year. In recent years, the issues surrounding the complexity of pain management have contributed to increased demand for alternative strategies for treating pain. One such strategy is to expand use of topical pain medicationsâ€"medications applied to intact skin. This nonoral route of administration for pain medication has the potential benefit, in theory, of local activity and fewer systemic side effects. Compounding is an age-old pharmaceutical practice of combining, mixing, or adjusting ingredients to create a tailored medication to meet the needs of a patient. The aim of compounding, historically, has been to provide patients with access to therapeutic alternatives that are safe and effective, especially for people with clinical needs that cannot otherwise be met by commercially available FDA-approved drugs. Compounded Topical Pain Creams explores issues regarding the safety and effectiveness of the ingredients in these pain creams. This report analyzes the available scientific data relating to the ingredients used in compounded topical pain creams and offers recommendations regarding the treatment of patients.

Rare Diseases and Orphan Products

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309158060
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rare Diseases and Orphan Products by : Institute of Medicine

Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Dermatological Drug Development

Author : Tomoko Maeda-Chubachi
Publisher : Cambridge Scholars Publishing
ISBN 13 : 152755967X
Total Pages : 146 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis Dermatological Drug Development by : Tomoko Maeda-Chubachi

Download or read book Dermatological Drug Development written by Tomoko Maeda-Chubachi and published by Cambridge Scholars Publishing. This book was released on 2020-09-18 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uniquely summarizes approaches to developing dermatological drugs in a regulated environment from the perspective of the pharmaceutical industry. It brings together the insights of skilled and experienced industry experts to reveal the complexities of dermatological drug development, covering topical, oral, and biologic drugs. This book fills an important gap, as there is currently no other textbook addressing dermatological drug development, explaining and illustrating why unique nonclinical and clinical studies are necessary and how they are typically designed and conducted. The drug development process is also an evolving strategy that is characterized by communicating, negotiating, and agreeing with regulatory agencies, such as FDA (US), EMA (EU), and PMDA (Japan).

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

Author : Ryan F. Donnelly
Publisher : John Wiley & Sons
ISBN 13 : 1118734513
Total Pages : 290 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Novel Delivery Systems for Transdermal and Intradermal Drug Delivery by : Ryan F. Donnelly

Download or read book Novel Delivery Systems for Transdermal and Intradermal Drug Delivery written by Ryan F. Donnelly and published by John Wiley & Sons. This book was released on 2015-09-28 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

Handbook of Formulating Dermal Applications

Author : Nava Dayan
Publisher : John Wiley & Sons
ISBN 13 : 1119364248
Total Pages : 701 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Handbook of Formulating Dermal Applications by : Nava Dayan

Download or read book Handbook of Formulating Dermal Applications written by Nava Dayan and published by John Wiley & Sons. This book was released on 2016-12-07 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: The conceptualization and formulation of skin care products intended for topical use is a multifaceted and evolving area of science. Formulators must account for myriad skin types, emerging opportunities for product development as well as a very temperamental retail market. Originally published as "Apply Topically" in 2013 (now out of print), this reissued detailed and comprehensive handbook offers a practical approach to the formulation chemist's day-to-day endeavors by: Addressing the innumerable challenges facing the chemist both in design and at the bench, such as formulating with/for specific properties; formulation, processing and production techniques; sensory and elegancy; stability and preservation; color cosmetics; sunscreens; Offering valuable guidance to troubleshooting issues regarding ingredient selection and interaction, regulatory concerns that must be addressed early in development, and the extrapolation of preservative systems, fragrances, stability and texture aids; Exploring the advantages and limitations of raw materials; Addressing scale-up and pilot production process and concerns; Testing and Measurements Methods. The 22 chapters written by industry experts such as Roger L. McMullen, Paul Thau, Hemi Nae, Ada Polla, Howard Epstein, Joseph Albanese, Mark Chandler, Steve Herman, Gary Kelm, Patricia Aikens, and Sam Shefer, along with many others, give the reader and user the ultimate handbook on topical product development.

Drug Delivery Approaches

Author : Bret Berner
Publisher : John Wiley & Sons
ISBN 13 : 1119772737
Total Pages : 466 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Drug Delivery Approaches by : Bret Berner

Download or read book Drug Delivery Approaches written by Bret Berner and published by John Wiley & Sons. This book was released on 2021-08-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

Modeling and Control of Drug Delivery Systems

Author : Ahmad Taher Azar
Publisher : Academic Press
ISBN 13 : 0128211954
Total Pages : 410 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Modeling and Control of Drug Delivery Systems by : Ahmad Taher Azar

Download or read book Modeling and Control of Drug Delivery Systems written by Ahmad Taher Azar and published by Academic Press. This book was released on 2021-02-06 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. - Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring - Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area - Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Percutaneous Absorption

Author : Robert L. Bronaugh
Publisher : CRC Press
ISBN 13 : 9781420000948
Total Pages : 992 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by CRC Press. This book was released on 1999-05-28 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Skin Tissue Engineering and Regenerative Medicine

Author : Mohammad Albanna
Publisher : Academic Press
ISBN 13 : 012801797X
Total Pages : 468 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Skin Tissue Engineering and Regenerative Medicine by : Mohammad Albanna

Download or read book Skin Tissue Engineering and Regenerative Medicine written by Mohammad Albanna and published by Academic Press. This book was released on 2016-01-14 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. - Explores cellular and molecular processes of wound healing, scar formation, and dermal repair - Includes examples of animal models for wound healing and translation to the clinical world - Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management - Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies

Topical and Transdermal Drug Delivery

Author : Heather A. E. Benson
Publisher : John Wiley & Sons
ISBN 13 : 1118140494
Total Pages : 393 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Topical and Transdermal Drug Delivery by : Heather A. E. Benson

Download or read book Topical and Transdermal Drug Delivery written by Heather A. E. Benson and published by John Wiley & Sons. This book was released on 2012-02-03 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.

Transdermal Drug Delivery Systems

Author : Jonathan Hadgraft
Publisher : CRC Press
ISBN 13 : 1135565198
Total Pages : 296 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Transdermal Drug Delivery Systems by : Jonathan Hadgraft

Download or read book Transdermal Drug Delivery Systems written by Jonathan Hadgraft and published by CRC Press. This book was released on 2002-10-29 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator