Dermal Absorption And Decontamination

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Skin Decontamination

Author : Hanjiang Zhu
Publisher : Springer Nature
ISBN 13 : 3030240096
Total Pages : 284 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Skin Decontamination by : Hanjiang Zhu

Download or read book Skin Decontamination written by Hanjiang Zhu and published by Springer Nature. This book was released on 2019-09-26 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. However, some chemicals act directly on the skin including vesicants sulfur mustard and corrosive compounds such as strong acids or bases, and do not have to gain access to systemic circulation to cause extensive skin damage. Early and rapid skin decontamination is extremely important following exposure to chemical warfare agents and toxic industrial chemicals because it decreases serious skin damage to the patient and, potentially, their doctor. This multi-authored international text pulls together a century of decontamination research and helps the reader expedite solutions that will decrease morbidity and mortality. Complete with dozens of hiqh quality photographs and illustrations, Skin Decontamination aids industrial hygiene, dermatology, occupational physicians and those involved in the public health arena.

Percutaneous Absorption

Author : Robert L. Bronaugh
Publisher : CRC Press
ISBN 13 : 9781420000948
Total Pages : 992 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by CRC Press. This book was released on 1999-05-28 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Dermal Absorption and Decontamination

Author : Aileen M. Feschuk
Publisher : Springer Nature
ISBN 13 : 3031092228
Total Pages : 339 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Dermal Absorption and Decontamination by : Aileen M. Feschuk

Download or read book Dermal Absorption and Decontamination written by Aileen M. Feschuk and published by Springer Nature. This book was released on 2022-10-05 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a “wash-in effect” (an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date. Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists.

Dermal Exposure

Author : World Health Organization
Publisher : Environmental Health Criteria
ISBN 13 : 9789241572422
Total Pages : 0 pages
Book Rating : 4.5/5 (724 download)

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Book Synopsis Dermal Exposure by : World Health Organization

Download or read book Dermal Exposure written by World Health Organization and published by Environmental Health Criteria. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "IPCS, International Programme on Chemical Safety."

Wildlife Toxicity Assessments for Chemicals of Military Concern

Author : Marc Williams
Publisher : Elsevier
ISBN 13 : 0128004800
Total Pages : 725 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Wildlife Toxicity Assessments for Chemicals of Military Concern by : Marc Williams

Download or read book Wildlife Toxicity Assessments for Chemicals of Military Concern written by Marc Williams and published by Elsevier. This book was released on 2015-05-21 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species. - Provides detailed information on how Wildlife Toxicity Values (TRVs) for military chemicals of concern are derived and evaluated. - Covers wildlife toxicity assessments of explosives, metals and environmental chemicals. - Compiles relevant information on the environmental effects of chemicals on wildlife in relation to public and environmental health.

Chemical and Biological Terrorism

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309061954
Total Pages : 303 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Chemical and Biological Terrorism by : Institute of Medicine

Download or read book Chemical and Biological Terrorism written by Institute of Medicine and published by National Academies Press. This book was released on 1999-03-12 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The threat of domestic terrorism today looms larger than ever. Bombings at the World Trade Center and Oklahoma City's Federal Building, as well as nerve gas attacks in Japan, have made it tragically obvious that American civilians must be ready for terrorist attacks. What do we need to know to help emergency and medical personnel prepare for these attacks? Chemical and Biological Terrorism identifies the R&D efforts needed to implement recommendations in key areas: pre-incident intelligence, detection and identification of chemical and biological agents, protective clothing and equipment, early recognition that a population has been covertly exposed to a pathogen, mass casualty decontamination and triage, use of vaccines and pharmaceuticals, and the psychological effects of terror. Specific objectives for computer software development are also identified. The book addresses the differences between a biological and chemical attack, the distinct challenges to the military and civilian medical communities, and other broader issues. This book will be of critical interest to anyone involved in civilian preparedness for terrorist attack: planners, administrators, responders, medical professionals, public health and emergency personnel, and technology designers and engineers.

Kanerva’s Occupational Dermatology

Author : Thomas Rustemeyer
Publisher : Springer
ISBN 13 : 9783642020346
Total Pages : 2020 pages
Book Rating : 4.0/5 (23 download)

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Book Synopsis Kanerva’s Occupational Dermatology by : Thomas Rustemeyer

Download or read book Kanerva’s Occupational Dermatology written by Thomas Rustemeyer and published by Springer. This book was released on 2012-07-13 with total page 2020 pages. Available in PDF, EPUB and Kindle. Book excerpt: Occupational skin diseases are a field of increasing interest in today’s dermatology. Due to rapid developments in several areas of modern industry, new dermatological problems constantly occur amongst workers. The 1st edition of this Handbook of Occupational Dermatology was published in 2000 and has served as the main reference book of occupational skin diseases for general and occupational dermatologists and occupational physicians. The new edition is completely revised, updated and extended with respect to new developments. The layout allows for both quick access to practical information and in-depth reading. Included are concise tables, algorithms and figures on how to optimize the diagnostic procedure for daily patient management and expert opinion. The new edition will continue the success as major source of reference for clinical and experimental work in the field of occupational skin diseases, both for students and experts.

Emergency Response Guidebook

Author : U.S. Department of Transportation
Publisher : Simon and Schuster
ISBN 13 : 1626363765
Total Pages : 352 pages
Book Rating : 4.6/5 (263 download)

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Book Synopsis Emergency Response Guidebook by : U.S. Department of Transportation

Download or read book Emergency Response Guidebook written by U.S. Department of Transportation and published by Simon and Schuster. This book was released on 2013-06-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does the identification number 60 indicate a toxic substance or a flammable solid, in the molten state at an elevated temperature? Does the identification number 1035 indicate ethane or butane? What is the difference between natural gas transmission pipelines and natural gas distribution pipelines? If you came upon an overturned truck on the highway that was leaking, would you be able to identify if it was hazardous and know what steps to take? Questions like these and more are answered in the Emergency Response Guidebook. Learn how to identify symbols for and vehicles carrying toxic, flammable, explosive, radioactive, or otherwise harmful substances and how to respond once an incident involving those substances has been identified. Always be prepared in situations that are unfamiliar and dangerous and know how to rectify them. Keeping this guide around at all times will ensure that, if you were to come upon a transportation situation involving hazardous substances or dangerous goods, you will be able to help keep others and yourself out of danger. With color-coded pages for quick and easy reference, this is the official manual used by first responders in the United States and Canada for transportation incidents involving dangerous goods or hazardous materials.

Compounded Topical Pain Creams

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030967218X
Total Pages : 353 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Compounded Topical Pain Creams by : National Academies of Sciences, Engineering, and Medicine

Download or read book Compounded Topical Pain Creams written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-21 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is both a symptom and a disease. It manifests in multiple forms and its treatment is complex. Physical, social, economic, and emotional consequences of pain can impair an individual's overall health, well-being, productivity, and relationships in myriad ways. The impact of pain at a population level is vast and, while estimates differ, the Centers for Disease Control and Prevention reported that 50 million U.S. adults are living in pain. In terms of pain's global impact, estimates suggest the problem affects approximately 1 in 5 adults across the world, with nearly 1 in 10 adults newly diagnosed with chronic pain each year. In recent years, the issues surrounding the complexity of pain management have contributed to increased demand for alternative strategies for treating pain. One such strategy is to expand use of topical pain medicationsâ€"medications applied to intact skin. This nonoral route of administration for pain medication has the potential benefit, in theory, of local activity and fewer systemic side effects. Compounding is an age-old pharmaceutical practice of combining, mixing, or adjusting ingredients to create a tailored medication to meet the needs of a patient. The aim of compounding, historically, has been to provide patients with access to therapeutic alternatives that are safe and effective, especially for people with clinical needs that cannot otherwise be met by commercially available FDA-approved drugs. Compounded Topical Pain Creams explores issues regarding the safety and effectiveness of the ingredients in these pain creams. This report analyzes the available scientific data relating to the ingredients used in compounded topical pain creams and offers recommendations regarding the treatment of patients.

Toxicologic Assessment of Jet-Propulsion Fuel 8

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309168708
Total Pages : 229 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicologic Assessment of Jet-Propulsion Fuel 8 by : National Research Council

Download or read book Toxicologic Assessment of Jet-Propulsion Fuel 8 written by National Research Council and published by National Academies Press. This book was released on 2003-02-14 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report provides a critical review of toxicologic, epidemiologic, and other relevant data on jet-propulsion fuel 8, a type of fuel in wide use by the U.S. Department of Defense (DOD), and an evaluation of the scientific basis of DOD's interim permissible exposure level of 350 mg/m3

Skin Barrier

Author : Hans Schaefer
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Skin Barrier by : Hans Schaefer

Download or read book Skin Barrier written by Hans Schaefer and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin Barrier is the first book to be written exclusively by researchers for researchers as a convenient desktop reference. It focuses on several key aspects of the skin barrier including composition and structure and a description of the properties governing the diffusion of compounds across the skin. Although there has been a large number of laboratories involved in measuring percutaneous absorption over the past 15 to 20 years, it is only recently that there has been a general consensus in the scientific community regarding the development of standard protocols. Recognizing the importance of this, the authors have included two chapters detailing the protocol used in measuring and predicting percutaneous absorption and a discussion on the practical application of these techniques to solve associated problems. In order to provide the researcher and especially the student with access to more detailed information, the book features a comprehensive listing of references published over the past 10 years. Skin Barrier is the only desktop reference for dermatologists, cosmetologists, biochemists, biologists, and those in the pharmaceutics industry, who need detailed and accurate information about the skin barrier on a daily basis. No R & D department should be without a copy.

Oxford Textbook of Critical Care

Author : Webb
Publisher : Oxford University Press
ISBN 13 : 0198855435
Total Pages : 1961 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Oxford Textbook of Critical Care by : Webb

Download or read book Oxford Textbook of Critical Care written by Webb and published by Oxford University Press. This book was released on 2020-01-10 with total page 1961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

Topical Drug Bioavailability, Bioequivalence, and Penetration

Author : Vinod P. Shah
Publisher : Springer
ISBN 13 : 1493912895
Total Pages : 393 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Topical Drug Bioavailability, Bioequivalence, and Penetration by : Vinod P. Shah

Download or read book Topical Drug Bioavailability, Bioequivalence, and Penetration written by Vinod P. Shah and published by Springer. This book was released on 2015-01-30 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Skin Permeability

Author : H. Schaefer
Publisher : Springer Science & Business Media
ISBN 13 : 3642687342
Total Pages : 365 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Skin Permeability by : H. Schaefer

Download or read book Skin Permeability written by H. Schaefer and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dermal Absorption Models in Toxicology and Pharmacology

Author : Jim E. Riviere
Publisher : CRC Press
ISBN 13 : 9780203020821
Total Pages : 392 pages
Book Rating : 4.0/5 (28 download)

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Book Synopsis Dermal Absorption Models in Toxicology and Pharmacology by : Jim E. Riviere

Download or read book Dermal Absorption Models in Toxicology and Pharmacology written by Jim E. Riviere and published by CRC Press. This book was released on 2005-08-24 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.

Dermatotoxicology Methods

Author : Francis N. Marzulli
Publisher : CRC Press
ISBN 13 : 9781439805879
Total Pages : 420 pages
Book Rating : 4.8/5 (58 download)

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Book Synopsis Dermatotoxicology Methods by : Francis N. Marzulli

Download or read book Dermatotoxicology Methods written by Francis N. Marzulli and published by CRC Press. This book was released on 2019-05-07 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.

Prudent Practices in the Laboratory

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309211581
Total Pages : 360 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Prudent Practices in the Laboratory by : National Research Council

Download or read book Prudent Practices in the Laboratory written by National Research Council and published by National Academies Press. This book was released on 2011-03-25 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prudent Practices in the Laboratory-the book that has served for decades as the standard for chemical laboratory safety practice-now features updates and new topics. This revised edition has an expanded chapter on chemical management and delves into new areas, such as nanotechnology, laboratory security, and emergency planning. Developed by experts from academia and industry, with specialties in such areas as chemical sciences, pollution prevention, and laboratory safety, Prudent Practices in the Laboratory provides guidance on planning procedures for the handling, storage, and disposal of chemicals. The book offers prudent practices designed to promote safety and includes practical information on assessing hazards, managing chemicals, disposing of wastes, and more. Prudent Practices in the Laboratory will continue to serve as the leading source of chemical safety guidelines for people working with laboratory chemicals: research chemists, technicians, safety officers, educators, and students.