Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Dendritic Cells And Virus Infection
Download Dendritic Cells And Virus Infection full books in PDF, epub, and Kindle. Read online Dendritic Cells And Virus Infection ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author :Alexander Steinkasserer Publisher :Springer Science & Business Media ISBN 13 :3662065088 Total Pages :318 pages Book Rating :4.6/5 (62 download)
Book Synopsis Dendritic Cells and Virus Infection by : Alexander Steinkasserer
Download or read book Dendritic Cells and Virus Infection written by Alexander Steinkasserer and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendritic cells are vital to induce potent anti-viral immune responses. It will become clear to the reader that dendritic cells often play a dual role during viral infections. On the one hand they are able to mount potent antiviral immune responses, and on the other hand several viruses, including HIV-1, use DC as a vector to be transferred from the periphery to the lymph nodes where they infect their prime target.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis Dendritic Cells and Virus Infection by : Alexander Steinkasserer
Download or read book Dendritic Cells and Virus Infection written by Alexander Steinkasserer and published by . This book was released on 2014-01-15 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Biology of Dendritic Cells and HIV Infection by : Sandra Gessani
Download or read book The Biology of Dendritic Cells and HIV Infection written by Sandra Gessani and published by Springer Science & Business Media. This book was released on 2007-03-09 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendritic cells play the most vital part in inducing anti-viral immune responses in HIV and AIDS among many other viruses. Research on dendritic cells (DCs) is emerging as a fundamental aspect for the comprehension of the mechanisms underlying the pathogenesis of viral diseases. This volume focuses on the role of DCs in the pathogenesis and immunity of HIV-1 infection. It is the only comprehensive volume on pathogenesis and immunity of Dendritic Cells that also focuses on HIV.
Book Synopsis Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS by : Yechiel Becker
Download or read book Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS written by Yechiel Becker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the generations the skin has been the site for immunization against smallpox. This method of immunization was described in a letter written by Lady Mary Montagu on April 1, 1717 in Adrianopole, Turkey: "The small-pox, so fatal, and so general amongst us, is here entirely harmless by the invention of ingrafting, which is the term they give it. . . The old woman comes with a nut-shell full of the matter of the best sort of small-pox . . . She immediately rips open (the skin) with a large needle . . . and puts into the vein as much venom as can lie upon the head of her needle, and after binds up the wound. There is no example of anyone that died of it; and you may believe that I am satisfied of the safety of this experiment since I intend to try it on my dear little son" (Letters from the right Honourable Lady Mary Montagu 1709-1762. Published by J. M. Dent and Co. London, 2nd edition, September, 1906, p. 124. ) The "variolation" method was, 80 years later, markedly improved by the use of cowpox virus, as reported by Edward Jenner in 1796. The successful method of intradermal immunization against smallpox and later against other virus diseases is in fact based on the presence of anitigen-presenting dendritic cells in the skin.
Book Synopsis HIV Interactions with Dendritic Cells by : Li Wu
Download or read book HIV Interactions with Dendritic Cells written by Li Wu and published by Springer Science & Business Media. This book was released on 2012-09-11 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given rapid research progress and advance of the techniques in studying HIV interactions with host cells and factors, there is a critical need for a book on HIV interactions with DCs. The proposed book will aim for a broad readership to facilitate HIV/AIDS research and provide a practical tool for HIV researchers to continuously address novel questions. Specifically, the editors will summarize the literature in this field and provide critical analysis and future directions. International researchers will be invited as contributors of the book, highlighting authors who have contributed significantly to the field from different angles and aspects of virology, cell biology and immunology, etc.
Book Synopsis The Role of Langerhans Cells and Dendritic Cells in Viral Dissemination by : Leanne Helgers
Download or read book The Role of Langerhans Cells and Dendritic Cells in Viral Dissemination written by Leanne Helgers and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dendritic cells and Langerhans cells are antigen presenting cells and therefore critical in the initiation of immune responses to control viral infections. However, various viruses hijack the function of these immune cells for establishing infection and dissemination in the host, Thus, the cellular and molecular characteristics of dendritic cells and Langerhans cells are among the first determinants that control either viral restriction or dissemination. The research described in this thesis is focused on the different ways in which viruses exploit the function of dendritic cells and Langerhans cells for dissemination in a newly infected host. We have mainly focused on cell-to-cell transmission of different viruses (human immunodeficiency virus, Dengue virus, enterovirus A71) mediated by dendritic cells and Langerhans cells during early transmission, and we have identified various receptors and their cellular internalization pathways involved. Moreover, we have shown that external factors such as a dysbiotic human microbiome influences not only immune responses via dendritic cells, but also cell-to-cell transmission by Langerhans cells, thereby enhancing susceptibility to viruses. Our results demonstrate that the specific characteristics of dendritic cells and Langerhans cells impact the rate of viral dissemination and emphasize the significant contribution of cellular internalization pathways in cell-to-cell transmission. The mode of viral transmission is an important determinant in the approach of therapeutic strategies. Hence, progress in the understanding of early transmission events can provide alternative treatment approaches to interfere with this process or provide early diagnostics tools to identify populations at risk."--
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Book Synopsis Encyclopedia of AIDS by : Thomas J. Hope
Download or read book Encyclopedia of AIDS written by Thomas J. Hope and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Interaction written by Bhawana Singh and published by BoD – Books on Demand. This book was released on 2021-04-07 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses contemporary ideas on different molecular and immunological aspects of diseases. Different signaling mediators drive the production of messenger molecules that mediate their action, leading to the elicitation/suppression of immune responses. It provides a balanced approach to the study of different molecular phenomena that eventually drive infection outcomes and that can be manipulated for therapeutic benefits.
Book Synopsis Effects of Complement Opsonization of HIV on Dendritic Cells by : Rada Ellegård
Download or read book Effects of Complement Opsonization of HIV on Dendritic Cells written by Rada Ellegård and published by Linköping University Electronic Press. This book was released on 2018-09-28 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendritic cells are key players during HIV pathogenesis, and shape both the immediate immune response at the site of infection as well as directing the adaptive immune response against the virus. HIV has developed a plethora of immune evasion mechanisms that hijack dendritic cell functions, suppressing their ability to mount an accurate immune response and exploiting them for efficient viral transfer to target T cells. To achieve successful replication within dendritic cells without triggering danger signaling, HIV accomplishes a delicate balance where only a low level of transcription can be sustained without triggering antiviral responses that would harm the virus. Here, we describe how the presence of HSV2 coinfection, which is very common in geographic areas with a high HIV prevalence and almost triples the risk of HIV acquisition, alters dendritic cell state to support much higher levels of HIV infection. We found this effect to be mediated by the STING pathway, which is involved in the sensing of DNA in the cell cytosol. STING activation led to an upregulation of factors such as IRF3 and NFkB that can be used for HIV transcription and a degradation of factors that restrict HIV replication. In addition, we describe how HIV exploits the human complement system, a group of proteins that usually help the human body to identify dangerous pathogens while avoiding reaction towards self. HIV can coat itself, i.e. become opsonized, in complement fragments that are typically only present on the body’s own cells, allowing it to activate signaling pathways that are associated with tolerance. Dendritic cells that come into contact with complement opsonized HIV do not mount danger responses, despite the fact that HIV-derived single stranded RNA triggers the pathogen recognition receptor TLR8. The suppression of danger responses is mediated by activation of complement receptor 3, and leads to an increased infection of the dendritic cell and affects its interactions with other immune cells. There is a lack of recruitment of NK cells to the site of infection, and an inhibition of NK cell killing, which plays an important role in the destruction of HIV-infected cells in vivo. T cells primed by dendritic cells exposed to complement opsonized HIV have a lower ability to develop towards effector phenotype, and have an increased expression of the markers PD1, TIM3 and LAG3 which are associated with T cell dysfunction and exhaustion. In addition, T cells primed by these dendritic cells in the presence of NK cells upregulate markers CD38, CXCR3 and CCR4, which have been linked to an increased susceptibility to HIV infection. In summary, we add to the current knowledge on HIV immune evasion mechanisms that allow the virus to establish infection, as well as describing mechanisms that govern whether dendritic cells mount danger signaling and an immune response or not.
Book Synopsis Viruses and the Cellular Immune Response by : D. Brian Thomas
Download or read book Viruses and the Cellular Immune Response written by D. Brian Thomas and published by CRC Press. This book was released on 1993-06-23 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a comprehensive review of cell-mediated immunity to viral infection, highlighting aspects relevant to HIV research. Opening chapters discuss antigen processing and presentation, and lymphokine function. Subsequent chapters consider immune responses to individual viruses including: HIV, visn
Book Synopsis Mathematical Immunology of Virus Infections by : Gennady Bocharov
Download or read book Mathematical Immunology of Virus Infections written by Gennady Bocharov and published by Springer. This book was released on 2018-06-12 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph concisely but thoroughly introduces the reader to the field of mathematical immunology. The book covers first basic principles of formulating a mathematical model, and an outline on data-driven parameter estimation and model selection. The authors then introduce the modeling of experimental and human infections and provide the reader with helpful exercises. The target audience primarily comprises researchers and graduate students in the field of mathematical biology who wish to be concisely introduced into mathematical immunology.
Book Synopsis The Role of Plasmacytoid Dendritic Cells in Immune Responses to Influenza Virus Infection by : Amaya Iparraguirre Heydemann
Download or read book The Role of Plasmacytoid Dendritic Cells in Immune Responses to Influenza Virus Infection written by Amaya Iparraguirre Heydemann and published by . This book was released on 2007 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Paola Ricciardi-Castagnoli Publisher :Springer Science & Business Media ISBN 13 :1475799667 Total Pages :566 pages Book Rating :4.4/5 (757 download)
Book Synopsis Dendritic Cells in Fundamental and Clinical Immunology by : Paola Ricciardi-Castagnoli
Download or read book Dendritic Cells in Fundamental and Clinical Immunology written by Paola Ricciardi-Castagnoli and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings contain selected contributions from the participants to the Fourth International Symposium on Dendritic cells that was held in Venice (Lido) Italy, from Oc tober 5 to 10, 1996. The symposium was attended by more than 500 scientists coming from 24 different countries. Studies on dendritic cells (DC) have been greatly hampered by the difficulties in preparing sufficient cell numbers and in a reasonable pure form. At this meeting it has been shown that large quantities of DC can be generated from precursors in both mice and humans, and this possibility has enormously encouraged studies aimed to characterize DC physiology and DC-specific genes, and to employ DC therapeutically as adjuvants for im munization. The possibility of generating large numbers of autologous DC that can be used in the manipulation of the immune response against cancer and infectious diseases has tremendously boosted dendritic cell research and the role of DC in a number of medi cal areas has been heatedly discussed.
Book Synopsis The Role of Dendritic Cells in Epstein-Barr Virus Infection by : Yichen Chen
Download or read book The Role of Dendritic Cells in Epstein-Barr Virus Infection written by Yichen Chen and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "The Role of Dendritic Cells in Epstein-Barr Virus Infection" by Yichen, Chen, 陳以晨, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled The Role of Dendritic Cells in Epstein-Barr Virus Infection Submitted by Chen Yi Chen for the degree of Doctor of Philosophy at the University of Hong Kong In May 2006 Dendritic cells (DCs) are professional antigen-presenting cells and work as the sentinels against infection. Epstein-Barr virus (EBV) is a ubiquitous human B-lymphotropic herpesvirus that is present in more than 95% of the world adults regardless of geographical location. EBV is generally spread among young children, and has been implicated in association with a wide variety of diseases. The role of DCs in the pathogenesis of EBV infection, however, is not clearly understood. By in-situ hybridization, polymerase chain reaction (PCR), reverse transcription coupled-PCR (RT-PCR), western blotting and quantitative PCR analysis, it was demonstrated that both myeloid and plasmacytoid DCs could be latently infected by EBV. In addition, EBV DNA could also be detected in the autologous B cells after co-culturing with EBV-exposed DCs. Since these B cells had no detectable EBV DNA immediately after primary isolation, the results suggested that either DNA or the viral particle might be transmitted from DCs to B cells. Exposure to EBV did not affect the function or survival of myeloid DCs. However, maturation of plasmacytoid DCs induced by CpG-oligonucleotides (CpG-ODN) and their ability to secrete alpha-interferon (IFN-α), a key factor involved in antiviral mechanism of the innate immune system, was impaired by EBV infection. Moreover, - 1 - the maturation and the functions of myeloid DCs could be indirectly affected by EBV through plasmacytoid DCs. When MDC were co-cultured with EBV infected plasmacytoid DCs, its ability to produce inflammatory cytokines such as IL-12 and TNF-alpha were reduced, which may result in a dysregulated anti-viral defense mechanism. Taken together, both myeloid and plasmacytoid DCs are the targets of EBV and can present EBV genome to autologous lymphocytes. On the other hand, EBV can directly affect plasmacytoid DCs maturation and functions, which in turn could impair the maturation of myeloid DC in vicinity. Data presented in the current study reveal possible pathways by which EBV could escape immune surveillance through its suppressive effects on DCs functions. (word count: 316) - 2 - DOI: 10.5353/th_b3747339 Subjects: Dendritic cells Epstein-Barr virus Epstein-Barr virus diseases - Immunological aspects
