Delivery Of Protein And Peptide Drugs In Cancer

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Delivery of Protein and Peptide Drugs in Cancer

Author : Vladimir P Torchilin
Publisher : World Scientific
ISBN 13 : 1783260009
Total Pages : 392 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Delivery of Protein and Peptide Drugs in Cancer by : Vladimir P Torchilin

Download or read book Delivery of Protein and Peptide Drugs in Cancer written by Vladimir P Torchilin and published by World Scientific. This book was released on 2006-04-05 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading scientists in the field of delivery of protein and peptide drugs to tumors for cancer therapy, this important book provides a broad introduction to the field, with discussion by key experts on the physiological barriers for protein and peptide drugs in tumors, and the different approaches to stabilization of these drugs in biological surroundings, as well as their enhanced delivery to tumors and inside cancer cells. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, physiology, experimental and clinical oncology and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting as well as in a more specialized topics of using protein and peptide drugs for tumor therapy. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Contents:Influence of Tumor Physiology on Delivery of Therapeutics (R B Campbell)Enhanced Permeability and Retention (EPR) Effect and Tumor-Selective Delivery of Anticancer Drugs (K Greish et al.)Basic Strategies for PEGylation of Peptide and Protein Drugs (G Pasut et al.)PEGylated Proteins as Cancer Therapeutics (M Morpurgo et al.)PEGylated Proteins in Immunotherapy of Cancer (J F Eliason)Silencing Proteins: Nanotechnological Approaches to Deliver of siRNA for Cancer Therapy (R M Schiffelers et al.)Anti-Cancer Proteins and Peptides in Liposomes (V Torchilin)Folate-Mediated Delivery of Protein and Peptide Drugs into Tumors (J A Reddy et al.)Transferrin Receptor Mediated Delivery of Protein and Peptide Drugs into Tumors (J Fahrmeir & M Ogris)Transmembrane Delivery of Protein and Peptide Drugs into Cancer Cells (C C Saenz & S F Dowdy)Protein and Peptide Drugs to Suppress Tumor Angiogenesis (C Rüegg)Utilizing Lymphatic Transport in Enhancing the Delivery of Drugs, Including Proteins, and Peptides, to Metastatic Tumors (E K Wasan & K M Wasan)Delivery of Protein and Peptide Drugs to Brain Tumors (H B Newton)Protein and Peptide-Based Cancer Gene Therapy (S Chada & R Ramesh) Readership: Graduate students & academics from cancer therapy, protein & peptide drugs, drug delivery, & tumor targeting areas; non-experts interested in drug delivery to tumors. Key Features:Written by leading scientists such as Prof Veronese, Prof Maeda, Prof Dowdy, Prof Torchilin & Prof WasanDetailed explanation of physiological barriers for protein and peptide drugs in tumorsDifferent approaches to the stabilization of proteins and peptides in biological surroundings and their enhanced delivery into tumors and inside cancer cellsKeywords:Cancer;Protein & Peptide Drugs;Delivery;Tumor Physiology;Drug Carriers;Pegylation;Liposomes;Angiogenesis;Lymphatic Transport;Protein Transduction

Peptide and Protein Delivery

Author : Chris Van Der Walle
Publisher : Academic Press
ISBN 13 : 9780123849366
Total Pages : 380 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Peptide and Protein Delivery by : Chris Van Der Walle

Download or read book Peptide and Protein Delivery written by Chris Van Der Walle and published by Academic Press. This book was released on 2011-05-12 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Drug Delivery Systems

Author : Kewal K. Jain
Publisher : Springer Science & Business Media
ISBN 13 : 1588298914
Total Pages : 255 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Drug Delivery Systems by : Kewal K. Jain

Download or read book Drug Delivery Systems written by Kewal K. Jain and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Proteins and Peptides

Author : Randall J. Mrsny
Publisher : CRC Press
ISBN 13 : 1420078070
Total Pages : 288 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Proteins and Peptides by : Randall J. Mrsny

Download or read book Proteins and Peptides written by Randall J. Mrsny and published by CRC Press. This book was released on 2009-10-19 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is

Drug Delivery

Author : Binghe Wang
Publisher : John Wiley & Sons
ISBN 13 : 1118833236
Total Pages : 720 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Drug Delivery by : Binghe Wang

Download or read book Drug Delivery written by Binghe Wang and published by John Wiley & Sons. This book was released on 2016-03-09 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Protein and Peptide Nanoparticles for Drug Delivery

Author :
Publisher : Academic Press
ISBN 13 : 012802870X
Total Pages : 396 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Protein and Peptide Nanoparticles for Drug Delivery by :

Download or read book Protein and Peptide Nanoparticles for Drug Delivery written by and published by Academic Press. This book was released on 2015-03-26 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in a wide bioscience area Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables

Peptide and Peptidomimetic Therapeutics

Author : Nir Qvit
Publisher : Academic Press
ISBN 13 : 0128204478
Total Pages : 792 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Peptide and Peptidomimetic Therapeutics by : Nir Qvit

Download or read book Peptide and Peptidomimetic Therapeutics written by Nir Qvit and published by Academic Press. This book was released on 2022-09-22 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development

Delivery Technologies for Biopharmaceuticals

Author : Lene Jorgensen
Publisher : John Wiley & Sons
ISBN 13 : 0470688408
Total Pages : 442 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Delivery Technologies for Biopharmaceuticals by : Lene Jorgensen

Download or read book Delivery Technologies for Biopharmaceuticals written by Lene Jorgensen and published by John Wiley & Sons. This book was released on 2009-10-23 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

Peptide Drug Delivery to the Brain

Author : William M. Pardridge
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 378 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Peptide Drug Delivery to the Brain by : William M. Pardridge

Download or read book Peptide Drug Delivery to the Brain written by William M. Pardridge and published by Raven Press (ID). This book was released on 1991 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses new and established strategies for delivering peptides and antibodies through the blood-brain barrier. It reviews concepts on blood-brain barrier transport biology, assesses the utility and limitations of traditional brain drug delivery methods and describes new drug delivery techniques.

Intracellular Delivery

Author : Aleš Prokop
Publisher : Springer Science & Business Media
ISBN 13 : 9400712480
Total Pages : 871 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Intracellular Delivery by : Aleš Prokop

Download or read book Intracellular Delivery written by Aleš Prokop and published by Springer Science & Business Media. This book was released on 2011-05-26 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.

Peptide and Protein Drug Delivery Using Polysaccharides

Author : Aakanchha Jain
Publisher : Elsevier
ISBN 13 : 0443189269
Total Pages : 331 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Peptide and Protein Drug Delivery Using Polysaccharides by : Aakanchha Jain

Download or read book Peptide and Protein Drug Delivery Using Polysaccharides written by Aakanchha Jain and published by Elsevier. This book was released on 2023-10-10 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding. Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran. Adopts an interdisciplinary approach across biochemistry, molecular biology, pharmaceutical sciences and drug delivery, and biotechnological perspectives Features accessible figures, tables and graphical abstracts across all chapters to support understanding Examines various polysaccharides of current interest and aspects affecting their absorption, metabolism, excretion and detection

Therapeutic Peptides and Proteins

Author : Ajay K. Banga
Publisher : CRC Press
ISBN 13 : 1466566078
Total Pages : 396 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Therapeutic Peptides and Proteins by : Ajay K. Banga

Download or read book Therapeutic Peptides and Proteins written by Ajay K. Banga and published by CRC Press. This book was released on 2015-04-23 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The c

Multifunctional Theranostic Nanomedicines in Cancer

Author : Malay K. Das
Publisher : Academic Press
ISBN 13 : 0128217006
Total Pages : 428 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Multifunctional Theranostic Nanomedicines in Cancer by : Malay K. Das

Download or read book Multifunctional Theranostic Nanomedicines in Cancer written by Malay K. Das and published by Academic Press. This book was released on 2021-03-16 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines Discusses treatment options from a pharmaceutical sciences perspective Includes translational science and targeted CNS cancer treatment

Frontiers of Engineering

Author : National Academy of Engineering
Publisher : National Academies Press
ISBN 13 : 030945039X
Total Pages : 145 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Frontiers of Engineering by : National Academy of Engineering

Download or read book Frontiers of Engineering written by National Academy of Engineering and published by National Academies Press. This book was released on 2017-01-30 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents papers on the topics covered at the National Academy of Engineering's 2016 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2016 symposium was held September 19-21 at the Arnold and Mabel Beckman Center in Irvine, California. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.

Oral Delivery of Therapeutic Peptides and Proteins

Author : Puneet Tyagi
Publisher : Academic Press
ISBN 13 : 0128210605
Total Pages : 318 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Oral Delivery of Therapeutic Peptides and Proteins by : Puneet Tyagi

Download or read book Oral Delivery of Therapeutic Peptides and Proteins written by Puneet Tyagi and published by Academic Press. This book was released on 2022-08-18 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development

Silk-based Drug Delivery Systems

Author : Elia Bari
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017722
Total Pages : 243 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Silk-based Drug Delivery Systems by : Elia Bari

Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.

Peptides as Drugs

Author : Bernd Groner
Publisher : John Wiley & Sons
ISBN 13 : 3527626840
Total Pages : 242 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Peptides as Drugs by : Bernd Groner

Download or read book Peptides as Drugs written by Bernd Groner and published by John Wiley & Sons. This book was released on 2009-11-18 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs. With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.