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Delineating Health And Health System Mechanistic Insights Into Covid 19 Complications
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Book Synopsis Delineating Health and Health System: Mechanistic Insights into Covid 19 Complications by : R. C. Sobti
Download or read book Delineating Health and Health System: Mechanistic Insights into Covid 19 Complications written by R. C. Sobti and published by Springer Nature. This book was released on 2021-11-30 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It summarizes the neurological aspects of SARS-CoV2, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection. Lastly, it discusses the perturbation of gut microbiota by SARS-CoV-2 and uncovers the potential risk of virus infection on reproductive health.
Book Synopsis New Advances on Zika Virus Research by : Luis Martinez-Sobrido
Download or read book New Advances on Zika Virus Research written by Luis Martinez-Sobrido and published by MDPI. This book was released on 2019-04-02 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.
Book Synopsis Hospital-Based Health Technology Assessment by : Laura Sampietro-Colom
Download or read book Hospital-Based Health Technology Assessment written by Laura Sampietro-Colom and published by Springer. This book was released on 2017-01-23 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely work describing how localized hospital-based health technology assessment (HB-HTA) complements general, ‘arms-length’ HTA agency efforts, and what has been the collective global impact of HB-HTA across the globe. While HB-HTA has gained significant momentum over the past few years, expertise in the field, and information on the operation and organization of HB-HTA, has been scattered. This book serves to bring this information together to inform those who are currently working in the field of HTA at the hospital, regional, national or global level. In addition, this book is intended for decision-makers and policy-makers with a stake in determining the uptake and decommissioning of new and established technologies in the hospital setting. HTA has traditionally been performed at the National/Regional level by HTA Agencies, typically linked to governments. Yet hospitals are the main entry door for most health technologies (HTs). Hospital decision-makers must undertake multiple high stakes investment and disinvestment decisions annually for innovative HTs, usually without adequate information. Despite the existence of arms-length HTA Agencies, inadequate information is available to hospital decision-makers either because relevant HTA reports are not yet released at the time of entry of new technologies to the field, or because even when the report exists, the information contained is insufficient to clarify the contextualized informational needs of hospital decision makers. Therefore, there has recently been a rising trend toward hospital-based HTA units and programs. These units/programs complement the work of National/Regional HTA Agencies by providing the key and relevant evidence needed by hospital decision makers in their specific hospital context, and within required decision-making timelines. The emergence of HB-HTA is creating a comprehensive HTA ecosystem across health care levels, which creates better bridges for knowledge translation through relevance and timeliness.
Book Synopsis Ethical and Legal Considerations in Mitigating Pandemic Disease by : Institute of Medicine
Download or read book Ethical and Legal Considerations in Mitigating Pandemic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2007-07-08 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent public workshops and working group meetings, the Forum on Microbial Threats of the Institute of Medicine (IOM) has examined a variety of infectious disease outbreaks with pandemic potential, including those caused by influenza (IOM, 2005) and severe acute respiratory syndrome (SARS) (IOM, 2004). Particular attention has been paid to the potential pandemic threat posed by the H5N1 strain of avian influenza, which is now endemic in many Southeast Asian bird populations. Since 2003, the H5N1 subtype of avian influenza has caused 185 confirmed human deaths in 11 countries, including some cases of viral transmission from human to human (WHO, 2007). But as worrisome as these developments are, at least they are caused by known pathogens. The next pandemic could well be caused by the emergence of a microbe that is still unknown, much as happened in the 1980s with the emergence of the human immunodeficiency virus (HIV) and in 2003 with the appearance of the SARS coronavirus. Previous Forum meetings on pandemic disease have discussed the scientific and logistical challenges associated with pandemic disease recognition, identification, and response. Participants in these earlier meetings also recognized the difficulty of implementing disease control strategies effectively. Ethical and Legal Considerations in Mitigating Pandemic Disease: Workshop Summary as a factual summary of what occurred at the workshop.
Book Synopsis Mathematical Modelling in Biomedicine by : Vitaly Volpert
Download or read book Mathematical Modelling in Biomedicine written by Vitaly Volpert and published by MDPI. This book was released on 2021-01-26 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modelling in biomedicine is a rapidly developing scientific discipline at the intersection of medicine, biology, mathematics, physics, and computer science. Its progress is stimulated by fundamental scientific questions and by the applications to public health. This book represents a collection of papers devoted to mathematical modelling of various physiological problems in normal and pathological conditions. It covers a broad range of topics including cardiovascular system and diseases, heart and brain modelling, tumor growth, viral infections, and immune response. Computational models of blood circulation are used to study the influence of heart arrhythmias on coronary blood flow and on operating modes for left-ventricle-assisted devices. Wave propagation in the cardiac tissue is investigated in order to show the influence of tissue heterogeneity and fibrosis. The models of tumor growth are used to determine optimal protocols of antiangiogenic and radiotherapy. The models of viral hepatitis kinetics are considered for the parameter identification, and the evolution of viral quasi-species is investigated. The book presents the state-of-the-art in mathematical modelling in biomedicine and opens new perspectives in this passionate field of research.
Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon
Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
Book Synopsis COVID-19 Current Challenges and Future Perspectives by : Anoop Kumar
Download or read book COVID-19 Current Challenges and Future Perspectives written by Anoop Kumar and published by Bentham Science Publishers. This book was released on 2021-03-03 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: COVID-19: Current Challenges and Future Perspectives informs readers about the current status of knowledge on COVID-19 infection. The book begins by presenting basic information about the history, epidemiology, pathogenesis, diagnosis, treatment and preventive measures against COVID-19. The second part of the book contains information about the repurposing of drugs, herbal medicines, and immunotherapy against COVID-19 infections. Integrating both general and advanced information about Sars-cov-2, this book updates a wide range of readers including students, researchers (virologists, pharmacologists), health care professionals (physicians, nurses, pharmacists, paramedics) and the general public on novel coronaviruses and COVID-19.
Book Synopsis Lumpy Skin Disease by : Eeva S. M. Tuppurainen
Download or read book Lumpy Skin Disease written by Eeva S. M. Tuppurainen and published by Springer. This book was released on 2018-07-03 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive but concise overview on the economically important emerging cattle pox virus derived Lumpy Skin Disease, including the characteristics of causative agent, description of clinical signs in cattle, pathology and histopathology, immunity, geographical distribution, epidemiology and transmission pathways, control and eradication of the disease. In addition the recent developments in vaccination, mathematical modeling and risk assessment are discussed. Lumpy Skin Disease currently spreads aggressively across the Middle and Near East. The first incursion to the European Union territory occurred in Greece in autumn 2015. The book targets clinicians and field veterinarians in Lumpy Skin Disease affected regions, veterinary authorities as well as advanced students in veterinary medicine and virology.
Book Synopsis Textbook of Global Health by : Anne-Emanuelle Birn
Download or read book Textbook of Global Health written by Anne-Emanuelle Birn and published by Oxford University Press. This book was released on 2017-01-24 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE CRITICAL WORK IN GLOBAL HEALTH, NOW COMPLETELY REVISED AND UPDATED "This book compels us to better understand the contexts in which health problems emerge and the forces that underlie and propel them." -Archbishop Emeritus Desmond Mpilo Tutu H1N1. Diabetes. Ebola. Zika. Each of these health problems is rooted in a confluence of social, political, economic, and biomedical factors that together inform our understanding of global health. The imperative for those who study global health is to understand these factors individually and, especially, synergistically. Fully revised and updated, this fourth edition of Oxford's Textbook of Global Health offers a critical examination of the array of societal factors that shape health within and across countries, including how health inequities create consequences that must be addressed by public health, international aid, and social and economic policymaking. The text equips students, activists, and health professionals with the building blocks for a contextualized understanding of global health, including essential threads that are combined in no other work: · historical dynamics of the field · the political economy of health and development · analysis of the current global health structure, including its actors, agencies, and activities · societal determinants of health, from global trade and investment treaties to social policies to living and working conditions · the role of health data and measuring health inequities · major causes of global illness and death, including under crises, from a political economy of health vantage point that goes beyond communicable vs. non-communicable diseases to incorporate contexts of social and economic deprivation, work, and globalization · the role of trade/investment and financial liberalization, precarious work, and environmental degradation and contamination · principles of health systems and the politics of health financing · community, national, and transnational social justice approaches to building healthy societies and practicing global health ethically and equitably Through this approach the Textbook of Global Health encourages the reader -- be it student, professional, or advocate -- to embrace a wider view of the global health paradigm, one that draws from political economy considerations at community, national, and transnational levels. It is essential and current reading for anyone working in or around global health.
Download or read book Stigma written by Gerhard Falk and published by Prometheus Books. This book was released on 2010-04-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is it in human nature that leads us to label some as insiders and stigmatize others as outsiders?Sociologist Gerhard Falk examines the social psychology that motivates this process of exclusion, focusing on the outcasts in contemporary American society and comparing current experience with examples from the past. Referring to the work of Emile Durkheim and Erving Goffman, Falk reviews the whole range of stigmatized people from the mentally ill to ordinary people with unpopular occupations, like undertakers and trash collectors. Amid the wide diversity of stigmatized persons, he finds two basic types of outsiders: the "existential" and the "achieved." The first group comprises those who are stigmatized because of their very existence, regardless of their specific actions: the mentally handicapped, for example. The second group describes those whose actions or life conditions have resulted in stigma: from high achievers (often subject to resentment) to criminals. Falk also looks at the ways in which writers past and present have dramatized stigmatized characters in literature.This fascinating overview of a long-standing and widespread social problem will be of interest to all those concerned about creating a more fair-minded society.
Download or read book METABIOTICS written by Boris A. Shenderov and published by Springer Nature. This book was released on 2020-02-13 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aimed at students, researchers, nutritionists, and developers in food technology, this research text addresses the nascent field of metabiotics. Metabiotics are products based on components of cells, metabolites, and signaling molecules released by probiotic strains, engineered to optimize host-specific physiological functions in a way that traditional probiotics cannot. This book examines the history, processes, design, classifications, and functions of metabiotics. It includes an overview of the composition and function of the gut microbiota, and discusses development of target-specific metabiotics. Further coverage includes comparisons to traditional probiotics, as well as probiotic safety and side-effects. Metabiotics: Present State, Challenges and Perspectives provides a complete history and understanding of this new field, the next phase of the probiotic industry.
Book Synopsis Genome-Scale Algorithm Design by : Veli Mäkinen
Download or read book Genome-Scale Algorithm Design written by Veli Mäkinen and published by Cambridge University Press. This book was released on 2023-10-12 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guided by standard bioscience workflows in high-throughput sequencing analysis, this book for graduate students, researchers, and professionals in bioinformatics and computer science offers a unified presentation of genome-scale algorithms. This new edition covers the use of minimizers and other advanced data structures in pangenomics approaches.
Book Synopsis Electrochemical Biosensors by : Serge Cosnier
Download or read book Electrochemical Biosensors written by Serge Cosnier and published by CRC Press. This book was released on 2015-01-26 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
Book Synopsis Toxicological Survey of African Medicinal Plants by : Victor Kuete
Download or read book Toxicological Survey of African Medicinal Plants written by Victor Kuete and published by Elsevier. This book was released on 2014-05-30 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicological Survey of African Medicinal Plants provides a detailed overview of toxicological studies relating to traditionally used medicinal plants in Africa, with special emphasis on the methodologies and tools used for data collection and interpretation. The book considers the physical parameters of these plants and their effect upon various areas of the body and human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.Following this discussion of the effects of medicinal plants is a critical review of the guidelines and methods in use for toxicological research as well as the state of toxicology studies in Africa. With up-to-date research provided by a team of experts, Toxicological Survey of African Medicinal Plants is an invaluable resource for researchers and students involved in pharmacology, toxicology, phytochemistry, medicine, pharmacognosy, and pharmaceutical biology. - Offers a critical review of the methods used in toxicological survey of medicinal plants - Provides up-to-date toxicological data on African medicinal plants and families - Serves as a resource tool for students and scientists in the various areas of toxicology
Book Synopsis Replication-Competent Reporter-Expressing Viruses by : Luis Martinez-Sobrido
Download or read book Replication-Competent Reporter-Expressing Viruses written by Luis Martinez-Sobrido and published by . This book was released on 2016 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Recombinant viruses expressing reporter fluorescent or bioluminescent proteins are an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of viral infection. Reporter proteins are valid surrogates for direct detection of infected cells in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating the need of secondary labeling, tractable replicating-competent, reporter-expressing viruses provide an ideal approach to monitor viral infections in real time, representing a significant advance in the study of the biology of viruses, to evaluate vaccination approaches, and to identify new therapeutics against viral infections using high-throughput screening settings. In this Special Issue "Replication-Competent Reporter-Expressing Viruses" we review replication-competent, reporter-expressing viruses belonging to different families, methods of characterization, and applications to facilitate the study of in vitro and in vivo viral infections. We also seek to discuss disadvantages and limitations associated with these reporter-expressing viruses. Finally, we provide rational future perspectives and additional avenues for the development, characterization, and applications of recombinant, reporter-expressing, competent viruses.
Book Synopsis The Logic of Failure by : Dietrich Dörner
Download or read book The Logic of Failure written by Dietrich Dörner and published by . This book was released on 1997 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do we make mistakes? Are there certain errors common to failure, whether in a complex enterprise or daily life? In this truly indispensable book, Dietrich Dörner identifies what he calls the?logic of failure??certain tendencies in our patterns of thought that, while appropriate to an older, simpler world, prove disastrous for the complex world we live in now. Working with imaginative and often hilarious computer simulations, he analyzes the roots of catastrophe, showing city planners in the very act of creating gridlock and disaster, or public health authorities setting the scene for starvation. The Logic of Failure is a compass for intelligent planning and decision-making that can sharpen the skills of managers, policymakers and everyone involved in the daily challenge of getting from point A to point B. -- Publisher description.
Download or read book Neuroprotection written by Bae Hwan Lee and published by Mdpi AG. This book was released on 2021-09-27 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dear Colleagues, The brain is vulnerable to injury. Following injury in the brain, apoptosis or necrosis may occur easily, leading to various functional disabilities. Neuronal death is associated with a number of neurological disorders including hypoxic ischemia, epileptic seizures, and neurodegenerative diseases. The brain subjected to injury is regarded to be responsible for the alterations in neurotransmission processes, resulting in functional changes. Oxidative stress produced by reactive oxygen species has been shown to be related to the death of neurons in traumatic injury, stroke, and neurodegenerative diseases. Therefore, scavenging or decreasing free radicals may be crucial for preventing neural tissues from harmful adversities in the brain. Neurotrophic factors, bioactive compounds, dietary nutrients, or cell engineering may ameliorate the pathological processes related to neuronal death or neurodegeneration and appear beneficial for improving neuroprotection. As a result of neuronal death or neuroprotection, the brain undergoes activity-dependent long-lasting changes in synaptic transmission, which is also known as functional plasticity. Neuroprotection implying the rescue from neuronal death is now becoming one of global health concerns. This Special Issue attempts to explore the recent advances in neuroprotection related to the brain. This Special Issue welcomes original research or review papers demonstrating the mechanisms of neuroprotection against brain injury using in vivo or in vitro models of animals as well as in clinical settings. The issues in a paper should be supported by sufficient data or evidence. Prof. Bae Hwan Lee Guest Editor
