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Decellularized Materials
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Book Synopsis Decellularized Materials by : Xiaoming Li
Download or read book Decellularized Materials written by Xiaoming Li and published by Springer Nature. This book was released on 2021-04-28 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will consist of 8 chapters, in which important issues regarding decellularized materials (DMs) will be discussed. This book will provide special knowledge of materials for the persons with biomedical background, and special biomedical knowledge for the persons with the background of materials, which will hopefully become a valuable informative read for the researchers and students of biomedical engineering major.
Book Synopsis Decellularized Extracellular Matrix by : Takashi Hoshiba
Download or read book Decellularized Extracellular Matrix written by Takashi Hoshiba and published by Royal Society of Chemistry. This book was released on 2019-12-05 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using this book, the reader will gain a good foundation to the field complemented with a broad overview of characterisation, microfabrication and applications.
Book Synopsis Decellularized Scaffolds and Organogenesis by : Kursad Turksen
Download or read book Decellularized Scaffolds and Organogenesis written by Kursad Turksen and published by Humana Press. This book was released on 2018-07-21 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical, hands-on volume examines the use of decellularized tissues and organs as biologically-active scaffolds by providing numerous approaches from experts in the field. While knowledge of how to grow and differentiate cells in culture has dramatically improved over time, the book addresses the challenges of how to instruct particular cells of interest to recognize and respond to their environment so as to proliferate, differentiate, and function for restoration of original tissue and organ form and function. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Decellularized Scaffolds and Organogenesis: Methods and Protocols share novel approaches and insights that will provide new opportunities for those already in the field or moving to enter the field.
Book Synopsis Decellularized Extracellular Matrix by : Tetsuji Yamaoka
Download or read book Decellularized Extracellular Matrix written by Tetsuji Yamaoka and published by Royal Society of Chemistry. This book was released on 2019-12-05 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix (ECM) supports cells and regulates various cellular functions in our body. The native ECM promises to provide an excellent scaffold for regenerative medicine. In order to use the ECM as a scaffold in medicine, its cellular fractions need to be removed while retaining its structural and compositional properties. This process is called decellularization, and the resulting product is known as the decellularized extracellular matrix (dECM). This book focuses on the sources of dECM and its preparation, characterization techniques, fabrication, and applications in regenerative medicine and biological studies. Using this book, the reader will gain a good foundation in the field of ECM decellularization complemented with a broad overview of dECM characterization, ranging from structural observation and compositional assessment to immune responses against dECM and applications, ranging from microfabrication and 3D-printing to the application of tissue-derived dECM in vascular grafts and corneal tissue engineering etc. The book closes with a section dedicated to cultured cell dECM, a complementary technique of tissue-derived dECM preparation, for application in tissue engineering and regenerative medicine, addressing its use in stem cell differentiation and how it can help in the study of the tumor microenvironment as well as in clinical trials of peripheral nerve regeneration.
Book Synopsis Decellularization Methods of Tissue and Whole Organ in Tissue Engineering by : Abdol-Mohammad Kajbafzadeh
Download or read book Decellularization Methods of Tissue and Whole Organ in Tissue Engineering written by Abdol-Mohammad Kajbafzadeh and published by Springer Nature. This book was released on 2021-09-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume is the first of a series that introduces safe, feasible, and practical decellularization and recellularization techniques for tissue and organ reconstruction. We have put special emphasis on the research areas most likely to develop well-engineered scaffolds for tissue and organ engineering, while presenting easily applicable bench-to-bedside approaches highlighting the latest technical innovations in the field. This book includes both a fundamental discussion for a broad understanding of the basis of tissue repair and substitution, as well as chapters written by world renowned specialists from 20 countries providing deeper discussions and analysis of related sub disciplines. Within these pages, the reader will find state-of-the-art protocols and current clinical challenges in cell and tissue biology, including accurate and comprehensive information on extracellular matrices, natural biomaterials, tissue dynamics, morphogenesis, stem cells, cellular fate progressions, cell and tissue properties for in-vitro and in-vivo applications. This comprehensive and carefully organized treatise provides a clear framework for graduate students and postdoctoral researchers new to the field, but also for researchers and practitioners looking to expand their knowledge on tissue and organ reconstruction.
Book Synopsis Musculoskeletal Tissue Regeneration by : William S. Pietrzak
Download or read book Musculoskeletal Tissue Regeneration written by William S. Pietrzak and published by Springer Science & Business Media. This book was released on 2008-04-11 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.
Book Synopsis Decellularized Biomaterials for Cell Culture and Repair After Ischemic Injury by : Jessica Ann DeQuach
Download or read book Decellularized Biomaterials for Cell Culture and Repair After Ischemic Injury written by Jessica Ann DeQuach and published by . This book was released on 2012 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ischemic disease, which involves tissue death and dysfunction due to vessel blockage, is one of the largest causes of morbidity and mortality across the world. Ischemia that targets the brain can lead to a stroke, which causes functional impairment. Blockage of the coronary artery can lead to a myocardial infarction (MI) which can eventually lead to heart failure. Ischemia of the vessels in the skeletal muscle causes peripheral artery disease, which can lead to tissue damage that may necessitate amputation of the affected limb. The severity of the downstream effects of ischemia indicates the need for some sort of treatment to repair the tissue after ischemic attack. Yet, there are few clinical treatments available for patients, creating a need for novel therapies for treating this disease. The use of biomaterials in tissue engineering strategies have recently been studied to alleviate these conditions, however this approach has been met with limited success as many of these therapies require an invasive surgery for delivery to the affected site. Injectable biomaterials offer the advantage of minimally invasive delivery to improve patient outcomes, which would be attractive to reduce patient recovery time. The materials that have been studied often do not mimic the microenvironment of the tissue that it is trying to repair. This is similar to how cells are often cultured on a substrate that do not mimic the in vivo environment, which may be important for assessing cellular function. Thus, the objective of this dissertation was to generate biomaterials derived from decellularized tissue from the brain, skeletal muscle, and cardiac tissue, and test whether they could be used as cell culture platforms that would provide biomimetic substrates and be used as scaffolds for tissue engineering. In this work, I have developed a method to decellularize each tissue leaving behind only the extracellular matrix. The matrix material was then characterized using gel electrophoresis, mass spectrometry, glycosaminoglycan quantification and DNA quantification, indicating that the cellular remnants have been removed, but that the biocomplexity has been retained. These tissue specific biomaterials were tested as a cell culture coating platform in vitro and as a potential therapy for ischemia in vivo. The material was enzymatically digested and used as a cell culture coating and compared to conventionally used substrates. It was found that progenitor cells cultured on the tissue-matched coatings display a more mature morphology on the decellularized extracellular matrix (ECM) coatings. For instance, skeletal muscle progenitors differentiate into larger, thicker myotubes, cardiomyocytes derived from human embryonic stem cells localize their intracellular junctions into a more mature organization, and neurons from induced pluripotent stem cells display a clear axon and increased dendritic branching. The maturation of these cell types on the coatings demonstrate a more in vivo like phenotype which could be useful for studying cellular behavior and to translate in vitro findings into an in vivo setting. This material was able to self-assemble upon injection in vivo, forming a nanofibrous and porous scaffold that could be used as an injectable biomaterial for ischemic repair. Additionally, in vitro assays measuring proliferation and migration show that some of the matrix materials act as a chemoattractant and as a mitogenic agent on cells in culture. The skeletal muscle matrix has been used in a rat hindlimb ischemia model and compared to a collagen scaffold. It was shown that the skeletal muscle matrix stimulates increased neovascularization, which is important for bringing blood flow to an ischemic region, as well as recruits endogenous muscle progenitor cells into the scaffold. The cardiac matrix is able to gel in situ upon injection and has been explored by others in our lab. The brain matrix was also able to self-assemble and form a gel after subcutaneous injection into a mouse, demonstrating proof-of-concept for its use as a tissue engineering scaffold. To investigate whether the material might be derived from an allogeneic source instead of from porcine origin, the decellularization process was also performed on human cardiac tissue. It was found that additional steps were needed to fully decellularize the material and render it into a usable form. However, this could provide a potentially allogeneic source for this material. This work demonstrates that decellularized extracellular matrices derived from various tissues provide a biomimetic platform for cell culture that increases maturation of progenitor and stem cells cultured upon the surface. The maturation of these cells could be important for understanding and regulating cellular processes. The same material can be used as an injectable scaffold that could be delivered through minimally invasive means to treat ischemic damage in the brain, heart and skeletal muscle. When applied in a hindlimb ischemia model, the skeletal muscle matrix is able to increase neovascularization, recruit more muscle progenitor cells, and recruit more proliferating muscle cells when compared to a collagen control. This work shows that decellularized matrices hold great potential for both in vitro and in vivo applications.
Book Synopsis Scaffolds for Tissue Engineering by : Claudio Migliaresi
Download or read book Scaffolds for Tissue Engineering written by Claudio Migliaresi and published by CRC Press. This book was released on 2014-06-10 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scaffolds for tissue engineering are devices that exploit specific and complex physical and biological functions, in vitro or in vivo, and communicate through biochemical and physical signals with cells and, when implanted, with the body environment. Scaffolds are produced mainly with synthetic materials, and their fabrication technologies are deri
Book Synopsis Biofabrication and 3D Tissue Modeling by : Dong-Woo Cho
Download or read book Biofabrication and 3D Tissue Modeling written by Dong-Woo Cho and published by Royal Society of Chemistry. This book was released on 2019-01-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field.
Book Synopsis Cells and Materials for Disease Modeling and Regenerative Medicine by : Ander Abarrategi
Download or read book Cells and Materials for Disease Modeling and Regenerative Medicine written by Ander Abarrategi and published by MDPI. This book was released on 2021-05-05 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.
Book Synopsis Handbook of the Extracellular Matrix by : F. Raquel Maia
Download or read book Handbook of the Extracellular Matrix written by F. Raquel Maia and published by Springer Nature. This book was released on with total page 1322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomimetic Materials for Tissue Regenerations, 2nd edition by : Mariappan Rajan
Download or read book Biomimetic Materials for Tissue Regenerations, 2nd edition written by Mariappan Rajan and published by Frontiers Media SA. This book was released on 2022-10-20 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: In tissue engineering, the ultimate goal is to engineer an entire functioning organ that requires building complex structures of different tissue types. A three-dimensional scaffold seeded with desired cell types. In order to resemble the natural formations of the organs, cells have to be correctly located in relation to one another. It has been shown in cocultures that cells have the capability of spontaneous tissue-like organization when seeded into the scaffold. The ideal scaffolds should have an interconnected porous structure, well-designed pore size and adequate porosity to allow cell attachment, proliferation and differentiation. Moreover, effective bioactive agents and nutrient exchange are crucial during new tissue development. Thus the individual organ cell is a specific mechanism for the construction or regeneration of the cells. Artificial scaffolds have been applied and used as supporting structures for cell cultures as well as for the domination of cell growth in the repair of impaired tissues or organs. During the cell regeneration, the scaffold temporarily helps in cell regeneration and gradually biodegrade either in the course of the healing process or after, and a new tissue with a desired shape and properties is produced. The challenge of tissue engineering is to mimic what happens in nature. Attempts are being made to engineer in vitro practically every tissue and organ in the body. Work is proceeding in creating tissue-engineered liver, nerve, kidney, intestine, pancreas, and even heart muscle and valves. In the area of connective tissues, work has been ongoing worldwide for many years in the engineering of tendon, ligament, bone, and cartilage. Recently, the number of reports was succeeded in skin, bladder, airway, and bone, where tissue-engineered constructs have been used successfully in patients. This Research Topic is the collection of body organ regeneration materials and their cell adhesion and migration for the development and regeneration of tissues. Biomimetic materials promise to advance in current understanding of organ regeneration and repair by providing tools to recapitulate and monitor relevant properties of cellular - microenvironment interactions. Although cell adhesion, migration, and development aspects of tissues have shown success in the clinic, better, more intricate models are needed to understand drivers of tissue repair and regeneration fully. Tissue engineering bears tremendous potential toward gaining a complete understanding of the underlying biological and physical mechanisms advancing the treatment of damaged organs. The following Research Topic “Bio-mimetic materials for tissue regenerations” discusses examples of progress toward this objective. • Bio-mimicking scaffold materials for tissue regeneration • Cell adhesion to scaffold materials • Role of materials for the migration of cells • Mechanisms of cell growth for organ development
Book Synopsis Biomimetic Medical Materials by : Insup Noh
Download or read book Biomimetic Medical Materials written by Insup Noh and published by Springer. This book was released on 2018-11-23 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.
Book Synopsis Biomaterials for Skin Repair and Regeneration by : Elena Garcia-Gareta
Download or read book Biomaterials for Skin Repair and Regeneration written by Elena Garcia-Gareta and published by Woodhead Publishing. This book was released on 2019-06-05 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for Skin Repair and Regeneration examines a range of materials and technologies used for regenerating or repairing skin. With a strong focus on biomaterials and scaffolds, the book also examines the testing and evaluation pathway for human clinical trials. Beginning by introducing the fundamentals on skin tissue, the book goes on to describe contemporary technology used in skin repair as well as currently available biomaterials suitable for skin tissue repair and regeneration. Skin tissue engineering and the ideal requirements to take into account when developing skin biomaterials are discussed, followed by information on the individual materials used for skin repair and regeneration. As evaluation of biomaterials in animal models is mandatory before proceeding into human clinical trials, the book also examines the different animal models available. With a strong focus on materials, engineering, and application, this book is a valuable resource for materials scientists, skin biologists, and bioengineers with an interest in tissue engineering, regeneration, and repair of skin. - Provides an understanding of basic skin biology - Comprehensively examines a variety of biomaterial approaches - Looks at animal models for the evaluation of biomaterial-based skin constructs
Book Synopsis Engineering Materials for Stem Cell Regeneration by : Faheem A. Sheikh
Download or read book Engineering Materials for Stem Cell Regeneration written by Faheem A. Sheikh and published by Springer. This book was released on 2022-10-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the interface of stem cell biology and biomaterials for regenerative medicine. It presents the applications of biomaterials to support stem cell growth and regeneration. The book discusses the stem cell interactions’ with nanofiber, gradient biomaterial, polymer- and ceramic biomaterials, integrating top-down and bottom-up approaches, adhesive properties of stem cells on materials, cell-laden hydrogels, micro-and nanospheres, de-cellularization techniques, and use of porous scaffolds. Further, this book provides a basic introduction to the fabrication techniques for creating various biomaterials that can be used for stem cell differentiation. It also elucidates the properties of stem cells, their characteristic features, tissue culture technology, properties of pluripotency, osteogenesis, and biomaterial interaction with de-cellularized organs, cell lineage in vivo and in vitro, gene expression, embryonic development, and cell differentiation. Further, the book reviews the latest applications of bio-instructive scaffold for supporting stem cell differentiation and tissue regeneration. The book also presents stem cell for dental, alveolar bone and cardiac regeneration. Lastly, it introduces engineered stem cells for delivering small molecule therapeutics and their potential biomedical applications.
Book Synopsis Encyclopedia of Biomedical Engineering by :
Download or read book Encyclopedia of Biomedical Engineering written by and published by Elsevier. This book was released on 2018-09-01 with total page 2069 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Biomedical Engineering, Three Volume Set is a unique source for rapidly evolving updates on topics that are at the interface of the biological sciences and engineering. Biomaterials, biomedical devices and techniques play a significant role in improving the quality of health care in the developed world. The book covers an extensive range of topics related to biomedical engineering, including biomaterials, sensors, medical devices, imaging modalities and imaging processing. In addition, applications of biomedical engineering, advances in cardiology, drug delivery, gene therapy, orthopedics, ophthalmology, sensing and tissue engineering are explored. This important reference work serves many groups working at the interface of the biological sciences and engineering, including engineering students, biological science students, clinicians, and industrial researchers. Provides students with a concise description of the technologies at the interface of the biological sciences and engineering Covers all aspects of biomedical engineering, also incorporating perspectives from experts working within the domains of biomedicine, medical engineering, biology, chemistry, physics, electrical engineering, and more Contains reputable, multidisciplinary content from domain experts Presents a ‘one-stop’ resource for access to information written by world-leading scholars in the field
Book Synopsis Vascular and Valvular Tissue Engineering: Treating and modeling vasculopathies and valvulopathies by : Laura Iop
Download or read book Vascular and Valvular Tissue Engineering: Treating and modeling vasculopathies and valvulopathies written by Laura Iop and published by Frontiers Media SA. This book was released on 2022-12-23 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
